{"id":33533,"date":"2019-02-12T00:00:35","date_gmt":"2019-02-11T16:00:35","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33533"},"modified":"2019-01-31T10:56:39","modified_gmt":"2019-01-31T02:56:39","slug":"%e7%b3%96%e5%b0%bf%e7%97%85%e8%80%81%e8%97%a5%ef%bc%8b%e9%ab%98%e8%a1%80%e5%a3%93%e8%80%81%e8%97%a5-%e6%b2%bb%e7%99%82%e7%99%8c%e7%97%87%e6%96%b0%e7%94%a8%e9%80%94%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33533","title":{"rendered":"\u7cd6\u5c3f\u75c5\u8001\u85e5\uff0b\u9ad8\u8840\u58d3\u8001\u85e5 = \u6cbb\u7642\u764c\u75c7\u65b0\u7528\u9014\uff1f"},"content":{"rendered":"

\u25a0\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u58d3\u3001\u764c\u75c7\uff0c\u4e09\u7a2e\u770b\u4f3c\u6c92\u6709\u95dc\u806f\u6027\u7684\u75be\u75c5\uff0c\u600e\u9ebc\u7cd6\u5c3f\u75c5\u8001\u85e5 metformin \u5408\u4f75\u4e86\u9ad8\u8840\u58d3\u8001\u85e5 syrosingopine \u4e4b\u5f8c\uff0c\u7adf\u7136\u53ef\u4ee5\u7a81\u767c\u5947\u60f3\u7528\u65bc\u6cbb\u7642\u764c\u75c7\uff1f\u9019\u80cc\u5f8c\u96b1\u85cf\u8457\u4ec0\u9ebc\u6a5f\u5236\u539f\u7406\uff0c\u4ee5\u53ca\u4ee3\u8868\u8457\u4ec0\u9ebc\u542b\u7fa9\u5462\uff1f<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u51fa\u8655\uff1apixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u25cf\u8001\u85e5\u65b0\u7528\u662f\u85e5\u7269\u958b\u767c\u7684\u6975\u4f73\u6377<\/strong>\u5f91<\/strong><\/span><\/p>\n

\u767c\u8868\u5728 Cell Reports<\/em> \u671f\u520a\u7684\u6700\u65b0\u7814\u7a76\u6307\u51fa\uff0cmetformin \u5408\u4f75 syrosingopine \u7684\u85e5\u7269\u7d44\u5408\u53ef\u4ee5\u6bba\u6b7b\u764c\u7d30\u80de\u3002\u5947\u5999\u4e4b\u8655\u5728\u65bc\uff0c\u5176\u4e2d metformin \u70ba\u4e00\u7a2e\u964d\u8840\u7cd6\u85e5\u7528\u65bc\u6cbb\u7642\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\uff0c\u5df2\u662f\u500b\u63a8\u51fa\u8d85\u904e 50 \u5e74\u3001\u4f7f\u7528\u5ee3\u6cdb\u7684\u8001\u85e5\uff0c\u800c syrosingopine \u70ba\u4e00\u7a2e\u964d\u8840\u58d3\u85e5\u7528\u65bc\u6cbb\u7642\u9ad8\u8840\u58d3\uff0c\u4e5f\u662f\u500b\u4e0a\u5e02\u8d85\u904e 50 \u5e74\u7684\u6230\u5834\u8001\u5c07\u3002\u5728\u7af6\u722d\u6fc0\u70c8\u7684\u91ab\u85e5\u958b\u767c\u9818\u57df\uff0c\u5f80\u5f80\u662f\u9577\u6c5f\u5f8c\u6d6a\u63a8\u524d\u6d6a\uff0c\u4e00\u4ee3\u65b0\u85e5\u52dd\u820a\u85e5\u3002\u4e0d\u904e\u9019\u6b21\u8001\u5175\u4e0d\u6b7b\uff0c\u4e5f\u4e0d\u51cb\u96f6\uff0c\u900f\u904e\u770b\u4f3c\u4e0d\u76f8\u5e72\u7684\u5169\u500b\u8001\u85e5\u7269\u806f\u624b\uff0c\u7d50\u679c\u62d3\u5c55\u51fa\u4e86\u6cbb\u7642\u764c\u75c7\u7684\u65b0\u9053\u8def\u3002\u5176\u5be6\u9019\u6a23\u70ba\u8001\u85e5\u627e\u51fa\u65b0\u7528\u9014\u7684\u60f3\u6cd5\uff0c\u662f\u500b\u5341\u5206\u80fd\u7bc0\u7701\u6642\u9593\u3001\u6e1b\u5c11\u7814\u767c\u7d93\u8cbb\u7684\u7b56\u7565\u3002\u56e0\u70ba\u8001\u85e5\u6bd4\u8d77\u65b0\u85e5\u7684\u512a\u52e2\uff0c\u5728\u65bc\u5df2\u6709\u8f03\u591a\u3001\u8f03\u5b8c\u6574\u7684\u81e8\u5e8a\u85e5\u7269\u8cc7\u6599\uff0c\u8001\u85e5\u5728\u81e8\u5e8a\u4e0a\u4e5f\u7d2f\u7a4d\u4e86\u66f4\u591a\u4eba\u9ad4\u4f7f\u7528\u7684\u5b89\u5168\u6027\u6578\u64da\uff0c\u6240\u4ee5\u5373\u4f7f\u5728\u65b0\u7528\u9014\u4e0a\u5fc5\u9700\u6539\u8b8a\u5291\u91cf\u6216\u5291\u578b\uff0c\u90fd\u80fd\u5920\u66f4\u5bb9\u6613\u7684\u63a8\u6e2c\u51fa\u5176\u526f\u4f5c\u7528\u3002\u7562\u7adf\u8001\u85e5\u7576\u521d\u4e0a\u5e02\u6642\u4e5f\u662f\u8017\u8cbb\u4e86\u5de8\u5927\u7684\u6642\u9593\u3001\u4eba\u529b\u3001\u53ca\u7d93\u8cbb\uff0c\u6240\u4ee5\u958b\u767c\u51fa\u65b0\u7528\u9014\u66f4\u80fd\u5c07\u8001\u85e5\u7684\u6f5b\u80fd\u767c\u63ee\u5f97\u6dcb\u6f13\u76e1\u81f4\u3002<\/p>\n

