{"id":33544,"date":"2019-02-15T00:18:59","date_gmt":"2019-02-14T16:18:59","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33544"},"modified":"2019-02-15T09:47:31","modified_gmt":"2019-02-15T01:47:31","slug":"%e5%b0%8f%e8%82%a5%e8%82%9a%ef%bc%8c%e4%b8%8d%e7%99%bc%e6%84%81%ef%bc%9b%e5%ae%83%e6%97%a2%e8%a6%86%e4%ba%86%e8%88%9f%ef%bc%8c%e5%b0%b1%e5%8f%af%e8%bc%89%e8%88%9f%e3%80%82","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33544","title":{"rendered":"\u5c0f\u80a5\u809a\uff0c\u4e0d\u767c\u6101\uff1b\u5b83\u65e2\u8986\u4e86\u821f\uff0c\u5c31\u53ef\u8f09\u821f"},"content":{"rendered":"

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\u9019\u7bc7\u8ad6\u6587\u4e00\u767c\u8868\uff0c\u5f15\u8d77\u8a31\u591a\u81e8\u5e8a\u91ab\u751f\u8207\u7814\u7a76\u4eba\u54e1\u7684\u6295\u66f8\u3002\u8cea\u7591\u7684\u8072\u6d6a\u7121\u5916\u4e4e BMI \u6307\u6578\u7528\u65bc\u8a55\u4f30\u764c\u75c7\u75c5\u60a3\u5c0d\u65bc\u514d\u75ab\u6cbb\u7642\u7684\u53cd\u61c9\uff0c\u4f3c\u4e4e\u904e\u65bc\u7c97\u679d\u5927\u8449\u3002\u4e00\u5247\uff0cBMI \u6307\u6578\u7121\u6cd5\u59a5\u5207\u53cd\u61c9\u75c5\u4eba\u8eab\u9ad4\u5167\uff0c\u808c\u8089\u8207\u8102\u80aa\u7d44\u7e54\u7684\u76f8\u5c0d\u7d44\u6210\u3002\u4e8c\u5247\uff0c\u764c\u75c7\u75c5\u4eba\u7684\u9ad4\u91cd\uff0c\u672c\u8eab\u5c31\u662f\u6d6e\u52d5\u7684\u6307\u6578\uff1b\u6cc1\u4e14\uff0c\u764c\u75c7\u53c8\u662f\u76f8\u7576\u8017\u640d\u7cbe\u795e\u6c23\u529b\u7684\u75be\u75c5\uff0c\u75c5\u4eba\u5728\u63a5\u53d7\u764c\u75c7\u6cbb\u7642\u6642\u7684\u9ad4\u91cd\uff0c\u771f\u5f97\u80fd\u5920\u4f5c\u70ba\u89c0\u671b\u9810\u5f8c\u72c0\u6cc1\u7684\u9b54\u93e1\u55ce\uff1f<\/p>\n

\u6211\u5011\u59d1\u4e14\u4e0d\u8ad6 Jennifer McQuade \u91ab\u751f\u8207 Michael Davies \u91ab\u751f\u5c0d\u9019\u4e9b\u8cea\u7591\u7684\u56de\u61c9\uff0c\u5012\u662f\u4f86\u4e00\u8d77\u770b\u770b\u6700\u8fd1\u5728 Nature Medicine<\/em> \u671f\u520a\u4e0a\uff0c\u52a0\u5dde\u5927\u5b78\u6234\u7dad\u65af\u5206\u6821\u7684 William Murphy \u6559\u6388\u548c Arta Monjazeb \u6559\u6388\u5be6\u9a57\u5ba4\uff0c\u767c\u73fe\u4e86\u4ec0\u9ebc\u5427\u3002\u6216\u8a31\uff0c\u4ed6\u5011\u5728 Nature Medicine <\/em>\u4e0a\u7684\u767c\u73fe\uff0c\u6b63\u5de7\u80fd\u5920\u89e3\u91cbJennifer McQuade \u91ab\u751f\u8207 Michael Davies \u91ab\u751f\u5728\u81e8\u5e8a\u4e0a\u7684\u89c0\u5bdf\u5462\u3002<\/p>\n

