{"id":33131,"date":"2019-02-01T00:05:32","date_gmt":"2019-01-31T16:05:32","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33131"},"modified":"2020-07-23T15:25:04","modified_gmt":"2020-07-23T07:25:04","slug":"%e9%97%9c%e6%96%bc%e4%ba%ba%e9%a1%9e%e9%80%99%e9%a1%86%e5%a4%a7%e9%a0%ad%ef%bc%8c%e8%88%87%e7%b2%be%e7%a5%9e%e9%9a%9c%e7%a4%99%e4%b9%8b%e9%96%93%e7%9a%84%e9%9b%a3%e5%88%86%e9%9b%a3%e6%8d%a8","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33131","title":{"rendered":"\u95dc\u65bc\u4eba\u985e\u9019\u9846\u5927\u982d\uff0c\u8207\u7cbe\u795e\u969c\u7919\u4e4b\u9593\u7684\u96e3\u5206\u96e3\u6368"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u8001\u751f\u5e38\u8ac7\u88e1\u7e3d\u662f\u8aaa\u8457\uff0c\u4eba\u985e\u56e0\u70ba\u6709\u4e86\u9019\u9846\u5927\u982d\uff0c\u624d\u6709\u4e86\u6f14\u5316\u70ba\u300c\u4eba\u300d\u7684\u672c\u9322\u3002\u4eba\u985e\u9019\u9846\u5927\u982d\uff0c\u8b93\u4eba\u6709\u8457\u5275\u9020\u529b\u3001\u57f7\u884c\u529b\uff0c\u63a8\u52d5\u8457\u4e16\u754c\u7684\u904b\u8f49\u3001\u4e5f\u4e3b\u5bb0\u8457\u5982\u4eca\u7684\u5730\u7403\u3002\u4f46\u6240\u8b02\u6709\u967d\u5149\u7684\u5730\u65b9\u5c31\u6709\u9ed1\u6697\uff0c\u9023\u592a\u967d\u90fd\u7121\u6cd5\u8b93\u5730\u7403\u6574\u9846\u4e00\u8d77\u4eae\uff1b\u90a3\u4eba\u985e\u9019\u9846\u5927\u982d\uff0c\u53c8\u5728\u6b61\u559c\u4e4b\u5916\uff0c\u5728\u6f14\u5316\u8def\u4e0a\u7684\u4ee3\u50f9\u88e1\uff0c\u5e36\u4f86\u4e86\u54ea\u4e9b\u6182\u50b7\u5462\uff1f<\/strong><\/span><\/p>\n<p><strong><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft wp-image-33149\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/10\/fig-1-1.jpg\" alt=\"\" width=\"400\" height=\"400\" data-wp-pid=\"33149\">\u64b0\u6587\uff5c\u99f1\u5b9b\u7433<\/strong><\/p>\n<p>\u4eba\u985e\u4e4b\u65bc\u5176\u4ed6\u52d5\u7269\uff0c\u6709\u8457\u8a31\u591a\u4eba\u985e\u6240\u7368\u6709\u7684\u7279\u9577\uff1a\u50cf\u662f\u9ad8\u5ea6\u767c\u5c55\u7684\u793e\u4ea4\u884c\u70ba\u8207\u793e\u6703\u7fa4\u805a\u6d3b\u52d5\u3001\u4e0d\u50c5\u6975\u5ea6\u8907\u96dc\u751a\u81f3\u9084\u6709\u6587\u6cd5\u67b6\u69cb\u53ef\u4f9b\u4f9d\u9644\u7684\u8a9e\u8a00\uff0c\u9084\u6709\u65e2\u591a\u5143\u591a\u5f69\u53c8\u5bcc\u6709\u5f15\u7533\u610f\u6db5\u7684\u6587