\u25cf\u7cd6\u5c3f\u75c5\u8207\u764c\u75c7<\/strong>\u7684\u95dc\u4fc2<\/strong>\uff0c<\/strong>\u526a\u4e0d\u65b7<\/strong>\uff0c<\/strong>\u7406\u9084\u4e82\uff1f<\/strong><\/span><\/p>\n

\u96d6\u7136\u662f metformin \u5408\u4f75 syrosingopine \u7684\u5169\u7a2e\u85e5\u7269\u7d44\u5408\uff0c\u4e0d\u904e\u626e\u6f14\u6297\u764c\u4f5c\u7528\u6838\u5fc3\u7684\u4e3b\u89d2\u662f\u964d\u8840\u7cd6\u85e5 metformin\uff0c\u800c\u964d\u8840\u58d3\u85e5 syrosingopine \u5247\u662f\u64d4\u7576\u914d\u89d2\u4f5c\u70ba\u5f9e\u65c1\u5354\u52a9\u7684\u5e6b\u624b\u3002\u7cd6\u5c3f\u75c5\u8207\u764c\u75c7\u7684\u95dc\u4fc2\u65e9\u5728 1934 \u5e74\u5b78\u8005 Marble A \u5c31\u5df2\u6307\u51fa\u5169\u8005\u7684\u95dc\u806f\u6027\uff0c\u8fd1\u5341\u5e7e\u5e74\u4f86\u4e5f\u7372\u5f97\u8d8a\u4f86\u8d8a\u591a\u7814\u7a76\u7684\u8a8d\u53ef\u3002\u5f9e\u6d41\u884c\u75c5\u5b78\u8b49\u64da\u986f\u793a\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u7372\u5f97\u764c\u75c7\u7684\u98a8\u96aa\u9ad8\u65bc\u4e00\u822c\u4eba\uff1b\u53cd\u904e\u4f86\u770b\uff0c\u764c\u75c7\u60a3\u8005\u51fa\u73fe\u8840\u7cd6\u4ee3\u8b1d\u7570\u5e38\u7684\u6a5f\u7387\u4e5f\u6bd4\u8f03\u9ad8\uff0c\u8d77\u56e0\u5728\u65bc\u764c\u75c7\u7642\u6cd5\u904e\u7a0b\u4e2d\u7684\u526f\u4f5c\u7528\u53ef\u80fd\u5f15\u767c\u9ad8\u8840\u7cd6\u3002\u7cd6\u5c3f\u75c5\u8207\u764c\u75c7\u4e4b\u9593\u7684\u8907\u96dc\u95dc\u4fc2\u7531\u8a31\u591a\u56e0\u7d20\u6240\u5171\u540c\u69cb\u6210\uff0c\u624d\u5c0e\u81f4\u6700\u7d42\u89c0\u5bdf\u5230\u9019\u6a23\u7684\u73fe\u8c61\uff0c\u56e0\u6b64\u5c1a\u4e0d\u80fd\u76f4\u63a5\u65b7\u8a00\u7cd6\u5c3f\u75c5\u6703\u9020\u6210\u764c\u75c7\uff0c\u4f46\u78ba\u5be6\u5169\u8005\u4e92\u70ba\u5f71\u97ff\u56e0\u5b50\u3002\u5f9e\u9019\u500b\u89d2\u5ea6\u4f86\u770b\uff0c\u7cd6\u5c3f\u75c5\u85e5\u7269 metformin \u6709\u6297\u764c\u7684\u6548\u679c\u4f3c\u4e4e\u5c31\u4e0d\u90a3\u9ebc\u5947\u602a\u4e86\uff0c\u5be6\u969b\u4e0a\u4e0d\u5c11\u6d41\u884c\u75c5\u5b78\u548c\u57fa\u790e\u7814\u7a76\u5df2\u7d93\u8b49\u660e metformin \u80fd\u6291\u5236\u591a\u7a2e\u764c\u7d30\u80de\u7684\u751f\u9577\uff0c\u4e26\u4e14\u8d8a\u4f86\u8d8a\u591a\u95dc\u65bc metformin \u6297\u764c\u6d3b\u6027\u7684\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u9032\u884c\u3002<\/p>\n