William Murphy \u6559\u6388\u548c Arta Monjazeb \u6559\u6388\u5be6\u9a57\u5ba4\u5148\u5229\u7528\u8001\u9f20\u70ba\u5be6\u9a57\u6a21\u578b\uff0c\u4e26\u5229\u7528\u9ad8\u8102\u98fc\u6599\u4f86\u628a\u90e8\u5206\u8001\u9f20\u990a\u80a5\u3002\u516d\u500b\u6708\u5927\uff0c\u6216\u5341\u4e00\u3001\u5341\u4e8c\u500b\u6708\u5927\u5403\u9ad8\u8102\u98fc\u6599\u7684\u8001\u9f20\uff0c\u8981\u6bd4\u5403\u6b63\u5e38\u98fc\u6599\u7684\u8001\u9f20\u80a5\u80d6\u8a31\u591a\uff1a\u76ae\u4e0b\u3001\u8179\u90e8\uff0c\u6eff\u6eff\u7684\u90fd\u662f\u8102\u80aa\u3002\u800c\u9019\u4e9b\u5c0f\u80a5\u9f20\u7684\u809d\u81df\u3001\u813e\u81df\u3001\u5468\u908a\u8840\u6db2\u3001\u8207\u6dcb\u5df4\u7d50\u6aa2\u9ad4\u88e1\uff0c\u514d\u75ab\u7d30\u80de T \u7d30\u80de\u90fd\u8868\u73fe\u9ad8\u91cf\u7684 PD-1\uff0c\u8207\u5176\u4ed6\u986f\u793a T \u7d30\u80de\u8017\u7aed\u7684\u7d30\u80de\u8868\u9762\u5206\u5b50\u3002\u5728\u5206\u6790\u9019\u4e9b T \u7d30\u80de\u7684\u529f\u80fd\u6642\uff0c\u767c\u73fe\u9019\u4e9b T \u7d30\u80de\u4e5f\u7684\u78ba\u50cf\u904e\u52de\u4e00\u6a23\uff0c\u65e2\u7121\u6cd5\u5feb\u901f\u589e\u751f\uff0c\u4e5f\u7121\u6cd5\u6709\u6548\u7387\u5730\u88fd\u9020\u7d30\u80de\u6fc0\u7d20\uff08\u50cf\u662f\u5e72\u64fe\u7d20\u7b49\uff09\u3002\u800c\u5728\u80a5\u80d6\u7684\u6046\u6cb3\u7334\u88e1\uff0c\u4ed6\u5011\u4e5f\u89c0\u5bdf\u5230\u76f8\u61c9\u7684\u985e\u4f3c\u7d50\u679c\u3002\u4e26\u4e14\uff0c\u5728\u816b\u7624\u6a21\u578b\u88e1\uff0c\u9019\u4e9b T \u7d30\u80de\u4e5f\u7121\u6cd5\u6709\u6548\u7684\u904f\u5236\u816b\u7624\u589e\u5927\u3002<\/p>\n

