{"id":32760,"date":"2018-09-05T00:46:24","date_gmt":"2018-09-04T16:46:24","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=32760"},"modified":"2019-07-31T11:08:38","modified_gmt":"2019-07-31T03:08:38","slug":"%e9%81%8b%e7%94%a8%e9%85%b5%e6%af%8d%e8%8f%8c%e7%aa%ba%e8%a6%8b%e4%ba%ba%e5%b7%a5%e6%99%ba%e6%85%a7%e7%9a%84%e9%bb%91%e7%9b%92%e5%ad%90","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=32760","title":{"rendered":"\u904b\u7528\u9175\u6bcd\u83cc\u7aba\u898b\u4eba\u5de5\u667a\u6167\u7684\u9ed1\u76d2\u5b50"},"content":{"rendered":"

\u25a0\u73fe\u4eca\u8a31\u591a\u4eba\u5de5\u667a\u6167\u7cfb\u7d71\u6240\u61c9\u7528\u7684\u6df1\u5ea6\u795e\u7d93\u7db2\u8def\uff08Deep neural network, DNN\uff09\u9084\u662f\u6709\u4e9b\u795e\u79d8\u3002\u900f\u904e\u9175\u6bcd\u83cc\u6211\u5011\u5f97\u4ee5\u7aba\u898b\u9019\u500b\u9ed1\u76d2\u5b50\u3002<\/strong><\/span><\/p>\n

\"\"\u64b0\u6587\uff5c\u9ec3\u4f73\u6b23<\/strong><\/p>\n

\u4e00\u7bc7\u767c\u8868\u5728 Nature Methods<\/em> \u671f\u520a\u4e0a\u7684\u7814\u7a76\u8ad6\u6587\uff0c\u4f86\u81ea\u52a0\u5dde\u5927\u5b78\u8056\u5730\u4e9e\u54e5\u5206\u6821\u7684\u5718\u968a\u958b\u767c\u51fa\u4e00\u5957\u300c\u53ef\u8996\u5316\u795e\u7d93\u7db2\u8def\u300d\uff08visible neural network, VNN\uff09\u6a21\u578b\uff0c\u4ed6\u5011\u628a\u9175\u6bcd\u83cc\u7684\u57fa\u56e0\u7b49\u5206\u5b50\u968e\u5c64\u7db2\u8def\u6620\u5c04\u5230\u6df1\u5ea6\u795e\u7d93\u7db2\u8def\u7684\u57fa\u672c\u67b6\u69cb\uff0c\u8b93\u7814\u7a76\u4eba\u54e1\u80fd\u5920\u89c0\u5bdf\u4eba\u5de5\u667a\u6167\u7cfb\u7d71\u7684\u904b\u4f5c\u60c5\u6cc1\uff0c\u4e26\u900f\u904e\u6a5f\u5668\u6d1e\u5bdf\u7d30\u80de\u7684\u5167\u90e8\u904b\u4f5c\uff0c\u7531\u6b64\u7522\u751f\u7684\u6280\u8853\u671f\u5f85\u672a\u4f86\u53ef\u4ee5\u5c0b\u6c42\u65b0\u7684\u6297\u764c\u85e5\u7269\u6216\u662f\u61c9\u7528\u5728\u500b\u4eba\u5316\u6cbb\u7642\u3002<\/p>\n

\u25cf<\/b>\u4eba\u5de5\u667a\u6167\u662f\u500b\u9ed1\u76d2\u5b50<\/strong><\/span><\/p>\n

\u9996\u5148\u8b93\u6211\u5011\u4f86\u56de\u9867\u4e00\u4e0b\u6700\u8fd1\u6df1\u5ea6\u795e\u7d93\u7db2\u8def\u70ba\u4eba\u5de5\u667a\u6167\u7684\u9818\u57df\u5e36\u4f86\u7a81\u7834\u6027\u7684\u767c\u5c55\uff0c\u6a5f\u5668\u4e0d\u50c5\u80fd\u5920\u8ddf\u4eba\u4e00\u6a23\u807d\u8aaa\u8b80\u5beb\uff0c\u9084\u80fd\u5920\u4e0b\u570d\u68cb\uff0c\u958b\u8eca\u4e0a\u8def\u3002<\/p>\n

