{"id":33835,"date":"2019-04-16T00:10:57","date_gmt":"2019-04-15T16:10:57","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33835"},"modified":"2019-04-12T15:02:26","modified_gmt":"2019-04-12T07:02:26","slug":"%e9%98%bb%e6%96%b7%e7%98%a7%e7%96%be%e6%96%b0%e6%96%b9%e6%b3%95%ef%bc%81%e7%9b%b4%e6%8e%a5%e6%b2%bb%e5%a5%bd%e8%9a%8a%e9%ab%94%e5%85%a7%e7%9a%84%e7%98%a7%e5%8e%9f%e8%9f%b2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33835","title":{"rendered":"\u963b\u65b7\u7627\u75be\u65b0\u65b9\u6cd5\uff01\u76f4\u63a5\u6cbb\u597d\u868a\u9ad4\u5167\u7684\u7627\u539f\u87f2"},"content":{"rendered":"

\u60f3\u963b\u65b7\u868a\u5b50\u50b3\u64ad\u7627\u75be\u7b49\u53ef\u6015\u7684\u75be\u75c5\uff0c\u6700\u7c21\u55ae\u7c97\u66b4\u4e4b\u65b9\u6cd5\u5c31\u662f\u6d88\u6ec5\u5b83\uff0c\u53ef\u4ee5\u904b\u7528\u4f60\u7684\u5982\u4f86\u795e\u638c\u3001\u96fb\u868a\u62cd\u3001\u6bba\u87f2\u5291\u7b49\u9019\u4e9b\u6ec5\u868a\u6cd5\u5bf6\u3002\u4e0d\u904e\uff0c\u9664\u4e86\u63a1\u53d6\u6ec5\u868a\u624b\u6bb5\u4f86\u675c\u7d55\u7627\u75be\uff0c\u79d1\u5b78\u5bb6\u6700\u8fd1\u767c\u73fe\u76f4\u63a5\u6cbb\u597d\u868a\u9ad4\u5167\u7684\u7627\u539f\u87f2\uff0c\u6216\u8a31\u4e0d\u5931\u70ba\u53e6\u4e00\u7a2e\u6709\u6548\u7684\u7b56\u7565\u3002<\/span><\/strong><\/p>\n

\"\"
\u5716\u7247\u51fa\u8655 @pixnio<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u25cf\u7627\u868a\u51fa\u73fe\u6297\u85e5\u6027\u5df2\u662f\u5168\u7403\u516c\u5171\u885b\u751f\u554f\u984c<\/strong><\/span><\/p>\n

\u7576\u5929\u6c23\u9010\u6f38\u71b1\u8d77\u4f86\u6642\uff0c\u868a\u5b50\u5011\u53c8\u958b\u59cb\u8822\u8822\u6b32\u52d5\uff0c\u7531\u96cc\u6027\u7627\u868a (Anopheles) \u53ee\u54ac\u4eba\u985e\u50b3\u67d3\uf9b9\u6027\u7627\u539f\u87f2 (Plasmodium falciparum<\/em>) \u6240\u5c0e\u81f4\u7684\u7627\u75be (malaria)\uff0c\u6bcf\u5e74\u9020\u6210\u5168\u7403\u6578\u5341\u842c\u4eba\u6b7b\u4ea1\u3002\u904e\u53bb\u901a\u904e\u5927\u898f\u6a21\u767c\u653e\u7d93\u6bba\u87f2\u5291\u8655\u7406\u904e\u7684\u868a\u5e33\uff0c\u4f86\u9632\u6b62\u9019\u4e9b\u5bc4\u751f\u87f2\u50b3\u64ad\uff0c\u7372\u5f97\u4e86\u6975\u5927\u7684\u6210\u529f\uff0c\u56e0\u7627\u75be\u6b7b\u4ea1\u7684\u4eba\u6578\u4e5f\u7a7a\u524d\u51cf\u5c11\u3002<\/p>\n

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\u25cf\u868a\u5e33\u6dfb\u52a0\u6297\u7627\u75be\u85e5\u7269\u5c31\u80fd\u963b\u65b7\u7627\u539f\u87f2\u50b3\u64ad<\/strong><\/span><\/p>\n

