{"id":32756,"date":"2018-08-30T00:31:10","date_gmt":"2018-08-29T16:31:10","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=32756"},"modified":"2019-07-31T11:08:33","modified_gmt":"2019-07-31T03:08:33","slug":"%e5%a6%82%e3%80%8c%e8%8f%8c%e3%80%8d%e5%8f%af%e6%95%99%e4%b9%8b%ef%bc%9a%e6%98%af%e8%aa%b0%e6%b1%ba%e5%ae%9a%e4%ba%86%e6%88%91%e5%80%91%e8%82%9a%e8%a3%a1%e7%9a%84%e8%85%b8%e9%81%93%e8%8f%8c%e5%8f%a2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=32756","title":{"rendered":"\u5982\u300c\u83cc\u300d\u53ef\u6559\u4e4b\uff1a\u662f\u8ab0\u6c7a\u5b9a\u4e86\u6211\u5011\u809a\u88e1\u7684\u8178\u9053\u83cc\u53e2\uff1f"},"content":{"rendered":"

\u25a0\u6240\u8b02\u4eba\u751f\u4e09\u5927\u4e8b\uff1a\u4e00\u5247\u4ed6\u9109\u9047\u6545\u77e5\uff0c\u4e8c\u662f\u91d1\u699c\u984c\u540d\u6642\uff0c\u4e09\u70ba\u6d1e\u623f\u82b1\u71ed\u591c\u3002\u4f46\u5c0d\u514d\u75ab\u5b78\u5bb6\u4f86\u8aaa\uff0c\u9019\u5343\u7b97\u842c\u7b97\uff0c\u537b\u5c11\u7b97\u4e86\u4e00\u6a23\uff1b\u540d\u526f\u5176\u5be6\u7684\u809a\u88e1\u86d4\u87f2\uff1a\u8178\u9053\u83cc\u53e2\u3002<\/strong><\/span><\/p>\n

\"\"\u64b0\u6587\uff5c\u99f1\u5b9b\u7433<\/strong><\/p>\n

\u8fd1\u5e7e\u5e74\uff0c\u8178\u9053\u83cc\u53e2\u53ef\u662f\u773e\u6240\u77da\u76ee\u7684\u7126\u9ede\u3002\u81e8\u5e8a\u7814\u7a76\u4e5f\u597d\uff0c\u57fa\u790e\u7814\u767c\u4e5f\u597d\uff0c\u8178\u9053\u83cc\u53e2\u7684\u300c\u5065\u5eb7\u5ea6\u300d\u4f3c\u4e4e\u6c7a\u5b9a\u4e86\u8a31\u591a\u751f\u8001\u75c5\u6b7b\u7684\u5927\u5c0f\u4e8b\u3002\u8209\u51e1\u4ee3\u8b1d\u6027\u75be\u75c5\u3001\u514d\u75ab\u80fd\u529b\u3001\u7cbe\u795e\u969c\u7919\uff0c\u751a\u81f3\u8ac7\u5230\u6297\u764c\u6cbb\u7642\u7684\u9810\u5f8c\uff0c\u8178\u9053\u83cc\u53e2\u90fd\u88ab\u767c\u73fe\u6216\u591a\u6216\u5c11\u5730\u53c3\u4e86\u4e00\u8173\u5728\u5176\u4e2d\u3002\u6b63\u6240\u8b02\u6293\u4f4f\u4e86\u4e00\u500b\u4eba\u7684\u8178\u9053\u83cc\u53e2\uff0c\u5c31\u6293\u4f4f\u4e86\u4ed6\u7684\u5065\u5eb7\u3002\u8a72\u5982\u4f55\u5efa\u7acb\u3001\u91cd\u6574\u8178\u9053\u83cc\u53e2\u7684\u5065\u5eb7\u5ea6\uff0c\u4e00\u76f4\u662f\u5c0d\u9019\u9818\u57df\u6709\u8208\u8da3\u7684\u7814\u7a76\u4eba\u54e1\u52aa\u529b\u6293\u7834\u982d\u4e5f\u8981\u7406\u89e3\u7b87\u4e2d\u6a5f\u8f49\uff0c\u60f3\u51fa\u5c0d\u7b56\u7684\u5927\u4e8b\u3002\u800c\u5728\u5fb7\u570b Hannover Medical School \u7684\u7814\u7a76\u4eba\u54e1\u4e5f\u4e0d\u4f8b\u5916\u3002\u6700\u8fd1\uff0c\u7531 Hornef \u535a\u58eb\u6240\u5e36\u9818\u7684\u5be6\u9a57\u5ba4\u5728 \u300aNature<\/em>\u300b\u671f\u520a\u4e0a\u767c\u8868\u4e86\u4e00\u7bc7\u5f88\u6709\u8da3\u7684\u7814\u7a76\u6210\u679c\u3002\u4ed6\u5011\u60f3\u8981\u77e5\u9053\uff0c\u8178\u9053\u83cc\u53e2\u65e2\u7136\u662f\u6211\u5011\u7684\u809a\u88e1\u86d4\u87f2\uff0c\u662f\u4ec0\u9ebc\u56e0\u7d20\u6c7a\u5b9a\u6211\u5011\u8981\u8ddf\u5343\u5343\u842c\u842c\u500b\u5b83\u5011\u4e4b\u4e2d\u7684\u8ab0\uff0c\u5957\u9019\u500b\u5f88\u53ef\u80fd\u727d\u626f\u4e00\u751f\u7684\u4ea4\u60c5\u5462\uff1f<\/p>\n