\u8209\u500b\u4f8b\u5b50\u7c21\u77ed\u5730\u8aaa\u660e\u6df1\u5ea6\u795e\u7d93\u7db2\u8def\u7684\u904b\u4f5c\u65b9\u5f0f\uff0c\u96fb\u8166\u79d1\u5b78\u5bb6\u6703\u8a2d\u7f6e\u8a31\u591a\u300c\u5c64\u300d\u4f86\u63d0\u4f9b\u6df1\u5ea6\u795e\u7d93\u7db2\u8def\u7684\u6846\u67b6\uff0c\u6bcf\u4e00\u5c64\u5305\u542b\u4e0a\u5343\u500b\u8ca0\u8cac\u8a08\u7b97\u4efb\u52d9\u7684\u300c\u795e\u7d93\u5143\u300d\u3002\u8f38\u5165\u6578\u842c\u5f35\u7684\u8c93\u548c\u72d7\u7167\u7247\uff08\u6216\u662f\u68cb\u8b5c\u7b49\u5927\u91cf\u7684\u6578\u64da\u8cc7\u6599\uff09\u7d66\u96fb\u8166\u5b78\u7fd2\u6216\u7a31\u505a\u8a13\u7df4\uff0c\u900f\u904e\u6bcf\u4e00\u5c64\u7684\u795e\u7d93\u5143\u500b\u5225\u8a08\u7b97\u770b\u5230\u7167\u7247\u7684\u7279\u5fb5\uff0c\u8f38\u51fa\u6578\u503c\u50b3\u5230\u4e0b\u4e00\u5c64\uff0c\u7d93\u904e\u975e\u5e38\u591a\u5c64\u4e4b\u5f8c\uff0c\u7cfb\u7d71\u9023\u63a5\u5404\u5c64\u4e2d\u7684\u795e\u7d93\u5143\u4ee5\u88fd\u4f5c\u7d50\u69cb\u5316\u8a08\u7b97\u5e8f\u5217\uff0c\u63a5\u8457\u6aa2\u9a57\u6a5f\u5668\u662f\u5426\u6e96\u78ba\u5730\u5340\u5206\u8c93\u548c\u72d7\uff0c\u7136\u5f8c\u53cd\u994b\u7d50\u679c\u5f9e\u6700\u5f8c\u4e00\u5c64\u795e\u7d93\u5143\u56de\u5230\u7b2c\u4e00\u5c64\uff0c\u85c9\u6b64\u8b93\u795e\u7d93\u5143\u4e4b\u9593\u7684\u9023\u63a5\u6a21\u5f0f\u91cd\u65b0\u6392\u5217\uff0c\u7d93\u904e\u53cd\u8986\u5e7e\u842c\u6b21\u7684\u8a13\u7df4\u904e\u7a0b\uff0c\u7576\u795e\u7d93\u7db2\u7d61\u80fd\u5920\u975e\u5e38\u9054\u5230\u5927\u7d04\u4e5d\u6210\u4ee5\u4e0a\u7684\u6e96\u78ba\u9810\u6e2c\u7387\u6642\uff0c\u90a3\u9ebc\u6a21\u578b\u5c31\u7b97\u662f\u8a13\u7df4\u6210\u529f\u3002<\/p>\n

\u5118\u7ba1 AI \u904b\u7528\u6df1\u5ea6\u795e\u7d93\u7db2\u8def\u6a21\u578b\u53ef\u4ee5\u91dd\u5c0d\u4e00\u500b\u554f\u984c\u7d66\u51fa\u6b63\u78ba\u7684\u7b54\u6848\uff0c\u6211\u5011\u77e5\u9053\u5b83\u78ba\u5be6\u53ef\u884c\uff0c\u4f46\u662f\u6211\u5011\u537b\u5f88\u96e3\u7406\u89e3\u5c64\u8207\u5c64\u4e4b\u9593\u7684\u795e\u7d93\u5143\u662f\u5982\u4f55\u5354\u540c\u5de5\u4f5c\u7684\uff0c\u6a5f\u5668\u5167\u90e8\u7684\u591a\u5c64\u96b1\u85cf\u7d50\u69cb\u5c31\u50cf\u662f\u500b\u9ed1\u76d2\u5b50\u3002<\/p>\n

