{"id":33708,"date":"2019-03-08T00:19:10","date_gmt":"2019-03-07T16:19:10","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33708"},"modified":"2019-03-05T15:00:02","modified_gmt":"2019-03-05T07:00:02","slug":"%e9%9a%b1%e8%97%8f%e5%9c%a8%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e8%83%8c%e5%be%8c%e7%9a%84%e7%96%be%e7%97%85","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33708","title":{"rendered":"\u96b1\u85cf\u5728\u75c5\u6bd2\u611f\u67d3\u80cc\u5f8c\u7684\u75be\u75c5"},"content":{"rendered":"

\u25a0\u75c5\u6bd2\u662f\u4e00\u7a2e\u5f97\u5bc4\u751f\u65bc\u5bbf\u4e3b\u624d\u80fd\u5b58\u6d3b\u7684\u5fae\u751f\u7269\uff0c\u70ba\u4e86\u53ef\u4ee5\u7e41\u884d\u5b50\u5b6b\u842c\u4ee3\uff0c\u4e0d\u5c11\u75c5\u6bd2\u60f3\u65b9\u8a2d\u6cd5\u5730\u8207\u5bbf\u4e3b\u5171\u5b58\u3002\u66f4\u4ee4\u4eba\u64d4\u5fc3\u7684\u662f\uff0c\u8207\u4eba\u9ad4\u9577\u4e45\u5171\u5b58\u7684\u75c5\u6bd2\uff0c\u9664\u4e86\u76f4\u63a5\u5f15\u8d77\u611f\u67d3\u7684\u75c7\u72c0\uff0c\u6709\u4e9b\u610f\u6599\u4e4b\u5916\u7684\u9593\u63a5\u75be\u75c5\u4e5f\u96b1\u85cf\u5728\u75c5\u6bd2\u611f\u67d3\u80cc\u5f8c\u3002<\/strong><\/span><\/p>\n

\"\"\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u25cf\u4e0d\u8d77\u773c\u7684\u75b1\u75b9\u75c5\u6bd2\u85cf\u533f\u5728\u8166\u90e8\u4f3a\u6a5f\u800c\u52d5<\/strong><\/span><\/p>\n

\u75c5\u6bd2\u8207\u4eba\u985e\u9577\u4e45\u5171\u5b58\u7684\u60c5\u6cc1\uff0c\u5728\u53f0\u7063\u6700\u70ba\u5178\u578b\u7684\u4f8b\u5b50\u662f\u6162\u6027 B \u578b\u809d\u708e\uff0c\u7531\u65bc\u5728 1984 \u5e74\u4e4b\u524d\u65b0\u751f\u5152\u5c1a\u672a\u5168\u9762\u63a8\u5ee3\u63a5\u7a2e B \u809d\u75ab\u82d7\uff0c\u9020\u6210\u5168\u53f0\u7063\u7684 B \u578b\u809d\u708e\u75c5\u6bd2\u5e36\u539f\u7387\u9ad8\u9054 15%\uff0c\u4ee3\u8868\u8457 5-6 \u500b\u4eba\u7576\u4e2d\u6709 1 \u500b\u4eba\u662f\u5e36\u539f\u8005\u3002<\/p>\n

\u4e0d\u904e\uff0c\u672c\u7bc7\u8981\u8ac7\u7684\u4e3b\u89d2\u662f\u770b\u4f3c\u6beb\u4e0d\u8d77\u773c\u7684\u55ae\u7d14\u75b1\u75b9\u75c5\u6bd2 (herpes simplex virus, HSV)\uff0c\u5e38\u898b\u7684\u53e3\u5507\u75b1\u75b9\u662f\u7531\u7b2c\u4e00\u578b\u55ae\u7d14\u75b1\u75b9\u75c5\u6bd2 (HSV-1) \u611f\u67d3\u5f15\u8d77\uff0c\u6c34\u6ce1\u6a23\u7684\u75c5\u7076\u597d\u767c\u65bc\u5634\u90e8\u3001\u9f3b\u5b50\u3001\u4e0b\u5df4\u7b49\uff0c\u7531\u65bc\u6709\u8457\u7121\u9700\u6cbb\u7642\u81ea\u5df1\u5c31\u6703\u597d\u7684\u7279\u6027\uff0c\u8a31\u591a\u4eba\u751a\u81f3\u6c92\u6709\u5bdf\u89ba\u5230\u5df2\u7d93\u88ab\u611f\u67d3\u3002<\/p>\n