\u4f46\u7576\u80ce\u5152\u9084\u5728\u5abd\u5abd\u809a\u5b50\u88e1\u7684\u6642\u5019\uff0c\u80ce\u5152\u8178\u9053\u88e1\u662f\u7121\u83cc\u7684\u4e00\u5875\u4e0d\u67d3\u3002\u7576\u5b30\u5152\u5728\u7d93\u904e\u7522\u9053\u6642\uff0c\u9084\u6709\u5471\u5471\u843d\u5730\u4e4b\u5f8c\uff0c\u74b0\u5883\u88e1\u7684\u5404\u7a2e\u7d30\u83cc\u624d\u958b\u59cb\u85c9\u8457\u5b30\u5152\u8ddf\u74b0\u5883\u7684\u63a5\u89f8\u3001\u98f2\u98df\u559d\u6c34\u7b49\u6a5f\u6703\uff0c\u6162\u6162\u5728\u8178\u9053\u88e1\u958b\u7586\u95e2\u571f\u3002\u4ee5\u4eba\u985e\u5b30\u5152\u4f86\u8aaa\uff0c\u9019\u6bb5\u300c\u8178\u9580\u6d1e\u958b\u300d\u7684\u6642\u9593\u5927\u6982\u5230\u5b30\u5152\u4e00\u6b72\u534a\u5de6\u53f3\u3002\u5b5f\u5b50\u6709\u5b5f\u6bcd\u5e6b\u5fd9\u64c7\u9130\u8655\uff0c\u8b93\u5b5f\u5b50\u597d\u597d\u4ea4\u670b\u53cb\uff1b\u800c\u5b30\u5152\uff0c\u6709\u6bcd\u4e73\u3002\u5148\u524d\u7684\u7814\u7a76\u5df2\u7d93\u767c\u73fe\u5abd\u5abd\u9ad4\u5167\u7684\u6297\u9ad4\uff0c\u53ef\u4ee5\u900f\u904e\u54fa\u9935\u6bcd\u4e73\u7684\u65b9\u5f0f\uff0c\u63a5\u68d2\u7d66\u5b30\u5152\uff0c\u5e6b\u5fd9\u6c7a\u5b9a\u54ea\u4e9b\u597d\u83cc\u53e2\u53ef\u4ee5\u5728\u5b30\u5152\u8178\u9053\u5167\u53d7\u5230\u6b61\u8fce\u800c\u7559\u4e0b\u4f86\uff0c\u4e5f\u53ef\u4ee5\u5e6b\u52a9\u5b30\u5152\u8178\u9053\u6b63\u5728\u767c\u80b2\u4e2d\u7684\u514d\u75ab\u7cfb\u7d71\u4e0d\u8981\u8aa4\u628a\u597d\u83cc\u7576\u58de\u86cb\u800c\u904e\u5ea6\u53cd\u61c9\u3002\u9664\u4e86\u6bcd\u4e73\uff0c\u5b30\u5152\u9ad4\u5167\u7684\u8178\u9053\u514d\u75ab\u7cfb\u7d71\u4e5f\u9084\u662f\u5f88\u81ea\u7acb\u81ea\u5f37\u7684\uff0c\u6709\u5176\u4ed6\u751f\u7406\u6a5f\u8f49\u5e6b\u5fd9\u628a\u95dc\u3002\u800c Hornef \u535a\u58eb\u5be6\u9a57\u5ba4\u5728 Nature <\/em>\u4e0a\u6240\u767c\u8868\u7684\u7814\u7a76\u6210\u679c\uff0c\u5c31\u662f\u627e\u5230\u4e86\u5176\u4e2d\u4e00\u9805\u628a\u95dc\u6a5f\u8f49\u3002Hornef \u535a\u58eb\u5be6\u9a57\u5ba4\u5229\u7528\u5be6\u9a57\u5c0f\u9f20\u505a\u70ba\u5be6\u9a57\u6a21\u578b\u3002\u5be6\u9a57\u5c0f\u9f20\u5728\u8178\u9053\u83cc\u53e2\u8207\u8178\u9053\u514d\u75ab\u7cfb\u7d71\u7684\u7814\u7a76\u767c\u5c55\u88e1\uff0c\u53ef\u8b02\u8ca2\u737b\u826f\u591a\u3002\u5c0f\u9f20\u8eab\u4e0a\u6240\u767c\u73fe\u7684\u7814\u7a76\u6210\u679c\uff0c\u4e5f\u8b49\u660e\u5c0d\u61c9\u7528\u5728\u81e8\u5e8a\u91ab\u7642\u4e0a\u6975\u6709\u5e6b\u52a9\u3002<\/p>\n

