{"id":33010,"date":"2018-10-05T00:28:03","date_gmt":"2018-10-04T16:28:03","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33010"},"modified":"2018-10-04T14:07:20","modified_gmt":"2018-10-04T06:07:20","slug":"%e3%80%902018%e8%ab%be%e8%b2%9d%e7%88%be%e7%94%9f%e9%86%ab%e7%8d%8e%e3%80%91","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33010","title":{"rendered":"\u30102018\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u3011\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u65b0\u7a81\u7834"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-33011\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/10\/allison-honjo_portraits1-1024x594.jpg\" alt=\"\" width=\"700\" height=\"342\" data-wp-pid=\"33011\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/10\/allison-honjo_portraits1-1024x594.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/10\/allison-honjo_portraits1-1024x594-800x391.jpg 800w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p><span style=\"color: #333399;\"><strong>\u25a0\u4e00\u8f49\u773c\uff0c\u53c8\u5230\u4e86\u4e00\u5e74\u4e00\u5ea6\u8afe\u8c9d\u723e\u596c\u5728\u5404\u9818\u57df\u72c2\u653e\u97ad\u70ae\u7684\u65e5\u5b50\u3002\u4eca\u5e74\u7684\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u9019\u4e00\u4e32\u5927\u7d05\u97ad\u70ae\uff0c\u70b8\u5230\u4e86\u5169\u4f4d\u514d\u75ab\u5b78\u6cf0\u6597\uff1a\u7f8e\u570b\u514d\u75ab\u5b78\u5bb6 James Allison \u548c\u65e5\u672c\u514d\u75ab\u5b78\u5bb6\u672c\u5eb6\u4f51\uff08Tasuku Honjo\uff09\uff0c\u70ba\u4ed6\u5011\u5728\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u958b\u7586\u95e2\u571f\u7684\u8ca2\u737b\uff0c\u5408\u7d66\u4e86\u4e00\u9802\u5927\u6842\u51a0\u3002<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5c\u99f1\u5b9b\u7433&nbsp;<\/strong><\/p>\n<p>James Allison \u535a\u58eb\u548c\u672c\u5eb6\u4f51\u535a\u58eb\u9019\u5e7e\u5e74\u4f86\u5728\u5404\u5927\u79d1\u5b78\u734e\u9805\u4e0a\u7372\u734e\u7121\u6578\u3002\u5169\u4eba\u7686\u662f 2014 \u5e74\u81fa\u7063\u5510\u734e\u751f\u6280\u91ab\u85e5\u734e\u7684\u5f97\u4e3b\uff1b\u9694\u5e74\uff0cAllison \u535a\u58eb\u53c8\u62ff\u5230\u4e86\u53e6\u4e00\u500b\u6975\u5176\u6b8a\u69ae\u7684 Lasker