{"id":32981,"date":"2018-10-18T00:27:56","date_gmt":"2018-10-17T16:27:56","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=32981"},"modified":"2019-07-31T11:07:10","modified_gmt":"2019-07-31T03:07:10","slug":"%e8%85%ab%e7%98%a4%e5%be%ae%e7%92%b0%e5%a2%83%e4%b8%8d%e5%8f%aa%e6%98%af%e4%bd%a0%e8%bf%bd%e6%88%91%e8%b7%91","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=32981","title":{"rendered":"\u816b\u7624\u5fae\u74b0\u5883\u4e0d\u53ea\u662f\u4f60\u8ffd\u6211\u8dd1"},"content":{"rendered":"

\u25a0\u816b\u7624\u7d30\u80de\u76f8\u7576\u523b\u82e6\u8010\u52de\u7684\u843d\u5be6\u8457\u300a\u4f8f\u7f85\u7d00\u516c\u5712\u300b\u7684\u7d93\u5178\u540d\u8a00\u300c\u751f\u547d\u7d42\u7a76\u6703\u81ea\u5df1\u627e\u5230\u51fa\u8def\u300d\uff0c\u52aa\u529b\u5b58\u6d3b\u7684\u816b\u7624\u7d30\u80de\u5c0e\u81f4\u764c\u75c7\u96e3\u4ee5\u88ab\u6839\u6cbb\uff0c\u9019\u4e5f\u662f\u73fe\u4eca\u91ab\u5b78\u6975\u6b32\u89e3\u6c7a\u7684\u8ab2\u984c\u3002<\/strong><\/span><\/p>\n

\"\"\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

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\u4eba\u9ad4\u88e1\u7684\u514d\u75ab\u7cfb\u7d71\u5c31\u50cf\u662f\u6bcf\u5929\u5728\u8def\u4e0a\u5de1\u908f\u7684\u8b66\u5bdf\u4eba\u54e1\uff0c\u8eab\u8ca0\u902e\u6355\u58de\u4eba\u7684\u4efb\u52d9\u4ee5\u7dad\u6301\u793e\u6703\u7684\u5b89\u5b9a\u8207\u5e73\u7a69\u3002\u7136\u800c\uff0c\u8b66\u5bdf\u6293\u5c0f\u5077\uff0c\u4e0d\u50cf\u8001\u9df9\u6293\u5c0f\u96de\u53ea\u8981\u7dca\u76ef\u8457\u7375\u7269\uff0c\u4e00\u500b\u4fef\u885d\u5c31\u80fd\u624b\u5230\u64d2\u4f86\u9019\u9ebc\u5bb9\u6613\u3002\u8b66\u5bdf\u81f3\u5c11\u8981\u80fd\u8fa8\u8996\u7f6a\u72af\u5916\u89c0\u3001\u5224\u65b7\u72af\u6848\u52d5\u6a5f\u3001\u9810\u4f30\u9003\u8dd1\u8def\u7dda\uff0c\u624d\u80fd\u5faa\u5e8f\u6f38\u9032\u7684\u9396\u5b9a\u5acc\u7591\u72af\u3002\u53cd\u65b9\u9762\uff0c\u72af\u4eba\u4e5f\u4e0d\u60f3\u9019\u9ebc\u8f15\u6613\u7684\u88ab\u8b66\u5bdf\u6293\u5230\uff0c\u57fa\u672c\u7684\u8eb2\u85cf\u3001\u9762\u5bb9\u507d\u88dd\u3001\u96b1\u533f\u884c\u8e64\uff0c\u90fd\u662f\u72af\u4eba\u9003\u8dd1\u7684\u5fc5\u7136\u624b\u6bb5\u3002\u4eba\u9ad4\u816b\u7624\u7d30\u80de\u5982\u4f55\u9003\u907f\u514d\u75ab\u7cfb\u7d71\u8ffd\u6355\u7684\u5834\u666f\uff0c\u4e5f\u50cf\u662f\u4e00\u9f63\u8b66\u532a\u8ffd\u9010\u5287\uff0c\u76ee\u524d\u6709\u4e0d\u5c11\u7814\u7a76\u6574\u5408\u51fa\u4e86\u76f8\u95dc\u5047\u8aaa\u3002\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u80fd\u5920\u900f\u904e\u4e00\u7a2e\u50cf\u662f\u8b66\u5bdf\u5de1\u908f\uff0c\u540d\u70ba\u300c\u514d\u75ab\u76e3\u6e2c (immunosurveillance)\u300d\u7684\u904e\u7a0b\uff0c\u4f86\u8fa8\u8b58\u4e26\u6d88\u6ec5\u816b\u7624\u7d30\u80de\uff1b\u4f46\u662f\u816b\u7624\u7d30\u80de\u4e5f\u6703\u900f\u904e\u4e00\u7a2e\u7a31\u70ba\u300c\u514d\u75ab\u7de8\u8f2f (immunoediting)\u300d\u7684\u7b56\u7565\uff0c\u4f86\u907f\u958b\u514d\u75ab\u7cfb\u7d71\u7684\u653b\u64ca\u3002\u514d\u75ab\u7de8\u8f2f\u5c31\u662f\u816b\u7624\u7d30\u80de\u5f62\u6210\u514d\u75ab\u62b5\u6297\u6027\u7684\u4e00\u7cfb\u5217\u904e\u7a0b\uff0c\u9019\u4e9b\u904e\u7a0b\u6703\u9010\u6b65\u8b93\u9ad4\u5167\u7684\u67d0\u500b\u5c0f\u90e8\u4f4d\u8b8a\u6210\u9069\u5408\u816b\u7624\u751f\u9577\u7684\u5730\u65b9\uff0c\u514d\u75ab\u5b78\u4e0a\u7a31\u4e4b\u70ba\u816b\u7624\u5fae\u74b0\u5883 (tumor microenvironment)\u3002<\/p>\n

