{"id":33109,"date":"2018-10-14T00:55:01","date_gmt":"2018-10-13T16:55:01","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33109"},"modified":"2019-07-31T11:06:49","modified_gmt":"2019-07-31T03:06:49","slug":"%e5%bf%8d%e3%80%8c%e7%97%9b%e3%80%8d%e7%84%a1%e6%b3%95%e8%ae%93%e4%bd%a0%e9%a2%a8%e5%b9%b3%e6%b5%aa%e9%9d%9c","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33109","title":{"rendered":"\u5fcd\u300c\u75db\u300d\u7121\u6cd5\u8b93\u4f60\u98a8\u5e73\u6d6a\u975c"},"content":{"rendered":"

\u25a0\u52f8\u4e16\u540d\u8a00\uff1a\u300c\u5fcd\u4e00\u6642\u98a8\u5e73\u6d6a\u975c\uff0c\u9000\u4e00\u6b65\u6d77\u95ca\u5929\u7a7a\u3002\u300d\u9019\u9805\u9053\u7406\u5343\u842c\u5225\u904b\u7528\u5728\u8eab\u9ad4\u7684\u9577\u671f\u6162\u6027\u75bc\u75db\u4e0a\uff0c\u82e5\u6c92\u6709\u597d\u597d\u8655\u7406\u75bc\u75db\u554f\u984c\uff0c\u6700\u7d42\u53cd\u800c\u6703\u6f14\u8b8a\u70ba\u300c\u5fcd\u4e00\u6642\uff0c\u8b8a\u672c\u52a0\u53b2\uff01\u300d<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u4f86\u6e90:pixabay.com<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u25cf<\/b><\/strong>\u5ffd\u8996\u6162\u6027\u75bc<\/strong>\u75db<\/strong>\u6703<\/strong>\u9677<\/strong>\u5165\u60e1\u6027\u5faa\u74b0<\/strong><\/span><\/p>\n

\u623f\u5b50\u5931\u706b\u6642\uff0c\u706b\u707d\u8b66\u5831\u6703\u5927\u8072\u4f5c\u97ff\uff0c\u6b64\u6642\u61c9\u8a72\u8981\u8d95\u7dca\u6ec5\u706b\u624d\u5c0d\u3002\u5176\u5be6\uff0c\u75bc\u75db\u5c31\u662f\u4e00\u500b\u8eab\u9ad4\u7684\u6c42\u6551\u8a0a\u865f\uff0c\u61c9\u8a72\u8981\u627e\u51fa\u75bc\u75db\u7684\u6839\u6e90\uff0c\u8d95\u7dca\u5c31\u91ab\u6cbb\u7642\u6216\u9032\u884c\u75bc\u75db\u7ba1\u7406\uff0c\u5c31\u50cf\u706b\u707d\u6642\u8981\u5feb\u9ede\u64b2\u6ec5\u706b\u6e90\u7684\u9053\u7406\u4e00\u6a23\u3002\u4f46\u662f\uff0c\u9762\u5c0d\u8eab\u9ad4\u7684\u75bc\u75db\u554f\u984c\uff0c\u8a31\u591a\u4eba\u53ef\u80fd\u6703\u56e0\u70ba\u751f\u6d3b\u6216\u5de5\u4f5c\u7e41\u5fd9\uff0c\u5fc3\u5b58\u50e5\u5016\uff0c\u8a8d\u70ba\u5fcd\u4e00\u5fcd\u5c31\u904e\u53bb\u4e86\u3002\u5982\u679c\u53ea\u662f\u77ed\u66ab\u6027\u75bc\u75db\uff0c\u6216\u8a31\u5403\u500b\u6b62\u75db\u85e5\u6216\u4f11\u606f\u5e7e\u5929\u5c31\u6703\u6062\u5fa9\uff0c\u5047\u5982\u662f\u5287\u70c8\u75bc\u75db\u4e5f\u901a\u5e38\u6703\u7acb\u5373\u5c31\u91ab\u6cbb\u7642\uff0c\u4f46\u4e00\u822c\u6700\u5bb9\u6613\u88ab\u5927\u5bb6\u6240\u5ffd\u8996\u7684\u5f80\u5f80\u662f\u9577\u671f\u6162\u6027\u75bc\u75db\u3002\u6162\u6027\u75bc\u75db\u9664\u4e86\u9577\u6642\u9593\u9020\u6210\u8eab\u5fc3\u4e0d\u9069\uff0c\u7814\u7a76\u4e5f\u767c\u73fe\u6162\u6027\u75bc\u75db\u548c\u7761\u7720\u54c1\u8cea\uff0c\u5169\u8005\u4e4b\u9593\u7684\u95dc\u4fc2\u5c31\u50cf\u662f\u628a\u96d9\u9762\u5203\uff0c\u81f3\u5c11\u6709 50% \u7684\u5931\u7720\u60a3\u8005\u906d\u53d7\u6162\u6027\u75bc\u75db\u6240\u82e6\uff0c\u591a\u9054 67-88% \u7684\u6162\u6027\u75bc\u75db\u60a3\u8005\u6703\u62b1\u6028\u7761\u7720\u4e0d\u9069\u7684\u554f\u984c\u3002\u6162\u6027\u75bc\u75db\u9020\u6210\u7684\u96e3\u4ee5\u5165\u7720\uff0c\u6703\u6253\u65b7\u6b63\u5e38\u9ad4\u5167\u5c0d\u65bc\u75bc\u75db\u7684\u7652\u5408\u6a5f\u5236\uff0c\u518d\u8b93\u4f60\u7684\u795e\u7d93\u5c0d\u75bc\u75db\u66f4\u70ba\u654f\u611f\u4e5f\u7d2f\u7a4d\u66f4\u591a\u75bc\u75db\uff0c\u9032\u4e00\u6b65\u9020\u6210\u66f4\u56b4\u91cd\u7684\u7761\u7720\u554f\u984c\uff0c\u6700\u7d42\u6df1\u9677\u82e6\u6d77\u7121\u908a\u7684\u60e1\u6027\u5faa\u74b0 (\u4e0b\u5716)\u3002<\/p>\n

