{"id":33574,"date":"2019-02-19T00:43:01","date_gmt":"2019-02-18T16:43:01","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33574"},"modified":"2019-02-19T15:08:52","modified_gmt":"2019-02-19T07:08:52","slug":"%e5%88%b6%e4%bc%8f%e7%8c%b4%e5%ad%90%e8%ba%ab%e4%b8%8a%e6%84%9b%e6%bb%8b%e7%97%85%e6%af%92%e7%9a%84%e6%96%b0%e7%96%ab%e8%8b%97%e5%95%8f%e4%b8%96","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33574","title":{"rendered":"\u5236\u4f0f\u7334\u5b50\u611b\u6ecb\u75c5\u6bd2\u7684\u65b0\u75ab\u82d7\u554f\u4e16"},"content":{"rendered":"

\u25a0\u50cf\u5b6b\u609f\u7a7a\u4e00\u6a23\u6703\u4e03\u5341\u4e8c\u8b8a\u7684\u4eba\u985e\u514d\u75ab\u4e0d\u5168\u75c5\u6bd2 (human immunodeficiency virus, HIV)\uff0c\u9019\u6b21\u7d42\u65bc\u51fa\u73fe\u7dca\u7b8d\u5492\u53ef\u4ee5\u5236\u4f0f\u5b83\u4e86\u55ce\uff1f\u5728\u7334\u5b50\u52d5\u7269\u5be6\u9a57\u767c\u5c55\u51fa\u7684\u611b\u6ecb\u75c5\u65b0\u75ab\u82d7\uff0c\u770b\u4f86\u6709\u6a5f\u6703\u70ba\u9019\u5834\u4eba\u985e\u5c0d\u6297 HIV \u8d85\u904e 30 \u5e74\u7684\u6230\u722d\u6d6e\u73fe\u4e00\u9053\u66d9\u5149\u3002<\/span> <\/strong><\/p>\n

\"\"
\u5716\u7247\u51fa\u8655\uff1a\u6046\u6cb3\u737c\u7334 @ Wikipedia<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u25cf<\/b>\u4eba\u985e\u7684\u611b\u6ecb\u75ab\u82d7\u70ba\u4f55\u9072\u9072\u672a\u73fe\uff1f<\/strong><\/span><\/p>\n

HIV \u611f\u67d3\u5f8c\u6240\u5f15\u767c\u7684\u75be\u75c5\u7a31\u70ba\u5f8c\u5929\u514d\u75ab\u7f3a\u4e4f\u75c7\u5019\u7fa4 (acquired immunodeficiency syndrome, AIDS)\uff0c\u53c8\u97f3\u8b6f\u70ba\u611b\u6ecb\u75c5\uff0c\u7531\u65bc HIV \u80fd\u5920\u611f\u67d3\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u4e2d\u76f8\u7576\u91cd\u8981\u7684 CD4+ \u6dcb\u5df4\u7d30\u80de\uff0c\u4f7f\u5f97\u514d\u75ab\u7cfb\u7d71\u80fd\u529b\u4e0b\u964d\uff0c\u5c0e\u81f4\u539f\u672c\u4e0d\u6613\u611f\u67d3\u5065\u5eb7\u4eba\u9ad4\u7684\u5fae\u751f\u7269\u5f97\u4ee5\u8086\u610f\u5984\u70ba\u5730\u5165\u4fb5\u3002HIV \u7834\u58de\u5929\u7136\u514d\u75ab\u9632\u79a6\u7cfb\u7d71\uff0c\u8b93\u4eba\u9ad4\u7121\u6cd5\u53cd\u64ca\u7684\u624b\u6bb5\uff0c\u5c31\u662f\u6b64\u75c5\u6bd2\u6700\u70ba\u7368\u7279\u8207\u53ef\u6015\u4e4b\u8655\u3002<\/p>\n