\u25cf\u816b\u7624\u7d30\u80de\u9032\u64ca\u514d\u75ab\u7cfb\u7d71\u7684\u51f1\u65cb\u4e09\u90e8\u66f2<\/strong><\/span><\/p>\n

\u816b\u7624\u7684\u514d\u75ab\u7de8\u8f2f\u904e\u7a0b\u4f7f\u5f97\u514d\u75ab\u7cfb\u7d71\u9010\u6f38\u5931\u5e38\u7684\u60c5\u6cc1\uff0c\u5c31\u5982\u540c\u6839\u64da\u4eba\u5011\u7684\u624d\u667a\u512a\u52a3\u53ef\u4ee5\u5206\u70ba\u4e09\u500b\u7d1a\u5225\uff1a\u5148\u77e5\u5148\u89ba\u3001\u5f8c\u77e5\u5f8c\u89ba\uff0c\u4ee5\u53ca\u4e0d\u77e5\u4e0d\u89ba\u3002\u6240\u8b02\u5148\u77e5\u5148\u89ba\uff0c\u6307\u7684\u662f\u514d\u75ab\u7cfb\u7d71\u6b64\u6642\u9084\u795e\u667a\u6e05\u660e\uff0c\u80fd\u5920\u6b63\u5e38\u57f7\u884c\u514d\u75ab\u76e3\u6e2c\uff0c\u53ef\u8fa8\u8b58\u4e26\u6d88\u6ec5\u816b\u7624\u7d30\u80de\uff0c\u6b64\u6642\u7a31\u4e4b\u70ba\u300c\u6e05\u9664\u968e\u6bb5 (elimination)\u300d\u3002\u518d\u4f86\u662f\u5f8c\u77e5\u5f8c\u89ba\uff0c\u6307\u7684\u662f\u514d\u75ab\u7cfb\u7d71\u6b64\u6642\u5df2\u795e\u667a\u4e0d\u6e05\uff0c\u7121\u6cd5\u5b8c\u5168\u6839\u9664\u816b\u7624\u7d30\u80de\uff0c\u816b\u7624\u7d30\u80de\u7684\u6b98\u9ee8\u6703\u56e0\u70ba\u751f\u5b58\u58d3\u529b\u800c\u7522\u751f\u65b0\u7684\u816b\u7624\u7d30\u80de\u8b8a\u7570\u65cf\u7fa4\uff0c\u4f46\u6578\u91cf\u4e0a\u9084\u672a\u80fd\u5f15\u767c\u75be\u75c5\uff0c\u6b64\u6642\u7a31\u4e4b\u70ba\u300c\u5e73\u8861\u968e\u6bb5 (equilibrium)\u300d\u3002\u6700\u7cdf\u7684\u4e0d\u77e5\u4e0d\u89ba\uff0c\u6307\u7684\u662f\u514d\u75ab\u7cfb\u7d71\u6b64\u6642\u5df2\u8001\u773c\u660f\u82b1\uff0c\u7121\u6cd5\u8fa8\u8b58\u51fa\u9019\u4e9b\u8b8a\u7570\u7684\u816b\u7624\u7d30\u80de\uff0c\u4f7f\u5f97\u816b\u7624\u7d30\u80de\u53ef\u4ee5\u8d81\u52e2\u5750\u5927\uff0c\u9032\u800c\u958b\u59cb\u64da\u5be8\u70ba\u738b\uff0c\u751a\u81f3\u60f3\u8981\u5728\u9ad4\u5167\u8f49\u79fb\u4f86\u500b\u904d\u5730\u958b\u82b1\uff0c\u6b64\u6642\u7a31\u4e4b\u70ba\u300c\u9003\u812b\u968e\u6bb5 (escape)\u300d\u3002\u9019\u5c31\u662f\u816b\u7624\u7d30\u80de\u70ba\u4e86\u5b58\u6d3b\u4f7f\u51fa\u5343\u65b9\u767e\u8a08\uff0c\u6700\u5f8c\u8b93\u514d\u75ab\u7cfb\u7d71\u7121\u7528\u6b66\u4e4b\u5730\u7684\u6f14\u9032\u904e\u7a0b\uff0c\u4e5f\u662f\u764c\u75c7\u767c\u75c5\u7684\u5fc5\u7d93\u4e4b\u8def\u3002<\/p>\n