\u25cf\u5169\u500b\u8001\u85e5\u806f\u624b\u963b\u65b7\u764c\u7d30\u80de\u7684\u80fd\u91cf\u4f9b\u61c9<\/strong><\/span><\/p>\n

\u8a71\u984c\u7e5e\u56de Cell Reports<\/em> \u4e0a\u7684\u9019\u7bc7\u6587\u7ae0\uff0cmetformin \u5408\u4f75 syrosingopine \u70ba\u4f55\u5177\u6709\u6bba\u6b7b\u764c\u7d30\u80de\u7684\u6548\u679c\uff1f\u6211\u5011\u90fd\u66c9\u5f97\u764c\u7d30\u80de\u7684\u7279\u6027\u5c31\u662f\u80fd\u5920\u4e0d\u505c\u5730\u5206\u88c2\u751f\u9577\uff0c\u6240\u4ee5\u6bd4\u8d77\u6b63\u5e38\u7d30\u80de\u66f4\u9700\u8981\u5927\u7684\u80fd\u91cf\u4f86\u6e90\uff0c\u5f97\u6d88\u8017\u66f4\u591a\u7684\u8461\u8404\u7cd6\u3002\u5728\u7d30\u80de\u4e2d\u8461\u8404\u7cd6\u4ee3\u8b1d\u6210\u80fd\u91cf\u7684\u904e\u7a0b\uff0c\u4e0d\u53ef\u6216\u7f3a\u7684\u7269\u8cea\u5fc5\u9808\u4e0d\u65b7\u5f9e NADH \u751f\u6210 NAD+\uff0c\u800c\u964d\u8840\u7cd6\u85e5 metformin \u80fd\u76f4\u63a5\u6291\u5236\u6b64\u6b65\u9a5f\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u964d\u8840\u58d3\u85e5 syrosingopine \u53ef\u4ee5\u6291\u5236\u7d30\u80de\u4e0a\u7684\u4e73\u9178\u904b\u8f38\u86cb\u767d (lactate transporter)\uff0c\u4f7f\u5f97\u904e\u591a\u7684\u4e73\u9178\u5806\u7a4d\u5728\u7d30\u80de\u5167\uff0c\u9593\u63a5\u5730\u6291\u5236 NADH \u8b8a\u70ba NAD+\uff0c\u9032\u800c\u52a0\u5f37\u4e86 metformin \u7684\u6548\u679c\u3002\u5728\u5169\u7a2e\u85e5\u7269\u7684\u96d9\u91cd\u4f5c\u7528\u4e0b\uff0c\u7f3a\u4e4f NAD+ \u7684\u764c\u7d30\u80de\u56e0\u7121\u6cd5\u7372\u5f97\u8db3\u5920\u80fd\u91cf\u800c\u6b7b\u4ea1\u3002\u9019\u6a23\u7684\u85e5\u7269\u7d44\u5408\u9084\u89e3\u6c7a\u4e86\u4e00\u500b\u96e3\u984c\uff0c\u7531\u65bc\u4e00\u822c\u7528\u65bc\u6cbb\u7642\u7cd6\u5c3f\u75c5\u6642\u7684 metformin \u5291\u91cf\uff0c\u9084\u4e0d\u8db3\u4ee5\u6709\u6548\u5c0d\u6297\u764c\u75c7\uff0c\u4f46\u82e5\u662f\u5291\u91cf\u592a\u9ad8\u537b\u6703\u9020\u6210\u96e3\u4ee5\u627f\u53d7\u7684\u526f\u4f5c\u7528\uff0c\u6240\u4ee5\u5728\u81e8\u5e8a\u61c9\u7528\u4e0a\u6709\u5176\u969c\u7919\u3002\u4e0d\u904e\u7814\u7a76\u767c\u73fe\u642d\u914d syrosingopine \u5f8c\u80fd\u964d\u4f4e metformin \u7684\u5291\u91cf\uff0c\u4e26\u4fdd\u6709\u6297\u764c\u6d3b\u6027\u3002<\/p>\n