\u81ea\u5f9e\u4eba\u985e\u767c\u660e\u75ab\u82d7\u5c0d\u6297\u75c5\u6bd2\u5f8c\uff0c\u4e0d\u5c11\u50b3\u67d3\u75c5\u5927\u5e45\u7372\u5f97\u63a7\u5236\uff0c\u751a\u81f3\u662f\u60e1\u540d\u662d\u5f70\u7684\u5929\u82b1\u75c5\u6bd2\u90fd\u5df2\u88ab\u6d88\u6ec5\u3002\u75ab\u82d7\u7684\u539f\u7406\u662f\u904b\u7528\u514d\u75ab\u7cfb\u7d71\u5177\u6709\u8a18\u61b6\u529b\u7684\u7279\u6027\uff0c\u63d0\u524d\u63a5\u7a2e\u80fd\u5920\u5f15\u767c\u514d\u75ab\u53cd\u61c9\u7684\u6297\u539f\uff0c\u8b93\u9ad4\u5167\u4e8b\u5148\u9810\u6f14\u4e00\u6b21\u5047\u60f3\u6575\uff0c\u7576\u4e0b\u6b21\u9047\u5230\u771f\u6b63\u7684\u75c5\u6bd2\u6642\uff0c\u5c31\u80fd\u5feb\u901f\u53cd\u61c9\u4f86\u6d88\u6ec5\u6575\u4eba\u3002\u5176\u5be6\u79d1\u5b78\u5bb6\u65e9\u5728 1983-1984 \u5e74\u9593\u5c31\u5df2\u81ea\u8840\u6db2\u4e2d\u5206\u96e2\u51fa HIV\uff0c\u96d6\u7136\u627e\u51fa\u4e86\u7f6a\u9b41\u798d\u9996\u7684\u75c5\u539f\u9ad4\uff0c\u4f46\u81f3\u4eca\u8d85\u904e 30 \u5e74\u4e86\u537b\u7121\u6cd5\u767c\u5c55\u51fa\u6709\u6548\u5c0d\u6297 HIV \u7684\u75ab\u82d7\uff0c\u53ef\u4ee5\u60f3\u898b\u958b\u767c\u904e\u7a0b\u9019\u689d\u6f2b\u6f2b\u9577\u8def\u5c31\u5982\u540c\u5510\u50e7\u53d6\u7d93\u822c\u9762\u81e8\u4e86\u5343\u96e3\u842c\u96aa\u3002\u958b\u767c HIV \u75ab\u82d7\u6700\u4e3b\u8981\u906d\u9047\u7684\u56f0\u96e3\u5728\u65bc\uff0cHIV \u53ea\u611f\u67d3\u4eba\u985e\uff0c\u6240\u4ee5\u7f3a\u4e4f\u4e86\u53ef\u9760\u7684\u52d5\u7269\u6a21\u578b\uff1b\u9664\u6b64\u4e4b\u5916\uff0cHIV \u5177\u6709\u9ad8\u5ea6\u8b8a\u7570\u6027\u4e26\u662f\u500b\u7cbe\u660e\u7684\u507d\u88dd\u8005\uff0c\u9020\u6210\u96e3\u4ee5\u8457\u624b\u627e\u51fa\u9069\u5408\u7684\u6297\u539f\u4f5c\u70ba\u514d\u75ab\u7cfb\u7d71\u8fa8\u8b58\u7528\u7684\u5047\u60f3\u6575\u3002<\/p>\n

\u25cf<\/b>\u958b\u767c\u611b\u6ecb\u75ab\u82d7\u5fc5\u9700\u5177\u5099\u826f\u597d\u7684\u52d5\u7269\u6a21\u578b<\/strong>\u3001<\/strong>\u9069\u7576\u7684\u5047\u60f3\u6575\u6297\u539f<\/strong><\/span><\/p>\n

\u958b\u767c\u51fa\u7334\u5b50\u611b\u6ecb\u75c5\u65b0\u75ab\u82d7\u7684\u6a5f\u69cb\u4f4d\u65bc\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\uff0c\u8457\u540d\u7684\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240 (Scripps Research Institute) \u5728 2018 \u5e74\u5e95\u5c07\u5176\u7814\u7a76\u6210\u679c\u767c\u8868\u65bc\u300aImmunity\u300b\u671f\u520a\u3002\u5982\u524d\u6587\u6240\u63d0\uff0c\u67b6\u69cb\u826f\u597d\u53ef\u4fe1\u7684\u52d5\u7269\u6a21\u578b\u662f\u9996\u8981\u689d\u4ef6\uff0c\u7814\u7a76\u8005\u904b\u7528\u6046\u6cb3\u737c\u7334 (rhesus macaque) \u611f\u67d3\u4e00\u7a2e\u548c\u4eba\u985e HIV \u9ad8\u5ea6\u76f8\u4f3c\u7684\u75c5\u6bd2\uff0c\u6b64\u75c5\u6bd2\u7d93\u7531\u4eba\u5de5\u6539\u9020\uff0c\u5d4c\u5408\u4e86\u4eba\u985e\u8207\u7334\u5b50\u7684\u514d\u75ab\uf967\u5168\u75c5\u6bd2 (\u82f1\u6587\u7c21\u7a31 SHIV)\u3002\u6b64\u7279\u6b8a\u7684\u75c5\u6bd2\u682a\u540d\u70ba Tier 2\uff0c\u5df2\u8b49\u660e\u5f88\u96e3\u88ab\u6297\u9ad4\u4e2d\u548c\uff0c\u985e\u4f3c\u611b\u6ecb\u75c5\u6bd2\u5728\u4eba\u985e\u7fa4\u9ad4\u4e2d\u50b3\u64ad\u7684\u5f62\u5f0f\u3002\u56e0\u6b64\uff0c\u65b0\u75ab\u82d7\u7684\u4f5c\u7528\u76ee\u6a19\uff0c\u5c31\u662f\u6559\u5c0e\u7334\u5b50\u7684\u514d\u75ab\u7cfb\u7d71\u80fd\u4ee5\u6297\u9ad4\u6210\u529f\u5305\u8986\u4f4f\u75c5\u6bd2 (\u5c07\u5176\u4e2d\u548c)\uff0c\u9632\u6b62\u7d30\u80de\u88ab\u75c5\u6bd2\u4fb5\u5bb3\u3002<\/p>\n