Award\uff1b\u518d\u9694\u4e00\u5e74\uff0c\u672c\u5eb6\u4f51\u535a\u58eb\u4e5f\u98a8\u5149\u6458\u4e0b Kyoto Prize\u3002\u800c\u4eca\u5e74\u5341\u6708\uff0c\u5169\u4eba\u53c8\u4e00\u8d77\u5206\u5f97\u4e86\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u3002<\/p>\n<p>\u5169\u4eba\u7372\u734e\u6b77\u6b77\uff0c\u662f\u5be6\u81f3\u540d\u6b78\uff1a\u4ed6\u5011\u5404\u81ea\u5728\u57fa\u790e\u7814\u7a76\u4e0a\u7684\u8ca2\u737b\uff0c\u8b93\u6211\u5011\u5982\u4f55\u5c0d\u6297\u764c\u75c7\u6709\u4e86\u5957\u5d84\u65b0\u7684\u7814\u767c\u89d2\u5ea6\u8207\u6cbb\u7642\u7b56\u7565\u3002\u5728\u9019\u4e4b\u524d\uff0c\u5229\u7528\u514d\u75ab\u7d30\u80de\u4f86\u5c0d\u6297\u764c\u75c7\u9084\u662f\u500b\u6975\u5176\u7570\u60f3\u5929\u958b\u7684\u51b7\u9580\u8ab2\u984c\uff1b\u8981\u4e0d\u662f James Allison \u548c\u672c\u5eb6\u4f51\u535a\u58eb\uff08\u4ee5\u53ca\u8a31\u591a\u8afe\u8c9d\u723e\u596c\u5916\u7684\u907a\u73e0\u5011\uff09\u5e36\u982d\u885d\u92d2\u9677\u9663\uff0c\u4e00\u8def\u633a\u76f4\u8457\u8170\u687f\u8b93\u6578\u64da\u8aaa\u8a71\uff0c\u764c\u75c7\u514d\u75ab\u5b78\u6216\u8a31\u4e0d\u6703\u662f\u5982\u4eca\u9019\u822c\u71e6\u721b\u5149\u666f\u5462\u3002\u4e0d\u904e\uff0cJames Allison \u535a\u58eb\u8ddf\u672c\u5eb6\u4f51\u535a\u58eb\u5e74\u8f15\u7684\u6642\u5019\u5230\u5e95\u767c\u73fe\u4e86\u4ec0\u9ebc\u53b2\u5bb3\u7684\u6771\u897f\uff0c\u800c\u80fd\u5728\u4eca\u65e5\u8b93\u773e\u4eba\u540c\u53e3\u9f4a\u7a31\u8b9a\u5462\uff1f<\/p>\n<p>\u8aaa\u300c\u7576\u9019\u5169\u4f4d\u6cf0\u6597\u9084\u5e74\u8f15\u6642\u300d\uff0c\u5176\u5be6\u4e5f\u4e0d\u904e\u662f\u4e00\u4e5d\u4e5d\u5e7e\u5e74\u9593\u7684\u4e8b\u3002\u800c\u9019\u4e9b\u300c\u60f3\u7576\u5e74\u300d\u7684\u4e8b\uff0c\u8981\u5f9e\u514d\u75ab\u7cfb\u7d71\u88e1\u7684\u6700\u6709\u6230\u9b25\u529b\u4e4b\u4e00\u7684 T \u7d30\u80de\u958b\u59cb\u8aaa\u8d77\u3002\u65e9\u5728 1970 \u5e74\u5de6\u53f3\uff0c\u79d1\u5b78\u5bb6\u5df2\u7d93\u77e5\u9053 T \u7d30\u80de\u6703\u8d77\u4e86\u6bba\u5fc3\uff0c\u662f\u56e0\u70ba T \u7d30\u80de\u7d30\u80de\u8868\u9762\u7684 TCR \uff08T \u7d30\u80de\u8868\u9762\u6297\u539f\u53d7\u9ad4\uff09\uff0c\u50cf\u662f\u96a8\u8eab\u5e36\u4e86\u7167\u5996\u93e1\u4e00\u6a23\uff0c\u53ef\u4ee5\u85c9\u7531\u6383\u63cf\u5176\u4ed6\u7d30\u80de\u8868\u73fe\u5728\u7d30\u80de\u8868\u9762\u7684 