{"id":33175,"date":"2018-12-14T00:47:32","date_gmt":"2018-12-13T16:47:32","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33175"},"modified":"2018-12-06T11:03:20","modified_gmt":"2018-12-06T03:03:20","slug":"%e5%a4%a7%e8%b1%a1%e5%95%8a%e5%a4%a7%e8%b1%a1%ef%bc%8c%e7%82%ba%e4%bb%80%e9%ba%bc%e4%bd%a0%e7%9a%84%e5%ad%97%e5%85%b8%e8%a3%a1%e9%9d%a2%e6%b2%92%e6%9c%89%e3%80%8c%e7%99%8c%e7%97%87%e3%80%8d%e9%80%99","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33175","title":{"rendered":"\u5927\u8c61\u554a\u5927\u8c61\uff0c\u70ba\u4ec0\u9ebc\u4f60\u7684\u5b57\u5178\u88e1\u9762\u6c92\u6709\u300c\u764c\u75c7\u300d\u9019\u5169\u500b\u5b57\u5462\uff1f"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u5927\u8c61\u9f3b\u5b50\u9577\u3001\u8033\u6735\u5927\uff0c\u4f46\u4f60\u77e5\u9053\uff0c\u5927\u8c61\u9084\u4e0d\u7528\u7169\u60f1\u4eba\u985e\u7684\u5927\u7169\u60f1\u2014\u2014\u764c\u75c7\u55ce\uff1f<\/strong><\/span><\/p>\n<figure id=\"attachment_33241\" aria-describedby=\"caption-attachment-33241\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-33241\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/11\/elephant-2380009_960_720.jpg\" alt=\"\" width=\"450\" height=\"312\" data-wp-pid=\"33241\"><figcaption id=\"caption-attachment-33241\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90 pixabay.com<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c\u99f1\u5b9b\u7433<\/strong><\/p>\n<p>\u5927\u8c61\u53ef\u80fd\u7169\u60f1\u5f88\u591a\u4e8b\uff0c\u4f46\u5728\u5927\u8c61\u4e00\u7c6e\u7b50\u7684\u7169\u60f1\u88e1\uff0c\u537b\u6c92\u6709\u300c\u764c\u75c7\u300d\u9019\u4ef6\u4e8b\u3002\u9019\u807d\u8d77\u4f86\u53ef\u80fd\u53ea\u4e0d\u904e\u53c8\u662f\u4e00\u500b\u6709\u8da3\u7684\u51b7\u77e5\u8b58\u7f77\u4e86\uff0c\u4f46\u5982\u679c\u4ed4\u7d30\u5730\u60f3\u4e00\u60f3\uff0c\u537b\u662f\u50cf\u5091\u514b\u7684\u9b54\u8c46\u4e00\u6a23\uff0c\u662f\u90a3\u9ebc\u795e\u5947\u7684\u4e8b\u5462\u3002\u9019\u662f\u70ba\u4ec0\u9ebc\u5462\uff1f<\/p>\n<p>2015 \u5e74\u5e74\u521d\u7684\u6642\u5019\uff0cJohns Hopkins University \u91ab\u5b78\u9662\u8207\u516c\u885b\u5b78\u9662\u7684 Cristian Tomasetti\u6559\u6388\u8207\u764c\u75c7\u4e2d\u5fc3 Bert Vogelstein \u91ab\u751f\uff0c\u5728\u300a<em>Science<\/em>\u300b\u671f\u520a\u4e0a\u767c\u8868\u4e86\u4e00\u7bc7\u8ad6\u6587\uff0c\u5229\u7528\u6578\u5b78\u6a21\u578b\u4f86\u63a2\u8a0e\u70ba\u4ec0\u9ebc\u6709\u4e9b\u5668\u5b98\u6bd4\u8f03\u5bb9\u6613\u767c\u751f\u764c\u75c7\u3001\u6709\u4e9b\u5668\u5b98\u5247\u6bd4\u8f03\u4e0d\u5bb9\u6613\u767c\u751f\u3002\u9019\u5169\u4f4d\u5408\u639b\u901a\u8a0a\u4f5c\u8005\u3001\u4e5f\u662f\u8ad6\u6587\u88e1\u552f\u4e00\u4f5c\u8005\u7684\u6559\u6388\uff0c\u8aac\u6709\u4e09\u5206\u4e4b\u4e8c\u7684\u764c\u75c7\u4e4b\u6240\u4ee5\u6703\u767c\u751f\uff0c\u5c31\u53ea\u662f\u751f\u547d\u4e4b\u6240\u4ee5\u70ba\u751f\u547d\u3001\u7d14\u751f\u7269\u610f\u7fa9\u4e0a\u7684\u904b\u6c23\u4e0d\u4f73\u3002\u4ed6\u5011\u6240\u8b02\u7684\u300c\u904b\u6c23\u5dee\u300d\uff0c\u8df3\u812b\u4e86\u74b0\u5883\u56e0\u7d20\u3001\u57fa\u56e0\u7d44\u6210\uff1b\u800c\u5c31\u55ae\u55ae\u7d14\u7d14\uff0c\u6307\u5982\u679c\u4e00\u500b\u5668\u5b98\u7684\u5e79\u7d30\u80de\u5728\u4e00\u751f\u7684\u6642\u9593\u88e1\u5f97\u5206\u88c2\u8d8a\u591a\u6b21\uff0c\u9019\u500b\u5668\u5b98\u5c31\u6709\u6108\u5927\u7684\u6a5f\u7387\u6709\u53ef\u80fd\u6703\u767c\u751f\u764c\u75c7\u3002<\/p>\n<p>Cristian Tomasetti\u8207Bert Vogelstein \u5169\u4f4d\u6559\u6388\u7576\u6642\u7528\u4e86\u4e00\u500b\u5f88\u6709\u8da3\u7684\u6bd4\u55bb\u3002\u4ed6\u5011\u8b6c\u55bb\u8aaa\uff0c\u4e00\u500b\u4eba\u6703\u5f97\u5230\u764c\u75c7\u7684\u53ef\u80fd\u6027\uff0c\u5c31\u50cf\u958b\u8eca\u51fa\u9580\u65c5\u884c\u6703\u767c\u751f\u8eca\u798d\u7684\u53ef\u80fd\u6027\u3002\u76ee\u7684\u5730\u6108\u9059\u9060\uff0c\u51fa\u8eca\u798d\u7684\u6a5f\u7387\u5c31\u6bd4\u958b\u8eca\u4e94\u5206\u9418\u53bb\u5df7\u53e3\u8cb7\u5496\u5561\u8981\u5927\u4e0a\u8a31\u591a\u3002\u800c\u74b0\u5883\u56e0\u7d20\u5c31\u50cf\u662f\u8def\u6cc1\uff1b\u66b4\u98a8\u96ea\u8207\u98b1\u98a8\u597d\u6bd4\u662f\u62bd\u7159\u8207\u7d2b\u5916\u7dda\uff1a\u8def\u6cc1\u6108\u5dee\u3001\u5f97\u5230\u764c\u75c7\u7684\u6a5f\u6703\u5c31\u6108\u9ad8\u3002\u800c\u57fa\u56e0\u7d44\u6210\u5c31\u50cf\u662f\u8eca\u6cc1\uff1b\u500b\u9ad4\u8eab\u4e0a\u5e36\u6709\u591a\u5c11\u500b\u764c\u75c7\u7684\u9ad8\u5371\u96aa\u57fa\u56e0\u7d44\u6210\uff0c\u5c31\u50cf\u8eca\u4e0a\u6709\u591a\u5c11\u7d44\u6a5f\u4ef6\u51fa\u4e86\u554f\u984c\u3002\u4f8b\u5982\uff0c\u4e73\u764c\u7684\u9ad8\u5371\u96aa\u57fa\u56e0 BRCA1 \u8207 