William Murphy \u6559\u6388\u548c Arta Monjazeb \u6559\u6388\u5be6\u9a57\u5ba4\u767c\u73fe\uff0c\u9019\u662f\u56e0\u70ba\u8102\u80aa\u7d30\u80de\u6240\u5206\u6ccc\u7684\u7626\u7d20\uff08leptin\uff09\u5728\u4f5c\u602a\u3002\u5728\u80a5\u80d6\u7684\u500b\u9ad4\u5167\uff0c\u8eab\u9ad4\u5167\u74b0\u5883\u96d6\u7136\u6c92\u6709\u5916\u4f86\u75c5\u539f\u83cc\u4fb5\u5165\uff0c\u4f46\u6703\u8655\u5728\u4e00\u7a2e\u9577\u671f\u3001\u6162\u6027\u3001\u4f4e\u5ea6\u7684\u767c\u708e\u72c0\u614b\uff0c\u6703\u6709\u9ad8\u91cf\u7684\u4fc3\u767c\u708e\u7d30\u80de\u6fc0\u7d20\uff08\u50cf\u662f IL-6 \u8207 TNFa\uff09\u3001\u8461\u8404\u7cd6\u3001\u80f0\u5cf6\u7d20\u3001\u8102\u80aa\u9178\uff0c\u8207\u7626\u7d20\u7b49\u3002\u79d1\u5b78\u5bb6\u5df2\u77e5\u7626\u7d20\u5728\u80a5\u80d6\u500b\u9ad4\u5167\u904e\u91cf\u5b58\u5728\uff0c\u4e5f\u77e5\u9053\u7626\u7d20\u6703\u5f71\u97ff\u5230\u514d\u75ab\u7d30\u80de\u7684\u529f\u80fd\u3002\u4f46\u904e\u53bb\u7684\u7814\u7a76\uff0c\u9084\u6c92\u6709\u767c\u73fe\uff0c\u7626\u7d20\u6703\u5c0e\u81f4\u514d\u75ab T \u7d30\u80de\u5927\u91cf\u8868\u73fe PD-1\u3002<\/p>\n

\u800cMurphy \u8207 Monjazeb \u6559\u6388\u5be6\u9a57\u5ba4\u627e\u5230\u4e86\u7626\u7d20\u6703\u4fc3\u4f7f T \u7d30\u80de\u8868\u73fe PD-1\uff0c\u9032\u800c\u5c0e\u81f4 T \u7d30\u80de\u6d3b\u529b\u5927\u6e1b\u3002\u63a5\u4e0b\u4f86\uff0c\u4ed6\u5011\u66f4\u9032\u4e00\u6b65\uff0c\u5229\u7528\u816b\u7624\u5be6\u9a57\u6a21\u578b\uff0c\u6bd4\u8f03\u80a5\u80d6\u8001\u9f20\u8207\u6b63\u5e38\u9ad4\u91cd\u8001\u9f20\u5c0d\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\uff08\u6297 PD-1 \u6297\u9ad4\uff09\u7684\u6297\u764c\u53cd\u61c9\u3002\u80a5\u80d6\u8001\u9f20\u56e0\u70ba\u9ad4\u5167\u7684 T \u7d30\u80de\uff0c\u672c\u8eab\u5c31\u8868\u73fe\u5927\u91cf\u7684 PD-1\uff0c\u5c0d\u65bc PD-1 \u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\uff0c\u4e5f\u5c31\u7279\u5225\u6709\u53cd\u61c9\u3002\u5728\u75c5\u4eba\u8eab\u4e0a\uff0c\u7814\u7a76\u4eba\u54e1\u4e5f\u767c\u73fe\u985e\u4f3c\u7684\u7d50\u679c\uff1aPD-1 \u6297\u9ad4\u7684\u6297\u764c\u514d\u75ab\u7642\u6cd5\uff0c\u5c0d\u65bc BMI \u6307\u6578\u5927\u65bc 30 \u7684\u80a5\u80d6\u75c5\u4eba\uff0c\u7279\u5225\u6709\u6548\u5462\u3002\u65bc\u662f\u4e4e\uff0c\u56e0\u70ba\u80a5\u80d6\uff0c\u8b93 T \u7d30\u80de\u53d7\u56f0\u65bc\u4e0d\u6b63\u5e38\u3001\u9ad8\u91cf\u8868\u73fe\u7684 PD-1 \u800c\u529f\u80fd\u53d7\u640d\uff0c\u8b93\u500b\u9ad4\u53ef\u80fd\u56e0\u6b64\u6709\u6bd4\u8f03\u9ad8\u7684\u6a5f\u7387\u7f79\u60a3\u764c\u75c7\uff1b\u4f46\u4e5f\u6b63\u56e0\u70ba\u80a5\u80d6\uff0c\u800c\u8b93\u9019\u4e9b\u904e\u91cd\u75c5\u60a3\u9ad4\u5167\u7684 T \u7d30\u80de\uff0c\u80fd\u5920\u6700\u53d7\u76ca\u65bc\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\uff0c\u800c\u56de\u904e\u795e\u4f86\u52c7\u6562\u6297\u764c\u5462\u3002<\/p>\n