\u5316\u3002\u76f8\u4f3c\u7684\u4f8b\u5b50\u4e0d\u52dd\u679a\u8209\uff0c\u537b\u4f3c\u4e4e\u4e00\u500b\u500b\u90fd\u8ddf\u4eba\u985e\u9019\u9846\u5927\u982d\u88e1\u7684\u8166\u90e8\u8907\u96dc\u7d50\u69cb\u606f\u606f\u76f8\u95dc\u3002\u5148\u6709\u4eba\u985e\u9019\u9846\u5927\u982d\uff0c\u624d\u6709\u6211\u5011\u5f15\u4ee5\u70ba\u50b2\u7684\u8af8\u591a\u4eba\u985e\u7368\u6709\u7279\u9577\u554a\uff01<\/p>\n<p>\u4f46\u662f\uff0c\u5728\u6f14\u5316\u8def\u4e0a\uff0c\u4eba\u985e\u6709\u4e86\u9019\u9846\u5927\u982d\uff0c\u9019\u9846\u5927\u982d\u9664\u4e86\u8b93\u4eba\u985e\u6587\u660e\u958b\u82b1\u7d50\u679c\uff0c\u4e5f\u96e3\u514d\u6703\u6709\u843d\u8449\u67af\u9ec3\u7684\u6642\u5019\u3002\u5176\u4e2d\u6700\u8b93\u79d1\u5b78\u5bb6\u597d\u5947\u7684\uff0c\u5c31\u662f\u5927\u982d\u6f14\u5316\u53f2\u548c\u7cbe\u795e\u969c\u7919\u4e4b\u9593\u7684\u95dc\u806f\u3002\u8a31\u591a\u7cbe\u795e\u969c\u7919\u90fd\u53ef\u4ee5\u5728\u57fa\u56e0\u7de8\u78bc\u88e1\u627e\u5230\u86db\u7d72\u99ac\u8de1\u3002\u4e0d\u5c11\u7814\u7a76\u5831\u5c0e\u90fd\u6307\u51fa\u67d0\u4e9b\u7279\u5b9a\u7684\u57fa\u56e0\u578b\u3001\u6216\u662f\u67d0\u4e00\u4e9b\u55ae\u6838\u7518\u9178\u591a\u614b\u6027\uff0c\u90fd\u5728\u6697\u8655\u64cd\u63a7\u8457\u500b\u9ad4\u662f\u4e0d\u662f\u6bd4\u8f03\u5bb9\u6613\u7f79\u60a3\u7cbe\u795e\u969c\u7919\u3002<\/p>\n<p>\u5982\u679c\uff0c\u9019\u4e9b\u7cbe\u795e\u5931\u5e38\u8207\u5931\u8abf\uff0c\u80fd\u5728\u57fa\u56e0\u7de8\u78bc\u88e1\u5de6\u53f3\u8457\u500b\u9ad4\u60a3\u75c5\u7684\u53ef\u80fd\u6027\uff1b\u5982\u679c\uff0c\u9019\u4e9b\u7cbe\u795e\u969c\u7919\u5982\u6b64\u56f0\u64fe\u8457\u4eba\u985e\uff0c\u70ba\u4ec0\u9ebc\u9019\u4e9b\u6613\u7f79\u75c5\u7684\u57fa\u56e0\u591a\u614b\u6027\u80fd\u5728\u6f14\u5316\u904e\u7a0b\u88e1\u4e00\u76f4\u88ab\u4fdd\u7559\u4e86\u4e0b\u4f86\u5462\uff1f<\/p>\n<p>\u5e7e\u5e74\u524d\uff0c\u6fb3\u6d32 University of New South Wales \u7684\u79d1\u5b78\u5bb6 Derrick Silove \u535a\u58eb\u66fe\u548c\u82f1\u570b\u3001\u7f8e\u570b\u8207\u5370\u5ea6\u7684\u79d1\u5b78\u5bb6\u5408\u4f5c\uff0c\u5408\u529b\u5206\u6790\u4e86 1980 \u5230 2013 \u5e74\u9593\u6a6b\u8de8\u516d\u5341\u4e09\u500b\u570b\u5bb6\u6240\u767c\u8868\u7684 174 \u7bc7\u8abf\u67e5\u7814\u7a76\uff0c\u4f30\u7b97\u51fa\u73fe\u4ee3\u4eba\u5927\u7d04\u6bcf\u4e94\u500b\u4eba\u88e1\u9762\uff0c\u5c31\u6709\u4e00\u500b\u4eba\u5728\u4e00\u751f\u88e1\uff08\u66fe\uff09\u53d7\u5230\u6df1\u6dfa\u4e0d\u4e00\u7684\u7cbe\u795e\u75be\u60a3\uff08psychiatric disorder\uff09\u6240\u64fe\u3002\u7cbe\u795e\u75be\u60a3\u53ef\u80fd\u8b93\u4eba\u53ad\u4e16\uff0c\u591a\u591a\u5c11\u5c11\u5730\u5f71\u97ff\u4e86\u65cf\u7fa4\u6574\u9ad4\u7684\u5b58\u6d3b\u7387\uff0c\u56e0\u800c\u4ee5\u751f\u614b\u65cf\u7fa4\u7684\u89c0\u9ede\u4f86\u770b\uff0c\u4f3c\u4e4e\u662f\u767e\u5bb3\u800c\u7121\u4e00\u5229\u3002\u4f46\u662f\uff0c\u537b\u4e5f\u6709\u6108\u4f86\u6108\u591a\u7684\u7814\u7a76\u6307\u51fa\uff0c\u6709\u4e9b\u7cbe\u795e\u969c\u7919\u537b\u50cf\u662f\u6f14\u5316\u51fa\u4eba\u985e\u9019\u9846\u5927\u982d\u7684\u526f\u7522\u7269\u4e00\u6a23\u3002\u4f8b\u5982\uff0c\u6709\u7814\u7a76\u61f7\u7591\uff0c\u601d\u89ba\u5931\u8abf\u75c7\uff08schizophrenia\uff09 \u548c\u8907\u96dc\u7684\u8a9e\u8a00\u6e9d\u901a\u80fd\u529b\u3001\u5275\u9020\u529b\u548c\u8df3\u8e8d\u6027\u601d\u8003\u6709\u95dc\u806f\u6027\u3002\u800c\u4e00\u518d\u91cd\u8907\u7684\u6b77\u53f2\u88e1\uff0c\u5f9e\u68b5\u8c37\u5230\u7d0d\u8a31\uff0c\u5f9e\u5433\u723e\u8299\u5230\u6d77\u660e\u5a01\uff0c\u4e0d\u8ad6\u662f\u8e81\u9b31\u4e5f\u597d\u3001\u7cbe\u795e\u5d29\u6f70\u4e5f\u7f77\uff0c\u597d\u50cf\u5728\u81e8\u5e8a\u7d93\u9a57\u4e0a\uff0c\u4e00\u800c\u518d\u3001\u518d\u800c\u4e09\u5730\u5be6\u8e10\u8457\u4e9e\u91cc\u65af\u591a\u5fb7\u8aaa\u7684\uff1a\u300c\u6240\u6709\u5353\u8d8a\u7684\u5929\u624d\u90fd\u514d\u4e0d\u4e86\u8207\u760b\u72c2\u7cfe\u7e8f\u4e0d\u6e05\u300d\u3002<\/p>\n<p>\u6f14\u5316\u88e1\uff0c\u300c\u5929\u64c7\u300d\u5f37\u786c\u53c8\u4e0d\u7559\u60c5\u9762\uff0c\u552f\u6709\u9069\u8005\uff0c\u65b9\u53ef\u751f\u5b58\u3002\u90a3\u600e\u9ebc\u5f37\u5927\u7684\u5929\u64c7\u6c92\u6709\u8b93\u90a3\u4e9b\u8b93\u4eba\u5bb9\u6613\u7f79\u60a3\u7cbe\u795e\u969c\u7919\u7684\u57fa\u56e0\u7d66\u4e00\u4e00\u6dd8\u6c70\u6389\u5462\uff1f\u7814\u7a76\u8ddf\u7cbe\u795e\u75be\u75c5\u6709\u95dc\u7684\u6f14\u5316\u57fa\u56e0\u5b78\u5b78\u8005\u5c0d\u6b64\u5927\u54c9\u554f\u6709\u5e7e\u500b\u4e0d\u540c\u7684\u5047\u8a2d\uff1a<\/p>\n<p>\u9996\u5148\uff0c\u9019\u4e9b\u4ee5\u300c\u73fe\u4ee3\u300d\u7684\u89c0\u9