\u25cf\u5c0d\u816b\u7624\u77e5\u5df1\u77e5\u5f7c\uff0c\u6cbb\u7642\u65b9\u80fd\u767e\u6230\u4e0d\u6b86<\/strong><\/span><\/p>\n

\u816b\u7624\u7d30\u80de\u53ef\u4ee5\u5982\u6b64\u779e\u5929\u904e\u6d77\u7684\u8a08\u7b56\uff0c\u5927\u81f4\u5206\u70ba\u56db\u5927\u985e\u578b\uff1a\u6291\u5236\u816b\u7624\u4e0a\u7684\u6297\u539f\u5448\u73fe\u3001\u5206\u6ccc\u514d\u75ab\u6291\u5236\u6027\u56e0\u5b50\u3001\u6291\u5236\u514d\u75ab\u7d30\u80de\u7684\u653b\u64ca\u3001\u53ec\u96c6\u514d\u75ab\u6291\u5236\u6027\u7d30\u80de\u4f86\u5e6b\u5fd9\u3002\u4e0d\u904e\u842c\u8b8a\u4e0d\u96e2\u5176\u5b97\uff0c\u7121\u8ad6\u4ec0\u9ebc\u624b\u6bb5\uff0c\u5176\u5be6\u76ee\u7684\u90fd\u662f\u4e0d\u8b93\u514d\u75ab\u7d30\u80de\u6709\u6a5f\u6703\u88ab\u6d3b\u5316\uff0c\u800c\u8b8a\u8eab\u70ba\u5c0d\u816b\u7624\u7d30\u80de\u6709\u6bba\u50b7\u80fd\u529b\u7684\u72c0\u614b\u3002\u4f8b\u5982\u6291\u5236\u816b\u7624\u4e0a\u7684\u6297\u539f\u5448\u73fe\uff0c\u5c31\u50cf\u662f\u4f7f\u7528\u507d\u88dd\u8853\uff0c\u628a\u81ea\u5df1\u8b8a\u6210\u96b1\u5f62\u6230\u6a5f\uff0c\u4e0d\u8b93\u5c0d\u624b\u7684\u96f7\u9054\u80fd\u5075\u6e2c\u81ea\u5df1\u3002\u8fd1\u5e74\u4f86\uff0c\u764c\u75c7\u91ab\u5b78\u9818\u57df\u5c0d\u65bc\u816b\u7624\u9670\u8b00\u8d8a\u4f86\u8d8a\u6df1\u5165\u4e86\u89e3\uff0c\u4e5f\u958b\u767c\u51fa\u5e7e\u7a2e\u6709\u7a81\u7834\u6027\u7642\u6548\u7684\u85e5\u7269\u53ca\u65b9\u6cd5\uff0c\u6b63\u5982\u5b6b\u5b50\u5175\u6cd5\u6240\u4e91\uff1a\u300c\u591a\u7b97\u52dd\uff0c\u5c11\u7b97\u4e0d\u52dd\uff0c\u800c\u6cc1\u7121\u7b97\u4e4e\uff01\u300d\u3002<\/p>\n