\u96d6\u7136\uff0c\u5c31\u50cf\u79d1\u5b78\u5bb6\u5c0d Jennifer McQuade \u8207 Michael Davies \u90a3\u7bc7\u767c\u8868\u65bc The<\/em> Lancet Oncology <\/em>\u4e0a\u8ad6\u6587\uff0c\u6709\u8a31\u591a\u610f\u898b\u4e00\u6a23\u3002BMI \u6307\u6578\u8207\u764c\u75c7\u4e4b\u9593\u7684\u95dc\u4fc2\uff0c\u5b9a\u7136\u4e0d\u662f\u53ea\u6709\u7626\u7d20\u8207 PD-1 \u5f9e\u4e2d\u4f5c\u6897\u9019\u9ebc\u7c21\u55ae\uff0c\u80fd\u5920\u5c31\u6b64\u84cb\u68fa\u8ad6\u5b9a\u7684\u4e8b\u3002Murphy \u8207 Monjazeb \u6559\u6388\u5728 Nature Medicine <\/em>\u4e0a\u7684\u7814\u7a76\u6210\u679c\uff0c\u63d0\u4f9b\u4e86\u4e00\u500b\u53ef\u80fd\u7684\u75c5\u7406\u6a5f\u8f49\uff0c\u8b93\u6211\u5011\u5c0d\u65bc\u81e8\u5e8a\u4e0a\u89c0\u5bdf\u5230\u7684\u73fe\u8c61\uff0c\u80fd\u5920\u52a0\u4ee5\u89e3\u91cb\u3002\u4f46\uff0c\u5927\u5bb6\u4e5f\u5225\u5fd8\u8a18\uff0c\u751f\u7406\u7cfb\u7d71\u88e1\u5de7\u85cf\u4e86\u5343\u767e\u7a2e\u727d\u4e00\u9aee\u52d5\u5168\u8eab\u7684\u6a5f\u95dc\uff0c\u7d55\u975e\u55ae\u9760\u7626\u7d20\u8207 PD-1\uff0c\u5c31\u80fd\u5920\u5c07\u4e00\u5207\u6a5f\u95dc\u7b97\u76e1\u5594\u3002<\/p>\n

 <\/p>\n

\u539f\u59cb\u8ad6\u6587\uff1a<\/strong><\/p>\n

    \n
  1. Murphy \u8207 Monjazeb \u6559\u6388\u5728 Nature Medicine <\/em>\u4e0a\u7684\u7814\u7a76\u6210\u679c\uff1aWang Z et al. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med. 2018 Nov 12. doi: 10.1038\/s41591-018-0221-5.<\/li>\n<\/ol>\n
      \n
    1. Jennifer McQuade \u8207 Michael Davies \u90a3\u7bc7\u767c\u8868\u65bc The<\/em> Lancet Oncology <\/em>\u4e0a\u8ad6\u6587\uff1aMcQuade JL et al. Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis. Lancet Oncol. 2018 Mar;19(3):310-322. doi: 10.1016\/S1470-2045(18)30078-0. Epub 2018 Feb 12.<\/li>\n<\/ol>\n

      \u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

        \n
      1. Larsson SC et al. Excess body fatness: an important cause of most cancers. Lancet. 2008 Feb 16;371(9612):536-7. doi: 10.1016\/S0140-6736(08)60247-0.<\/li>\n
      2. Renehan AG, et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008; 371: 569\u201378.<\/li>\n
      3. Wherry, E. J. & Kurachi, M. Molecular and cellular insights into T cell exhaustion. Nat. Rev. Immunol. 15, 486\u2013499 (2015).<\/li>\n
      4. Deng, T., Lyon, C. J., Bergin, S., Caligiuri, M. A. & Hsueh, W. A. Obesity, inflammation, and cancer. Annu. Rev. Pathol. 11, 421\u2013449 (2016).<\/li>\n<\/ol>\n

        --<\/strong>
        \n\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/p>\n

         <\/p>\n

        \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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