{"id":33294,"date":"2019-01-04T00:51:38","date_gmt":"2019-01-03T16:51:38","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33294"},"modified":"2019-07-31T11:05:44","modified_gmt":"2019-07-31T03:05:44","slug":"%e4%be%86%e8%87%aa%e9%97%8c%e5%b0%be%e7%9a%84%e9%80%86%e8%a5%b2%ef%bc%9a%e6%98%af%e9%97%8c%e5%b0%be%e8%ae%93%e7%a5%9e%e7%b6%93%e7%b3%bb%e7%b5%b1%e5%81%a5%e5%ba%b7%e7%88%9b%e5%b0%be%e5%97%8e%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33294","title":{"rendered":"\u4f86\u81ea\u95cc\u5c3e\u7684\u9006\u8972\uff1a\u662f\u95cc\u5c3e\u8b93\u795e\u7d93\u7cfb\u7d71\u5065\u5eb7\u721b\u5c3e\u55ce\uff1f"},"content":{"rendered":"<p><span style=\"color: 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data-wp-pid=\"33300\">\u64b0\u6587\uff5c\u99f1\u5b9b\u7433<\/strong><\/p>\n<p>\u6f14\u5316\u5728\u4eba\u9ad4\u88e1\u7684\u907a\u8de1\u6709\u4e09\u5bf6\uff0c\u95cc\u5c3e\u3001\u5c3e\u690e\uff0c\u548c\u667a\u9f52\u3002\u667a\u9f52\u64fa\u4e86\u5728\u5634\u88e1\u6015\u5b83\u86c0\uff0c\u95cc\u5c3e\u64f1\u5728\u809a\u5b50\u88e1\u6015\u5b83\u767c\u708e\u4e86\u8b8a\u81c9\u6210\u4e00\u9846\u5b9a\u6642\u70b8\u5f48\u3002\u4f46\u6015\u86c0\u7259\u53ef\u4ee5\u5148\u62d4\u6389\u667a\u9f52\uff0c\u537b\u5f9e\u4f86\u6c92\u807d\u904e\u6709\u4eba\u6015\u95cc\u5c3e\u767c\u708e\u800c\u5148\u628a\u95cc\u5c3e\u5272\u6389\u3002<\/p>\n<p>\u4e0d\u904e\uff0c\u95cc\u5c3e\u5728\u4eba\u9ad4\u88e1\uff0c\u771f\u7684\u53ea\u662f\u500b\u64fa\u4e86\u9084\u6c92\u6709\u4ec0\u9ebc\u7f8e\u89c0\u6548\u679c\u7684\u82b1\u74f6\u55ce\uff1f\u7b2c\u4e00\u500b\u5c0d\u9019\u500b\u8001\u751f\u5e38\u8ac7\u4e0d\u4ee5\u70ba\u7136\u7684\u662f\u7f8e\u570b Duke University \u91ab\u5b78\u9662\u526f\u6559\u6388 William Parker\u3002William Parker \u535a\u58eb\u7684\u5be6\u9a57\u5ba4\u7814\u7a76\u5c08\u9577\u591a\u5143\uff0c\u5f9e\u63a2\u8a0e\u86cb\u767d\u8cea\u5982\u4f55\u6298\u758a\u6210\u7a69\u5b9a\u7684 3D \u7d50\u69cb\u3001\u5668\u5b98\u79fb\u690d\u8207\u514d\u75ab\u7cfb\u7d71\u7684\u6392\u65a5\u53cd\u61c9\uff0c\u5230\u8178\u9053\u83cc\u53e2\u8207\u8178\u9053\u514d\u75ab\u7cfb\u7d71\u4e4b\u9593\u5fae\u5999\u7684\u5e73\u8861\u95dc\u4fc2\uff0c\u90fd\u80fd\u770b\u5230\u4f86\u81ea\u4ed6\u5be6\u9a57\u5ba4\u7684\u91cd\u8981\u8ca2\u737b\u3002\u800c\u9664\u6b64\u4e4b\u5916\uff0cWilliam Parker \u535a\u58eb\u9084\u662f\u500b\u5916\u79d1\u91ab\u751f\u3002\u5c0d\u65bc\u5272\u9664\u95cc\u5c3e\u9019\u500b\u7fd2\u4ee5\u70ba\u5e38\u7684\u624b\u8853\uff0cParker \u535a\u58eb\u537b\u89ba\u5f97\u95cc\u5c3e\u7684\u5b58\u5728\u4e5f\u6709\u5176\u4e0d\u7a00\u5947\u7684\u751f\u7406\u610f\u7fa9\u3002Parker \u535a\u58eb\u89ba\u5f97\u95cc\u5c3e\u5c0d\u4eba\u985e\u7121\u7528\uff0c\u4f46\u4e0d\u4ee3\u8868\u95cc\u5c3e\u5c0d\u6211\u5011\u8178\u9053\u88e1\u64da\u4f30\u8a08\u6709\u4e0a\u5146\u7684\u8178\u9053\u83cc\u53e2\u4f86\u8aaa\uff0c\u4e5f\u7121\u7528\u3002\u5728 2007 \u5e74\u6642\uff0cParker \u5c07\u4ed6\u7684\u60f3\u6cd5\u767c\u8868\u5728\u300a<em>Journal of Theoretical Biology<\/em>\u300b\u3002Parker \u535a\u58eb\u89ba\u5f97\u95cc\u5c3e\u50cf\u662f\u5065\u5eb7\u8178\u9053\u83cc\u53e2\u7684\u907f\u96e3\u5730\u4e0b\u5ba4\uff0c\u7576\u6709\u81f4\u75c5\u83cc\u5165\u4fb5\uff08\u4f8b\u5982\u970d\u4e82\u5f27\u83cc\uff09\u6642\uff0c\u56b4\u91cd\u7684\u8179\u7009\u4e0d\u50c5\u50c5\u75b2\u5f31\u4e86\u8178\u80c3\u9053\uff0c\u4e5f\u50cf\u9f8d\u6372\u98a8\u4e00\u6a23\uff0c\u5c07\u8178\u9053\u83cc\u53e2\u6467\u6b98\u5730\u4e82\u4e03\u516b\u7cdf\u3002\u800c\u9019\u6642\u5019\uff0c\u8eb2\u5728\u95cc\u5c3e\u9019\u500b\u907f\u96e3\u5730\u4e0b\u5ba4\u88e1\u7684\u8178\u9053\u83cc\u53e2\uff0c\u8eb2\u904e\u4e86\u81f4\u75c5\u83cc\u7684\u8fa3\u624b\u6467\u82b1\uff0c\u4e26\u4e14\u53ef\u4ee5\u5728\u98a8\u66b4\u7a0d\u505c\u4e4b\u5f8c\uff0c\u6625\u98a8\u5439\u53c8\u751f\u5730\u91cd\u65b0\u5c07\u8178\u9053\u88e1\u7684\u83cc\u843d\u5fae\u751f\u614b\uff0c\u56de\u5fa9\u5230\u4e4b\u524d\u7684\u6a21\u6a23\u3002<\/p>\n<p>\u4f46\u4efb\u4f55\u79d1\u5b78\u65b0\u4e3b\u5f35\u8207\u65b0\u60f3\u6cd5\uff0c\u90fd\u662f\u9a57\u8b49\u51fa\u4f86\u7684\uff0c\u800c\u4e0d\u662f\u8aaa\u51fa\u4f86\u7684\u3002\u81ea 2012 \u5e74\u8d77\uff0c\u9678\u7e8c\u6709\u76f8\u95dc\u7814\u7a76\uff0c\u767c\u73fe\u95cc\u5c3e\u7684\u5b58\u5728\u7684\u78ba\u53ef\u4ee5\u8b93\u751f\u7269\u500b\u9ad4\u5728\u906d\u9022\u8178\u9053\u75c5\u539f\u83cc\u5165\u4fb5\u800c\u5f15\u767c\u8178\u708e\u6642\uff0c\u80fd\u5920\u66f4\u5feb\u901f\u7684\u6062\u5fa9\uff0c\u4e26\u4e14\u6e1b\u5c11\u8178\u764c\u5fa9\u767c\u7684\u6a5f\u7387\u3002\u9019\u4e9b\u7814\u7a76\u6210\u679c\uff0c\u70ba\u95cc\u5c3e\u4e26\u975e\u7121\u7528\u7684\u8ad6\u9ede\u63d0\u4f9b\u4e86\u81e8\u5e8a\u6578\u64da\u7684\u4f50\u8b49\uff0c\u70ba\u95cc\u5c3e\u6b63\u540d\u4e86\u4e9b\u3002<\/p>\n<p>2017 \u5e74\u521d\u6642\uff0c\u79d1\u5b78\u5bb6\u66f4\u5f9e\u6f14\u5316\u7684\u89d2\u5ea6\uff0c\u767c\u73fe\u95cc\u5c3e\u7684\u78ba\u5728\u8178\u9053\u514d\u75ab\u88e1\u626e\u6f14\u8457\u91cd\u8981\u7684\u89d2\u8272\u3002\u4f4d\u65bc\u7f8e\u570b Midwestern University \u7684 Heather Smith \u526f\u6559\u6388\u5728\u5c0f\u6642\u5019\u5c31\u63a5\u53d7\u4e86\u95cc\u5c3e\u5207\u9664\u624b\u8853\uff0c\u4ed6\u5c0d\u65bc\u95cc\u5c3e\u7684\u6f14\u5316\u6b77\u7a0b\u6709\u8457\u6fc3\u539a\u7684\u8208\u8da3\u3002Heather Smith \u535a\u58eb\u5f9e\u4e00\u500b\u7c21\u55ae\u7684\u554f\u984c\u958b\u59cb\u554f\u8d77\uff1a\u6709\u54ea\u4e9b\u52d5\u7269\u6709\u95cc\u5c3e\u5462\uff1f\u4ed6\u767c\u73fe\u7e3d\u5171\u6709 533 \u7a2e\u52d5\u7269\u3002\u5f9e\u597d\u731c\u7684\u7329\u7329\uff0c\u5230\u76ae\u5361\u4e18\u7684\u539f\u578b\u300c\u9f20\u5154\u300d\uff0c\u95cc\u5c3e\u7684\u5b58\u5728\u4ee5\u52d5\u7269\u7a2e\u7684\u89d2\u5ea6\u4f86\u770b\uff0c\u662f\u92ea\u5929\u84cb\u5730\u3002\u4f46\uff0c\u5f7c\u6b64\u4e4b\u9593\u4f3c\u4e4e\u6c92\u6709\u4ec0\u9ebc\u5171\u540c\u7684\u95dc\u806f\u6027\uff0c\u80fd\u5920\u70ba\u95cc\u5c3e\u7684\u751f\u7269\u529f\u80fd\u63d0\u4f9b\u4e00\u9ede\u7dda\u7d22\u3002<\/p>\n<p>\u4e0d\u904e\uff0cSmith \u535a\u58eb\u7684\u7814\u7a76\u5718\u968a\u4e5f\u767c\u73fe\uff0c\u5728\u6f14\u5316\u53f2\u88e1\uff0c\u95cc\u5c3e\u7684\u5b58\u5728\u4e5f\u4e26\u4e0d\u662f\u4e00\u76f4\u90fd\u5728\uff0c\u800c\u662f\u7368\u7acb\u6f14\u5316\u4e86\u81f3\u5c11\u4e09\u5341\u6b21\u3002\u800c\u4e14\u4e00\u4f46\u5728\u8a72\u7a2e\u65cf\u652f\u7cfb\u88e1\u51fa\u73fe\uff0c\u5c31\u5e7e\u4e4e\u4e0d\u66fe\u6d88\u5931\u3002\u9019\u8b93 Smith \u535a\u58eb\u5927\u81bd\u5047\u8a2d\uff0c\u95cc\u5c3e\u7684\u5b58\u5728\u7684\u78ba\u662f\u80fd\u63d0\u4f9b\u7269\u7a2e\u6f14\u5316\u4e0a\u7684\u512a\u52e2\u3002\u4f46\u9019\u512a\u52e2\u662f\u4ec0\u9ebc\u5462\uff1f<\/p>\n<p>\u4e0d\u662f\u98f2\u98df\u7fd2\u6163\u3001\u4e0d\u662f\u751f\u6d3b\u74b0\u5883\u3001\u4e0d\u662f\u9ad4\u614b\u5927\u5c0f\u3002\u522a\u9664\u4e86\u4e00\u500b\u53c8\u4e00\u500b\u7684\u53ef\u80fd\u5047\u8a2d\uff0c\u552f\u4e00\u6709\u76f8\u95dc\u7684\uff0c\u7adf\u7136\u662f\u8178\u9053\u6cbf\u58c1\u7684\u514d\u75ab\u7d44\u7e54\u3002\u64c1\u6709\u95cc\u5c3e\u7684\u7269\u7a2e\uff0c\u76f2\u8178\u8655\u7684\u6dcb\u5df4\u7d44\u7e54\u5bc6\u5ea6\u8981\u9ad8\u65bc\u6c92\u6709\u95cc\u5c3e\u7684\u7269\u7a2e\u3002<\/p>\n<p>\u9019\u4e00\u7dda\u7684\u7814\u7a76\uff0c\u4f3c\u4e4e\u90fd\u652f\u6301\u95cc\u5c3e\u7684\u597d\u8655\u3002\u53ea\u8981\u4e0d\u767c\u708e\uff0c\u95cc\u5c3e\u80fd\u8b93\u8178\u9053\u83cc\u53e2\u84ec\u52c3\uff0c\u8b93\u8178\u9053\u514d\u75ab\u7cfb\u7d71\u6709\u6d3b\u529b\u3002\u4f46\u6700\u8fd1\uff0c\u5728\u300a<em>Science Translational