\u9069\u7576\u7684\u5047\u60f3\u6575\u6297\u539f\uff0c\u9664\u4e86\u8981\u80fd\u5f15\u767c\u9ad4\u5167\u514d\u75ab\u53cd\u61c9\u7522\u751f\u6297\u9ad4\uff0c\u9084\u5fc5\u9808\u4f5c\u7528\u5728\u80fd\u963b\u65b7\u611b\u6ecb\u75c5\u6bd2\u611f\u67d3\u514d\u75ab\u7d30\u80de\u7684\u9014\u5f91\uff0c\u4e26\u4e14\u8981\u5c0d\u4e0d\u540c\u578b\u5225\u7684\u611b\u6ecb\u75c5\u6bd2\u5ee3\u6cdb\u6709\u6548\uff0c\u624d\u53ef\u7a31\u5f97\u4e0a\u662f\u6210\u529f\u75ab\u82d7\u7684\u6297\u539f\u3002\u65e9\u671f\u7814\u7a76\u6311\u9078\u7684\u5047\u60f3\u6575\u6297\u539f\u591a\u662f HIV \u5957\u819c (envelope) \u4e4b\u4e2d\u7684\u55ae\u4e00\u86cb\u767d\u8cea\uff0c\u4f46\u5957\u819c\u8b8a\u5316\u591a\u7aef\u4f7f\u5f97\u75ab\u82d7\u96e3\u4ee5\u9054\u5230\u5ee3\u6cdb\u6709\u6548\u3001\u6216\u7121\u6cd5\u5f15\u767c\u9ad4\u5167\u7522\u751f\u8db3\u5920\u591a\u7684\u6297\u9ad4\uff0c\u8a31\u591a\u7814\u7a76\u4e0d\u5f97\u4ee5\u5931\u6557\u544a\u7d42\u3002\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u901a\u904e\u57fa\u56e0\u5de5\u7a0b\uff0c\u6539\u9020\u51fa\u4e00\u7a2e\u6a21\u4eff\u5957\u819c\u6574\u9ad4\u7d50\u69cb\u7a31\u70ba\u300cSOSIP\u300d\u7684\u4e09\u805a\u9ad4\u86cb\u767d\u8cea\uff0c\u662f\u7531\u591a\u500b\u86cb\u767d\u6b21\u55ae\u5143\u7d44\u6210\u7684\u8907\u96dc\u7d50\u69cb\u3002\u5728\u6046\u6cb3\u737c\u7334\u7684\u52d5\u7269\u6a21\u578b\u4e0b\uff0cSOSIP \u6210\u529f\u5730\u5f15\u767c\u514d\u75ab\u53cd\u61c9\u4e26\u5728\u7334\u9ad4\u5167\u7522\u751f\u9ad8\u6548\u50f9\u7684\u4e2d\u548c\u6297\u9ad4\uff0c\u53ef\u4fdd\u8b77\u737c\u7334\u5011\u514d\u65bc\u611f\u67d3\u548c HIV \u9ad8\u5ea6\u76f8\u4f3c\u7684\u75c5\u6bd2\u3002<\/p>\n

\u25cf<\/b>\u4eba\u985e\u611b\u6ecb\u75ab\u82d7\u5c1a\u672a\u6210\u529f\uff0c\u79d1\u5b78\u5bb6\u4ecd\u9700\u52aa\u529b<\/strong><\/span><\/p>\n