p-MHC\uff0c\u8fa8\u8a8d\u51fa\u5176\u4ed6\u7d30\u80de\u662f\u4e0d\u662f\u5fc3\u61f7\u9b3c\u80ce\u3002MHC \u5c31\u662f\u5927\u540d\u9f0e\u9f0e\u4e3b\u8981\u7d44\u7e54\u76f8\u5bb9\u6027\u8907\u5408\u9ad4\u7684\u7e2e\u5beb\u3002\u6bcf\u500b\u4eba\u90fd\u4e0d\u4e00\u6a23\uff0c\u514d\u75ab\u7d30\u80de\u9760\u8457\u9019\u4e9b\u6253\u5f9e\u5a18\u80ce\u88e1\u81ea\u5e36\u7684 MHC \u6a19\u7c64\u4f86\u78ba\u8a8d\u5176\u4ed6\u7d30\u80de\u5230\u5e95\u662f\u4e0d\u662f\u81ea\u5bb6\u4eba\u3002MHC \u5206\u5169\u985e\uff0c\u4f46\u4e0d\u8ad6\u54ea\u4e00\u985e\uff0c\u90fd\u53ef\u4ee5\u50cf\u5c0f\u789f\u5b50\u4e00\u6a23\uff0c\u628a\u7d30\u80de\u5167\u86cb\u767d\u8cea\u964d\u89e3\u5f8c\u7684\u86cb\u767d\u8cea\u80dc\u80bd\uff0c\u4e00\u5c0f\u789f\u3001\u4e00\u5c0f\u789f\u7684\u5448\u5728\u7d30\u80de\u8868\u9762\u4f9b TCR \u9451\u8cde\uff0c\u9019\u5c31\u662f p-MHC\uff08peptide-MHC\uff09\u3002\u800c\u6709\u4e9b\u7d30\u80de\uff0c\u50cf\u662f\u6a39\u7a81\u7d30\u80de\uff08dendritic cells\uff09\uff0c\u66f4\u662f\u5176\u4e2d\u7ff9\u695a\uff0c\u662f\u5c08\u8077\u4e0a\u83dc\u7d66 T \u7d30\u80de\u6aa2\u67e5\u7684\u3002\u53ef\u5225\u5c0f\u770b\u9019\u4e9b\u4e00\u789f\u789f\u7684 p-MHC\uff0c\u5982\u679c\u7d30\u80de\u5167\u7684\u86cb\u767d\u8cea\u6709\u8b8a\u7570\u3001\u6216\u6709\u75c5\u539f\u83cc\u5165\u4fb5\uff0c\u9019\u4e9b\u975e\u5584\u985e\u86cb\u767d\u8cea\u964d\u89e3\u5f8c\u7684\u80dc\u80bd\uff0c\u5c31\u6703\u50cf\u71b1\u83dc\u4e0a\u684c\uff0c\u9999\u5473\u56db\u6ea2\u5730\u7acb\u523b\u5438\u5f15\u80fd\u5920\u300c\u55c5\u51fa\u300d\u4e0d\u5c0d\u52c1\u7684\u5c08\u4e00\u6027 T \u7d30\u80de\u3002\u5982\u679c T \u7d30\u80de\u8868\u9762\u7684 TCR \u525b\u597d\u78b0\u5230\u4e86\u80fd\u5920\u5c08\u4e00\u7d50\u5408\u7684 p-MHC\uff0cTCR \u5c31\u6703\u50b3\u905e\u8a0a\u606f\u6d3b\u5316 T \u7d30\u80de\uff0c\u514d\u75ab\u53cd\u61c9\u5c31\u6703\u88ab\u555f\u52d5\u4e86\u3002\u6bcf\u4e00\u500b T \u7d30\u80de\u53ea\u8868\u73fe\u4e00\u7a2e TCR\uff0c\u800c\u6bcf\u500b T \u7d30\u80de\u8868\u73fe\u7684 TCR \u5c08\u4e00\u6027\u90fd\u4e0d\u4e00\u6a23\u3002\u4ee5\u4eba\u985e\u4f86\u8aaa\uff0c\u64da\u4f30\u8a08\u5927\u6982\u6709\u4e00\u5104\u7a2e\u4e0d\u540c\u7684 TCRs \u5728\u4eba\u9ad4\u5167\u5e6b\u6211\u5011\u628a\u95dc\u3002<\/p>\n<p>1980 \u5e74\u5de6\u53f3\uff0c\u5927\u5bb6\u958b\u59cb\u767c\u73fe\u4e8b\u60c5\u6c92\u6709\u9019\u9ebc\u55ae\u7d14\u3002T \u7d30\u80de\u4e0d\u662f\u4e00\u982d\u76f2\u885d\uff0c\u53ea\u807d TCR \u8a71\u7684\u7b28\u86cb\u3002T \u7d30\u80de\u901a\u884c\u7684\u7b2c\u4e00\u500b\u7da0\u71c8\u662f TCR \u5c08\u4e00\u6027\uff0c\u6b64\u5916\u9084\u9700\u8981\u4f86\u81ea co-stimulation \u7684\u7b2c\u4e8c\u500b\u7da0\u71c8\u3002\u800c\u6709\u4e9b\u7d30\u80de\uff0c\u50cf\u5c08\u8077\u4e0a\u83dc\u7684\u6a39\u7a81\u7d30\u80de\uff0c\u5c31\u80fd\u5920\u63d0\u4f9b\u9019\u7b2c\u4e8c\u500b\u8a0a\u865f\uff1b\u6709\u4e9b\u7d30\u80de(\u50cf\u764c\u75c7\u7d30\u80de)\u5c31\u7121\u6cd5\uff0c\u4ee5\u81f3\u65bc\u764c\u75c7\u7d30\u80de\u5728 T \u7d30\u80de\u773c\u88e1\uff0c\u5c31\u50cf\u662f\u62ab\u4e86\u96b1\u5f62\u6597\u7bf7\u4e00\u6a23\uff0c\u5b8c\u5168\u8996\u82e5\u7121\u7779\u30021990 \u5e74\u6642\uff0cJames Allison \u7387\u5148\u767c\u73fe\u9019\u57f7\u638c\u7b2c\u4e8c\u500b\u7da0\u71c8\u7684\u5927\u7576\u5bb6\uff0c\u662f CD28\u3002\u4e0d\u4e45\u4e4b\u5f8c\uff0cCD28 \u7d50\u5408\u7684\u53d7\u9ad4\u4e5f\u88ab\u5176\u4ed6\u4eba\uff08Linsley\u535a\u58eb\u5be6\u9a57\u5ba4\uff09\u627e\u5230\u4e86\u3002CD28 \u8868\u73fe\u5728 T \u7d30\u80de\u4e0a\uff0c\u80fd\u5920\u548c\u6a39\u7a81\u7d30\u80de\uff08\u6216\u5176\u4ed6\u6297\u539f\u5448\u73fe\u7d30\u80de\uff09\u7684 B7 \u86cb\u767d\u8cea\u7d50\u5408\u3002Allison \u5be6\u9a57\u5ba4\u4e5f\u8b49\u660e\u5982\u679c\u8b93\u764c\u75c7\u7d30\u80de\u8868\u73fe\u5927\u91cf\u7684 B7 \u86cb\u767d\u8cea\uff0c\u764c\u75c7\u7d30\u80de\u7684\u96b1\u5f62\u6597\u7bf7\u5c31\u6703\u7acb\u523b\u5931\u53bb\u9b54\u6cd5\uff0c\u800c\u80fd\u5920\u5feb\u901f\u7684\u88ab\u514d\u75ab\u7cfb\u7d71\u6bb2\u6ec5\u3002<\/p>\n<p>\u4f46 James Allison \u53ef\u4e0d\u662f\u56e0\u6b64\u800c\u5f97\u5230\u8afe\u8c9d\u723e\u734e\uff0c\u9019\u6545\u4e8b\u9084\u5f97\u7e7c\u7e8c\u8aaa\u4e0b\u53bb\u3002\u53c8\u904e\u4e86\u5341\u5e74\uff0cAllison \u767c\u73fe\u8981\u8b93 T \u7d30\u80de\u8d77\u6bba\u5fc3\u9019\u4e8b\uff0c\u4e0d\u662f\u300cTCR + CD28\u300d\u9019\u5169\u500b\u7da0\u71c8\u4eae\u4e86\u53c8\u4eae\uff0c\u5c31\u80fd\u6982\u62ec\u7684\u4e8b\uff0c\u4ed6\u958b\u59cb\u89ba\u5f97\u4e8b\u60c5\u9435\u5b9a\u6c92\u6709\u9019\u9ebc\u55ae\u7d14\u3002\u5f8c\u4f86\uff0c\u6709\u79d1\u5b78\u5bb6\u89e3\u78bc\u4e86\u4e00\u500b\u50cf\u662f CD28 \u5b7f\u751f\u5144\u5f1f\u7684\u57fa\u56e0\uff0c\u5c31\u662f CTLA-4\u3002\u7576\u6642\uff0cCTLA-4 \u9019\u500b\u86cb\u767d\u6709\u4ec0\u9ebc\u5341\u516b\u822c\u6b66\u85dd\u9084\u672a\u77e5\uff0c\u4f46\u5149\u5b83\u8ddf CD28 \u6975\u7aef\u795e\u4f3c\u9019\u9ede\uff0c\u5c31\u6210\u4e86\u773e\u6240\u77da\u76ee\u7684\u7126\u9ede\u3002Linsley \u535a\u58eb\u5be6\u9a57\u5ba4\u767c\u73fe\uff0cCTLA-4 \u8ddf CD28 \u4e0d\u55ae\u662f\u9577\u5f97\u50cf\uff0c\u559c\u597d\u4e5f\u5f88\u50cf\uff1a\u5169\u500b\u86cb\u767d\u8cea\u90fd\u80fd\u5920\u8ddf B7 \u86cb\u767d\u8cea\u7d50\u5408\u3002Linsley \u535a\u58eb\u5be6\u9a57\u5ba4\u65bc\u662f\u63d0\u8b70\uff0cCTLA-4 \u61c9\u8a72\u5c31\u662f CD28 \u7684\u54e5\u5006\u597d\uff0c\u5169\u500b\u86cb\u767d\u8cea\u7684\u529f\u80fd\u662f\u770b\u5176\u4e00\uff0c\u77e5\u5176\u4e8c\u3002<\/p>\n<p>\u4f46\uff0cAllison \u5be6\u9a57\u5ba4\u505a\u4e86\u5be6\u9a57\uff0c\u63d0\u51fa\u4e86\u4e00\u500b\u5f88\u6709\u610f\u601d\u7684\u8ad6\u9ede\u3002CTLA-4 \u548c CD28 \u5176\u5be6\u662f\u5169\u500b\u4e92\u70ba\u6297\u8861\u7684\u89d2\u8272\u3002T \u7d30\u80de\u4e00\u908a\u7b49\u8457 CD28 \u7684\u7da0\u71c8\u628a\u4e00\u8173\u8e29\u5728\u6cb9\u9580\u4e0a\uff0c\u53e6\u4e00\u8173\u53ef\u662f\u8001\u8001\u5be6\u5be6\u5730\u8e29\u8457 CTLA-4 \u9019\u500b\u715e\u8eca\u5462\u3002\u56e0\u6b64\uff0c\u5c31\u7b97\u6a39\u7a81\u7d30\u80de\uff08\u6216\u662f\u5176\u4ed6\u6297\u539f\u5448\u73fe\u7d30\u80de\uff09\u628a\u764c\u7d30\u80de\u7684\u8b8a\u7570\u86cb\u767d\u80dc\u80bd\u7aef\u4e0a\u4e86\u5c0f\u789f\u5b50\u5448\u73fe\u5230 T \u7d30\u80de\u524d\uff0c\u5982\u679cT \u7d30\u80de\u8868\u9762\u7684 CTLA-4 \u4e5f\u555f\u52d5\u4e86\u6291\u5236\u6027\u8abf\u63a7\u6a5f\u8f49\uff0c\u6a39\u7a81\u7d30\u80de\u5c31\u7121\u6cd5\u8b93 T \u7d30\u80de\u88ab\u6d3b\u5316\u800c\u53bb\u6bba\u6575\u764c\u7d30\u80de\u3002<\/p>\n<p>\u5728\u90a3\u5e7e\u5e74\u9593\uff0c\u95dc\u65bc CTLA-4 \u7684\u722d\u8ad6\u6c92\u505c\u904e\uff1bCTLA-4 \u5230\u5e95\u662f\u6548\u9870 CD28 \u7684\u6771\u65bd\u4e00\u679a\uff0c\u9084\u662f\u7b2c\u4e00\u500b\u88ab\u767c\u73fe\u7684 