BRCA2\uff0c\u5c31\u50cf\u662f\u8eca\u5b50\u7684\u715e\u8eca\u5931\u9748\u3002\u4f46\u5373\u4fbf\u5982\u6b64\uff0c\u7576\u8eca\u7a0b\u6108\u9577\uff0c\u4e0d\u8ad6\u8eca\u6cc1\u8207\u8def\u6cc1\u5982\u4f55\uff0c\u767c\u751f\u610f\u5916\u7684\u6a5f\u7387\u4e5f\u9084\u662f\u6bd4\u77ed\u8eca\u7a0b\u8981\u9ad8\u4e0a\u8a31\u591a\u3002\u800c\u9019\u300c\u8eca\u7a0b\u300d\uff0c\u5c31\u662f\u500b\u9ad4\u4e00\u751f\u88e1\uff0c\u5e79\u7d30\u80de\u7684\u5206\u88c2\u6b21\u6578\u3002<\/p>\n<p>\u9019\u5169\u4f4d\u6559\u6388\u5229\u7528\u6578\u5b78\u6a21\u578b\uff0c\u767c\u73fe\u5e79\u7d30\u80de\u7684\u5206\u88c2\u6b21\u6578\u548c\u5927\u7d04\u4e09\u5206\u4e4b\u4e8c\u7684\u764c\u75c7\u767c\u751f\u6a5f\u7387\u6709\u8457\u6975\u9ad8\u95dc\u806f\u6027\u3002\u4f8b\u5982\uff0c\u5c0d\u4eba\u985e\u800c\u8a00\uff0c\u5927\u8178\u764c\u4e00\u76f4\u662f\u500b\u8d85\u5927\u96b1\u6182\u3002\u6839\u64da\u4ed6\u5011\u7684\u6a21\u578b\u63a8\u7b97\uff0c\u5927\u8178\u5e79\u7d30\u80de\u5e73\u5747\u5728\u4e00\u751f\u7684\u6642\u9593\u88e1\u5fc5\u9808\u5206\u88c2 10<sup>12<\/sup> \u6b21\uff1b\u76f8\u8f03\u65bc\u4eba\u985e\u5341\u4e8c\u6307\u8178\u5e79\u7d30\u80de\u7684 10<sup>10<\/sup> \u6b21\uff0c\u5927\u8178\u81ea\u7136\u6bd4\u5341\u4e8c\u6307\u8178\u6709\u66f4\u9ad8\u7684\u7f79\u764c\u98a8\u96aa\u3002\u4f46\u5c0d\u8001\u9f20\u800c\u8a00\uff0c\u8001\u9f20\u7684\u5c0f\u8178\u5e79\u7d30\u80de\uff0c\u5206\u88c2\u6b21\u6578\u6bd4\u5927\u8178\u5e79\u7d30\u80de\u591a\uff0c\u5c0f\u8178\u5340\u6bb5\u7684\u764c\u75c7\u767c\u751f\u7387\u5c31\u6bd4\u5927\u8178\u8981\u9ad8\u3002<\/p>\n<p>\u9019\u7bc7\u8ad6\u6587\u4e00\u520a\u767b\uff0c\u5c31\u8209\u4e16\u55a7\u5629\uff1b\u5f15\u8d77\u7684\u8a0e\u8ad6\u3001\u8faf\u8ad6\u8207\u95dc\u6ce8\uff0c\u662f\u7576\u6642\u4e00\u7d55\u3002\u77ed\u77ed\u4e09\u5e74\u7684\u529f\u592b\uff0c\u9019\u7bc7\u7814\u7a76\u5df2\u7d93\u88ab\u5f15\u7528\u4e86\u4e00\u5343\u591a\u6b21\u3002\u59d1\u4e14\u4e0d\u8ad6\u91dd\u5c0d Cristian Tomasetti\u8207Bert Vogelstein \u6559\u6388\u6240\u767c\u8868\u7684\u6578\u5b78\u6a21\u578b\uff0c\u79d1\u5b78\u754c\u6709\u54ea\u4e9b\u6b63\u53cd\u610f\u898b\uff1b\u65e9\u5f9e 1970 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\u6559\u6388\u5f88\u65e9\u5c31\u807d\u904e\u5927\u8c61\u4e0d\u592a\u5f97\u764c\u75c7\u9019\u500b\u51b7\u77e5\u8b58\uff0c\u4f46\u4e00\u76f4\u6c92\u6709\u653e\u5728\u5fc3\u4e0a\u3002\u76f4\u5230\u6709\u500b\u9031\u672b\uff0cSchiffman \u53d7\u5176\u592b\u4eba\u4e4b\u547d\uff0c\u5e36\u5c0f\u5b69\u53bb\u52d5\u7269\u5712\u73a9\uff1b\u884c\u9593\u4ed6\u966a\u8457\u5c0f\u5b69\u770b\u5927\u8c61\u8868\u6f14\uff0c\u8868\u6f14\u4e4b\u5f8c\uff0c\u4ed6\u5fcd\u4e0d\u4f4f\u8209\u624b\u8aaa\u4ed6\u6709\u4e00\u500b\u554f\u984c\u3002\u5927\u8c61\u4fdd\u80b2\u54e1\u8208\u9ad8\u91c7\u70c8\uff0c\u4e00\u81c9\u7d93\u9a57\u8001\u9053\u7684\u81ea\u4fe1\uff0c\u8aaa\u4f86\u4f86\u4f86\uff0c\u4f60\u6709\u4ec0\u9ebc\u554f\u984c\u5462\uff1fSchiffman \u5fcd\u4e0d\u4f4f\uff0c\u5148\u8aaa\u660e\u81ea\u5df1\u662f\u500b\u764c\u75c7\u5b78\u5bb6\uff0c\u60f3\u8acb\u554f\u2026 \u4ed6\u53ef\u4ee5\u62ff\u4e00\u7ba1\u5927\u8c61\u7684\u8840\u6db2\u6aa2\u9ad4\u55ce\uff1f<\/p>\n<p>\u5f8c\u4f86\uff0cSchiffman \u4e0d\u50c5\u53d6\u5f97\u4e86\u52d5\u7269\u5712\u88e1\u5927\u8c61\u7684\u8840\u6db2\u6aa2\u9ad4\uff0c\u9084\u62ff\u5230\u4e86\u4ee5\u5927\u8c61\u8868\u6f14\u70ba\u62db\u724c\u6232\u78bc\u7684\u7f8e\u570b\u73b2\u73b2\u99ac\u6232\u5718\u88e1\uff0c\u773e\u5927\u8c61\u7684\u8840\u6db2\u6aa2\u9ad4\u3002\u800c Schiffman \u4e5f\u771f\u767c\u73fe\u4e86\u5927\u8c61\u6297\u764c\u7684\u79d8\u5bc6\u6b66\u5668\u3002<\/p>\n<p>\u7d93\u904e Schiffman \u5be6\u9a57\u5ba4\u5206\u6790\u9019\u4e9b\u5927\u8c61\u8840\u6db2\u6aa2\u9ad4\uff0c\u767c\u73fe\u5927\u8c61\u7684\u57fa\u56e0\u9ad4\u88e1\uff0c\u64c1\u6709 20 \u7d44\u6291\u5236\u764c\u75c7\u7684\u91cd\u8981\u57fa\u56e0 <em>TP53<\/em>\u3002<em>TP53<\/em> \u57fa\u56e0\u80fd\u7522\u751f p53 \u86cb\u767d\u8cea\uff0c\u662f\u6975\u70ba\u91cd\u8981\u7684\u6291\u764c\u57fa\u56e0\uff0c\u5728\u5927\u591a\u6578\u7684\u764c\u75c7\u88e1\uff0c\u90fd\u53ef\u4ee5\u767c\u73fe <em>TP53<\/em> \u57fa\u56e0\u8b8a\u7570\u3002\u56e0\u6b64\uff0cp53 \u86cb\u767d\u8cea\u5c31\u88ab\u8b7d\u70ba\u662f\u57fa\u56e0\u9ad4\u7570\u653b\u968a\uff0c\u5982\u679c p53 \u86cb\u767d\u8cea\u767c\u751f\u7570\u5e38\uff0c\u5247\u7d30\u80de\u5c31\u6703\u51fa\u73fe\u764c\u7d30\u80de\u4e09\u7279\u8272\uff1a\u7d30\u80de\u51cb\u4ea1\u88ab\u6291\u5236\u3001\u7d30\u80de\u5206\u88c2\u8907\u88fd\u5287\u589e\u3001\u4ee5\u53ca\u57fa\u56e0\u9ad4\u4e0d\u7a69\u5b9a\u3002\u4eba\u985e\u64c1\u6709\u4e00\u7d44 <em>TP53<\/em> \u5c0d\u5076\u57fa\u56e0\uff0c\u5982\u679c\u5176\u4e2d\u4e00\u500b\u5c0d\u5076\u57fa\u56e0\u767c\u751f\u7570\u5e38\uff0c\u800c\u53ea\u6709\u4e00\u500b\u6709\u7528\u7684\u5c0d\u5076\u57fa\u56e0\u80fd\u5920\u7522\u751f\u6709\u529f\u80fd\u7684 p53 \u86cb\u767d\u8cea\uff0c\u5c31\u6703\u5c0e\u81f4\u674e-\u4f5b\u7f8e\u5c3c\u75c7\u5019\u7fa4\uff0c\u75c5\u60a3\u4e00\u751f\u88e1\u5f97\u5230\u764c\u75c7\u7684\u6a5f\u7387\u8d85\u904e\u4e5d\u6210\u3002\u6297\u764c\u4e4b <em>TP53<\/em> \u7684\u5c0d\u5076\u57fa\u56e0\u5c11\u4e00\u500b\u662f\u5669\u8017\uff0c\u800c\u5927\u8c61\u537b\u5e73\u5747\u6709 15 \u5230 20 \u7d44\u7684 TP53 \u5c0d\u5076\u57fa\u56e0\u3002<\/p>\n<p>Schiffman \u6559\u6388\u4e0d\u662f\u552f\u4e00\u5c0d\u6b64\u611f\u8208\u8da3\u7684\u79d1\u5b78\u5bb6\uff0c\u7576\u4ed6\u5011\u7684\u7814\u7a76\u7d50\u679c\u767c\u8868\u7684\u6642\u5019\uff0cUniversity of Chicago in Illinois \u6709\u4f4d Vincent Lynch \u6559\u6388\uff0c\u5176\u5be6\u9a57\u5ba4\u4e5f\u4e0d\u7d04\u800c\u540c\u5730\u767c\u73fe\u4e86\u5927\u8c61\u5229\u7528\u64f4\u8ecd TP53 \u7684\u65b9\u6cd5\u4f86\u6291\u5236\u764c\u75c7\u3002<\/p>\n<p>\u79d1\u5b78\u7814\u7a76\u50cf\u63a5\u529b\u8cfd\uff0c\u7e3d\u662f\u8981\u80fd\u5920\u50b3\u5230\u4e0b\u4e00\u68d2\uff0c\u624d\u662f\u597d\u7684\u7814\u7a76\u7d50\u679c\u3002\u800c\u5728\u4eca\u5e74\uff0c\u5728\u300a<em>Cell Report<\/em>\u300b\u671f\u520a\u4e0a\uff0cVincent Lynch \u5be6\u9a57\u5ba4\u53c8\u63a5\u8457\u767c\u73fe\uff0c\u9664\u4e86 <em>TP53<\/em> \u57fa\u56e0\uff0c\u5927\u8c61\u57fa\u56e0\u9ad4\u9084\u9ed8\u9ed8\u64f4\u5145\u4e86\u53e6\u4e00\u96bb\u80fd\u97ff\u61c9 p53 \u86cb\u767d\u8cea\u7684\u6297\u764c\u5927\u8ecd\uff1a<em>LIF6<\/em>\uff0c\u5168\u540d\u662f leukemia inhibitory factor 6\u3002<\/p>\n<p>Lynch \u6559\u6388\u7684\u5be6\u9a57\u5ba4\u767c\u73fe\uff0c\u5927\u8c61\u6709\u4e03\u5230\u5341\u4e00\u7d44\u984d\u5916\u7684 <em>LIF<\/em> \u57fa\u56e0\uff0c\u4f46\u5176\u4e2d\u7d55\u5927\u591a\u6578\u90fd\u5c11\u4e86 5\u2019-UTR\u3001\u6216\u662f\u7b2c\u4e00\u500b exon\uff0c\u5c0e\u81f4\u5927\u8c61\u57fa\u56e0\u9ad4\u5167\u7684 <em>LIF<\/em> \u57fa\u56e0\u96d6\u7136\u52e2\u773e\uff0c\u537b\u4f3c\u4e4e\u90fd\u53ea\u662f\u64fa\u8457\u597d\u770b\u7684\u82b1\u74f6\u3002\u4f46\u5728\u9019\u4e9b\u82b1\u74f6\u88e1\u9762\uff0c\u537b\u6709\u500b <em>LIF6<\/em>\uff0c \u4ecd\u7136\u4fdd\u6709\u88ab\u8f49\u9304\u518d\u8f49\u8b6f\u6210\u70ba\u4e00\u500b\u6709\u7528\u7684\u86cb\u767d\u8cea\u7684\u6f5b\u529b\u3002\u7d93\u904e\u5206\u6790\uff0c<em>LIF6<\/em> \u57fa\u56e0\u80fd\u5920\u76f4\u63a5\u53d7\u5230 p53 \u86cb\u767d\u8cea\u7684\u8abf\u63a7\u800c\u5927\u91cf\u8868\u73fe\uff0cLIF6 \u86cb\u767d\u8cea\u65bc\u662f\u63a5\u8457\u53bb\u57f7\u884c\u7d30\u80de\u51cb\u4ea1\u7684\u529f\u80fd\uff0c\u8b93\u6709\u8b8a\u6210\u764c\u7d30\u80de\u5371\u6a5f\u7684\u7d30\u80de\uff0c\u80fd\u5920\u6975\u65e9\u88ab\u963b\u6b62\u800c\u51cb\u4ea1\u3002<\/p>\n<p>\u6709\u8da3\u7684\u662f\uff0c<em>LIF6<\/em> \u57fa\u56e0\u4e00\u525b\u958b\u59cb\u7684\u6642\u5019\uff0c\u61c9\u8a72\u4e5f\u662f\u8ddf\u5176\u4ed6\u300c\u82b1\u74f6\u300d\u822c\u7684 LIF \u5206\u8eab\u4e00\u6a23\uff0c\u4e26\u6c92\u6709\u4ec0\u9ebc\u529f\u80fd\u3002\u4f46\u662f\uff0c\u5927\u7d04\u5728\u4e94\u5343\u4e5d\u767e\u842c\u5e74\u524d\uff0c\u7576\u5927\u8c61\u5728\u6f14\u5316\u53f2\u4e0a\u6b63\u8981\u958b\u59cb\u9ad4\u578b\u9010\u6f38\u6f14\u5316\u6210\u5927\u578b\u52d5\u7269\u7684\u6642\u5019\uff0c<em>LIF6<\/em> \u57fa\u56e0\u5f9e\u6b7b\u88e1\u5fa9\u6d3b\uff0c\u91cd\u65b0\u6709\u4e86\u529f\u80fd\uff0c\u4e26\u4e14\u8b8a\u6210\u4e86 p53 \u86cb\u767d\u6d3b\u5316\u8a0a\u606f\u7684\u6700\u597d\u5e6b\u624b\u3002<\/p>\n<p>\u65bc\u662f\uff0c\u9760\u8457\u591a\u7d44\u7684 <em>TP53<\/em>\uff0c\u4ee5\u53ca p53 \u86cb\u767d\u8cea\u7684\u597d\u5e6b\u624b <em>LIF6<\/em>\uff0c\u5927\u8c61\u96d6\u7136\u9ad4\u578b\u5927\u53c8\u6d3b\u5f97\u9577\uff0c\u537b\u4e00\u9ede\u4e5f\u4e0d\u53d7\u764c\u75c7\u6240\u64fe\u5462\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u539f\u59cb\u8ad6\u6587\uff1a<\/strong><\/p>\n<p><strong>\u95dc\u65bc\u5927\u8c61\u6709\u591a\u7d44 <em>TP53<\/em> \u57fa\u56e0\uff1a<\/strong><\/p>\n<ol>\n<li>Abegglen LM et al. Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. JAMA. 2015 Nov 3;314(17):1850-60. doi: 10.1001\/jama.2015.13134.<\/li>\n<li>Sulak M et al. TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. Elife. 2016 Sep 19;5. pii: e11994. doi: 10.7554\/eLife.11994. Erratum in: Elife. 2016 Dec 20;5<\/li>\n<\/ol>\n<p><strong>\u95dc\u65bc\u5927\u8c61 <em>LIF6<\/em> \u57fa\u56e0\uff1a<\/strong><\/p>\n<p>Vazquez JM et al. A Zombie LIF Gene in Elephants Is Upregulated by TP53 to Induce Apoptosis in Response to DNA Damage. Cell Rep. 2018 Aug 14;24(7):1765-1776. doi: 10.1016\/j.celrep.2018.07.042.