ede\u4f86\u770b\uff0c\u662f\u767e\u5bb3\u800c\u7121\u4e00\u76ca\u7684\u6613\u7f79\u7cbe\u795e\u969c\u7919\u57fa\u56e0\uff0c\u5c0d\u6211\u5011\u6709\u5982\u4e99\u53e4\u4e00\u822c\u8001\u7684\u9060\u53e4\u7956\u5148\u4f86\u8aaa\uff0c\u4e00\u9ede\u4e5f\u6c92\u6709\u4ec0\u9ebc\u5bb3\u8655\u3002\u53c8\u6216\u8005\uff0c\u8b93\u9019\u4e9b\u6613\u7f79\u75c5\u57fa\u56e0\u5b58\u5728\u65bc\u4eba\u985e\u65cf\u7fa4\u4e2d\uff0c\u7dad\u6301\u67d0\u4e9b\u57fa\u56e0\u7684\u591a\u6a23\u578b\u614b\uff0c\u5be6\u969b\u4e0a\u589e\u52a0\u4e86\u65cf\u7fa4\u6574\u9ad4\u7684\u9069\u61c9\u529b\uff1b\u4e5f\u5c31\u662f\u6240\u8b02\u7684\u5e73\u8861\u9078\u6c70\uff08balancing selection\uff09\u3002\u53e6\u4e00\u7a2e\u53ef\u80fd\u6027\uff0c\u5247\u662f\u9019\u4e9b\u57fa\u56e0\u591a\u6a23\u6027\uff0c\u53ea\u662f\u5fe0\u5be6\u5730\u53cd\u61c9\u4e86\u60f3\u7576\u521d\u6709\u591a\u5c11\u300c\u6709\u76ca\u7684\u300d\u57fa\u56e0\u7a81\u8b8a\u624d\u9020\u5c31\u4e86\u4eba\u985e\u5927\u8166\u3002\u7562\u7adf\uff0c\u5927\u591a\u6578\u7684\u7a81\u8b8a\u90fd\u662f\u6709\u5bb3\u7684\uff1b\u5c0d\u751f\u7269\u65cf\u7fa4\u6709\u76ca\u7684\u7a81\u8b8a\u662f\u5c11\u4e4b\u53c8\u5c11\u3002\u5982\u679c\uff0c\u56e0\u70ba\u4e0a\u5343\u500b\u6709\u76ca\u7684\u57fa\u56e0\u7a81\u8b8a\uff0c\u624d\u8b93\u4eba\u985e\u5927\u8166\u80fd\u5920\u767c\u5c55\u6210\u5982\u6b64\u8907\u96dc\u7684\u7d50\u69cb\u3002\u5c31\u7b97\u5929\u64c7\u80fd\u5920\u65bd\u52a0\u58d3\u529b\u8b93\u6709\u5bb3\u7684\u7a81\u8b8a\u5728\u6f14\u5316\u88e1\u88ab\u6dd8\u6c70\u6389\uff0c\u4f46\u60f3\u60f3\uff0c\u6709\u591a\u5c11\u7684\u300c\u58de\u7a81\u8b8a\u300d\u624d\u63db\u4f86\u4e86\u4eba\u985e\u9019\u9846\u5927\u982d\u5462\uff1b\u800c\u9019\uff0c\u4e5f\u5c31\u662f\u6240\u8b02\u7684\u591a\u57fa\u56e0\u7a81\u8b8a\u9078\u6c70\u5e73\u8861\uff08polygenic mutation-selection balance\uff09\u3002<\/p>\n<p>\u4e00\u76f4\u4ee5\u4f86\uff0c\u8d77\u8eab\u8fce\u6230\u9019\u500b\u5927\u54c9\u554f\u7684\u7814\u7a76\u5b78\u8005\u4e0d\u8a08\u5176\u6578\uff0c\u4e5f\u90fd\u6709\u5404\u81ea\u937e\u60c5\u7684\u57fa\u56e0\u5019\u9078\u540d\u55ae\uff0c\u689d\u5217\u8457\u54ea\u4e9b\u57fa\u56e0\u7684\u591a\u578b\u614b\u7d44\u5408\uff0c\u6703\u8b93\u500b\u9ad4\u589e\u52a0\u7f79\u60a3\u7cbe\u795e\u969c\u7919\u75be\u75c5\u7684