{"id":321,"date":"2009-10-07T15:14:22","date_gmt":"2009-10-07T07:14:22","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=321"},"modified":"2017-03-31T23:21:34","modified_gmt":"2017-03-31T15:21:34","slug":"%e3%80%902009-nobel%e7%b3%bb%e5%88%97%e5%a0%b1%e5%b0%8e%e4%ba%8c%e3%80%91%e7%b4%b0%e8%83%9e%e4%b9%8b%e8%ac%8e%ef%bc%9a%e8%80%81%e5%8c%96%e5%a6%82%e4%bd%95%e7%99%bc%e7%94%9f%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=321","title":{"rendered":"\u30102009 Nobel\u7cfb\u5217\u5831\u5c0e\u4e09\u3011\u7d30\u80de\u4e4b\u8b0e\uff1a\u8001\u5316\u5982\u4f55\u767c\u751f\uff1f"},"content":{"rendered":"<blockquote>\n<h5><span style=\"color: #800000;\"><strong>How we age\uff1f<\/strong><\/span><\/h5>\n<\/blockquote>\n<p><strong>\u6f14\u8b1b<\/strong>\u2223\u5468\u6210\u529f\u6559\u6388<\/p>\n<p><strong>\u6574\u7406<\/strong>\u2223\u53f0\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3\u7de8\u8f2f\u5c0f\u7d44<\/p>\n<figure id=\"attachment_325\" aria-describedby=\"caption-attachment-325\" style=\"width: 448px\" class=\"wp-caption alignnone\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2009\/10\/gview.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-325\" title=\"Telomere \u2605\u79fb\u52d5\u6ed1\u9f20\u9ede\u4e00\u4e0b\u53ef\u4ee5\u653e\u5927\u5594\uff01\uff01\uff01\uff01\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2009\/10\/gview.png\" alt=\"gview\" width=\"448\" height=\"634\" \/><\/a><br \/>\n<figcaption id=\"caption-attachment-325\" class=\"wp-caption-text\">\u7d30\u80de\u4e2d\u7684\u7aef\u7c92\u9577\u5ea6\u662f\u8001\u5316\u7684\u95dc\u9375\uff08\u9ede\u6211\u53ef\u4ee5\u770b\u5927\u5716\uff09<\/figcaption><\/figure>\n<p>\u8a0e\u8ad6\u904e\u751f\u7269\u70ba\u4ec0\u9ebc\u6703\u8001\u4e4b\u5f8c\uff0c\u63a5\u4e0b\u4f86\u7684\u554f\u984c\u662f\uff1a\u7522\u751f\u8001\u5316\u73fe\u8c61\u80cc\u5f8c\u7684\u5206\u5b50\u6a5f\u5236\u662f\u4ec0\u9ebc\uff1f\u4e5f\u5c31\u662f\u8aaa\uff0c\u5728\u751f\u7269\u6210\u9577\u7684\u6b72\u6708\u4e2d\uff0c\u8eab\u9ad4\u6216\u7d30\u80de\u5167\u7a76\u7adf\u767c\u751f\u4e86\u4ec0\u9ebc\u4e8b\uff0c\u8b93\u751f\u547d\u500b\u9ad4\u958b\u59cb\u5448\u73fe\u51fa\u5404\u7a2e\u4e0d\u540c\u7684\u8001\u5316\u7279\u5fb5\uff1f<\/p>\n<p>\u76ee\u524d\u6709\u4e8c\u500b\u91cd\u8981\u7684\u56e0\u5b50\u88ab\u8a8d\u70ba\u8207\u7d30\u80de\u6216\u662f\u500b\u9ad4\u7684\u8001\u5316\u904e\u7a0b\u6709\u95dc\u3002\u4e00\u662f\u4fdd\u8b77\u7d30\u80de\u67d3\u8272\u9ad4\u7aef\u9ede