\u75c7\u72c0\u8f15\u5fae\u7684\u5c0f\u5c0f\u75b1\u75b9\u75c5\u6bd2\uff0c\u6700\u8fd1\u537b\u6709\u8d8a\u4f86\u8d8a\u591a\u7814\u7a76\u8b49\u64da\u767c\u73fe\u5b83\u53ef\u80fd\u8207\u4e00\u7a2e\u8166\u90e8\u75be\u75c5\u6709\u95dc\uff0c\u4e5f\u5c31\u662f\u76ee\u524d\u5c1a\u7121\u6cd5\u6cbb\u7652\u3001\u4ee4\u4eba\u60f6\u6050\u7684\u963f\u8332\u6d77\u9ed8\u75c7 (\u8001\u5e74\u5931\u667a\u75c7)\u3002\u6700\u5927\u7684\u539f\u56e0\u51fa\u81ea HSV-1 \u5177\u5099\u53b2\u5bb3\u7684\u96b1\u8eab\u5927\u6cd5\uff0c\u5c31\u50cf\u9a45\u4e4b\u4e0d\u6563\u9670\u9b42\u822c\uff0c\u4e00\u65e6\u88ab HSV-1 \u611f\u67d3\uff0c\u53ef\u80fd\u7d42\u8eab\u7121\u6cd5\u6839\u9664\uff0c\u4e26\u4e14\u6f5b\u4f0f\u5728\u8166\u90e8\u795e\u7d93\u5167\uff0c\u7576\u8eab\u9ad4\u75b2\u618a\u6216\u514d\u75ab\u529b\u4e0d\u8db3\u6642\uff0c\u75c5\u6bd2\u6703\u6d3b\u5316\u800c\u518d\u6b21\u5fa9\u767c\u3002\u79d1\u5b78\u5bb6\u61f7\u7591\uff0c\u56e0\u70ba HSV-1 \u9577\u671f\u53cd\u8986\u7684\u6d3b\u5316\u611f\u67d3\uff0c\u6703\u7522\u751f\u8166\u90e8\u640d\u50b7\u7a4d\u7d2f\uff0c\u53ef\u80fd\u9032\u800c\u5f15\u767c\u4e86\u963f\u8332\u6d77\u9ed8\u75c7\u3002<\/p>\n

\u25cf\u75b1\u75b9\u75c5\u6bd2\u53ef\u80fd\u662f\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u81f4\u75c5\u539f\u56e0\u4e4b\u4e00<\/span><\/strong><\/p>\n

\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u75c5\u7a0b\u662f\u9010\u6b65\u3001\u7de9\u6162\u7684\u8a8d\u77e5\u529f\u80fd\u9000\u5316\uff0c\u7279\u5fb5\u70ba\u8166\u90e8\u51fa\u73fe \u03b2 \u578b\u6fb1\u7c89\u6a23\u86cb\u767d (\u03b2-amyloid, A\u03b2) \u7570\u5e38\u5806\u7a4d\uff0c\u5f62\u6210\u4e0d\u6b63\u5e38\u7684\u6591\u584a (plaque)\u3002\u8fd1\u5341\u5e7e\u5e74\uff0c\u570b\u969b\u9593\u5f88\u591a\u79d1\u5b78\u5bb6\u767c\u73fe\u75b1\u75b9\u75c5\u6bd2\u611f\u67d3\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u767c\u75c5\u7387\u606f\u606f\u76f8\u95dc\uff0c\u56e0\u6b64\u5c55\u958b\u4e86\u4e00\u7cfb\u5217\u63a2\u8a0e\u7814\u7a76\u3002HSV-1 \u548c\u963f\u8332\u6d77\u9ed8\u75c7\u4e4b\u9593\u7684\u95dc\u806f\u6027\u8b49\u64da\uff0c\u5305\u62ec\u4e86\u5728\u60a3\u8005\u8166\u90e8\u6591\u584a\u4e2d\u767c\u73fe\u75c5\u6bd2\u7684 DNA\uff1b\u5728\u9ad4\u5916 HSV-1 \u611f\u67d3\u7684\u57f9\u990a\u7d30\u80de\u4e2d\u6703\u7a4d\u7d2f A\u03b2\uff1b\u4e26\u4e14\u5728 HSV-1 \u611f\u67d3\u7684\u5c0f\u9f20\u52d5\u7269\u5be6\u9a57\u4e2d\uff0c\u4e5f\u770b\u5230\u9f20\u8166\u4e2d\u7a4d\u7d2f\u4e86 A\u03b2\u3002\u9019\u4e9b\u8b49\u64da\u610f\u5473\u8457\uff0cHSV-1 \u662f\u9020\u6210 A\u03b2 \u548c\u6591\u584a\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/p>\n