\u25cf<\/b>Hornef \u535a\u58eb\u7684\u5be6\u9a57\u5ba4\uff0c\u767c\u73fe\u4e86\u4ec0\u9ebc\u5462\uff1f<\/strong><\/span><\/p>\n

Hornef \u535a\u58eb\u5be6\u9a57\u5ba4\u7684\u7814\u7a76\u4eba\u54e1\u9996\u5148\u60f3\u77e5\u9053\uff0c\u525b\u51fa\u751f\u5f8c\u5167\u7684\u8178\u9053\u7d30\u80de\u662f\u4e0d\u662f\u6703\u8868\u73fe\u4e00\u4e9b\u548c\u5148\u5929\u514d\u75ab\u6a5f\u8f49\u76f8\u95dc\u7684\u514d\u75ab\u53d7\u9ad4\u3002\u65bc\u662f\uff0c\u4ed6\u5011\u6536\u96c6\u4e86\u51fa\u751f\u5f8c\u4e09\u5929\uff0c\u6216\u51fa\u751f\u5f8c\u4e8c\u5341\u4e00\u5929\u3001\u525b\u65b7\u5976\u5c0f\u9f20\u7684\u8178\u9053\u8868\u76ae\u7d30\u80de\uff0c\u62ff\u53bb\u5206\u6790\u548c\u5148\u5929\u514d\u75ab\u6a5f\u8f49\u6709\u95dc\u7684\u5404\u500b\u86cb\u767d\u8cea\uff0c\u6bd4\u8f03\u5176 RNA \u8868\u73fe\u91cf\u5728\u9019\u5169\u500b\u6642\u9593\u9ede\u6709\u6c92\u6709\u8b8a\u5316\u3002\u795e\u5947\u5730\uff0c\u4ed6\u5011\u767c\u73fe\u7b2c\u4e94\u985e\u985e\u9438\u53d7\u9ad4\uff08TLR5\uff1bTLR \u662f Toll like receptor \u7684\u7e2e\u5beb\uff09\u7684 RNA \u53ea\u6709\u5728\u525b\u51fa\u751f\u7684\u5c0f\u9f20\u8178\u9053\u8868\u76ae\u7d30\u80de\u5167\u5927\u91cf\u8868\u73fe\uff0c\u7b49\u5c0f\u9f20\u9010\u6f38\u9577\u5927\uff0cTLR5 \u7684\u8868\u73fe\u91cf\u5c31\u5927\u5e45\u964d\u4f4e\u4e86\u3002\u9019\u8b93\u4ed6\u5011\u5047\u8a2d\uff0cTLR5 \u53d7\u9ad4\u53ef\u4ee5\u7576\u4f5c\u525b\u51fa\u751f\u5c0f\u9f20\u8178\u9053\u5167\u7684\u7167\u5996\u93e1\uff0c\u5e6b\u525b\u51fa\u751f\u7684\u5c0f\u9f20\u300c\u5f62\u5851\u300d\u8178\u9053\u83cc\u53e2\u7684\u7d44\u6210\u3002<\/p>\n