\u7684\u7aef\u7c92\u5b50\u7d50\u69cb\uff0c\u6703\u56e0\u70ba\u6bcf\u6b21\u7d30\u80de\u5206\u88c2\u6642\u6d88\u8017\u4e00\u4e9b\uff0c\u56e0\u6b64\u6b63\u5e38\u7d30\u80de\u53ea\u80fd\u5206\u88c2\u4e00\u5b9a\u7684\u4ee3\u6578\uff0c\u7576\u7aef\u7c92\u5b50\u7684\u7d50\u69cb\u88ab\u6d88\u8017\u6b86\u76e1\u6642\u7d30\u80de\u5c31\u6703\u505c\u6b62\u751f\u9577\u800c\u5448\u73fe\u8001\u5316\u7684\u72c0\u614b\u3002\u53e6\u5916\u4e00\u500b\u91cd\u8981\u7684\u56e0\u7d20\u5c31\u662f\u6c27\u5316\u58d3\u529b\u3002\u751f\u547d\u7684\u7dad\u6301\u9700\u8981\u5f9e\u5916\u754c\u651d\u53d6\u98df\u7269\uff0c\u98df\u7269\u5728\u7d30\u80de\u88e1\u71c3\u71d2\uff0c\u7522\u751f\u80fd\u91cf\u4f86\u7dad\u6301\u5167\u90e8\u7684\u7d50\u69cb\u53ca\u751f\u547d\u7684\u904b\u4f5c\u3002\u4f46\u5728\u98df\u7269\u71c3\u71d2\u904e\u7a0b\u4e2d\u6240\u7522\u751f\u7684\u9ad8\u80fd\u91cf\u96fb\u5b50\u6703\u4e0d\u614e\u8207\u6c27\u63a5\u89f8\u800c\u7522\u751f\u6c27\u7684\u81ea\u7531\u57fa\u7b49\u526f\u7522\u54c1\uff0c\u9019\u4e9b\u6c27\u7684\u81ea\u7531\u57fa\u6703\u4e0d\u65b7\u5c0d\u7d30\u80de\u7684\u5206\u5b50\u50cfDNA\u6216\u7d30\u80de\u819c\u7522\u751f\u50b7\u5bb3\u3002\u5982\u679c\u7d30\u80de\u4fee\u88dc\u80fd\u529b\u4e0d\u8db3\uff0c\u9019\u4e9b\u50b7\u5bb3\u5c31\u6703\u96a8\u8457\u5e74\u6b72\u7684\u589e\u9577\u800c\u7d2f\u7a4d\uff0c\u6700\u5f8c\u5c0e\u81f4\u500b\u9ad4\u7684\u8001\u5316\u3002<!--more--><\/p>\n<p><strong> <\/strong><\/p>\n<p><span style=\"color: #003366;\"><strong>\u7aef\u7c92\u7d50\u69cb\u9010\u6f38\u8017\u640d<\/strong><\/span><\/p>\n<p>\u7d30\u80de\u6703\u4e0d\u6703\u8001\uff1f\u6b63\u5e38\u7684\u7d30\u80de\u5982\u679c\u5728\u9ad4\u5916\u57f9\u990a\uff0c\u7d66\u4e88\u5145\u5206\u7684\u71df\u990a\uff0c\u80fd\u4e0d\u80fd\u7121\u9650\u671f\u7684\u751f\u9577\u5206\u88c2\u5462\uff1f\u9019\u500b\u7b54\u6848\u5f88\u6e05\u695a\u662f\u300c\u4e0d\u80fd\u300d\u3002\u9ad4\u5916\u57f9\u990a\u7684\u7d30\u80de\u7d93\u904e\u4e00\u5b9a\u6b21\u6578\u7684\u5206\u88c2\u4e4b\u5f8c\u4e5f\u6703\u6162\u6162\u7684\u8b8a\u8001\u3002\u5206\u88c2\u7684\u6b21\u6578\u8d8a\u4f86\u8d8a\u591a\u7684\u6642\u5019\uff0c\u7d30\u80de\u7684\u578b\u614b\u5c31\u958b\u59cb\u767c\u73fe\u4e86\u4e00\u4e9b\u8f49\u8b8a\uff0c\u539f\u4f86\u7d30\u7d30\u9577\u9577\u7684\u7d30\u80de\u6b64\u6642\u8b8a\u5f97\u53c8\u6241\u53c8\u5e73\uff0c\u88e1\u9762\u958b\u59cb\u5806\u7a4d\u4e86\u4e00\u4e9b\u6709\u984f\u8272\u7684\u7269\u8cea\u3002\u9019\u4e9b\u7d30\u80de\u9084\u6c92\u6709\u6b7b\uff0c\u4f46\u662f\u5b83\u6c92\u8fa6\u6cd5\u518d\u5206\u88c2\u4e86\u3002\u5931\u53bb\u4e86\u5206\u88c2\u7684\u80fd\u529b\uff0c\u9019\u5c31\u662f\u7d30\u80de\u7684\u8001\u5316\u3002<\/p>\n<figure