Medicine<\/em>\u300b\u671f\u520a\u4e0a\uff0c\u4e5f\u51fa\u73fe\u4e00\u7bc7\u7814\u7a76\uff0c\u767c\u73fe\u5207\u9664\u95cc\u5c3e\u4e4b\u5f8c\uff0c\u7f79\u60a3\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u6a5f\u7387\u4e5f\u986f\u8457\u8f03\u4f4e\u5462\u3002<\/p>\n<p>\u5e15\u91d1\u68ee\u6c0f\u75c7\u8087\u56e0\u65bc\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684\u6162\u6027\u9000\u5316\u3002\u81e8\u5e8a\u4e0a\u7684\u4e3b\u8981\u75c5\u5fb5\u4ee5\u884c\u52d5\u56f0\u96e3\u70ba\u4e3b\uff0c\u4e3b\u8981\u662f\u56e0\u70ba\u5927\u8166\u4e2d\u8166\u5340\u7684\u9ed1\u8cea\uff08substantia nigra\uff09\u88e1\uff0c\u591a\u5df4\u80fa\u795e\u7d93\u7d30\u80de\u9010\u6f38\u6b7b\u4ea1\u3002\u591a\u5df4\u80fa\u662f\u4e00\u7a2e\u91cd\u8981\u7684\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0c\u8a31\u591a\u8ddf\u904b\u52d5\u6709\u95dc\u7684\u795e\u7d93\u50b3\u5c0e\u90fd\u5f97\u4ef0\u8cf4\u591a\u5df4\u80fa\u7684\u795e\u7d93\u50b3\u905e\u3002<\/p>\n<p>\u4f46\u9664\u6b64\u4e4b\u5916\uff0c\u5e15\u91d1\u68ee\u6c0f\u75c7\u5176\u5be6\u662f\u6a6b\u8de8\u591a\u7a2e\u751f\u7406\u7cfb\u7d71\u7684\u75be\u75c5\u3002\u4f8b\u5982\uff0c\u5728\u884c\u52d5\u9072\u7de9\u7684\u75c5\u5fb5\u51fa\u73fe\u4e4b\u524d\uff0c\u8178\u80c3\u9053\u7684\u529f\u80fd\u5931\u8abf\u4e5f\u662f\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u666e\u904d\u75c7\u72c0\u4e4b\u4e00\uff0c\u800c\u4e14\u53ef\u80fd\u6bd4\u904b\u52d5\u969c\u7919\u5f62\u65bc\u8868\u8c61\u524d\uff0c\u8981\u66f4\u65e9\u500b\u4e8c\u5341\u5e74\u3002\u5728\u9019\u65e9\u671f\u968e\u6bb5\uff0c\u53ef\u4ee5\u5728\u75c5\u60a3\u8178\u9053\u795e\u7d93\u53e2\u5167\u767c\u73fe\u6838\u7a81\u89f8\u86cb\u767d\uff08synuclein\uff09\uff0c\u50cf\u9eb5\u7c89\u548c\u6c34\u6642\u8abf\u4e0d\u958b\u7684\u5c0f\u9eb5\u7599\u7629\u4e00\u6a23\uff0c\u7e8f\u7d50\u5806\u7a4d\u6210\u8def\u6613\u6c0f\u9ad4\u5c0f\u5718\u584a\uff08synuclein aggregates\uff09\u3002\u800c\u5148\u524d\u6709\u7814\u7a76\u767c\u73fe\uff0c\u9019\u4e9b\u6838\u7a81\u89f8\u86cb\u767d\u7684\u5c0f\u7599\u7629\u86cb\u767d\u8cea\u5718\u584a\uff0c\u53ef\u4e0d\u662f\u7701\u6cb9\u7684\u71c8\uff0c\u5b83\u5011\u53ef\u4ee5\u50cf\u662f\u72c2\u725b\u75c5\u7684\u7570\u5e38\u86cb\u767d\u8cea\u666e\u6602\uff08prion\uff09\u4e00\u6a23\uff0c\u5f9e\u4e00\u500b\u7d30\u80de\u50b3\u67d3\u7d66\u53e6\u4e00\u500b\u7d30\u80de\u3002\u65e9\u671f\u51fa\u73fe\u5728\u8178\u9053\u7cfb\u7d71\u4e2d\u7684\u6838\u7a81\u89f8\u86cb\u767d\u5718\u584a\uff0c\u7591\u4f3c\u53ef\u4ee5\u900f\u904e\u8ff7\u8d70\u795e\u7d93\uff0c\u5c07\u9019\u8b8a\u7570\u5806\u7a4d\u7