\"\"<\/p>\n

\u25cf<\/b>\u5f71\u97ff\u7761\u7720\u6046\u5b9a\u7684\u6a5f\u5236\u8207\u7d30\u80de\u6fc0\u7d20\u606f\u606f\u76f8\u95dc<\/strong><\/span><\/p>\n

\u6574\u665a\u7761\u7761\u9192\u9192\u662f\u4ef6\u5341\u5206\u4ee4\u4eba\u96e3\u4ee5\u5fcd\u53d7\u7684\u4e8b\u60c5\uff0c\u6df1\u5c64\u597d\u7720\u5730\u4e00\u89ba\u5230\u5929\u4eae\uff0c\u80fd\u5920\u8b93\u4f60\u9694\u5929\u5145\u6eff\u6d3b\u529b\u3002\u4e0d\u904e\u5f71\u97ff\u7761\u7720\u6046\u5b9a\u7684\u56e0\u7d20\u5f88\u591a\uff0c\u50cf\u662f\u8eab\u9ad4\u4e0d\u9069\u3001\u7761\u7720\u74b0\u5883\u3001\u6216\u5fc3\u7406\u56e0\u7d20\u7b49\u7b49\uff0c\u53e6\u5916\u4e5f\u6709\u4e0d\u5c11\u7814\u7a76\u6307\u51fa\u7761\u7720\u6046\u5b9a\u8207\u7d30\u80de\u6fc0\u7d20 (cytokine) \u606f\u606f\u76f8\u95dc\uff0c\u5176\u4e2d\u5c0d\u65bc\u75bc\u75db\u8207\u767c\u708e\u53cd\u61c9\u5f88\u91cd\u8981\u7684\u816b\u7624\u58de\u6b7b\u56e0\u5b50-\u03b1 (tumor necrosis factor \u03b1, TNF-\u03b1) \u626e\u6f14\u4e86\u95dc\u9375\u7684\u89d2\u8272\uff0c\u6709\u6162\u6027\u75bc\u75db\u75be\u75c5\u7684\u60a3\u8005\u9ad4\u5167\u5e38\u5e38\u6703\u6709\u8f03\u9ad8\u6fc3\u5ea6\u7684 TNF-\u03b1\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u6709\u7761\u7720\u56f0\u96e3\u7684\u60a3\u8005\u4e5f\u6709\u76f8\u4f3c\u7684\u73fe\u8c61\uff0c\u7814\u7a76\u5206\u6790 2,857 \u540d\u7761\u7720\u547c\u5438\u4e2d\u6b62\u75c7 (obstructive sleep apnea syndrome) \u7684\u60a3\u8005\uff0c\u4e5f\u767c\u73fe\u60a3\u8005\u8840\u4e2d\u7684 TNF-\u03b1 \u6fc3\u5ea6\u9ad8\u65bc\u6b63\u5e38\u5c0d\u7167\u7d44\uff0c\u56e0\u6b64 TNF-\u03b1 \u6709\u6a5f\u6703\u4f5c\u70ba\u8a55\u4f30\u7761\u7720\u547c\u5438\u4e2d\u6b62\u75c7\u7684\u751f\u7269\u6a19\u8a18\u3002\u4f7f\u7528\u6297\u816b\u7624\u58de\u6b7b\u56e0\u5b50-\u03b1 (anti-TNF-\u03b1) \u85e5\u7269\u6cbb\u7642\u50f5\u76f4\u6027\u810a\u690e\u708e (ankylosing spondylitis) \u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u7d50\u679c\u4e5f\u767c\u73fe\uff0c\u85e5\u7269\u9664\u4e86\u6539\u5584\u75be\u75c5\u75c7\u72c0\uff0c\u9084\u80fd\u986f\u8457\u6539\u5584\u7761\u7720\u54c1\u8cea\u3002\u6240\u4ee5\u6839\u64da\u4e0a\u8ff0\u7684\u4f8b\u5b50\uff0c\u53ea\u8981\u80fd\u5920\u627e\u51fa\u6162\u6027\u75bc\u75db\u7684\u75c5\u6e90\u70ba\u4f55\uff0c\u7d66\u4e88\u9069\u7576\u7684\u6cbb\u7642\u5c31\u80fd\u907f\u514d\u524d\u6587\u63d0\u5230\u7684\u60e1\u6027\u5faa\u74b0\u3002<\/p>\n