id=\"attachment_326\" aria-describedby=\"caption-attachment-326\" style=\"width: 300px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"size-full wp-image-326\" title=\"Telomere2\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2009\/10\/Telomere.png\" alt=\"Telomere2\" width=\"300\" height=\"180\" \/><figcaption id=\"caption-attachment-326\" class=\"wp-caption-text\">wiki\u767e\u79d1\u4e0a\u7528\u53ef\u611b\u7684\u65b9\u5f0f\u756b\u7684\u7aef\u7c92\u5716<\/figcaption><\/figure>\n<p>\u70ba\u4ec0\u9ebc\u5e74\u8f15\u7684\u7d30\u80de\u6301\u7e8c\u5206\u88c2\u4ee5\u5f8c\uff0c\u7d93\u904e\u4e00\u5b9a\u4ee3\u6578\u7684\u5206\u88c2\u6703\u8b8a\u8001\u5462\uff1f\u7d30\u80de\u88e1\u9762\u6709\u4e00\u7a2e\u300c\u7aef\u7c92\u9175\u7d20\u300d\uff0c\u5b83\u6703\u88fd\u9020\u51fa\u7279\u5b9a\u7684\u7d50\u69cb\u4f86\u4fdd\u8b77\u67d3\u8272\u9ad4\u7684\u7aef\u9ede\u3002\u5728\u80da\u80ce\u767c\u80b2\u7684\u904e\u7a0b\u4e2d\uff0c\u7576\u7aef\u7c92\u628a\u67d3\u8272\u9ad4\u7aef\u9ede\u7684\u7d50\u69cb\u88fd\u9020\u51fa\u4f86\u4ee5\u5f8c\uff0c\u7aef\u7c92\u9175\u7d20\u5728\u6b63\u5e38\u7d30\u80de\u4e2d\u4fbf\u5feb\u901f\u6d88\u5931\u4e86\uff0c\u56e0\u6b64\u7aef\u7c92\u7d50\u69cb\u7684\u9577\u5ea6\u662f\u56fa\u5b9a\u7684\u3002\u7d30\u80de\u5728\u6bcf\u4e00\u6b21\u5206\u88c2\u7684\u904e\u7a0b\u4e2d\uff0c\u7aef\u7c92\u7d50\u69cb\u90fd\u6703\u88ab\u6d88\u8017\u6389\u4e00\u4e9b\uff0c\u6240\u4ee5\u96a8\u8457\u7d30\u80de\u5206\u88c2\u7684\u6b21\u6578\u589e\u52a0\uff0c\u7aef\u7c92\u5b50\u7684\u7d50\u69cb\u5c31\u8d8a\u4f86\u8d8a\u5c0f\uff0c\u5230\u6700\u5f8c\u7576\u7aef\u7c92\u7684\u7d50\u69cb\u4e0d\u8db3\u4ee5\u4fdd\u8b77\u67d3\u8272\u9ad4\u7684\u7aef\u9ede\u6642\uff0c\u67d3\u8272\u9ad4\u6240\u651c\u5e36\u7684\u907a\u50b3\u8cc7\u8a0a\u5c31\u6703\u5728\u5206\u88c2\u904e\u7a0b\u4e2d\u53d7\u5230\u50b7\u5bb3\u3002\u7d30\u80de\u5c31\u6703\u5931\u53bb\u5206\u88c2\u7684\u80fd\u529b\uff0c\u4e5f\u5c31\u662f\u6240\u8b02\u7684\u8b8a\u8001\uff0c\u7d42\u81f3\u65bc\u6b7b\u4ea1\u3002<\/p>\n<p>\u8457\u540d\u7684\u907a\u50b3\u6027\u75be\u75c5\u300c\u65e9\u8870\u75c7\u300d\uff0c\u7f79\u60a3\u8005\u7684\u7aef\u7c92\u7d50\u69cb\u9577\u5ea6\u6bd4\u540c\u5e74\u9f61\u6b63\u5e38\u4eba\u77ed\u5f88\u591a\u3002\u986f\u793a\u7aef\u7c92\u7d50\u69cb\u5728\u7d30\u80de\u