\u52a0\u5dde\u5927\u5b78\u8056\u5730\u4e9e\u54e5\u5206\u6821\u7684\u751f\u7269\u5de5\u7a0b\u548c\u91ab\u5b78\u7cfb\u6559\u6388Trey Ideker\u89e3\u91cb\u8aaa\uff1a\u300c\u96d6\u7136\u5b83\u5011\u88ab\u7a31\u4f5c\u795e\u7d93\u7db2\u8def\uff0c\u4f46\u9019\u4e9b\u7cfb\u7d71\u53ea\u662f\u53d7\u5230\u4eba\u985e\u795e\u7d93\u7cfb\u7d71\u7684\u555f\u767c\uff0c\u4f8b\u5982 AlphGo \u7684\u7cfb\u7d71\u5167\u90e8\u5de5\u4f5c\u60c5\u6cc1\u770b\u8d77\u4f86\u662f\u4e00\u6574\u500b\u6df7\u4e82\uff0c\u5176\u5be6\u4e00\u9ede\u4e5f\u4e0d\u50cf\u4eba\u985e\u7684\u5927\u8166\uff0c\u6df1\u5ea6\u795e\u7d93\u7db2\u8def\u6a21\u578b\u662f\u7368\u81ea\u767c\u5c55\u51fa\u7684\u4e00\u5957\u5f88\u597d\u7684\u9810\u6e2c\u7cfb\u7d71\u3002\u300d<\/p>\n

\u25cf<\/b>\u7528\u9175\u6bcd\u83cc\u6559\u96fb\u8166\u8a8d\u8b58\u907a\u50b3\u5bc6\u78bc\u6539\u8b8a\u7684\u5f71\u97ff<\/strong><\/span><\/p>\n

Ideker \u6559\u6388\u5e36\u9818\u5718\u968a\u5b8c\u6210\u4e00\u9805\u65b0\u7814\u7a76\uff0c\u63a1\u7528\u4e00\u4e9b\u8207\u773e\u4e0d\u540c\u7684\u65b9\u5f0f\u5c0e\u5165AI\u8207\u7d30\u80de\u751f\u7269\u5b78\u3002\u4ed6\u671f\u5f85\u795e\u7d93\u7db2\u8def\u4e0d\u50c5\u53ef\u4ee5\u4e1f\u51fa\u4e00\u500b\u7b54\u6848\uff0c\u9084\u53ef\u4ee5\u8b93\u7814\u7a76\u4eba\u54e1\u77e5\u9053\u6a5f\u5668\u662f\u600e\u9ebc\u300c\u60f3\u300d\u5230\u9019\u500b\u7b54\u6848\u3002\u4ed6\u7684\u5718\u968a\u5229\u7528\u9175\u6bcd\u83cc\u7d30\u80de\u5167\u5404\u500b\u57fa\u56e0\u7b49\u7d44\u6210\u5206\u5b50\u7684\u95dc\u806f\u968e\u5c64\u4f5c\u70ba\u795e\u7d93\u7db2\u8def\u5167\u5c64\u8207\u5c64\u7684\u6846\u67b6\uff0c\u85c9\u6b64\u4f86\u4e86\u89e3\u7d30\u80de\u7684\u904b\u4f5c\u65b9\u5f0f\u3002\u4ed6\u5011\u5e0c\u671b\u8b93\u795e\u7d93\u7db2\u8def\u7684\u968e\u5c64\u95dc\u4fc2\u4e0d\u662f\u7531\u96fb\u8166\u79d1\u5b78\u5bb6\u6240\u754c\u5b9a\uff0c\u800c\u662f\u7531\u751f\u547d\u7684\u6f14\u5316\u904e\u7a0b\u800c\u5f97\u3002<\/p>\n