\u96d6\u7136\u6ec5\u868a\u7684\u65b9\u6cd5\u5404\u6709\u5343\u79cb\uff0c\u4f46\u9020\u6210\u7627\u75be\u4e26\u975e\u662f\u868a\u5b50\u7684\u539f\u7f6a\uff0c\u4e8b\u5be6\u4e0a\u53ef\u6068\u7684\u5143\u51f6\u662f\u5bc4\u751f\u5728\u868a\u5b50\u9ad4\u5167\u7684\u7627\u539f\u87f2\uff0c\u868a\u5b50\u53ea\u662f\u53d7\u9023\u7d2f\u7684\u4ee3\u7f6a\u7f94\u7f8a\u3002\u4e0d\u904e\uff0c\u6700\u8fd1\u54c8\u4f5b\u5927\u5b78\u7684\u79d1\u5b78\u5bb6\u627e\u5230\u6709\u8da3\u7684\u66ff\u4ee3\u65b9\u6848\uff0c\u4e26\u767c\u8868\u5728\u91cd\u91cf\u7d1a\u7684 Nature <\/em>\u671f\u520a\u4e0a\uff0c\u5176\u65b9\u6cd5\u662f\u4e0d\u6bba\u868a\u5b50\uff0c\u800c\u662f\u76f4\u63a5\u6cbb\u597d\u868a\u9ad4\u5167\u7684\u7627\u539f\u87f2\uff0c\u5047\u5982\u868a\u5b50\u4e0d\u5e36\u6709\u75c5\u539f\uff0c\u5c31\u7b97\u4eba\u985e\u88ab\u53ee\u54ac\u4e5f\u4e0d\u6703\u611f\u67d3\u75be\u75c5\u3002<\/p>\n

\u6b64\u7814\u7a76\u7684\u5be6\u9a57\u65b9\u6cd5\uff0c\u662f\u85c9\u7531\u5e38\u7528\u5728\u6cbb\u7642\u548c\u9810\u9632\u4eba\u985e\u7684\u6297\u7627\u75be\u85e5\u7269\u300catovaquone\u300d\uff0c\u5c07\u6b64\u85e5\u7269\u5857\u62b9\u5728\u73bb\u7483\u8868\u9762\u4e0a\uff0c\u8b93\u96cc\u868a\u80fd\u5920\u505c\u7559\u5728\u5857\u85e5\u8868\u9762\uff0c\u4e26\u901a\u904e\u868a\u5b50\u817f\u90e8\u4f86\u5438\u6536\u85e5\u7269\uff0c\u7136\u5f8c\u6e2c\u8a66\u96cc\u868a\u5728\u611f\u67d3\u7627\u539f\u87f2\u7684\u524d\u5f8c\uff0c\u6bd4\u8f03\u85e5\u7269\u6fc3\u5ea6\u9ad8\u4f4e\u53ca\u505c\u7559\u6642\u9593\u9577\u77ed\u5c0d\u7627\u539f\u87f2\u7684\u5f71\u97ff\u3002\u7d50\u679c\u767c\u73fe\uff0c\u5373\u4f7f\u5728 atovaquone \u5f88\u4f4e\u6fc3\u5ea6 10 \u03bcmol\/m2<\/sup> \u505c\u7559\u77ed\u77ed\u7684 6 \u5206\u9418\uff0c\u4e5f\u8db3\u4ee5\u6d88\u6ec5\u96cc\u868a\u9ad4\u5167\u7684\u5927\u90e8\u5206\u7627\u539f\u87f2\u3002<\/p>\n