\u985e\u9438\u53d7\u9ad4\u662f\u5148\u5929\u514d\u75ab\u7cfb\u7d71\u88e1\u7684\u9a43\u608d\u89d2\u8272\uff0c\u5206\u6210\u8a31\u591a\u985e\uff0c\u6bcf\u4e00\u7a2e\u985e\u9438\u53d7\u9ad4\u90fd\u5c08\u8cac\u8fa8\u8b58\u7d30\u83cc\u6216\u75c5\u6bd2\u8eab\u4e0a\u7684\u67d0\u4e00\u7a2e\u7279\u5fb5\uff0c\u50cf\u662f\u7b2c\u4e09\u985e\u985e\u9438\u53d7\u9ad4 TLR3 \u53ef\u4ee5\u5075\u6e2c\u96d9\u80a1 RNA\uff08\u67d0\u4e9b RNA \u75c5\u6bd2\u7684\u7279\u5fb5\uff09\uff0c\u7b2c\u56db\u985e\u985e\u9438\u53d7\u9ad4 TLR4 \u53ef\u4ee5\u5075\u6e2c\u7d30\u83cc\u7d30\u80de\u58c1\u4e0a\u7684\u8102\u591a\u91a3\u3002\u800c\u7b2c\u4e94\u985e\u985e\u9438\u53d7\u9ad4 TLR5 \u53ef\u4ee5\u5075\u6e2c\u7d30\u83cc\u97ad\u6bdb\u4e0a\u7684\u4e3b\u8981\u7d44\u6210\u86cb\u767d\u8cea\uff1a\u97ad\u6bdb\u86cb\u767d\uff08flagellin\uff09\u3002\u97ad\u6bdb\u86cb\u767d\u53ef\u4ee5\u5e6b\u52a9\u7d30\u83cc\u7684\u6d3b\u52d5\u80fd\u529b\uff0c\u96d6\u7136\u4e0d\u662f\u6240\u6709\u8868\u73fe\u97ad\u6bdb\u7684\u7d30\u83cc\u90fd\u6709\u81f4\u75c5\u529b\uff0c\u4f46\u8a31\u591a\u6709\u5bb3\u7684\u75c5\u539f\u83cc\u90fd\u8868\u73fe\u97ad\u6bdb\u86cb\u767d\u3002\u7576\u8178\u9053\u8868\u76ae\u7d30\u80de\u819c\u4e0a\u6240\u8868\u73fe\u7684\u7b2c\u4e94\u985e\u985e\u9438\u53d7\u9ad4 TLR5 \u5075\u6e2c\u5230\u97ad\u6bdb\u86cb\u767d\u7684\u5b58\u5728\uff0c\u5c31\u50cf\u770b\u5230\u9577\u8116\u5b50\u6703\u60f3\u5230\u9577\u9838\u9e7f\u4e00\u6a23\uff0c\u6703\u8b93\u5075\u6e2c\u5230\u75c5\u539f\u83cc\u7684\u8b66\u5831\u5927\u97ff\uff0c\u800c\u555f\u52d5\u80fd\u8207\u4e4b\u5c0d\u6297\u7684\u514d\u75ab\u53cd\u61c9\uff0c\u50cf\u662f\u5206\u6ccc\u6297\u83cc\u80bd\uff08antimicrobial peptides\uff09\u3002<\/p>\n