\u5564\u9152\u9175\u6bcd\u83cc\uff08Saccharomyces cerevisiae<\/em>\uff09\u662f\u5f9e19\u4e16\u7d00\u5f8c\u671f\u958b\u59cb\u4e00\u76f4\u88ab\u79d1\u5b78\u5bb6\u4f5c\u70ba\u7814\u7a76\u57fa\u672c\u751f\u547d\u7cfb\u7d71\u7684\u6a21\u5f0f\u7269\u7a2e\uff0c\u56e0\u6b64\uff0c\u6211\u5011\u5c0d\u65bc\u9175\u6bcd\u83cc\u7684\u7d30\u80de\u5167\u5404\u500b\u529f\u80fd\u7cfb\u7d71\u7684\u95dc\u806f\u6027\u8ddf\u751f\u7269\u5b78\u77e5\u8b58\u662f\u76f8\u7576\u6e05\u695a\u7684\uff0c\u62ff\u9175\u6bcd\u83cc\u7684\u7d30\u80de\u5404\u500b\u55ae\u4f4d\u7d44\u6210\u7576\u4f5c\u6df1\u5ea6\u795e\u7d93\u7db2\u8def\u7684\u6846\u67b6\u662f\u53ef\u884c\u7684\u3002<\/p>\n

\u6839\u64da\u9175\u6bcd\u83cc\u7d30\u80de\u5167\u90e8\u7684\u7d44\u6210\uff0c\u5f9e\u6700\u57fa\u790e\u7684\u5143\u7d20 \uff08DNA \u7684\u6838\u82f7\u9178\u5e8f\u5217\uff09\u958b\u59cb\uff0c\u4e00\u8def\u4e32\u9023\u5230\u66f4\u5927\u7684\u7d50\u69cb\u5206\u5b50\u4f8b\u5982\u6838\u91a3\u9ad4\uff0c\u5230\u6700\u5f8c\u50cf\u7c92\u7dda\u9ad4\u548c\u7d30\u80de\u6838\u7b49\u80de\u5668\u7b49\u7d1a\u7684\u7d50\u69cb\u6216\u751f\u7406\u529f\u80fd\u3002\u4ed6\u5011\u7e3d\u5171\u5229\u7528\u4e86\u4f86\u81ea\u9175\u6bcd\u7d30\u80de\u7684 2,526\u500b\u5b50\u7cfb\u7d71\u4f86\u69cb\u6210\u4ed6\u5011\u6240\u4f7f\u7528\u7684\u795e\u7d93\u7db2\u8def\u7cfb\u7d71\uff08\u5716\u4e00\uff09\uff0c\u9019\u500b\u7cfb\u7d71\u8a72\u88ab\u53d6\u540d\u70ba DCell (http:\/\/d-cell.ucsd.edu\/)<\/a>\u3002<\/p>\n

\"\"<\/a>
\u5716\u4e00 \uff5c\u5229\u7528\u53ef\u8996\u5316\u795e\u7d93\u7db2\u8def\uff08Visible neural network, VNN\uff09\u9032\u884c\u7d30\u80de\u7d50\u69cb\u8207\u529f\u80fd\u7684\u5efa\u6a21\u3002(a)\u4e00\u822c\u6df1\u5ea6\u795e\u7d93\u7db2\u8def\u7684\u5167\u90e8\u904b\u4f5c\u662f\u4e00\u500b\u9ed1\u76d2\u5b50\u3002(b)\u5728\u53ef\u8996\u5316\u795e\u7d93\u7db2\u8def\u7684\u5167\u90e8\u7d50\u69cb\u662f\u57fa\u65bc\u9175\u6bcd\u7d30\u80de\u5df2\u77e5\u7684\u751f\u7269\u5b78\u7cfb\u7d71\u7d50\u69cb\u8207\u77e5\u8b58\u3002\u5728DCell\u7684\u7cfb\u7d71\u4e2d\uff0c\u57fa\u56e0\u7684\u6838\u82f7\u9178\u5e8f\u5217\u8b8a\u7570\u7d44\u5408\u70ba\u57fa\u56e0\u578b\uff08genotype\uff09\u8f38\u5165\u7684\u8cc7\u6599\uff0c\u5229\u7528\u7d30\u80de\u500b\u5206\u5b50\u7684\u7d50\u69cb\u968e\u5c64\u95dc\u806f\u6027\uff0c\u8f38\u51fa\u7d30\u80de\u751f\u9577\u7684\u60c5\u5f62\u70ba\u8868\u73fe\u578b\uff08phenotype\uff09\u3002
(c)\u6bcf\u500b\u795e\u7d93\u5143\u7684\u9023\u7d50\u662f\u900f\u904e\u5df2\u77e5\u7d30\u80de\u7684\u529f\u80fd\u5b50\u7cfb\u7d71\u4f86\u4f5c\u70ba\u795e\u7d93\u7db2\u8def\u7684\u67b6\u69cb\u3002\u5716\u7247\u4f86\u6e90: Fig. 1 in Ma et al. Nature methods 15 (4), 290 (2018)\u3002<\/figcaption><\/figure>\n