\u25cf\u85e5\u7269\u7684\u975e\u5c08\u4e00\u6027\u53cd\u800c\u5177\u5099\u4e86\u5176\u4ed6\u6548\u679c<\/strong><\/span><\/p>\n

Metformin \u9664\u4e86\u4e0a\u8ff0\u7684\u964d\u8840\u7cd6\u3001\u6297\u764c\u7684\u6548\u679c\uff0c\u76ee\u524d\u9084\u6709\u5176\u4ed6\u75be\u75c5\u7684\u61c9\u7528\u9678\u7e8c\u88ab\u767c\u73fe\uff0c\u4f8b\u5982\u7528\u65bc\u6cbb\u7642\u80ba\u7e96\u7dad\u5316 (pulmonary fibrosis)\u3002\u4ee5\u5f80\u85e5\u7269\u4f5c\u7528\u5728\u76ee\u6a19\u4e4b\u5916\u7684\u6548\u679c\uff0c\u4e5f\u5c31\u662f\u6240\u8b02\u7684\u812b\u9776\u6548\u61c9 (off-target effect) \u5e38\u88ab\u8996\u70ba\u662f\u7a2e\u7f3a\u9ede\uff0c\u56e0\u70ba\u85e5\u7269\u5c0d\u6a19\u9776\u7684\u5c08\u4e00\u6027\u4e0d\u5920\u9ad8\u3002\u4f46\u5176\u5be6\u63db\u500b\u89d2\u5ea6\u770b\uff0c\u9019\u8868\u793a\u6b64\u85e5\u7269\u5177\u6709\u300c\u591a\u9776\u85e5\u7406 (polypharmacology)\u300d\u7279\u6027\uff0c\u8aaa\u4e0d\u5b9a\u9084\u6f5b\u85cf\u8457\u5c0d\u4e0d\u540c\u75be\u75c5\u7684\u6cbb\u7642\u6548\u679c\u3002\u8fd1\u5e74\u4f86\u9019\u7a2e\u89c0\u9ede\u65e5\u6f38\u53d7\u5230\u91cd\u8996\uff0c\u8001\u85e5\u9664\u4e86\u5df2\u6709\u719f\u77e5\u7684\u5b89\u5168\u6027\uff0c\u50f9\u683c\u901a\u5e38\u4e5f\u8f03\u4fbf\u5b9c\uff0c\u767c\u5c55\u65b0\u7684\u75be\u75c5\u61c9\u7528\u986f\u7136\u53ef\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\uff0c\u671f\u5f85\u672a\u4f86\u80fd\u4e0d\u65b7\u5730\u6316\u6398\u51fa\u8001\u85e5\u65b0\u6f5b\u529b\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Benjamin D, et al. Cell Rep. 2018;25:3047-3058.e4. Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.<\/a><\/li>\n
  2. \u9ec3\u632f\u7d9c\uff0c\u79d1\u5b78\u6708\u520a\u7b2c558\u671f\uff0c\u5927\u6578\u64da\u5206\u6790\u2014\u63a2\u7d22\u8001\u85e5\u65b0\u7528<\/a><\/li>\n
  3. Zi F, et al. Oncol Lett. 2018;15:683-690. Metformin and cancer: An existing drug for cancer prevention and therapy.<\/a><\/li>\n
  4. \u6c88\u5b9c\u975c\uff0c\u5167\u79d1\u5b78\u8a8c 2011;22:19-30\uff0c\u7cd6\u5c3f\u75c5\u8207\u764c\u75c7\u4e4b\u95dc\u806f\u4ee5\u53ca\u81fa\u7063\u73fe\u6cc1\u63a2\u8a0e<\/a><\/li>\n
  5. \u674e\u6607\u806f\u91ab\u5e2b\uff0c\u548c\u4fe1\u6cbb\u7642\u4e2d\u5fc3\u91ab\u9662\u5c08\u984c\u8a2a\u8ac7 06.29\uff0c\u7cd6\u5c3f\u75c5\u8207\u764c\u75c7\u662f\u300c\u54e5\u5006\u597d\u300d\u55ce\uff1f<\/a><\/li>\n
  6. Dos Santos CC, et al. Cell Metab. 2018;28:334-36. Metformin: An Old Dog with a New Trick?<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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