{"id":33072,"date":"2018-10-15T00:00:38","date_gmt":"2018-10-14T16:00:38","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33072"},"modified":"2018-10-12T10:23:32","modified_gmt":"2018-10-12T02:23:32","slug":"%e3%80%8c%e6%9f%9a%e3%80%8d%e6%98%af%e6%88%91%e7%9a%84%e9%8c%af","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33072","title":{"rendered":"\u300c\u67da\u300d\u662f\u6211\u7684\u932f"},"content":{"rendered":"

\u25a0\u5728\u5927\u90fd\u5e02\u88e1\u958b\u8eca\uff0c\u6700\u6015\u7684\u5c31\u662f\u9047\u5230\u585e\u8eca\uff0c\u6216\u662f\u6b64\u8def\u4e0d\u901a\uff0c\u5927\u6392\u9577\u9f8d\u7684\u8eca\u968a\u6703\u8b93\u4ea4\u901a\u56b4\u91cd\u7671\u7613\u3002\u300c\u67da\u300d\u985e\u548c\u4e0d\u5c11\u85e5\u7269\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u5c31\u50cf\u662f\u5728\u8eab\u9ad4\u5167\u5f15\u767c\u4e00\u5834\u5927\u585e\u8eca\uff0c\u4f7f\u5f97\u85e5\u7269\u7d2f\u7a4d\u6fc3\u5ea6\u904e\u9ad8\u800c\u5f15\u767c\u4e0d\u826f\u53cd\u61c9\u3002<\/span><\/strong><\/p>\n

\"\"\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u25cf\u67da\u985e\u4e2d\u7684\u6210\u4efd\u963b\u64cb\u4e86\u85e5\u7269\u4ee3\u8b1d\u7684\u9014\u5f91<\/strong><\/span><\/p>\n

\u4e2d\u79cb\u7bc0\u524d\u5f8c\uff0c\u662f\u61c9\u666f\u6c34\u679c\u67da\u5b50\u7684\u76db\u7522\u5b63\u7bc0\uff0c\u4f46\u537b\u4e0d\u6642\u767c\u751f\u98df\u7269\u85e5\u7269\u4ea4\u4e92\u4f5c\u7528\u7684\u4e0d\u826f\u53cd\u61c9\u4e8b\u4ef6\uff0c\u50cf\u662f\u8001\u5976\u5976\u5403\u67da\u5b50\u72c2\u5674\u9f3b\u8840\u7b49\u65b0\u805e\uff0c\u4e5f\u5e38\u5e38\u6709\u76f8\u95dc\u7684\u885b\u6559\u5ba3\u5c0e\u88ab\u64ad\u5831\u3002\u5f88\u591a\u4eba\u611b\u597d\u67da\u985e\u6c34\u679c\u7368\u7279\u7684\u98a8\u5473\u8207\u53e3\u611f\uff0c\u7136\u800c\u70ba\u4ec0\u9ebc\u6703\u6709\u9019\u9ebc\u591a\u7684\u98df\u7528\u7981\u5fcc\uff1f\u554f\u984c\u5230\u5e95\u51fa\u5728\u54ea\u5462\uff1f\u9019\u662f\u7531\u65bc\u9ad4\u5167\u85e5\u7269\u4ee3\u8b1d\u7684\u4e3b\u8981\u8def\u5f91\uff0c\u662f\u901a\u904e\u86cb\u767d\u8cea\u5bb6\u65cf\u4e2d\u7684\u7d30\u80de\u8272\u7d20 (cytochrome) P450\uff0c\u5176\u4e2d\u7684\u4e00\u7a2e\u9175\u7d20 CYP3A4 \u8ca0\u8cac\u9ad4\u5167\u7d04 50% \u7684\u85e5\u7269\u4ee3\u8b1d\u4f5c\u7528\uff0c\u6b64 CYP3A4 \u9175\u7d20\u4e3b\u8981\u6703\u5728\u8178\u9053\u8207\u809d\u81df\u4e2d\u5e6b\u5fd9\u4eba\u9ad4\u4ee3\u8b1d\u8207\u6392\u9664\u85e5\u7269\u3002\u7136\u800c\uff0c\u5343\u932f\u842c\u932f\u7684\u539f\u56e0\uff0c\u5c31\u51fa\u5728\u8461\u8404\u67da\u548c\u67da\u5b50\u90fd\u542b\u6709\u8c50\u5bcc\u7684\u300c\u544b\u5583\u9999\u8c46\u7d20 (furanocoumarin)\u300d\uff0c\u9019\u7a2e\u7269\u8cea\u6703\u8207 CYP3A4 \u5f62\u6210\u4e0d\u53ef\u9006\u7684\u5171\u50f9\u9375\u7d50\u5408\uff0c\u4f7f\u5f97\u6b64\u9175\u7d20\u5931\u53bb\u6d3b\u6027\u3002\u6211\u5011\u53ef\u4ee5\u60f3\u50cf\u70ba\uff0c\u539f\u4f86\u9ad4\u5167\u7b46\u76f4\u66a2\u901a\u7684\u85e5\u7269\u4ee3\u8b1d\u8def\u5f91\uff0c\u7a81\u7136\u51fa\u73fe\u4e00\u500b\u8def\u969c\uff0c\u4e5f\u5c31\u662f\u67da\u985e\u7684\u544b\u5583\u9999\u8c46\u7d20\uff0c\u5c0e\u81f4\u85e5\u7269\u96e3\u4ee5\u6392\u9664\u800c\u7d2f\u7a4d\u5728\u9ad4\u5167\uff0c\u6700\u7d42\u9020\u6210\u85e5\u7269\u6fc3\u5ea6\u904e\u9ad8\u7684\u4e0d\u826f\u53cd\u61c9\u3002<\/p>\n