DCell \u8b93\u7814\u7a76\u4eba\u54e1\u53ef\u4ee5\u66f4\u6df1\u5165\u5730\u89e3\u958b\u57fa\u56e0\u578b\u8207\u8868\u73fe\u578b\u7684\u95dc\u806f\u6027\uff0c\u4e5f\u5c31\u662f\u7576\u57fa\u56e0\u7a81\u8b8a\u6216\u662f\u6578\u500b\u55ae\u4e00\u6838\u82f7\u9178\u8b8a\u7570\u7684\u7d44\u5408\uff08\u4e0d\u540c\u7684\u57fa\u56e0\u578b\uff09\uff0c\u9019\u4e9b\u907a\u50b3\u5bc6\u78bc\u7684\u6539\u8b8a\u5982\u4f55\u6ce2\u53ca\u6539\u8b8a\u7d30\u80de\u7684\u751f\u9577\u8207\u7e41\u6b96\uff08\u8868\u73fe\u578b\uff09\u3002\u4ed6\u5011\u63a1\u7528\u7684\u8a13\u7df4\u8cc7\u6599\u662f\u5f9e\u904e\u53bb\u5168\u4e16\u754c\u7684\u5be6\u9a57\u5ba4\u6240\u6536\u96c6\u5230\u7684\u9175\u6bcd\u7d30\u80de\u57fa\u56e0\u7a81\u8b8a\u7684\u907a\u50b3\u8cc7\u6599\u8ddf\u751f\u9577\u60c5\u6cc1\uff0c\u9ad8\u9054\u6578\u767e\u842c\u7b46\u7684\u771f\u5be6\u914d\u5c0d\u8cc7\u6599\u3002<\/p>\n

\u6839\u64da\u7814\u7a76\u8ad6\u6587\u7684\u7d50\u679c\u986f\u793a DCell \u78ba\u5be6\u53ef\u4ee5\u6839\u64da\u907a\u50b3\u7684\u8b8a\u7570\u6e96\u78ba\u5730\u9810\u6e2c\u9175\u6bcd\u7d30\u80de\u751f\u9577\u3002\u7531\u65bc\u5b83\u662f\u4e00\u500b\u300c\u53ef\u898b\u7684\u300d\u795e\u7d93\u7db2\u8def\uff0c\u7814\u7a76\u4eba\u54e1\u9084\u53ef\u4ee5\u5f9eDCell \u7cfb\u7d71\u4e2d\u89c0\u5bdf\u7576\u907a\u50b3\u7269\u8ceaDNA\u7684\u5e8f\u5217\u6216\u57fa\u56e0\u767c\u751f\u8b8a\u7570\u6709\u54ea\u4e9b\u5206\u5b50\u662f\u5171\u540c\u88ab\u5f71\u97ff\uff0c\u7e7c\u800c\u9810\u6e2c\u5230\u9175\u6bcd\u7d30\u80de\u7684\u751f\u9577\u60c5\u6cc1\u3002\u85c9\u6b64\u7cfb\u7d71\u9084\u53ef\u4ee5\u627e\u51fa\u4e3b\u8981\u5f71\u97ff\u8868\u73fe\u578b\u7684\u57fa\u56e0\u529f\u80fd\u5b50\u7cfb\u7d71\uff0c\u7d30\u80de\u904b\u4f5c\u7684\u907a\u50b3\u908f\u8f2f\uff08genetic logic\uff09\uff0c\u4ee5\u53ca\u767c\u73fe\u65b0\u7684\u751f\u7269\u9014\u5f91\uff08biological processes\uff09\u3002<\/p>\n