\u98a8\u96aa\u3002\u4f46\u9019\u4e9b\u7814\u7a76\u6709\u4e9b\u548c\u5176\u4ed6\u7814\u7a76\u7684\u7d50\u679c\u6709\u6240\u885d\u7a81\u3001\u83ab\u8877\u4e00\u662f\uff0c\u6709\u4e9b\u7814\u7a76\u767c\u73fe\u7684\u57fa\u56e0\u591a\u6a23\u6027\u4e5f\u4e0d\u55ae\u55ae\u662f\u5728\u4eba\u985e\u65cf\u7fa4\u88e1\u624d\u7368\u6709\u3002\u6700\u8fd1\uff0c\u65e5\u672c\u6771\u5317\u5927\u5b78\u7684\u7814\u7a76\u4eba\u54e1\u6cb3\u7530\u96c5\u572d\u6559\u6388\u5be6\u9a57\u5ba4\uff0c\u5012\u662f\u5728 <em>Evolution Letters <\/em>\u767c\u8868\u4e86\u4e00\u7bc7\u6975\u70ba\u6709\u8da3\u7684\u8ad6\u6587\uff0c\u503c\u5f97\u4e00\u804a\u3002<\/p>\n<p>\u6cb3\u7530\u96c5\u898f\u6559\u6388\u5be6\u9a57\u5ba4\u9996\u5148\u5c07\u7814\u7a76\u7126\u9ede\u653e\u5728\u4e94\u7a2e\u7cbe\u795e\u969c\u7919\uff1a\u6ce8\u610f\u529b\u4e0d\u8db3\u904e\u52d5\u75c7\uff08ADHD\uff09\u3001\u81ea\u9589\u75c7\u985e\u7fa4\u969c\u7919\uff08autism spectrum disorder\uff09\u3001\u8e81\u9b31\u75c7\uff08bipolar disorder\uff09\u3001\u91cd\u5ea6\u6291\u9b31\u969c\u7919\uff08major depression disorder\uff09\uff0c\u4ee5\u53ca\u601d\u89ba\u5931\u8abf\u75c7\uff08schizophrenia\uff09\u3002\u7136\u5f8c\uff0c\u6cb3\u7530\u5be6\u9a57\u5ba4\u91dd\u5c0d\u9019\u4e94\u7a2e\u969c\u7919\uff0c\u96c6\u7d50\u3001\u7d71\u6574\u4e86\u66fe\u7d93\u767c\u8868\u904e\u7684\u76f8\u95dc\u6613\u7f79\u75c5\u57fa\u56e0\u7814\u7a76\u6587\u737b\uff0c\u7be9\u51fa\u6709\u54ea\u4e9b\u57fa\u56e0\u591a\u578b\u614b\u7684\u6613\u7f79\u75c5\u6027\uff0c\u81f3\u5c11\u88ab\u5169\u500b\u4ee5\u4e0a\u7684\u7368\u7acb\u7814\u7a76\u6240\u8b49\u5be6\u904e\u3002<\/p>\n<p>\u7d93\u904e\u7b2c\u4e00\u968e\u6bb5\u7684\u7be9\u9078\uff0c\u6cb3\u7530\u5be6\u9a57\u5ba4\u767c\u73fe\u6709 588 \u500b\u57fa\u56e0\u7684\u591a\u578b\u614b\u53ef\u80fd\u6703\u8b93\u5e36\u6709\u8a72\u578b\u614b\u7684\u500b\u9ad4\u589e\u52a0\u4e0a\u9762\u4e94\u7a2e\u7cbe\u795e\u969c\u7919\u7684\u6613\u7f79\u75c5\u6027\u3002\u63a5\u8457\uff0c\u6cb3\u7530\u5be6\u9a57\u5ba4\u5c07\u9019\u4e9b\u57fa\u56e0\u7684\u591a\u578b\u614b\u52a0\u4ee5\u5206\u6790\uff0c\u4ed6\u5011\u53ea\u5c0d\u6703\u9020\u6210\u86cb\u767d\u8cea\u80fa\u57fa\u9178\u6539\u8b8a\u7684\u57fa\u56e0\u7a81\u8b8a\u5e8f\u5217\u6709\u8208\u8da3\uff1b\u4ed6\u5011\u4e5f\u53ea\u5c0d\u5728\