\u79d1\u5b78\u5bb6\u63a5\u8457\u904b\u7528\u7627\u75be\u50b3\u64ad\u6a21\u578b\u9810\u6e2c\uff0c\u6a21\u64ec\u5c07 atovaquone \u6dfb\u52a0\u81f3\u6bba\u87f2\u5291\u8655\u7406\u904e\u7684\u868a\u5e33\uff0c\u66f4\u80fd\u5920\u63d0\u9ad8\u868a\u5e33\u5c0d\u6297\u7627\u75be\u7684\u6709\u6548\u6027\u3002\u6b64\u5916\uff0c\u5176\u4ed6\u8207 atovaquone \u4f5c\u7528\u985e\u4f3c\u7684\u4e0d\u540c\u7d30\u80de\u8272\u7d20 b\u6291\u5236\u5291 (cytochrome b inhibitor)\uff0c\u4e5f\u53ef\u4ee5\u9054\u5230\u6d88\u6ec5\u96cc\u868a\u9ad4\u5167\u7627\u539f\u87f2\u7684\u6548\u679c\u3002\u9019\u610f\u5473\u8457\u672a\u4f86\u5728\u8861\u91cf\u5316\u5b78\u7269\u8cea\u6bd2\u6027\u3001\u914d\u65b9\u3001\u6210\u672c\u548c\u7a69\u5b9a\u6027\u7b49\u56e0\u7d20\u5f8c\uff0c\u9019\u7a2e\u6dfb\u52a0\u6297\u7627\u75be\u85e5\u7269\u7684\u868a\u5e33\uff0c\u80fd\u5920\u6210\u70ba\u963b\u65b7\u7627\u75be\u50b3\u64ad\u7684\u65b0\u7b56\u7565\uff0c\u800c\u4e14\u65b9\u4fbf\u6709\u6548\u3001\u53ef\u884c\u6027\u53c8\u9ad8\u3002<\/p>\n

\u7c21\u55ae\u4f86\u8aaa\uff0c\u8cab\u7a7f\u6b64\u7814\u7a76\u7684\u4e2d\u5fc3\u601d\u60f3\uff0c\u5c31\u662f\u5c07\u6cbb\u7642\u4eba\u985e\u7684\u6297\u7627\u75be\u85e5\u7269\uff0c\u76f4\u63a5\u7528\u5728\u7627\u868a\u8eab\u4e0a\u3002<\/p>\n

\u25cf\u76f4\u63a5\u628a\u5168\u4e16\u754c\u7684\u868a\u5b50\u64b2\u6ec5<\/strong>\uff0c<\/strong>\u4e0d\u597d\u55ce\uff1f<\/strong><\/span><\/p>\n

\u70ba\u4ec0\u9ebc\u8981\u7528\u9019\u9ebc\u8fc2\u8ff4\u7684\u6230\u8853\uff0c\u96e3\u9053\u9019\u597d\u6bd2\u3001\u53c8\u4ee4\u4eba\u53ad\u60e1\u7684\u868a\u5b50\u4e0d\u80fd\u5168\u90e8\u64b2\u6ec5\u5c31\u597d\uff1f\u9996\u5148\u7121\u89e3\u7684\u554f\u984c\u662f\uff0c\u868a\u5b50\u5e7e\u4e4e\u958b\u59cb\u5c0d\u5404\u7a2e\u6bba\u87f2\u5291\u7522\u751f\u6297\u85e5\u6027\uff0c\u5176\u9811\u5f37\u7684\u751f\u547d\u529b\u5c31\u50cf\u662f\u91ce\u8349\u822c\uff0c\u91ce\u706b\u71d2\u4e0d\u76e1\uff0c\u6625\u98a8\u5439\u53c8\u751f\u3002\u800c\u8d95\u76e1\u6bba\u7d55\u7684\u8fa8\u6cd5\uff0c\u53ef\u80fd\u53c8\u5c0d\u81ea\u7136\u751f\u614b\u7cfb\u7d71\u9020\u6210\u4e0d\u5229\u7684\u5f71\u97ff\uff0c\u5343\u842c\u5225\u55ae\u7d14\u7684\u4ee5\u70ba\u868a\u5b50\u53ea\u6709\u5438\u8840\u89d2\u8272\uff0c\u868a\u5b50\u4e5f\u64d4\u7576\u8a31\u591a\u690d\u7269\u7684\u91cd\u8981\u6388\u7c89\u8005\uff0c\u6216\u662f\u5176\u4ed6\u751f\u7269\u5982\u6606\u87f2\u3001\u9752\u86d9\u3001\u9b5a\u985e\u3001\u9ce5\u985e\u7684\u4e3b\u8981\u98df\u7269\u4f86\u6e90\u3002\u6240\u4ee5\uff0c\u5c31\u7b97\u60f3\u8981\u6d88\u6ec5\u868a\u5b50\uff0c\u61c9\u8a72\u53ea\u80fd\u6bba\u6b7b\u5c11\u6578\u50b3\u64ad\u75be\u75c5\u7684\u868a\u5b50\u7a2e\u985e\uff0c\u624d\u662f\u5408\u7406\u7684\u7b56\u7565\u8207\u65b9\u5411\u3002<\/p>\n