Hornef \u535a\u58eb\u7684\u5be6\u9a57\u5ba4\u767c\u73fe\uff0c\u7b2c\u4e94\u985e\u985e\u9438\u53d7\u9ad4 TLR5 \u53ef\u4ee5\u5e6b\u52a9\u6c92\u6709\u8868\u73fe\u97ad\u6bdb\u86cb\u767d\u7684\u7d30\u83cc\u5728\u525b\u51fa\u751f\u5c0f\u9f20\u8178\u9053\u5167\u597d\u597d\u5b89\u5c45\uff0c\u800c\u5c0d\u65bc\u8868\u73fe\u97ad\u6bdb\u86cb\u767d\u7684\u7d30\u83cc\uff0c\u5247\u6703\u5206\u6ccc\u6297\u83cc\u80bd\u3002\u65bc\u662f\uff0c\u5728\u525b\u51fa\u751f\u5c0f\u9f20\u7684\u8178\u9053\u5167\uff0c\u6c92\u6709\u8868\u73fe\u97ad\u6bdb\u86cb\u767d\u7684\u7d30\u83cc\u7fa4\u843d\uff0c\u662f\u6709\u97ad\u6bdb\u86cb\u767d\u7d30\u83cc\u7684\u5341\u500d\u6709\u9918\u3002\u800c\u5982\u679c\uff0c\u5229\u7528\u57fa\u56e0\u8f49\u6b96\u6280\u8853\u5c07\u8178\u9053\u8868\u76ae\u7d30\u80de\u5167\u7684\u7b2c\u4e94\u985e\u985e\u9438\u53d7\u9ad4 TLR5 \u57fa\u56e0\u5254\u9664\u6389\uff0c\u6709\u8868\u73fe\u97ad\u6bdb\u86cb\u767d\uff0c\u9084\u662f\u6c92\u6709\u8868\u73fe\u97ad\u6bdb\u86cb\u767d\u7684\u7d30\u83cc\uff0c\u5728\u5c0f\u9f20\u8178\u9053\u5167\u7684\u83cc\u843d\u7d44\u6210\u88e1\u5c31\u52e2\u5747\u529b\u6575\u4e86\u3002\u800c\u9019\u4e9b\u8868\u73fe\u300c\u6c92\u5dee\u300d\u7684\u8178\u9053\u83cc\u53e2\u7684\u5c0f\u9f20\uff0c\u4e5f\u7684\u78ba\u51fa\u73fe\u548c\u4e0d\u5065\u5eb7\u7684\u8178\u9053\u83cc\u53e2\u76f8\u95dc\u7684\u75c5\u5fb5\uff0c\u50cf\u662f\u4ee3\u8b1d\u5931\u8abf\u75be\u75c5\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u5982\u679c\u628a\u9019\u4e9b\u5728\u6b20\u7f3a TLR5 \u57fa\u56e0\u7684\u5c0f\u9f20\u9ad4\u5167\u6240\u5f62\u6210\u3001\u300c\u6c92\u5dee\u300d\u7684\u8178\u9053\u83cc\uff0c\u9935\u98df\u7d66\u6b63\u5e38\u5065\u5eb7\u7684\u525b\u51fa\u751f\u5c0f\u8001\u9f20\uff0c\u9019\u4e9b\u5c0f\u8001\u9f20\u4e5f\u6709\u80fd\u529b\u628a\u9019\u4e9b\u300c\u6c92\u5dee\u300d\u7684\u8178\u9053\u83cc\u53e2\uff0c\u91cd\u65b0\u5f62\u5851\u6210\u70ba\u4ee5\u6c92\u6709\u8868\u73fe\u97ad\u6bdb\u86cb\u767d\u7684\u83cc\u7a2e\u70ba\u4e3b\u7684\u8178\u9053\u83cc\u53e2\u3002\u4f46\u662f\uff0c\u53ea\u6709\u525b\u51fa\u751f\u7684\u5c0f\u8001\u9f20\u6709\u9019\u300c\u9ede\u77f3\u6210\u91d1\u300d\u7684\u80fd\u529b\uff0c\u9577\u5927\u5f8c\u7684\u6210\u9f20\u5c31\u7b97\u6709 TLR5 \u8868\u73fe\uff0c\u4e5f\u7121\u6fdf\u65bc\u4e8b\u4e86\u3002\u9019\u4e5f\u543b\u5408\u7814\u7a76\u4eba\u54e1\u767c\u73fe\u53ea\u6709\u525b\u51fa\u751f\u7684\u5c0f\u9f20\u9ad4\u5167\u8178\u9053\u8868\u76ae\u7d30\u80de\u6709\u5927\u91cf TLR5\uff0c\u597d\u57f7\u884c\u9019\u4e00\u751f\u4e00\u6b21\u7684\u8178\u9053\u5167\u83cc\u53e2\u9078\u79c0\u3002\u4e0d\u904e\uff0c\u4e0d\u8ad6\u662f\u9577\u5927\u6210\u4eba\uff08\u9084\u662f\u6210\u9f20\uff09\uff0c\u88ab\u6e1b\u5f31\u8868\u73fe\u91cf\u7684 TLR5 \u5c0d\u4eba\uff08\u6216\u9f20\uff09\u7684\u5065\u5eb7\uff0c\u53ef\u90fd\u662f\u626e\u6f14\u95dc\u9375\u6027\u89d2\u8272\u7684\u5462\u3002\u5148\u524d\u7684\u7814\u7a76\u5df2\u7d93\u767c\u73fe\uff0cTLR5 \u7684\u8868\u73fe\u91cf\u548c\u6210\u4eba\u8178\u9053\u767c\u708e\u7684\u514b\u9686\u6c0f\u75c7\u6709\u5bc6\u5207\u95dc\u4fc2\uff1b\u5728\u6210\u4eba\u968e\u6bb5\u529f\u80fd\u9084\u592a\u904e\u6d3b\u8e8d\u7684 TLR5\uff0c\u6703\u5927\u5927\u589e\u52a0\u514b\u9686\u6c0f\u75c7\u7684\u7f79\u75c5\u98a8\u96aa\u3002<\/p>\n