\u25cf<\/b>DCell<\/strong>\u7684\u5ef6\u4f38\u61c9\u7528<\/strong><\/span><\/p>\n

DCell \u900f\u660e\u5316\u7684\u795e\u7d93\u7db2\u8def\u5c0d\u65bc\u7d30\u80de\u751f\u7269\u5b78\u7684\u7814\u7a76\u6709\u8a31\u591a\u5177\u6709\u6f5b\u529b\u7684\u5ef6\u4f38\u3002\u4f8b\u5982\uff0c\u5982\u679c\u80fd\u5efa\u69cb\u4e00\u500b\u5b8c\u6574\u4eba\u9ad4\u7d30\u80de\u7684\u5167\u90e8\u6a21\u578b\uff0c\u4e26\u4e14\u5c0d\u5176\u9032\u884c\u6a21\u64ec\u3002\u9019\u5c07\u6703\u6f88\u5e95\u6539\u8b8a\u7cbe\u6e96\u91ab\u7642\u8207\u85e5\u7269\u958b\u767c\u7684\u6d41\u7a0b\u3002<\/p>\n

\u5c0b\u627e\u65b0\u578b\u6297\u764c\u85e5\u7269\u7684\u88fd\u85e5\u516c\u53f8\u7d93\u5e38\u628a\u7d30\u80de\u751f\u9577\u4f5c\u70ba\u6210\u529f\u6216\u5931\u6557\u7684\u8861\u91cf\u6a19\u6e96\uff0c\u4ed6\u5011\u9762\u5c0d\u7684\u96e3\u984c\u662f\u91dd\u5c0d\u6bcf\u500b\u85e5\u7269\u80fd\u5920\u6253\u958b\u8207\u95dc\u9589\u4e0d\u540c\u57fa\u56e0\u7684\u7d50\u679c\u662f\u5426\u53ef\u4ee5\u5c0e\u81f4\u816b\u7624\u7d30\u80de\u505c\u6b62\u7e41\u6b96\u8207\u751f\u9577\u3002\u5982\u679c\u6709\u4e00\u500b\u6e96\u78ba\u7684AI\u7d30\u80de\u6a21\u578b\u4f86\u9032\u884c\u9810\u5148\u6a21\u64ec\uff0c\u90a3\u5c07\u6703\u662f\u975e\u5e38\u5be6\u7528\u7684\u5de5\u5177\u3002<\/p>\n

\u5f9e\u9175\u6bcd\u5230\u4eba\u9ad4\u7d30\u80de\u7684\u5347\u7d1a\u4e0d\u662f\u4e00\u4ef6\u5bb9\u6613\u7684\u4e8b\u3002\u7814\u7a76\u4eba\u54e1\u9700\u8981\u6536\u96c6\u6709\u95dc\u4eba\u985e\u60a3\u8005\u7684\u8db3\u5920\u8cc7\u6599\uff0c\u4ee5\u5f62\u6210\u795e\u7d93\u7db2\u7d61\u7684\u8a13\u7df4\u6578\u64da\u2014\u2014\u9700\u8981\u6578\u767e\u842c\u689d\u8a18\u9304\uff0c\u5176\u4e2d\u5305\u62ec\u60a3\u8005\u7684\u907a\u50b3\u7279\u5fb5\u53ca\u5176\u5065\u5eb7\u7d50\u679c\u3002\u66f4\u68d8\u624b\u7684\u662f\u6211\u5011\u4e5f\u8981\u5c0d\u764c\u7d30\u80de\u5982\u4f55\u904b\u4f5c\u540c\u6a23\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u8207\u77e5\u8b58\u7684\u7d2f\u7a4d\uff0cIdeker \u5718\u968a\u4e5f\u53c3\u8207\u4e86\u4e00\u9805\u5927\u578b\u7684\u764c\u7d30\u80de\u5716\u8b5c\u8a08\u756bCancer Cell Map Initiative\uff08http:\/\/ccmi.org\/<\/a>\uff09\u8457\u624b\u8655\u7406\u9019\u500b\u96e3\u984c\u3002<\/p>\n