\u85c9\u7531\u868a\u5e33\u6dfb\u52a0\u6297\u7627\u75be\u85e5\u7269 atovaquone \u7684\u65b0\u65b9\u6cd5\uff0c\u79d1\u5b78\u5bb6\u8a55\u4f30\u4e26\u4e0d\u6703\u5f71\u97ff\u868a\u5b50\u7684\u58fd\u547d\u6216\u7e41\u6b96\u80fd\u529b\uff0c\u9084\u80fd\u5920\u6709\u6548\u963b\u65b7\u7627\u75be\u7684\u50b3\u64ad\uff0c\u5c0d\u65bc\u4eba\u985e\u3001\u868a\u5b50\u6216\u751f\u614b\u7cfb\u7d71\u4e5f\u76f8\u7576\u5b89\u5168\u53ca\u53cb\u5584\uff0c\u5341\u5206\u503c\u5f97\u63a8\u5ee3\uff0c\u4e5f\u4e0d\u96e3\u7406\u89e3\u70ba\u4ec0\u9ebc\u6b64\u7bc7\u7814\u7a76\u6703\u520a\u767b\u65bc Nature<\/em> \u671f\u520a\u4e0a\u3002\u4e00\u76f4\u4ee5\u4f86\uff0c\u868a\u5b50\u50b3\u64ad\u8457\u4e0d\u5c11\u53ef\u6015\u7684\u75be\u75c5\uff0c\u5982\u7627\u75be\u3001\u9ec3\u71b1\u75c5\u3001\u767b\u9769\u71b1\u3001\u65e5\u672c\u8166\u708e\u3001\u8332\u5361\u75c5\u6bd2\u7b49\uff0c\u800c\u4eba\u985e\u8207\u868a\u5b50\u7684\u6230\u722d\u4e5f\u5df2\u6301\u7e8c\u4e86\u5343\u5e74\u4e4b\u4e45\uff0c\u8fb2\u8015\u6587\u660e\u5230\u96fb\u6c23\u6642\u4ee3\u9019\u6f2b\u9577\u904e\u7a0b\u4e2d\uff0c\u4eba\u985e\u7684\u89d2\u8272\u4e5f\u5f9e\u6700\u521d\u7684\u53d7\u5bb3\u8005\u5230\u5f8c\u4f86\u7684\u4e3b\u52d5\u5927\u91cf\u64b2\u6bba\u3002\u900f\u904e\u9019\u9805\u7814\u7a76\u6210\u679c\uff0c\u6216\u8a31\u662f\u6642\u5019\u958b\u59cb\u601d\u8003\uff0c\u8a72\u600e\u9ebc\u8207\u868a\u5b50\u4e92\u4e0d\u4fb5\u72af\u7684\u5171\u8655\u4e4b\u9053\uff0c\u7562\u7adf\u4eba\u985e\u7684\u6700\u7d42\u76ee\u6a19\u53ea\u9700\u9054\u5230\u907f\u514d\u53ee\u54ac\u3001\u53ca\u963b\u6b62\u868a\u5b50\u50b3\u64ad\u75be\u75c5\u5373\u53ef\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. To\u00e9 KH, et al. Emerg Infect Dis. 2014;20:1691-6. Increased pyrethroid resistance in malaria vectors and decreased bed net effectiveness, Burkina Faso.<\/a><\/li>\n
  2. TechNews\uff0c12.10\uff0cGoogle \u5b50\u516c\u53f8\u900f\u904e\u57fa\u56e0\u6539\u9020\u6ec5\u868a\uff0c\u6548\u679c\u9084\u53ef\u4ee5<\/a><\/li>\n
  3. Paton DG, et al. Nature. 2019 Feb 27. Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission.<\/a><\/li>\n
  4. Fang J. Nature. 2010;466:432-4. Ecology: A world without mosquitoes.<\/a><\/li>\n
  5. Patterson GM. Insects. 2016;7(4). pii: E56. Looking Backward, Looking Forward: The Long, Torturous Struggle with Mosquitoes.<\/a><\/li>\n<\/ol>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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