\u6700\u8fd1\u706b\u7d05\u7684\u514d\u75ab\u816b\u7624\u5b78 (Immuno-Oncology, IO) \u7642\u6cd5\u6240\u904b\u7528\u7684\u6a5f\u5236\uff0c\u5c31\u662f\u4e86\u89e3\u5230\u816b\u7624\u4e0a\u6703\u8868\u73fe\u5f88\u591a\u53ef\u6291\u5236\u514d\u75ab T \u7d30\u80de\u6d3b\u6027\u7684\u5206\u5b50 PD-L1\uff0c\u5176\u70ba\u4e00\u7a2e\u514d\u75ab\u7d30\u80de\u4e0a PD-1 \u7684\u914d\u9ad4\uff0c\u6b64\u7b56\u7565\u5c31\u50cf\u662f\u7f6a\u72af\u8eab\u4e0a\u5e36\u8457\u5f88\u591a\u5f35\u826f\u6c11\u8b49\u6216\u597d\u4eba\u5361\uff0c\u85c9\u6b64\u5c0d\u8b66\u5bdf\u7684\u81e8\u6aa2\u779e\u6df7\u904e\u95dc\u3002\u56e0\u6b64\u963b\u65b7\u9019\u689d\u8def\u5f91\u7684\u85e5\u7269\u9678\u7e8c\u88ab\u767c\u5c55\u51fa\u4f86\uff0c\u4e5f\u5c31\u73fe\u5728\u5404\u85e5\u5ee0\u706b\u529b\u5168\u958b\u7684 PD-1 \u6297\u9ad4\u6216 PD-L1 \u6297\u9ad4\uff0c\u8a31\u591a\u81e8\u5e8a\u8a66\u9a57\u4e5f\u5df2\u8b49\u5be6\u5176\u6297\u816b\u7624\u7642\u6548\u3002\u6b64\u5916\uff0c\u7531\u65bc\u4f5c\u7528\u8def\u5f91\u7684\u5c08\u4e00\u6027\u8f03\u9ad8\uff0c\u4e0d\u50cf\u50b3\u7d71\u5316\u7642\u85e5\u7269\u7684\u526f\u4f5c\u7528\u9019\u9ebc\u5927\u3002\u9019\u985e\u85e5\u7269\u7684\u6548\u679c\uff0c\u5c31\u50cf\u662f\u8b93\u514d\u75ab\u7cfb\u7d71\u7684\u529f\u80fd\uff0c\u5f9e\u5c0d\u816b\u7624\u300c\u4e0d\u77e5\u4e0d\u89ba\u300d\u7684\u72c0\u614b\uff0c\u6062\u5fa9\u5230\u81f3\u5c11\u662f\u300c\u5f8c\u77e5\u5f8c\u89ba\u300d\u7684\u72c0\u614b\u3002<\/p>\n

\u6df1\u4fe1\u53ea\u8981\u91ab\u5b78\u9818\u57df\u6301\u7e8c\u5730\u7814\u7a76\u816b\u7624\u7684\u9670\u8b00\uff0c\u764c\u75c7\u6cbb\u7642\u7d42\u6709\u4e00\u5929\u80fd\u5920\u6230\u7121\u4e0d\u52dd\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599<\/strong>\uff1a<\/strong><\/p>\n

    \n
  1. Coico R, et al. Immunology: A Short Course. Hoboken, NJ: John Wiley & Sons; 2009.<\/li>\n
  2. Abbas AK, et al. Cellular and Molecular Immunology. 6th ed. Philadelphia, PA: Elsevier Saunders; 2010.<\/li>\n
  3. Dermani FK, et al. PD-1\/PD-L1 immune checkpoint: Potential target for cancer therapy. J Cell Physiol. 2018 Sep 7. [link]<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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