\u5118\u7ba1\u5982\u6b64\uff0cIdeker\u6559\u6388\u4e5f\u63d0\u5230\u4ed6\u5e0c\u671b\u5617\u8a66\u4f7f\u7528\u4e00\u7a2e\u7a31\u70ba\u8f49\u79fb\u5b78\u7fd2\uff08transfer learning\uff09\u7684\u6a5f\u5668\u5b78\u7fd2\u6280\u8853\uff0c\u5c07\u4e00\u500b\u6a21\u64ec\u9175\u6bcd\u7d30\u80de\u7684\u795e\u7d93\u7db2\u8def\u64f4\u589e\u61c9\u7528\u5230\u4e00\u500b\u6a21\u64ec\u4eba\u985e\u7d30\u80de\u7684\u795e\u7d93\u7db2\u8def\u7cfb\u7d71\u3002<\/p>\n

 <\/strong><\/p>\n

 <\/p>\n

\u539f\u6587\u51fa\u8655\uff1a<\/strong>Cracking Open the Black Box of AI with Cell Biology<\/a><\/p>\n

\u539f\u59cb\u8ad6\u6587\uff1aJianzhu Ma, Michael Ku Yu, Samson Fong, Keiichiro Ono, Eric Sage, Barry Demchak, Roded Sharan & Trey Ideker. 2018. Using deep learning to model the hierarchical structure and function of a cell. Nature Methods, Nature methods<\/em> 15 (4), 290. doi: 10.1038\/nmeth.4627<\/a><\/p>\n

 <\/p>\n

\u4f5c\u8005\uff1a\u9ec3\u4f73\u6b23\uff0c\u81fa\u7063\u5927\u5b78\u6606\u87f2\u5b78\u535a\u58eb\u3002\u73fe\u70ba\u4e2d\u592e\u7814\u7a76\u9662\u8cc7\u8a0a\u79d1\u5b78\u6240\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u3002\u904e\u53bb\u4ee5\u6606\u87f2\u751f\u7406\u53ca\u8178\u9053\u83cc\u5171\u751f\u95dc\u4fc2\u70ba\u7814\u7a76\u4e3b\u984c\uff0c\u76ee\u524d\u805a\u7126\u65bc\u751f\u7269\u8cc7\u8a0a\u8207\u529f\u80fd\u6027\u57fa\u56e0\u9ad4\u5b78\u3002<\/strong><\/p>\n

 <\/p>\n

\"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u25a0\u73fe\u4eca\u8a31\u591a\u4eba\u5de5\u667a\u6167\u7cfb\u7d71\u6240\u61c9\u7528\u7684\u6df1\u5ea6\u795e\u7d93\u7db2\u8def\uff08Deep neural network, DNN\uff09\u9084\u662f\u6709\u4e9b\u795e\u79d8\u3002\u900f\u904e\u9175\u6bcd\u83cc\u6211\u5011\u5f97\u4ee5\u7aba\u898b\u9019\u500b\u9ed1\u76d2\u5b50\u3002<\/p>\n","protected":false},"author":20,"featured_media":32761,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3772,3293],"tags":[3959,3032,3792,727,1410],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/08\/0816.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/32760"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=32760"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/32760\/revisions"}],"predecessor-version":[{"id":32822,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/32760\/revisions\/32822"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/32761"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=32760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=32760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=32760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}