u6f14\u5316\u58d3\u529b\u4e0b\u88ab\u7279\u610f\u4fdd\u7559\u4e0b\u4f86\u7684\u591a\u6a23\u6027\u57fa\u56e0\u6709\u8208\u8da3\u3002<\/p>\n<p>\u7d93\u904e\u5206\u6790\u8a08\u7b97\uff0c\u6cb3\u7530\u5be6\u9a57\u5ba4\u522a\u9664\u6389\u57fa\u56e0\u591a\u614b\u6027\u7684\u8b8a\u7570\u662f\u51fa\u81ea\u65bc\u96a8\u6a5f\u7684\u57fa\u56e0\u6f02\u79fb\uff0c\u6700\u5f8c\u5269\u4e0b\u4e09\u500b\u5019\u9078\u57fa\u56e0\uff1a<em>CLSTN2<\/em>\u3001<em>FAT1<\/em>\u3001\u4ee5\u53ca<em>SLC18A1<\/em>\u3002\u9019\u4e09\u500b\u57fa\u56e0\u5728\u4eba\u985e\u65cf\u7fa4\u88e1\u90fd\u5177\u6709\u591a\u6a23\u7684\u55ae\u6838\u7518\u9178\u591a\u614b\u6027\uff0c\u5176\u4e2d\u53c8\u4ee5 <em>SLC18A1<\/em> \u9019\u500b\u57fa\u56e0\u6700\u8b93\u6cb3\u7530\u5be6\u9a57\u5ba4\u773c\u775b\u4e00\u4eae\u3002<\/p>\n<p><em>SLC18A1<\/em>\u6240\u7de8\u78bc\u7684\u86cb\u767d\u8cea\u53eb\u505a VMAT1\uff08vesicular monoamine transporter 1\uff09\uff0c\u65e9\u88ab\u767c\u73fe\u5c0d\u65bc\u8840\u6e05\u7d20\u3001\u591a\u5df4\u80fa\u7b49\u55ae\u80fa\u985e\u7269\u8cea\uff0c\u5728\u7d30\u80de\u56ca\u6ce1\u5167\u7684\u904b\u8f38\u626e\u6f14\u8457\u81f3\u95dc\u91cd\u8981\u7684\u89d2\u8272\u3002VMAT1 \u9019\u500b\u904b\u8f38\u86cb\u767d\u5c0d\u8840\u6e05\u7d20\u7684\u89aa\u548c\u529b\u6975\u9ad8\uff0c\u800c\u8840\u6e05\u7d20\u8eab\u70ba\u4e3b\u8981\u7684\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u4e4b\u4e00\uff0c\u5c0d\u60c5\u7dd2\u3001\u7761\u7720\u3001\u793e\u6703\u884c\u70ba\u6a21\u5f0f\u7b49\u90fd\u6709\u8457\u5f71\u97ff\u3002\u6cb3\u7530\u5be6\u9a57\u5ba4\u767c\u73fe\uff0c\u900f\u904e\u5e73\u8861\u9078\u6c70\u7684\u6f14\u5316\u58d3\u529b\uff0c<em>SLC18A1<\/em>\u5728\u4eba\u985e\u65cf\u7fa4\u88e1\u4fdd\u6709\u5169\u7a2e\u591a\u614b\u6027\uff1a\u5728\u86cb\u767d\u8cea\u5e8f\u5217\u7684\u7b2c 136\u500b\u80fa\u57fa\u9178\u4e0a\uff0c\u4eba\u985e\u65cf\u7fa4\u88e1\u53ef\u4ee5\u767c\u73fe\u6709\u606f\u5be7\u80fa\u9178\uff08Threonine\uff1bThr\uff09 \u6216\u662f\u7570\u767d\u80fa\u9178\uff08Isoleucine\uff1bIle\uff09\u5169\u7a2e\u53ef\u80fd\u3002\u800c\u4e14\uff0c\u4e0d\u8ad6 VMAT1 \u662f\u64c1\u6709 136Thr \u9084\u662f 