\u25cf<\/b>\u6cbb\u7642\u75bc\u75db\u6839\u6e90\u6216\u505a\u597d\u75bc\u75db\u7ba1\u7406\u624d\u662f\u6cbb\u672c\u4e4b\u6cd5<\/strong><\/span><\/p>\n

\u6162\u6027\u75bc\u75db\u9664\u4e86\u6703\u5f71\u97ff\u7761\u7720\u54c1\u8cea\uff0c\u4e26\u5c0e\u81f4\u8b8a\u672c\u52a0\u53b2\u7684\u60e1\u6027\u5faa\u74b0\u4e4b\u5916\u3002\u66f4\u56b4\u91cd\u7684\u60c5\u6cc1\u751a\u81f3\u6703\u9020\u6210\u5927\u8166\u9000\u5316\uff0c\u7814\u7a76\u767c\u73fe\u6162\u6027\u80cc\u75db\u7684\u60a3\u8005\uff0c\u5728\u5fcd\u75db\u4e00\u5e74\u5f8c\u5c0e\u81f4\u5927\u8166\u7070\u8cea\u5bc6\u5ea6\u964d\u4f4e\uff1b\u53f0\u7063\u7814\u7a76\u4e5f\u6709\u985e\u4f3c\u7684\u767c\u73fe\uff0c\u539f\u767c\u6027\u7d93\u75db\u7684\u5973\u6027\u6703\u5f15\u8d77\u77ed\u671f\u5927\u8166\u7070\u8cea\u9ad4\u7a4d\u8b8a\u5316\uff0c\u4ee5\u53ca\u795e\u7d93\u529f\u80fd\u6027\u9023\u7d50\u964d\u4f4e\u3002\u65e9\u5728 1990 \u5e74\uff0c\u4e16\u754c\u885b\u751f\u7d44\u7e54 (World Health Organization, WHO) \u5c31\u5df2\u5ba3\u4f48\u300c\u514d\u65bc\u75bc\u75db\u662f\u4e00\u7a2e\u57fa\u672c\u4eba\u6b0a\u300d\uff0c\u6211\u5011\u6709\u514d\u65bc\u53d7\u75bc\u75db\u4e4b\u82e6\u7684\u6b0a\u5229\u3002\u6240\u4ee5\u8207\u5176\u4e00\u76f4\u5fcd\u8010\u75bc\u75db\uff0c\u4e0d\u5982\u8ffd\u6839\u7a76\u67e2\u7684\u6cbb\u7642\u75be\u75c5\uff0c\u76e1\u65e9\u505a\u597d\u75bc\u75db\u7ba1\u7406\uff0c\u624d\u4e0d\u6703\u56e0\u5fcd\u75db\u800c\u82e6\u4e86\u81ea\u5df1\uff0c\u53c8\u56e0\u5c0f\u5931\u5927\u3002\u6b63\u6240\u8b02\u99ac\u5584\u88ab\u4eba\u9a0e\uff0c\u4eba\u5584\u88ab\u4eba\u6b3a\uff0c\u5c31\u662f\u56e0\u70ba\u4f60\u7684\u5fcd\u8010\uff0c\u624d\u6703\u653e\u7e31\u8207\u9ed8\u8a31\u6162\u6027\u75bc\u75db\u9010\u6b65\u5750\u5927\uff0c\u6240\u4ee5\u5fcd\u7121\u53ef\u5fcd\u6642\uff0c\u5247\u7121\u9808\u518d\u5fcd\uff0c\u8d95\u7dca\u5c31\u91ab\u53bb\u5427\uff01<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Finan PH, et al. J Pain. 2013;14:1539-52. The association of sleep and pain: an update and a path forward.<\/a><\/li>\n
  2. Lautenbacher S, et al. Sleep Med Rev. 2006;10:357-69. Sleep deprivation and pain perception.<\/a><\/li>\n
  3. Krueger JM. Curr Pharm Des. 2008;14:3408-16. The role of cytokines in sleep regulation.<\/a><\/li>\n
  4. Li Q, et al. Oncotarget. 2017;8:27616-27626. Tumor necrosis factor alpha is a promising circulating biomarker for the development of obstructive sleep apnea syndrome: a meta-analysis.<\/a><\/li>\n