\u6240\u4ee5\u4f60\u8aaa\uff0c\u9019\u5b30\u5152\u7368\u6709\u7684\u7b2c\u4e94\u985e\u985e\u9438\u53d7\u9ad4\u5927\u986f\u795e\u5a01\u6642\u671f\uff0c\u662f\u4e0d\u662f\u4e5f\u662f\u4e00\u4ef6\u4eba\u751f\u5927\u4e8b\u5462\u3002<\/p>\n

 <\/p>\n

\u539f\u59cb\u8ad6\u6587\uff1a<\/strong>Fulde M, et al. Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. Nature. 2018 Aug 8. doi: 10.1038\/s41586-018-0395-5.<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Vijay-Kumar, M. et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328, 228\u2013231 (2010).<\/li>\n
  2. Cahenzli, J., K\u00f6ller, Y., Wyss, M., Geuking, M. B. & McCoy, K. D. Intestinal microbial diversity during early-life colonization shapes long-term IgE levels. Cell Host Microbe 14, 559\u2013570 (2013).<\/li>\n
  3. B\u00e4ckhed, F. et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17, 852 (2015).<\/li>\n
  4. Faith, J. J. et al. The long-term stability of the human gut microbiota. Science 341, 1237439 (2013).<\/li>\n
  5. Torow, N. & Hornef, M. W. The neonatal window of opportunity: Setting the stage for life-long host-microbial interaction and immune homeostasis. J. Immunol. 198, 557\u2013563 (2017).<\/li>\n<\/ol>\n

    --<\/strong>
    \n\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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