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\u7136\u800c\uff0c\u6703\u5728\u6b64\u689d\u85e5\u7269\u4ee3\u8b1d\u9014\u5f91\u72ed\u8def\u76f8\u9022\u7684\u5acc\u7591\u72af\uff0c\u4e0d\u53ea\u6709\u8461\u8404\u67da\u548c\u67da\u5b50\uff0c\u9084\u5305\u542b\u6587\u65e6\u3001\u5927\u767d\u67da\u3001\u897f\u65bd\u67da\u7b49\u4e5f\u90fd\u5c6c\u65bc\u67da\u985e\uff0c\u53e6\u5916\u9084\u6709\u82e6\u6a59\u548c\u840a\u59c6\u90fd\u6709\u53ef\u80fd\u7522\u751f\u76f8\u4f3c\u7684\u85e5\u7269\u4ea4\u4e92\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u53d7\u5f71\u97ff\u7684\u85e5\u7269\u65e2\u5ee3\u53c8\u591a\uff0c\u76ee\u524d\u5df2\u77e5\u6709\u773e\u591a\u985e\u578b\u7684\u4ee5\u4e0b\u85e5\u7269\uff1a(1) \u964d\u8840\u58d3\u85e5\u7269\u3001(2) \u964d\u8840\u8102\u85e5\u7269\u3001(3) \u6297\u51dd\u8840\u5291\u3001(4) \u6297\u904e\u654f\u85e5\u7269\u3001(5) \u514d\u75ab\u6291\u5236\u5291\u3001(6) \u6297\u611f\u67d3\u5291\u3001(7) \u4e2d\u6a1e\u795e\u7d93\u4f5c\u7528\u5291\u3001(8) \u6297\u764c\u85e5\u7269\u3001(9) \u8178\u80c3\u9053\u85e5\u7269\u3001(10) \u6027\u529f\u80fd\u969c\u7919\u85e5\u7269\u3001(11) \u8377\u723e\u8499\u88fd\u5291\u3002\u5728 2013 \u5e74\u300a\u52a0\u62ff\u5927\u91ab\u7642\u5354\u6703\u671f\u520a (Canadian Medical Association Journal, CMAJ) \u300b\u6574\u7406\u7684\u76f8\u95dc\u7814\u7a76\u66f4\u6307\u51fa\uff0c\u8d85\u904e 85 \u7a2e\u85e5\u7269\u6703\u8207\u8461\u8404\u67da\u6709\u4ea4\u4e92\u4f5c\u7528\uff0c\u5176\u4e2d\u9ad8\u9054 43 \u7a2e\u85e5\u7269\u6703\u7522\u751f\u56b4\u91cd\u7684\u4e0d\u826f\u53cd\u61c9\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u9664\u4e86\u4e0d\u80fd\u548c\u4e0a\u8ff0\u85e5\u7269\u540c\u6642\u4e00\u8d77\u5403\uff0c\u5982\u679c\u5206\u958b\u5403\uff0c\u4e5f\u53ea\u662f\u8b93\u526f\u4f5c\u7528\u7684\u6a5f\u7387\u964d\u4f4e\u800c\u5df2\uff0c\u56e0\u70ba\u8461\u8404\u67da\u6c41\u5c0d\u9175\u7d20 CYP3A4 \u7684\u5f71\u97ff\uff0c\u53ef\u6301\u7e8c\u9577\u9054 24 \u5c0f\u6642\u4ee5\u4e0a\uff0c\u559d\u4e00\u676f 250 \u6beb\u5347\u7684\u8461\u8404\u67da\u6c41\uff0c\u81f3\u5c11\u8981\u904e 3 \u5929\u624d\u80fd\u5b8c\u5168\u6062\u5fa9\u8178\u9053\u4e2d\u7684\u9175\u7d20\u6d3b\u6027\u3002<\/p>\n