T \u7d30\u80de\u5167\u5efa\u715e\u8eca\u5668\u5462\u3002\u4e00\u76f4\u5230 CTLA-4 \u57fa\u56e0\u5254\u9664\u8001\u9f20\u554f\u4e16\uff0c\u9019\u4e9b\u722d\u8ad6\u624d\u7b97\u5875\u57c3\u843d\u5b9a\u3002\u5c0f\u8001\u9f20\u5982\u679c\u6b20\u7f3a\u4e86 CTLA-4 \u7684\u57fa\u56e0\uff0c\u4e0d\u51fa\u5e7e\u500b\u79ae\u62dc\u90fd\u592d\u6298\u65bc\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u3002\u53ef\u898b\uff0cCTLA-4 \u5728 T \u7d30\u80de\u5167\uff0c\u626e\u6f14\u8457\u6291\u5236\u6027\u8abf\u7bc0\u7684\u89d2\u8272\u3002<\/p>\n<p>\u81ea\u6b64\uff0c\u8a31\u591a\u4eba\u90fd\u60f3\u8457 CTLA-4 \u5728\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u65b9\u9762\u7684\u61c9\u7528\u50f9\u503c\u3002\u4f46 Allison \u4e0d\u4e00\u6a23\uff0c\u4ed6\u60f3\uff0c T \u7d30\u80de\u514d\u75ab\u96d6\u7136\uff08\u5e7e\u4e4e\uff09\u6230\u7121\u4e0d\u514b\uff0c\u537b\u8001\u5728\u5c0d\u6297\u764c\u75c7\u4e0a\u4e00\u76f4\u5403\u60b6\u8667\uff0c\u641e\u4e0d\u597d\u90fd\u662f\u56e0\u70ba CTLA-4\u3002\u5982\u679c\u6709\u4e00\u652f\u6297\u9ad4\u80fd\u5920\u7d50\u5408\u4e0a CTLA-4\uff0c\u7136\u5f8c\u963b\u65b7 CTLA-4 \u6240\u50b3\u905e\u7684\u6291\u5236\u8abf\u7bc0\u8a0a\u606f\uff0c\u6216\u8a31 T \u7d30\u80de\u5c31\u80fd\u50cf\u77c7\u773c\u7684\u99ac\u4e0d\u53d7\u9a5a\uff0c\u62fc\u547d\u5411\u524d\u885d\uff0c\u6bba\u5f97\u764c\u75c7\u7d30\u80de\u7247\u7532\u4e0d\u7559\u3002\u81ea 1996 \u5e74\u958b\u59cb\uff0cAllison \u5be6\u9a57\u5ba4\u958b\u59cb\u767c\u8868\u4e00\u7cfb\u5217\u76f8\u95dc\u7814\u7a76\u4f86\u652f\u6301\u4ed6\u5011\u7684\u8ad6\u9ede\u30021997 \u5e74\uff0c\u4ed6\u5011\u6210\u529f\u5229\u7528\u86cb\u767d\u8cea\u8207\u6297\u9ad4\u5de5\u7a0b\u6280\u8853\uff0c\u751f\u7522\u51fa\u4e00\u682a\u53ef\u4ee5\u7d50\u5408\u4e0a CTLA-4\u3001\u963b\u65b7 CTLA-4 \u7684\u8a0a\u606f\u50b3\u5c0e\u8def\u5f91\u7684\u6297\u9ad4\uff0c\u8b93 T \u7d30\u80de\u4e0d\u518d\u4e00\u76f4\u8e29\u8457\u715e\u8eca\uff0c\u800c\u80fd\u5920\u66f4\u6709\u6548\u7387\u5730\u628a\u764c\u7d30\u80de\u6bb2\u6ec5\u3002\u63a5\u4e0b\u4f86\u7684\u81e8\u5e8a\u5be6\u9a57\u4e5f\u4e0d\u8ca0\u773e\u671b\uff0cCTLA-4 \u6297\u9ad4\u5c0d\u6cbb\u7642\u5f8c\u671f\u9ed1\u8272\u7d20\u7624\u7684\u76ae\u819a\u764c\u7279\u5225\u6709\u6548\u3002<\/p>\n<p>\u800c