{"id":33589,"date":"2019-02-22T00:47:28","date_gmt":"2019-02-21T16:47:28","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33589"},"modified":"2019-07-31T11:05:51","modified_gmt":"2019-07-31T03:05:51","slug":"%e7%82%ba%e4%bb%80%e9%ba%bc%e6%8a%97%e7%b2%be%e7%a5%9e%e7%96%be%e7%97%85%e8%97%a5%e7%89%a9%e8%ae%93%e4%ba%ba%e6%84%88%e5%90%83%e6%84%88%e8%83%96%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33589","title":{"rendered":"\u70ba\u4ec0\u9ebc\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\u8b93\u4eba\u6108\u5403\u6108\u80d6\uff1f"},"content":{"rendered":"<p><span style=\"color: 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The Scripps Research Institute \u7814\u7a76\u4e2d\u5fc3\u5206\u5b50\u91ab\u5b78\u7684\u6559\u6388 Michael Petrascheck \u535a\u58eb\u5be6\u9a57\u5ba4\uff0c\u548c\u52a0\u5dde\u5927\u5b78\u8056\u5730\u7259\u54e5\u5206\u6821\u7684\u6559\u6388 Olivia Osborn \u535a\u58eb\u5be6\u9a57\u5ba4\uff0c\u5c0d\u9019\u60f1\u4eba\u7684\u554f\u984c\uff0c\u4f3c\u4e4e\u627e\u5230\u4e86\u89e3\u6c7a\u826f\u7b56\u5462\u3002\u4ed6\u5011\u7684\u7814\u7a76\u7d50\u679c\uff0c\u767c\u8868\u5728\u5341\u4e8c\u6708\u4efd&nbsp;<em>Nature Communication&nbsp;<\/em>\u671f\u520a\u4e0a\u3002<\/p>\n<p>\u4eba\u985e\u7684\u9032\u98df\u884c\u70ba\u8207\u504f\u597d\uff0c\u662f\u500b\u8907\u96dc\u7684\u554f\u984c\u3002\u90a3\u6709\u6c92\u6709\u53ef\u80fd\u628a\u9019\u500b\u554f\u984c\u7c21\u5316\u5462\uff1f\u7562\u7adf\uff0c\u9032\u98df\u9019\u4ef6\u4e8b\uff0c\u8aaa\u5230\u5e95\u9084\u662f\u8ddf\u751f\u5b58\u6709\u95dc\u3002\u800c\u5404\u7a2e\u52d5\u7269\u6240\u8cf4\u4ee5\u751f\u5b58\u7684\u71df\u990a\uff0c\u4e5f\u812b\u4e0d\u4e86\u91a3\u985e\u3001\u8102\u8cea\u3001\u8207\u80fa\u57fa\u9178\u4e09\u5927\u985e\u3002\u7814\u7a76\u4eba\u54e1\u9996\u5148\u5927\u81bd\u5047\u8a2d\uff0c\u6216\u8a31\uff0c\u5c0d\u65bc\u98df\u617e\u7684\u8abf\u63a7\u6a5f\u5236\uff0c\u662f\u88ab\u67d0\u7a2e\u6a6b\u8de8\u7269\u7a2e\u7684\u53e4\u8001\u6f14\u5316\u6a5f\u5236\u6240\u63a7\u7ba1\u3002\u4ed6\u5011\u65bc\u662f\u6311\u6230\uff0c\u662f\u4e0d\u662f\u53ef\u4ee5\u5728\u6bd4\u8f03\u7c21\u55ae\u7684\u7269\u7a2e\u8eab\u4e0a\uff0c\u4e5f\u89c0\u5bdf\u5230\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\u5f15\u8d77\u7684\u8caa\u98df\u73fe\u8c61\u3002<\/p>\n<p>\u4ed6\u5011\u9078\u64c7\u52d5\u7269\u6a21\u578b\u7684\u982d\u865f\u6240\u597d\uff0c\u662f\u559c\u6b61\u5403\u7d30\u83cc\u7684\u7dda\u87f2 <em>Caenorhabditis elegans<\/em>\u3002\u4ee5\u7dda\u87f2\u70ba\u52d5\u7269\u6a21\u578b\u7684\u597d\u8655\uff0c\u662f\u53ef\u4ee5\u597d\u597d\u7684\u5c07\u5176\u990a\u5728 96 \u5b54\u7684\u57f9\u990a\u76e4\u88e1\u3002\u800c\u4e14\u7dda\u87f2\u611b\u5403\u7d30\u83cc\u7684\u7fd2\u6027\uff0c\u8b93\u7814\u7a76\u4eba\u54e1\u53ef\u4ee5\u8f15\u6613\u5730\u85c9\u7531\u6aa2\u6e2c\u7dda\u87f2\u5728\u57f9\u990a\u671f\u9593\uff0c\u7d30\u83cc\u300c\u6fc3\u5ea6\u300d\u7684\u964d\u4f4e\uff0c\u4f86\u7cbe\u78ba\u91cf\u5316\u7dda\u87f2\u5230\u5e95\u9910\u9910\u5403\u4e86\u591a\u5c11\u3002\u7814\u7a76\u4eba\u54e1\u5728\u7dda\u87f2\u8eab\u4e0a\uff0c\u5be6\u6e2c\u4e86\u8a31\u591a\u5728\u4eba\u985e\u8eab\u4e0a\u89c0\u5bdf\u5230\u6703\u5c0e\u81f4\u8caa\u98df\u55dc\u5403\u7684\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\uff0c\u7136\u5f8c\u767c\u73fe\u9019\u4e9b\u85e5\u7269\u5c0d\u7dda\u87f2\u4e5f\u6709\u540c\u6a23\u7684\u526f\u4f5c\u7528\u3002<\/p>\n<p>\u65e2\u7136\u6297\u7cbe\u795e\u75be\u75c5\u7528\u85e5\u5728\u7dda\u87f2\u8eab\u4e0a\u6703\u5c0e\u81f4\u985e\u4f3c\u7684\u6548\u61c9\uff0c\u9019\u4e0b\u5c31\u53ef\u4ee5\u5229\u7528\u7dda\u87f2\uff0c\u4f86\u63a2\u8a0e\u85e5\u7269\u5c0e\u81f4\u8caa\u98df\u80cc\u5f8c\u7684\u5206\u5b50\u6a5f\u8f49\uff0c\u8b93\u7dda\u87f2\u4f86\u5c0f\u5175\u7acb\u5927\u529f\u4e86\u3002<\/p>\n<p>\u56e0\u70ba\u5df2\u77e5\u80fd\u5206\u6ccc\u591a\u5df4\u80fa\u8207\u8840\u6e05\u7d20\u7684\u795e\u7d93\u5143\u662f\u7ba1\u63a7\u98df\u617e\u7684\u4e2d\u9593\u7825\u67f1\uff0c\u81e8\u5e8a\u4e0a\u4e5f\u4e00\u76f4\u61f7\u7591\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\u662f\u56e0\u70ba\u9023\u5e36\u5f71\u97ff\u5230\u4e86\u9019\u4e9b\u795e\u7d93\u5143\uff0c\u800c\u4f7f\u5f97\u75c5\u4eba\u8b8a\u5f97\u8caa\u5403\uff0c\u7814\u7a76\u4eba\u54e1\u65bc\u662f\u76f4\u63a5\u5229\u7528\u57fa\u56e0\u7a81\u8b8a\u7684\u7dda\u87f2\uff0c\u4f86\u7814\u7a76\u54ea\u4e00\u7a2e\u795e\u7d93\u5143\u624d\u662f\u9020\u6210\u55dc\u98df\u7684\u5143\u5147<\/p>\n<p>\u7814\u7a76\u4eba\u54e1\u628a\u5404\u500b\u80fd\u5920\u5206\u6ccc\u591a\u5df4\u80fa\u8207\u8840\u6e05\u7d20\u7684\u795e\u7d93\u5143\u4e00\u500b\u63a5\u8457\u4e00\u500b\u5728\u7dda\u87f2\u57fa\u56e0\u9ad4\u5167\u5206\u5225\u5254\u9664\u6389\uff0c\u7136\u5f8c\u89c0\u5bdf\u662f\u4e0d\u662f\u6709\u54ea\u7a2e\u7dda\u87f2\uff0c\u6703\u56e0\u70ba\u67d0\u7a2e\u795e\u7d93\u5143\u7684\u7f3a\u5931\uff0c\u800c\u80fd\u5920\u53d7\u5230\u4fdd\u8b77\u3001\u4e0d\u88ab\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\u5f71\u97ff\u800c\u6539\u8b8a\u9032\u98df\u884c\u70ba\u3002\u7814\u7a76\u7d50\u679c\u767c\u73fe\uff0c\u7dda\u87f2\u7dad\u6301\u4ee3\u8b1d\u7684\u57fa\u790e\u9032\u98df\u884c\u70ba\uff0c\u548c\u56e0\u70ba\u53d7\u5230\u85e5\u7269\u5f71\u97ff\u800c\u5c0e\u81f4\u7684\u8caa\u98df\u884c\u70ba\uff0c\u662f\u53d7\u5230\u4e0d\u540c\u7684\u795e\u7d93\u5143\u6240\u63a7\u7ba1\u5462\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u54e1\u767c\u73fe\uff0c\u5c07 <em>ser-5<\/em> \u57fa\u56e0\u5254\u9664\u6389\u7684\u7dda\u87f2\uff0c\u4e0d\u518d\u6703\u56e0\u70ba\u6297\u7cbe\u795e\u75be\u75c5\u7528\u85e5\u7684\u5f71\u97ff\u800c\u8caa\u5403\u4e86\uff0c\u800c\u4e14\u4e5f\u4e0d\u5c0d\u57fa\u790e\u9032\u98df\u884c\u70ba\u6709\u6240\u5f71\u97ff\u3002\u76f8\u53cd\u7684\uff0c\u5c07 <em>ser-7<\/em> \u57fa\u56e0\u5254\u9664\u6389\u7684\u7dda\u87f2\uff0c\u5728\u6297\u7cbe\u795e\u75be\u75c5\u7528\u85e5\u7684\u5f71\u97ff\u4e0b\uff0c\u9084\u662f\u975e\u5e38\u8caa\u5403\uff0c\u4f46\u5728\u6c92\u6709\u7528\u85e5\u7684\u60c5\u6cc1\u4e0b\u6642\uff0c\u57fa\u790e\u9032\u98df\u884c\u70ba\u537b\u53d7\u5230\u5f88\u5927\u7684\u5f71\u97ff\uff0c\u8b8a\u5f97\u4e00\u9ede\u98df\u617e\u90fd\u6c92\u6709\u3002\u81f3\u65bc\u591a\u5df4\u80fa\u985e\u795e\u7d93\u5143\u5462\uff1f\u7814\u7a76\u4eba\u54e1\u628a\u6bcf\u4e00\u7a2e\u591a\u5df4\u80fa\u985e\u795e\u7d93\u5143\u5206\u5225\u5254\u9664\u6389\u4e4b\u5f8c\uff0c\u4e26\u7121\u6cd5\u633d\u6551\u7dda\u87f2\u56e0\u70ba\u85e5\u7269\u800c\u5c0e\u81f4\u7684\u8caa\u5403\uff0c\u57fa\u790e\u9032\u98df\u537b\u53cd\u800c\u53d7\u5230\u5f71\u97ff\u800c\u964d\u4f4e\uff0c\u986f\u793a\u591a\u5df4\u80fa\u795e\u7d93\u5143\u4e5f\u662f\u5728\u57fa\u790e\u9032\u98df\u884c\u70ba\u4e0a\uff0c\u626e\u6f14\u8457\u6bd4\u8f03\u91cd\u8981\u7684\u89d2\u8272\uff0c\u4f46\u537b\u8ddf\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\u6240\u5f15\u8d77\u7684\u8caa\u98df\u884c\u70ba\u7121\u95dc\u3002<\/p>\n<p>\u9019\u767c\u73fe\uff0c\u4e0d\u50c5\u5f88\u6709\u8da3\uff0c\u4e5f\u8b93\u7814\u7a76\u4eba\u54e1\u80fd\u5920\u66f4\u8fd1\u4e00\u6b65\u7684\u6aa2\u6e2c\u4e86 192 \u7a2e\u5df2\u7d93\u88ab\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\u6240\u6838\u51c6\u901a\u904e\u7684\u85e5\u7269\uff0c\u770b\u770b\u88e1\u9762\u6703\u4e0d\u6703\u6709\u85e5\u7269\uff0c\u53ef\u4ee5\u8b93\u7dda\u87f2\u4e0d\u518d\u53d7\u5230\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\u7684\u5f71\u97ff\u800c\u8caa\u5403\u3002\u800c\u4ed6\u5011\u4e5f\u6210\u529f\u7be9\u9078\u51fa minocycline \u8207 doxycycline \u80fd\u5920\u4fdd\u8b77\u7dda\u87f2\uff0c\u4e0d\u53d7\u5230\u85e5\u7269\u7684\u5f71\u97ff\u8b8a\u5f97\u8caa\u5403\uff0c\u4e5f\u4e0d\u5f71\u97ff\u5230\u7dda\u87f2\u7684\u57fa\u790e\u9032\u98df\u884c\u70ba\u3002<\/p>\n<p>\u4e0d\u904e\uff0cminocycline \u548c doxycycline \u90fd\u662f\u6297\u751f\u7d20\uff0c\u800c\u7dda\u87f2\u55dc\u5403\u7d30\u83cc\u3002\u6703\u662f\u56e0\u70baminocycline \u548c doxycycline \u628a\u7dda\u87f2\u7684\u7d30\u83cc\u5927\u9910\u8b8a\u5f97\u4e0d\u7f8e\u5473\u624d\u5931\u53bb\u80c3\u53e3\u55ce\uff1f\u7814\u7a76\u4eba\u54e1\u767c\u73fe\uff0cminocycline \u548c doxycycline \u7684\u4fdd\u8b77\u4f5c\u7528\uff0c\u548c\u9019\u5169\u500b\u85e5\u7269\u7684\u6297\u751f\u7d20\u5c6c\u6027\u4e00\u9ede\u95dc\u4fc2\u90fd\u6c92\u6709\u3002\u9996\u5148\uff0c\u9935\u98df\u7dda\u87f2\u7684\u7d30\u83cc\u5df2\u7d93\u900f\u904e\u4f3d\u78bc\u5c04\u7dda\u8655\u7406\uff0c\u6240\u4ee5\u672c\u8eab\u5c31\u5df2\u662f\u6b7b\u7d30\u83cc\u3002\u518d\u8005\uff0c\u5176\u4ed6\u8207minocycline \u548c doxycycline \u5728\u7d50\u69cb\u4e0a\u985e\u4f3c\u7684\u6297\u751f\u7d20\uff0c\u4e26\u6c92\u6709\u8b93\u7dda\u87f2\u4e0d\u518d\u8caa\u5403\u7684\u795e\u5947\u7642\u6548\u3002\u53e6\u5169\u7a2e\u6297\u751f\u7d20 ampicillin \u8207 streptomycin\uff0c\u4e00\u6a23\u5c0d\u85e5\u7269\u5c0e\u81f4\u7684\u8caa\u5403\u6c92\u6709\u4efb\u4f55\u5e6b\u52a9\u3002<\/p>\n<p>\u66f4\u91cd\u8981\u7684\uff0c\u5728\u5be6\u9a57\u5c0f\u9f20\u8eab\u4e0a\uff0cminocycline \u4e5f\u6709\u540c\u6a23\u7684\u4fdd\u8b77\u6548\u679c\uff0c\u53ef\u4ee5\u907f\u514d\u5c0f\u9f20\u5728\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7684\u6295\u85e5\u4e4b\u5f8c\u8b8a\u5f97\u8caa\u5403\u3002\u66f4\u6709\u8da3\u7684\u662f\uff0c\u65e9\u5728 2010 \u5e74\u6642\uff0c\u5c31\u6709\u81e8\u5e8a\u7814\u7a76\u6b6a\u6253\u6b63\u8457\uff0c\u4e0d\u5c0f\u5fc3\u767c\u73fe\u7576\u670d\u7528\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\u7684\u8eab\u5fc3\u5931\u8abf\u75c7\u75c5\u4eba\uff0c\u540c\u6642\u7d66\u4e88 minocycline \u6642\uff0c\u4e0d\u50c5\u80fd\u5920\u8b93\u65e9\u671f\u8eab\u5fc3\u5931\u8abf\u75c7\u7684\u75c5\u4eba\u5c0d\u85e5\u7269\u6709\u6bd4\u8f03\u597d\u7684\u7642\u6548\u53cd\u61c9\uff0c\u4e5f\u540c\u6642\u8b93\u75c5\u4eba\u7684\u9ad4\u91cd\u6709\u6bd4\u8f03\u597d\u7684\u63a7\u5236\u3002\u5728\u8a72\u8d77\u81e8\u5e8a\u5be6\u9a57\u88e1\uff0c\u53ea\u670d\u7528\u6297\u7cbe\u795e\u75c5\u85e5\u7269\u7684\u75c5\u4eba\u5e73\u5747\u589e\u91cd\u4e86 10.7 \u516c\u65a4\uff0c\u4f46\u540c\u6642\u670d\u7528minocycline \u7684\u75c5\u4eba\uff0c\u537b\u5e73\u5747\u53ea\u589e\u52a0\u4e86 2.08 \u516c\u65a4\u5462\u3002<\/p>\n<p>Michael Petrascheck \u535a\u58eb\u548c Olivia Osborn \u535a\u58eb\u5408\u529b\u7684\u9019\u7bc7\u7814\u7a76\uff0c\u6703\u4e0d\u6703\u8b93\u670d\u7528\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\u7684\u75c5\u60a3\uff0c\u4e0d\u518d\u70ba\u9ad4\u91cd\u63a7\u5236\u6240\u56f0\u64fe\u5462\uff1f\u5f8c\u7e8c\u7814\u7a76\u7684\u767c\u5c55\u8207\u61c9\u7528\uff0c\u5f88\u503c\u5f97\u671f\u5f85\u5462\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u539f\u59cb\u8ad6\u6587\uff1a<\/strong>Perez-Gomez A et al. A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia. Nat Commun. 2018 Dec 10;9(1):5272. doi: 10.1038\/s41467-018-07684-y.