\u53f0\u7063\u570b\u9632\u91ab\u5b78\u9662\u7814\u7a76\u5718\u968a\u8fd1\u5e74\u767c\u8868\u7684\u8ad6\u6587\u4e5f\u70ba\u6b64\u9818\u57df\u4f9b\u737b\u4e86\u5145\u4efd\u7684\u8b49\u64da\uff0c\u6839\u64da\u5065\u4fdd\u8cc7\u6599\u5eab\u6bd4\u8f03 8,362 \u540d\u76b0\u75b9\u75c5\u6bd2\u611f\u8005\u8207 25,086 \u540d\u7121\u611f\u67d3\u8005\u7684\u5dee\u7570\uff0c\u7d50\u679c\u767c\u73fe\u76b0\u75b9\u75c5\u6bd2\u611f\u67d3\u8005\u7684\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u75c5\u98a8\u96aa\u6703\u9ad8\u51fa\u7d04 2.6 \u500d\uff0c\u4e26\u4e14\u5229\u7528\u6297\u75b1\u75b9\u75c5\u6bd2\u7684\u85e5\u7269\u6cbb\u7642\u5f8c\uff0c\u80fd\u660e\u986f\u964d\u4f4e\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u98a8\u96aa\u3002<\/p>\n

\u6240\u4ee5\u79d1\u5b78\u5bb6\u4e5f\u5efa\u8b70\uff0c\u5931\u667a\u9ad8\u98a8\u96aa\u60a3\u8005\u53ef\u4f7f\u7528\u6297\u75b1\u75b9\u75c5\u6bd2\u85e5\u7269\u4f5c\u70ba\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u9810\u9632\u6027\u6cbb\u7642\uff0c\u800c\u672a\u4f86\u958b\u767c HSV \u75ab\u82d7\u624d\u662f\u6cbb\u672c\u7684\u89e3\u6c7a\u4e4b\u9053\u3002\u6f5b\u4f0f\u7684\u75b1\u75b9\u75c5\u6bd2\u4e0d\u6642\u5fa9\u767c\u611f\u67d3\u4e4b\u73fe\u8c61\uff0c\u5c31\u5982\u540c\u6295\u77f3\u64ca\u6c34\uff0c\u96d6\u4e00\u6642\u4e0d\u8d77\u6d6a\u82b1\uff0c\u4e5f\u6cdb\u6f23\u6f2a\uff0c\u4f46\u9019\u7a2e\u9577\u671f\u9023\u9396\u53cd\u61c9\u662f\u6211\u5011\u7d55\u4e0d\u60f3\u8981\u7684\u7d50\u5c40\u3002\u6b64\u5916\uff0c\u6211\u5011\u8981\u7279\u5225\u7559\u610f\u7684\u662f\uff0c\u76ee\u524d\u9019\u4e9b\u8cc7\u6599\u90fd\u9084\u50c5\u662f\u76f8\u95dc\u6027\u7684\u7814\u7a76\uff0c\u5c1a\u7f3a\u4e4f\u660e\u78ba\u7684\u76f4\u63a5\u56e0\u679c\u95dc\u4fc2\u8b49\u64da\uff0c\u6240\u4ee5\u611f\u67d3\u76b0\u75b9\u75c5\u6bd2\u4e5f\u4e0d\u4ee3\u8868\u4e00\u5b9a\u6703\u5c0e\u81f4\u963f\u8332\u6d77\u9ed8\u75c7\u3002<\/p>\n

\u25cf\u6709\u4e9b\u75c5\u6bd2\u4e5f\u53ef\u80fd\u5f15\u767c\u764c\u75c7<\/span><\/strong><\/p>\n