T \u7d30\u80de\u9664\u4e86 CTLA-4\uff0c\u9084\u6709\u5176\u4ed6\u7684\u715e\u8eca\u626e\u6f14\u8457\u6291\u5236\u6027\u8abf\u7bc0\u7684\u89d2\u8272\u3002\u50cf\u662f\u7531\u672c\u5eb6\u4f51\u535a\u58eb\u6240\u767c\u73fe\u7684 PD-1 \u96d6\u7136\u4f5c\u7528\u6a5f\u5236\u8ddf CTLA-4 \u5927\u5927\u4e0d\u540c\uff0c\u4f46\u4e5f\u662f\u626e\u6f14\u8457\u6291\u5236\u6027\u8abf\u7bc0\u7684\u8981\u89d2\u3002PD-1 \u7684\u53d7\u9ad4\u662f PD-L1\uff0c\u5982\u679cT \u7d30\u80de\u8868\u9762\u7684 PD-1 \u7d50\u5408\u4e0a\u4e86 PD-L1\uff0cT \u7d30\u80de\u529f\u80fd\u5c31\u6703\u88ab\u6291\u5236\u3002\u8a31\u591a\u764c\u75c7\u7d30\u80de\u90fd\u6703\u5927\u91cf\u8868\u73fe PD-L1\uff0c\u85c9\u4ee5\u9003\u907f\u514d\u75ab\u7d30\u80de\u7684\u8ffd\u64ca\u3002\u56e0\u6b64\uff0c\u5c31\u50cf\u5229\u7528\u963b\u65b7 CTLA-4 \u4f86\u6cbb\u7642\u764c\u75c7\u540c\u6a23\u7684\u7b56\u7565\uff0c\u5229\u7528\u6297\u9ad4\u963b\u65b7 PD-1\uff0cT \u7d30\u80de\u5c31\u80fd\u5c0d\u764c\u75c7\u7d30\u80de\u5927\u767c\u5a01\u3002\u800c\u4e14\uff0c\u81e8\u5e8a\u8a66\u9a57\u8b49\u660e PD-1 \u624d\u662f\u66f4\u6709\u6548\u53c8\u526f\u4f5c\u7528\u6bd4\u8f03\u5c0f\u7684\u65b9\u5f0f\u5462\u3002<\/p>\n<p>James Allison \u535a\u58eb\u548c\u672c\u5eb6\u4f51\u535a\u58eb\u5c0d\u764c\u75c7\u514d\u75ab\u5b78\u7684\u8ca2\u737b\u662f\u6709\u76ee\u5171\u7779\u3002\u4ed6\u5011\u7684\u7814\u7a76\u6210\u679c\u4e0d\u50c5\u8b93\u514d\u75ab\u5b78\u5bb6\u5c0d T \u7d30\u80de\u6d3b\u5316\u6a5f\u8f49\u6709\u66f4\u5168\u76e4\u7684\u8a8d\u8b58\u8207\u4e86\u89e3\uff0c\u66f4\u662f\u5f15\u9032\u4e86\u764c\u75c7\u6cbb\u7642\u65b0\u7b56\u7565\u3002Allison \u66fe\u8aaa\uff0c\u7576\u5e74\u8981\u628a CTLA-4 \u9019\u652f\u6297\u9ad4\u63a8\u5ee3\u5230\u85e5\u5ee0\u8207\u81e8\u5e8a\u8a66\u9a57\u6642\uff0c\u8dd1\u4e86\u4e00\u5bb6\u53c8\u4e00\u5bb6\u7684\u85e5\u5ee0\uff0c\u537b\u88ab\u5927\u591a\u6578\u7684\u85e5\u5ee0\u62d2\u7d55\u3002\u5f8c\u4f86\uff0c\u7f8e\u570b\u5927\u85e5\u5ee0 Bristol-Myers Squibb \u9f0e\u529b\u76f8\u52a9\u800c\u8b93 CTLA-4 \u7684\u81e8\u5e8a\u61c9\u7528\u4e00\u8209\u8dd1\u904e\u4e86\u7d42\u9ede\u7dda\u3002\u9019\u9802\u6842\u51a0\u8a8d\u8b49\u4e86 James Allison \u535a\u58eb\u8207\u672c\u5eb6\u4f51\u535a\u58eb\u7684\u773c\u754c\u8207\u601d\u8003\u6df1\u5ea6\uff0c\u66f4\u8b9a\u69ae\u4e86\u90a3\u500b\u5e74\u4ee3\u5728\u9019\u500b\u7814\u7a76\u8ab2\u984c\u4e0a\u4f60\u4e00\u8a00\u3001\u6211\u4e00\u8a9e\uff0c\u4e00\u500b\u53c8\u4e00\u500b\u7684\u79d1\u5b78\u5bb6\u3002\u6842\u51a0\u5e95\u4e0b\u7684\u907a\u73e0\u592a\u591a\uff0c\u4f46\u4e00\u8d77\u6210\u5c31\u7684\u662f\u4e0d\u50c5\u662f\u7d30\u63cf\u4e86\u77e5\u8b58\u7684\u7f8e\uff0c\u66f4\u662f\u8b93\u4eba\u985e\u80fd\u66f4\u5065\u5eb7\u7684\u53ef\u80fd\u5462\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>--<br \/>\n<a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2018\/press-release\/\">\u8afe\u8c9d\u723e\u5b98\u7db2<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u4e00\u8f49\u773c\uff0c\u53c8\u5230\u4e86\u4e00\u5e74\u4e00\u5ea6\u8afe\u8c9d\u723e\u596c\u5728\u5404\u9818\u57df\u72c2\u653e\u97ad\u70ae\u7684\u65e5\u5b50\u3002\u4eca\u5e74\u7684\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u9019\u4e00\u4e32\u5927\u7d05\u97ad\u70ae\uff0c\u70b8\u5230\u4e86\u5169\u4f4d\u514d\u75ab\u5b78\u6cf0\u6597\uff1a\u7f8e\u570b\u514d\u75ab\u5b78\u5bb6 James Allison \u548c\u65e5\u672c\u514d\u75ab\u5b78\u5bb6\u672c\u5eb6\u4f51\uff08Tasuku Honjo\uff09\uff0c\u70ba\u4ed6\u5011\u5728\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u958b\u7586\u95e2\u571f\u7684\u8ca2\u737b\uff0c\u5408\u7d66\u4e86\u4e00\u9802\u5927\u6842\u51a0\u3002<\/p>\n","protected":false},"author":20,"featured_media":33012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1027,3293,1025],"tags":[3531,3530,4018,4019,1645,177],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/10\/0-1.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33010"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33010"}],"version-history":[{"count":5,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33010\/revisions"}],"predecessor-version":[{"id":33017,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33010\/revisions\/33017"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/33012"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=33010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=33010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}