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 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. \u806f\u5408\u5831 2018\/09\/17\uff0c\u670d\u7528\u9019\u4e9b\u85e5\u7269\u7684\u4eba \u67da\u5b50\u8981\u6dfa\u5617\u5373\u6b62<\/a><\/li>\n
  2. \u806f\u5408\u5831 2018\/09\/21\uff0c\u8001\u5976\u5976\u5403\u67da\u5b50\u72c2\u5674\u9f3b\u8840 \u91ab\uff1a\u5403\u7279\u5b9a\u85e5\u54c1\u8981\u907f\u958b<\/a><\/li>\n
  3. \u83ef\u4eba\u5065\u5eb7\u7db2\uff0c2018\/09\/16\uff0c\u4e2d\u79cb\u5927\u53e3\u5403\u67da\uff1f5\u5927\u985e\u85e5\u7269\u300c\u85e5\u300d\u5c0f\u5fc3<\/a><\/li>\n
  4. \u9ec3\u5b97\u8ce2\uff0c\u85e5\u5b78\u96dc\u8a8c 97 \u671f\uff0c\u8461\u8404\u67da\u6c41\u4e4b\u85e5\u7269\u4ea4\u4e92\u4f5c\u7528<\/a><\/li>\n
  5. \u9673\u7389\u5029\uff0c\u85e5\u5b78\u96dc\u8a8c\u96fb\u5b50\u5831 117 \u518a\uff0c\u8461\u8404\u67da\u8207\u85e5\u7269\u5c0e\u81f4\u7684\u4e0d\u826f\u53cd\u61c9\u63a2\u8a0e<\/a><\/li>\n
  6. \u6797\u975c\u8389\uff0cMababy 2018\/09\/21\uff0c\u4e00\u5f35\u8868\u544a\u8a34\u4f60\uff0c\u5403\u67da\u5b50\u61c9\u8a72\u907f\u514d\u9019\u4e9b\u85e5<\/a><\/li>\n
  7. CBC News, Nov 27, 2012, Grapefruit juice interaction with drugs can be deadly<\/a><\/li>\n
  8. Bailey DG, et al. CMAJ. 2013;185:309-16. Grapefruit-medication interactions: forbidden fruit or avoidable consequences?<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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