136Ile\uff0c\u9019\u5169\u500b\u7248\u672c\u90fd\u662f\u4eba\u985e\u6240\u7368\u6709\u3002\u5176\u4ed6\u9748\u9577\u985e\u5728\u76f8\u4f3c\u7684\u80fa\u57fa\u9178\u4f4d\u7f6e\u4e0a\uff0c\u90fd\u662f\u7528\u5929\u9580\u51ac\u91af\u9178\uff08Asparagine\uff1bAsn\uff09\u3002&nbsp;&nbsp;&nbsp;<\/p>\n<p>\u800c\u4e14\uff0c\u66f4\u6709\u8da3\u7684\u662f\uff0c<em>SLC18A1 <\/em>\u86cb\u767d\u8cea\u5728\u7b2c 136 \u500b\u4f4d\u7f6e\u662f\u7528\u54ea\u500b\u80fa\u57fa\u9178\uff0c\u548c\u4eba\u985e\u5730\u57df\u6027\u6709\u8457\u95dc\u806f\u3002\u5927\u90e8\u5206\u7684\u975e\u6d32\u4eba\u90fd\u9084\u662f\u4fdd\u6709\u8457\u606f\u5be7\u80fa\u9178\uff08136Thr\uff09\uff0c\u4f46\u5728\u7f8e\u6d32\u3001\u6b50\u6d32\u3001\u8207\u4e9e\u6d32\u7b49\u5730\u65b9\uff0c\u537b\u6709\u76f8\u7576\u9ad8\u6bd4\u4f8b\u7684\u4eba\u5e36\u6709\u8457\u7570\u767d\u80fa\u9178\uff08136Ile\uff09\u7684\u5e8f\u5217\u3002\u9032\u4e00\u6b65\u5206\u6790\uff0c\u6cb3\u7530\u5be6\u9a57\u5ba4\u767c\u73fe\u9019\u500b\u57fa\u56e0\u8b8a\u7570 136Thr \u5927\u7d04\u51fa\u73fe\u5728\u5341\u842c\u5e74\u524d\uff0c\u6070\u6070\u662f\u4eba\u985e\u9060\u53e4\u7956\u5148\u5f9e\u975e\u6d32\u5927\u9678\u9077\u5f99\u51fa\u4f86\u7684\u6642\u9593\u9ede\u3002\u800c\u9019\u767c\u73fe\u4e5f\u8b93\u6cb3\u7530\u5be6\u9a57\u5ba4\u63a8\u65b7\u51fa\u4e00\u500b\u5047\u8a2d\uff0c\u7576\u4eba\u985e\u5f9e\u9748\u9577\u985e\u6f14\u5316\u70ba\u9060\u53e4\u4eba\u7a2e\u7684\u904e\u7a0b\u4e2d\uff0c\u6f14\u5316\u7684\u5929\u64c7\u58d3\u529b\u8b93\u5177\u6709 136Thr \u7684\u4eba\u7a2e\u66f4\u6709\u9069\u61c9\u6027\uff0c\u96d6\u7136136Thr \u7684\u8b8a\u7570 VMAT1 \u8b93\u4eba\u985e\u9060\u53e4\u7956\u5148\u53ef\u80fd\u6bd4\u8f03\u5bb9\u6613\u7126\u616e\u3001\u6291\u9b31\uff0c\u4f46\u6216\u8a31\u4e5f\u6b63\u662f\u56e0\u70ba\u9019\u6a23\u7684\u4eba\u683c\u7279\u8cea\uff0c\u8b93\u9060\u53e4\u7956\u5148\u5b89\u5168\u5730\u96e2\u958b\u4e86\u975e\u6d32\u5927\u9678\u5462\u3002\u5f8c\u4f86\uff0c136Ile\u8b8a\u7570VMAT1 \u4e5f\u51fa\u73fe\uff0c\u4e26\u548c\u64c1\u6709 136Thr \u9019\u500b\u80fa\u57fa\u9178\u7d44\u5408\u7684 VMAT1 \u4e00\u8d77\u5171\u5b58\u5728\u4e86\u4eba\u985e\u7fa4\u9ad4\u88e1\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u539f\u59cb\u8ad6\u6587\uff1a<br \/>\n<\/strong>Sato DX, Kawata M. Evol Lett. Positive and balancing selection on SLC18A1 gene associated with psychiatric disorders and human-unique personality traits. 