\u96d6\u7136\u65b0\u75ab\u82d7\u6210\u529f\u5236\u4f0f\u7334\u5b50\u8eab\u4e0a\u7684\u611b\u6ecb\u75c5\u6bd2\uff0c\u4f46\u5c0d\u65bc\u767c\u5c55\u4eba\u985e\u611b\u6ecb\u75ab\u82d7\u4ecd\u7136\u5b58\u5728\u4e00\u4e9b\u672a\u89e3\u4e4b\u8b0e\u3002\u9996\u5148\u6700\u4e3b\u8981\u7684\u554f\u984c\uff0c\u7814\u7a76\u9084\u8655\u65bc\u52d5\u7269\u5be6\u9a57\u968e\u6bb5\uff0c\u4e0d\u8ad6\u7334\u5b50\u8eab\u4e0a\u7684\u611b\u6ecb\u75c5\u6bd2\u548c\u4eba\u985e\u7684\u6709\u591a\u9ebc\u9ad8\u5ea6\u76f8\u4f3c\uff0c\u7562\u7adf\u9084\u662f\u6709\u6240\u4e0d\u540c\u3002\u5176\u6b21\u662f\u4e26\u975e\u6240\u6709\u7684\u737c\u7334\u90fd\u7372\u5f97\u9ad8\u6548\u50f9\u6297\u9ad4\uff0c\u800c\u6297\u9ad4\u6548\u50f9\u8d8a\u4f4e\u5247\u5c0d\u6297\u75c5\u6bd2\u7684\u4fdd\u8b77\u529b\u8d8a\u5dee\uff0c\u9019\u4e5f\u518d\u884d\u751f\u51fa\u9ad8\u6548\u50f9\u6297\u9ad4\u80fd\u5920\u7dad\u6301\u7684\u6642\u9593\u6709\u591a\u4e45\uff1f\u96d6\u7136\u9084\u6709\u4e00\u7c6e\u7b50\u7684\u56f0\u96e3\u6709\u5f85\u514b\u670d\uff0c\u4e0d\u904e\u7e3d\u9ad4\u4f86\u8aaa\uff0c\u8ddd\u96e2\u958b\u767c\u51fa\u4eba\u985e\u611b\u6ecb\u75ab\u82d7\u9019\u500b\u7406\u60f3\uff0c\u79d1\u5b78\u5bb6\u5011\u53c8\u5411\u524d\u9081\u9032\u4e86\u4e00\u5927\u6b65\u3002\u611b\u6ecb\u75c5\u4e00\u76f4\u4ee5\u4f86\u90fd\u662f\u4ee4\u4eba\u805e\u4e4b\u8272\u8b8a\u7684\u75be\u75c5\uff0c\u5982\u4eca\u51fa\u73fe\u6b64\u9805\u7814\u7a76\u6210\u679c\u8b93\u4eba\u611f\u5230\u4e86\u5e0c\u671b\u548c\u632f\u596e\uff0c\u96d6\u5230\u4eba\u985e\u75ab\u82d7\u6b63\u5f0f\u554f\u4e16\u80af\u5b9a\u9084\u6709\u4e00\u6bb5\u8def\u8981\u8d70\uff0c\u4f46\u4ecd\u671f\u5f85\u7dca\u63a5\u800c\u4f86\u7684\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u4e5f\u80fd\u7d66 HIV \u4e00\u8a18\u91cd\u64ca\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. \u885b\u751f\u798f\u5229\u90e8\u75be\u75c5\u7ba1\u5236\u7f72\uff1a\u4eba\u985e\u514d\u75ab\u7f3a\u4e4f\u75c5\u6bd2\u611f\u67d3<\/a><\/li>\n
  2. The history of vaccines: The Development of HIV Vaccines.<\/a><\/li>\n
  3. Pauthner MG, et al. Immunity. 2018. pii: S1074-7613(18)30493-X. Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.<\/a><\/li>\n
  4. Haynes BF, et al. Science. 2017;355:1129-30. Developing an HIV vaccine.<\/a><\/li>\n<\/ol>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    \u25a0\u50cf\u5b6b\u609f\u7a7a\u4e00\u6a23\u6703\u4e03\u5341\u4e8c\u8b8a\u7684\u4eba\u985e\u514d\u75ab\u4e0d\u5168\u75c5\u6bd2 (human immunodeficiency virus, HIV)\uff0c\u9019\u6b21\u7d42\u65bc\u51fa\u73fe\u7dca\u7b8d\u5492\u53ef\u4ee5\u5236\u4f0f\u5b83\u4e86\u55ce\uff1f\u5728\u7334\u5b50\u52d5\u7269\u5be6\u9a57\u767c\u5c55\u51fa\u7684\u611b\u6ecb\u75c5\u65b0\u75ab\u82d7\uff0c\u770b\u4f86\u6709\u6a5f\u6703\u70ba\u9019\u5834\u4eba\u985e\u5c0d\u6297 HIV \u8d85\u904e 30 \u5e74\u7684\u6230\u722d\u6d6e\u73fe\u4e00\u9053\u66d9\u5149\u3002 <\/p>\n","protected":false},"author":20,"featured_media":33575,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[3244,256,4163,254,714],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/01\/1024px-Macaque_India_4.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33574"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33574"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33574\/revisions"}],"predecessor-version":[{"id":33682,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33574\/revisions\/33682"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/33575"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=33574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=33574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}