<\/p>\n<p><strong>\u95dc\u65bc\u7f79\u60a3\u764c\u75c7\u7684\u58de\u904b\u6c23\uff1a<\/strong><\/p>\n<p>Tomasetti C, Vogelstein B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015 Jan 2;347(6217):78-81. doi: 10.1126\/science.1260825. PMID: 25554788<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Peto R, Roe FJ, Lee PN, Levy L, Clack J. Cancer and ageing in mice and men. Br J Cancer. 1975 Oct;32(4):411-26.<\/li>\n<li>Baxter E.W. Milner J. p53 regulates LIF expression in human medulloblastoma cells. J. Neurooncol. 2010; 97: 373-382<\/li>\n<li>Caulin A.F. Maley C.C. Peto\u2019s paradox: evolution\u2019s prescription for cancer prevention. Trends Ecol. Evol. 2011; 26: 175-182<\/li>\n<li>Hu W. Feng Z. Teresky A.K. Levine A.J. p53 regulates maternal reproduction through LIF. Nature. 2007; 450: 721-724<\/li>\n<\/ol>\n<p><strong>--<br \/>\n\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u5927\u8c61\u53ef\u80fd\u7169\u60f1\u5f88\u591a\u4e8b\uff0c\u4f46\u5728\u5927\u8c61\u4e00\u7c6e\u7b50\u7684\u7169\u60f1\u88e1\uff0c\u537b\u6c92\u6709\u300c\u764c\u75c7\u300d\u9019\u4ef6\u4e8b\u3002\u9019\u807d\u8d77\u4f86\u53ef\u80fd\u53ea\u4e0d\u904e\u53c8\u662f\u4e00\u500b\u6709\u8da3\u7684\u51b7\u77e5\u8b58\u7f77\u4e86\uff0c\u4f46\u5982\u679c\u4ed4\u7d30\u5730\u60f3\u4e00\u60f3\uff0c\u537b\u662f\u50cf\u5091\u514b\u7684\u9b54\u8c46\u4e00\u6a23\uff0c\u662f\u90a3\u9ebc\u795e\u5947\u7684\u4e8b\u5462\u3002\u9019\u662f\u70ba\u4ec0\u9ebc\u5462\uff1f<\/p>\n","protected":false},"author":20,"featured_media":33241,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4091,129,750,378],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/11\/elephant-2380009_960_720.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33175"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33175"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33175\/revisions"}],"predecessor-version":[{"id":33242,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33175\/revisions\/33242"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/33241"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=33175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=33175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}