2018 Aug 21;2(5):499-510. doi: 10.1002\/evl3.81. eCollection 2018 Oct.<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Steel Z, Marnane C, Iranpour C, Chey T, Jackson JW, Patel V, Silove D. The global prevalence of common mental disorders: a systematic review and meta-analysis 1980-2013. Int J Epidemiol. 2014 Apr;43(2):476-93. doi: 10.1093\/ije\/dyu038. Epub 2014 Mar 19.<\/li>\n<li>Keller MC, Miller G. Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best? Behav Brain Sci. 2006 Aug;29(4):385-404; discussion 405-52.<\/li>\n<\/ol>\n<p><strong>--<\/strong><br \/>\n<strong>\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u8001\u751f\u5e38\u8ac7\u88e1\u7e3d\u662f\u8aaa\u8457\uff0c\u4eba\u985e\u56e0\u70ba\u6709\u4e86\u9019\u9846\u5927\u982d\uff0c\u624d\u6709\u4e86\u6f14\u5316\u70ba\u300c\u4eba\u300d\u7684\u672c\u9322\u3002\u4eba\u985e\u9019\u9846\u5927\u982d\uff0c\u8b93\u4eba\u6709\u8457\u5275\u9020\u529b\u3001\u57f7\u884c\u529b\uff0c\u63a8\u52d5\u8457\u4e16\u754c\u7684\u904b\u8f49\u3001\u4e5f\u4e3b\u5bb0\u8457\u5982\u4eca\u7684\u5730\u7403\u3002\u4f46\u6240\u8b02\u6709\u967d\u5149\u7684\u5730\u65b9\u5c31\u6709\u9ed1\u6697\uff0c\u9023\u592a\u967d\u90fd\u7121\u6cd5\u8b93\u5730\u7403\u6574\u9846\u4e00\u8d77\u4eae\uff1b\u90a3\u4eba\u985e\u9019\u9846\u5927\u982d\uff0c\u53c8\u5728\u6b61\u559c\u4e4b\u5916\uff0c\u5728\u6f14\u5316\u8def\u4e0a\u7684\u4ee3\u50f9\u88e1\uff0c\u5e36\u4f86\u4e86\u54ea\u4e9b\u6182\u50b7\u5462\uff1f<\/p>\n","protected":false},"author":20,"featured_media":33148,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[129,4070],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/10\/0-3.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33131"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33131"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33131\/revisions"}],"predecessor-version":[{"id":35503,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33131\/revisions\/35503"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/33148"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33131"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=33131"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=33131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}