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Jensen, G. L. Drug-induced hyperphagia: what can we learn from psychiatric medications? JPEN J. Parenter. Enter. Nutr. 32, 578\u2013581 (2008).<\/li>\n<li>Wofford, M. R. et al. T. K. Drug-induced metabolic syndrome. J. Clin. Hypertens. 8, 114\u2013119 (2006).<\/li>\n<li>Verhaegen, A. A. et al. Drug-induced obesity and its metabolic consequences: a review with a focus on mechanisms and possible therapeutic options. J. Endocrinol. Invest. 40, 1165\u20131174 (2017).<\/li>\n<li>Solmi, M. et al. Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review. Ther. Clin. Risk. Manag. 13, 757\u2013777 (2017).<\/li>\n<li>Levkovitz, Y. et al. A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. J. Clin. Psychiatry 71, 138\u2013149 (2010).<\/li>\n<li>Voigt, J. P. et al. Serotonin controlling feeding and satiety. Behav. Brain. Res. 277, 14\u201331 (2015).<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u4f60\u7684\u65b0\u5e74\u65b0\u5e0c\u671b\u60f3\u8981\u66f4\u7626\u4e00\u9ede\u55ce\uff1f\u96d6\u7136\u9ad4\u91cd\u662f\u6e1b\u904e\u4e00\u5c71\u3001\u9084\u6709\u4e00\u5c71\uff1b\u96d6\u7136\u4e00\u5473\u8ffd\u6c42\u9ad4\u91cd\u8a08\u4e0a\u7684\u6578\u5b57\u4e00\u5929\u5c11\u904e\u4e00\u5929\uff0c\u9060\u4e0d\u5982\u52e4\u591a\u904b\u52d5\u3001\u5403\u597d\u7761\u98fd\uff1b\u4f46\u4e0d\u53ef\u5426\u8a8d\u5730\uff0c\u904e\u91cd\u3001\u80a5\u80d6\u8207\u809a\u76ae\u4e0a\u7684\u80a5\u8102\u80aa\uff0c\u662f\u73fe\u4ee3\u4eba\u7684\u5fc3\u982d\u5927\u60a3\u3002\u90a3\u4f60\u77e5\u9053\uff0c\u6709\u4e9b\u85e5\u7269\u7684\u526f\u4f5c\u7528\u6703\u8b93\u4eba\u5bb9\u6613\u8b8a\u80d6\u55ce\uff1f\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\u5c31\u662f\u5176\u4e2d\u4e4b\u4e00\u3002\u5982\u4eca\uff0c\u79d1\u5b78\u5bb6\u5c0d\u6297\u7cbe\u795e\u75be\u75c5\u85e5\u7269\u6240\u9020\u6210\u7684\u80a5\u80d6\uff0c\u53ef\u80fd\u6709\u89e3\u4e86\u3002<\/p>\n","protected":false},"author":20,"featured_media":33590,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4168,593,377],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/01\/GKpnIGp.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33589"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33589"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33589\/revisions"}],"predecessor-version":[{"id":33727,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33589\/revisions\/33727"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/33590"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33589"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=33589"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=33589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}