  5. Karatas G, et al. Int J Rheum Dis. 2018;21:1263-1269. Evaluation of sleep quality in patients with ankylosing spondylitis and efficacy of anti-TNF-\u03b1 therapy on sleep problems: A polisomnographic study.<\/a><\/li>\n
  6. \u8a31\u5609\u9e9f\uff0c\u65e9\u5b89\u5065\u5eb7 2018-06-27\u3002\u7d93\u75db\u6ce8\u610f\uff01\u570b\u969b\u7814\u7a76\u8b66\u544a\uff1a\u5fcd\u75db1\u5e74\uff0c\u5927\u8166\u9000\u531620\u5e74<\/a><\/li>\n
  7. \u738b\u6885\uff0c\u5eb7\u5065\u96dc\u8a8c 135 \u671f\u3002\u5fcd\u75db\uff1f\u4e0d\u5982\u505a\u597d\u75bc\u75db\u7ba1\u7406<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u25a0\u6162\u6027\u75bc\u75db\u9664\u4e86\u9577\u6642\u9593\u9020\u6210\u8eab\u5fc3\u4e0d\u9069\uff0c\u7814\u7a76\u4e5f\u767c\u73fe\u6162\u6027\u75bc\u75db\u548c\u7761\u7720\u54c1\u8cea\uff0c\u5169\u8005\u4e4b\u9593\u7684\u95dc\u4fc2\u5c31\u50cf\u662f\u628a\u96d9\u9762\u5203\uff0c\u81f3\u5c11\u6709 50% \u7684\u5931\u7720\u60a3\u8005\u906d\u53d7\u6162\u6027\u75bc\u75db\u6240\u82e6\uff0c\u591a\u9054 67-88% \u7684\u6162\u6027\u75bc\u75db\u60a3\u8005\u6703\u62b1\u6028\u7761\u7720\u4e0d\u9069\u7684\u554f\u984c\u3002\u6162\u6027\u75bc\u75db\u9020\u6210\u7684\u96e3\u4ee5\u5165\u7720\uff0c\u6703\u6253\u65b7\u6b63\u5e38\u9ad4\u5167\u5c0d\u65bc\u75bc\u75db\u7684\u7652\u5408\u6a5f\u5236\uff0c\u518d\u8b93\u4f60\u7684\u795e\u7d93\u5c0d\u75bc\u75db\u66f4\u70ba\u654f\u611f\u4e5f\u7d2f\u7a4d\u66f4\u591a\u75bc\u75db\uff0c\u9032\u4e00\u6b65\u9020\u6210\u66f4\u56b4\u91cd\u7684\u7761\u7720\u554f\u984c\uff0c\u6700\u7d42\u6df1\u9677\u82e6\u6d77\u7121\u908a\u7684\u60e1\u6027\u5faa\u74b0\u3002<\/p>\n","protected":false},"author":20,"featured_media":33116,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4060,4057,4061,4058,4059],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/10\/headache-1910649_1280.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33109"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33109"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33109\/revisions"}],"predecessor-version":[{"id":33120,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33109\/revisions\/33120"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/33116"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=33109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=33109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}