684\u6838\u7a81\u89f8\u86cb\u767d\u50b3\u5230\u5927\u8166\u3002\u5982\u6b64\uff0c\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u7f6a\u9b41\u798d\u9996\u4e0d\u5728\u5927\u8166\u88e1\uff0c\u800c\u6709\u53ef\u80fd\u662f\u4f86\u81ea\u8178\u80c3\u9053\u5462\u3002<\/p>\n<p>\u800c\u8eab\u70ba\u8178\u80c3\u9053\u7684\u9644\u5c6c\u4e4b\u4e00\uff0c\u95cc\u5c3e\u81ea\u7136\u4e5f\u96e3\u9003\u74dc\u7530\u674e\u4e0b\u4e4b\u5acc\u3002\u65e9\u5148\uff0c\u5df2\u6709\u7814\u7a76\u5728\u95cc\u5c3e\u767c\u73fe\u6838\u7a81\u89f8\u86cb\u767d\u8981\u5806\u7a4d\u6210\u8b8a\u7570\u5c0f\u7599\u7629\u524d\u7684\u524d\u9a45\u7269\u3002\u86cb\u767d\u8cea\u6709\u300c\u7fa7\u57fa\uff0f\u6c2e\u7aef\u300d\u8207\u300c\u78b3\u7aef\u300d\u7684\u65b9\u5411\u6027\uff0c\u800c\u78b3\u7aef\u7684\u6838\u7a81\u89f8\u86cb\u767d\u6b63\u662f\u80fd\u5920\u50ac\u751f\u7570\u5e38\u86cb\u767d\u5806\u7a4d\u7684\u7f6a\u9b41\u798d\u9996\u3002\u800c\u95cc\u5c3e\u7d30\u80de\u5167\uff0c\u6b63\u597d\u6703\u8868\u73fe\u80fd\u5920\u5c07\u6838\u7a81\u89f8\u86cb\u767d\u7684\u78b3\u7aef\u5207\u4e0b\u4f86\u7684\u86cb\u767d\u9176\u3002\u5982\u6b64\u7d30\u7d30\u6b78\u548e\u4e0b\u4f86\uff0c\u8db3\u4ee5\u8b93\u95cc\u5c3e\u7684\u5acc\u7591\u64c4\u7372\u79d1\u5b78\u5bb6\u7684\u8208\u8da3\u3002\u6700\u8fd1\uff0c\u7531\u7f8e\u570b\u3001\u52a0\u62ff\u5927\u3001\u745e\u5178\u8207\u6cd5\u570b\u7684\u5e7e\u4f4d\u79d1\u5b78\u5bb6\uff0c\u806f\u624b\u767c\u8868\u7684\u4e00\u7bc7\u7814\u7a76\uff0c\u66f4\u662f\u4f3c\u4e4e\u5b9a\u4e86\u95cc\u5c3e\u7684\u9435\u7f6a\u3002<\/p>\n<p>\u5982\u4f55\u5b9a\u95cc\u5c3e\u7684\u7f6a\uff1f\u9996\u5148\uff0c\u5982\u679c\u8a72\u5047\u8aaa\u70ba\u771f\uff0c\u90a3\u66fe\u7d93\u5207\u9664\u95cc\u5c3e\u7684\u4eba\uff0c\u662f\u4e0d\u662f\u5c31\u80fd\u5920\u6c38\u7d55\u5f8c\u60a3\u4e86\u5462\uff1f\u9019\u5e7e\u4f4d\u79d1\u5b78\u5bb6\u5c07\u76ee\u5149\u653e\u5230\u4e86\u745e\u5178\u5169\u5927\u81e8\u5e8a\u8cc7\u6599\u5eab\u4e0a\u3002\u5176\u4e00\uff0c\u662f\u745e\u5178\u7684\u5168\u570b\u75c5\u60a3\u8cc7\u6599\u5eab\uff08Swedish National Patient Registry\uff1bSNPR\uff09\u3002\u9019\u500b\u8cc7\u6599\u5eab\u8ffd\u8e64\u4e86\u745e\u5178\u570b\u5167\u4e00\u767e\u516d\u5341\u842c\u4eba\u53e3\uff0c\u9577\u9054\u4e94\u5341\u4e8c\u5e74\u7684\u5065\u5eb7\u8cc7\u6599\uff0c\u4e26\u5305\u542b\u4e86\u8d85\u904e\u4e94\u5341\u4e94\u842c\u3001\u66fe\u7d93\u63a5\u53d7\u904e\u95cc\u5c3e\u5207\u9664\u8853\u7684\u4eba\u3002 \u5728\u6bd4\u8f03\u5207\u9664\u904e\u95cc\u5c3e\u3001\u8207\u6c92\u6709\u5207\u9664\u7684\u7fa4\u9ad4\u5f8c\u767c\u73fe\uff0c\u5207\u9664\u904e\u7684\u4eba\u65e5\u5f8c\u5f97\u5230\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u6bd4\u4f8b\uff0c\u8981\u6bd4\u4e00\u822c\u5927\u773e\u5c11\u4e86 19.3 %\uff0c\u75c5\u767c\u4e5f\u665a\u3002\u6108\u65e9\u63a5\u53d7\u95cc\u5c3e\u5207\u9664\uff0c\u5c0d\u514d\u65bc\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u4fdd\u8b77\u529b\u4e5f\u6108\u5f37\u3002\u5982\u679c\uff0c\u5c07\u7126\u9ede\u653e\u5728\u88ab\u8a3a\u65b7\u70ba\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u75c5\u4eba\u8eab\u4e0a\uff0c\u82e5\u75c5\u4eba\u5728\u75c5\u767c\u81f3\u5c11\u4e8c\u5341\u5e74\u524d\u5c31\u5207\u9664\u4e86\u95cc\u5c3e\uff0c\u5176\u767c\u75c5\u7684\u5e74\u7d00\u8981\u6bd4\u6c92\u6709\u5207\u9664\u95cc\u5c3e\u7684\u5e15\u91d1\u68ee\u6c0f\u75c5\u4eba\uff0c\u665a\u4e86\u4e00\u5e74\u534a\u6709\u9918\u624d\u75c5\u767c\u3002<\/p>\n<p>\u4e0d\u904e\uff0c\u5168\u570b\u75c5\u60a3\u8cc7\u6599\u5eab\u52dd\u5728\u4eba\u591a\u3001\u6db5\u84cb\u7684\u6642\u9593\u4e5f\u5ee3\uff0c\u4f46\u5c0d\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u8a3a\u65b7\u537b\u4e0d\u4e00\u5b9a\u4eba\u4eba\u7cbe\u6e96\u3002\u65bc\u662f\uff0c\u7814\u7a76\u5718\u968a\u5c07\u7126\u9ede\u653e\u5230\u4e86\u53e6\u4e00\u7d44\u4ee5\u5e15\u91d1\u68ee\u5f0f\u75c7\u75c5\u60a3\u70ba\u4e3b\u7684\u8cc7\u6599\u5eab\u4e0a\uff08Parkinson\u2019s Progression Markers Initiative\uff1bPPMI\uff09\u3002\u5728\u9019\u7d44\u8cc7\u6599\u5eab\u88e1\uff0c\u96d6\u7136\u6536\u9304\u7684\u75c5\u4eba\u8f03\u5c11\uff0c\u53ea\u6709 849 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vermiform appendix impacts the risk of developing Parkinson's disease. Killinger BA, Madaj Z, Sikora JW, Rey N, Haas AJ, Vepa Y, Lindqvist D, Chen H, Thomas PM, Brundin P, Brundin L, Labrie V. Sci Transl Med. 2018 Oct 31;10(465). pii: eaar5280. doi: 10.1126\/scitranslmed.aar5280. PMID: 30381408<\/p>\n<p>\u95dc\u65bc\u95cc\u5c3e\u4e5f\u662f\u6709\u751f\u7406\u529f\u80fd\u7684\u7814\u7a76\uff1a<\/p>\n<ol>\n<li>Morphological evolution of the mammalian cecum and cecal appendix. Smith HF, Parker W, Kotz\u00e9d SH, Laurine M. Comptes Rendus Palevol. 12 (6) 339-354.<\/li>\n<li>Biofilms in the large bowel suggest an apparent function of the human vermiform appendix. Randal Bollinger R, Barbas AS, Bush EL, Lin SS, Parker W. J Theor Biol. 2007 Dec 21;249(4):826-31. Epub 2007 Sep 7. Review. PMID: 17936308<\/li>\n<\/ol>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>The cecal appendix: one more immune component with a function disturbed by post-industrial culture. Anat Rec (Hoboken). 