\u5f15\u767c\u611f\u67d3\u75c7\u72c0\u80cc\u5f8c\u7684\u9593\u63a5\u75be\u75c5\uff0c\u4e0d\u53ea\u6709\u76b0\u75b9\u75c5\u6bd2\u3002\u6709\u4e9b\u75c5\u6bd2\u9020\u6210\u764c\u75c7\u7684\u76f8\u95dc\u6027\uff0c\u5176\u8b49\u64da\u66f4\u5df2\u662f\u7121\u5eb8\u7f6e\u7591\u3002\u5728\u6b64\u8209\u5e7e\u500b\u4f8b\u5b50\uff0cB \u578b\u53ca C \u578b\u809d\u708e\u75c5\u6bd2\u53ef\u80fd\u5c0e\u81f4\u809d\u764c\uff1b\u4eba\u985e\u4e73\u7a81\u75c5\u6bd2 (human papillomatus virus, HPV) \u53ef\u80fd\u5c0e\u81f4\u5b50\u5bae\u9838\u764c\uff1bEB\u75c5\u6bd2 (Epstein-Barr virus) \u53ef\u80fd\u5c0e\u81f4\u9f3b\u54bd\u764c\u3002\u7576\u7136\uff0c\u53ef\u6068\u7684\u58de\u75c5\u6bd2\u4e0d\u53ea\u6709\u9019\u5e7e\u7a2e\uff0c\u9084\u6709\u5176\u4ed6\u7684\u75c5\u6bd2\u4e5f\u6703\u5f15\u767c\u764c\u75c7\u3002<\/p>\n

\u96d6\u7136\uff0c\u4e0d\u540c\u75c5\u6bd2\u5f15\u767c\u764c\u75c7\u7684\u6a5f\u5236\u76f8\u7570\uff0c\u4f46\u591a\u6578\u90fd\u6d89\u53ca\u75c5\u6bd2\u50b3\u64ad DNA \u5f71\u97ff\u5065\u5eb7\u7d30\u80de\u7684\u57fa\u56e0\u7d44\u6210\uff0c\u9032\u800c\u9020\u6210\u7d30\u80de\u81f4\u764c\u5316\u3002\u81e8\u5e8a\u4e0a\u4e5f\u6703\u76e1\u91cf\u4ee5\u85e5\u7269\u6216\u75ab\u82d7\u6d88\u6ec5\u9019\u4e9b\u75c5\u6bd2\uff0c\u4f86\u964d\u4f4e\u75c5\u6bd2\u611f\u67d3\u6240\u4f34\u96a8\u7684\u81f4\u764c\u98a8\u96aa\u3002<\/p>\n

\u7406\u60f3\u4e0a\uff0c\u6211\u5011\u90fd\u5e0c\u671b\u80fd\u8207\u9019\u4e9b\u75c5\u6bd2\u5011\u4e95\u6c34\u4e0d\u72af\u6cb3\u6c34\uff0c\u76f8\u5b89\u7121\u4e8b\uff0c\u4f46\u7406\u60f3\u60c5\u5883\u53ef\u80fd\u53ea\u5b58\u5728\u65bc\u5922\u4e2d\u6216\u5730\u7403\u5916\u7684\u5b87\u5b99\u3002\u5728\u75c5\u6bd2\u5371\u6a5f\u56db\u4f0f\u7684\u771f\u5be6\u4e16\u754c\u88e1\uff0c\u6211\u5011\u9084\u9700\u9760\u8457\u79d1\u5b78\u5bb6\u4e0d\u65b7\u4e00\u6b65\u4e00\u8173\u5370\u5730\u6316\u6398\u5404\u7a2e\u75be\u75c5\u771f\u76f8\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. \u8a31\u8000\u5cfb\u91ab\u5e2b\uff0c\u7fa9\u5927\u91ab\u9662\u80c3\u8178\u809d\u81bd\u79d1\uff0c\u6162\u6027B\u578b\u809d\u708e<\/a><\/li>\n
  2. Itzhaki RF. Front Aging Neurosci. 2018;10:324. Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer's Disease.<\/a><\/li>\n
  3. Tzeng NS, et al. Neurotherapeutics. 2018;15:417-29. Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections-a Nationwide, Population-Based Cohort Study in Taiwan.<\/a><\/li>\n
  4. \u53f0\u7063\u764c\u75c7\u81e8\u5e8a\u7814\u7a76\u767c\u5c55\u57fa\u91d1\u6703-\u8ac7\u809d\u764c\u8207B\u578bC\u578b\u809d\u708e\u7684\u95dc\u4fc2<\/a><\/li>\n
  5. \u4f55\u5fd7\u660e\u91ab\u5e2b\uff0c\u570b\u6cf0\u7d9c\u5408\u91ab\u9662\u5a66\u764c\u4e2d\u5fc3\uff0c\u5b50\u5bae\u9838\u764c<\/a><\/li>\n
  6. \u53f0\u7063\u764c\u75c7\u81e8\u5e8a\u7814\u7a76\u767c\u5c55\u57fa\u91d1\u6703-EB\u75c5\u6bd2\u8207\u9f3b\u54bd\u764c\u7684\u95dc\u4fc2<\/a><\/li>\n<\/ol>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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