2011 Apr;294(4):567-79. doi: 10.1002\/ar.21357. Epub 2011 Mar 2. Review.<\/li>\n<li>The immunological functions of the Appendix: An example of redundancy? Semin Immunol. 2018 Apr;36:31-44. doi: 10.1016\/j.smim.2018.02.005. Epub 2018 Mar 2. Review.<\/li>\n<li>Gut, Microbiome, and Brain Regulatory Axis: Relevance to Neurodegenerative and Psychiatric Disorders. Cell Mol Neurobiol. 2018 Aug;38(6):1197-1206. doi: 10.1007\/s10571-018-0589-2. Epub 2018 May 25. Review.<\/li>\n<\/ol>\n<p><strong>--<\/strong><br \/>\n<strong>\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u4e00\u60f3\u5230\u95cc\u5c3e\uff08appendix\uff09\uff0c\u5927\u5bb6\u7684\u7b2c\u4e00\u500b\u53cd\u61c9\u53ef\u80fd\u90fd\u662f\uff1a\u554a\uff0c\u90a3\u500b\u6bd4\u5c3e\u5df4\u5e78\u904b\u4e00\u9ede\uff0c\u5728\u6f14\u5316\u53f2\u88e1\u6c92\u6709\u88ab\u6dd8\u6c70\uff0c\u9ed8\u9ed8\u7559\u4e0b\u4f86\u537b\u4e5f\u6c92\u6709\u4ec0\u9ebc\u7528\u7684\u5668\u5b98\u3002\u53ea\u8981\u95cc\u5c3e\u4e0d\u767c\u708e\uff0c\u96d6\u7136\u7559\u8457\u7121\u7528\uff0c\u4f46\u4e5f\u5be6\u5728\u662f\u6c92\u6709\u5fc5\u8981\u9084\u7279\u5730\u958b\u8178\u7834\u809a\uff0c\u50cf\u62d4\u667a\u9f52\u4e00\u6a23\u7279\u5730\u5728\u5b83\u80e1\u9b27\u524d\u5148\u4e0b\u624b\u70ba\u5f37\u3002\u4f46\uff0c\u95cc\u5c3e\u771f\u7684\u662f\u53ea\u8981\u4e0d\u9b27\u4e8b\uff0c\u5c31\u80fd\u597d\u597d\u7684\u8ddf\u6211\u5011\u76f8\u5b89\u7121\u4e8b\u55ce\uff1f\u6700\u8fd1\u6709\u7bc7\u7814\u7a76\uff0c\u767c\u73fe\u5207\u9664\u4e86\u95cc\u5c3e\uff0c\u53ef\u4ee5\u986f\u8457\u964d\u4f4e\u7f79\u60a3\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u98a8\u96aa\u5462\u3002<\/p>\n","protected":false},"author":20,"featured_media":33300,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[2582,4100],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/11\/steel-3309870_960_720.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33294"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33294"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33294\/revisions"}],"predecessor-version":[{"id":33301,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33294\/revisions\/33301"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/33300"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=33294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=33294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}