88e1\u7684\u8017\u640d\u4e0d\u80fd\u88dc\u5145\uff0c\u7684\u78ba\u53ef\u80fd\u662f\u9020\u6210\u8001\u5316\u7684\u91cd\u8981\u539f\u56e0\u3002\u6843\u8389\u7f8a2003\u5e74\u8a95\u751f\uff0c2007\u5e74\u5c31\u53bb\u4e16\u4e86\uff0c\u7260\u662f\u53e6\u5916\u4e00\u500b\u5feb\u901f\u8001\u5316\u7684\u4f8b\u5b50\uff0c\u79d1\u5b78\u5bb6\u5206\u6790\u7260\u7d30\u80de\u88e1\u9762\u7684\u7aef\u7c92\u5b50\u7684\u7d50\u69cb\uff0c\u4e00\u6a23\u767c\u73fe\u6bd4\u6b63\u5e38\u7684\u7f8a\u77ed\u5f88\u591a\u3002\u65bc\u662f\u6709\u4eba\u60f3\u5230\uff0c\u5982\u679c\u6211\u5011\u91cd\u65b0\u9001\u4e00\u500b\u6b63\u5e38\u7684\u7aef\u7c92\u9175\u7d20\u56de\u5230\u7d30\u80de\u88e1\uff0c\u8b93\u5b83\u4fee\u88dc\u7aef\u7c92\u7d50\u69cb\uff0c\u8c48\u4e0d\u5999\u54c9\uff1f<\/p>\n<p>\u4f46\u7d30\u80de\u771f\u7684\u53ef\u4ee5\u8fd4\u8001\u9084\u7ae5\u55ce\uff1f\u7a76\u7adf\u6211\u5011\u8eab\u4e0a\u4ec0\u9ebc\u6a23\u7684\u7d30\u80de\u6703\u6709\u9577\u751f\u4e0d\u8001\u7684\u80fd\u529b\uff1f\u53ea\u6709\u764c\u7d30\u80de\u5728\u6211\u5011\u8eab\u9ad4\u88e1\u9762\u624d\u662f\u6c38\u751f\u7684\uff0c\u6240\u4ee5\u57fa\u672c\u4e0a\u7d30\u80de\u56de\u6625\u9019\u689d\u8def\u662f\u8d70\u4e0d\u901a\u7684\u3002\u90a3\u5982\u679c\u9019\u689d\u8def\u8d70\u4e0d\u901a\uff0c\u6211\u5011\u80fd\u4e0d\u80fd\u770b\u53e6\u5916\u7684\u5176\u4ed6\u7684\u8001\u5316\u539f\u56e0\u5462\uff1f<\/p>\n<p><span style=\"color: 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style=\"color: #003366;\"><strong>\u7dda\u87f2\u8207\u9175\u6bcd\u83cc\u7684\u555f\u793a<\/strong><\/span><\/p>\n<p>\u8981\u63a2\u8a0e\u8001\u5316\u80cc\u5f8c\u7684\u5206\u5b50\u6a5f\u5236\uff0c\u7279\u5225\u662f\u60f3\u8981\u627e\u51fa\u90a3\u4e9b\u57fa\u56e0\u7684\u6d3b\u6027\u8207\u52d5\u7269\u7684\u8001\u5316\u76f8\u95dc\u5c31\u5fc5\u9808\u85c9\u91cd\u5bb9\u6613\u5f9e\u4e8b\u907a\u50b3\u4f5c\u7528\u7684\u6a21\u5f0f\u751f\u7269\uff0c\u5728\u9019\u65b9\u9762\u7684\u7814\u7a76\u8fd1\u5e74\u4f86\u6709\u7a81\u98db\u731b\u9032\u7684\u767c\u5c55\uff0c\u5176\u4e2d\u6700\u91cd\u8981\u7684\u4e8c\u7a2e\u6a21\u5f0f\u52d5\u7269\u5c31\u662f\u7dda\u87f2\u548c\u9175\u6bcd\u83cc\u3002<\/p>\n<p>\u7dda\u87f2\uff08C. elegans\uff09\u7684\u69cb\u9020\u7c21\u55ae\uff0c\u5168\u8eab\u53ea\u6709959\u500b\u9ad4\u7d30\u80de\uff0c\u6211\u5011\u76ee\u524d\u5df2\u7d93\u53ef\u4ee5\u7cbe\u78ba\u5730\u63cf\u8ff0\u4e00\u500b\u53d7\u7cbe\u5375\uff0c\u5230\u5982\u4f55\u767c\u80b2\u9577\u6210\u4e00\u500b\u6210\u87f2\u3002\u5728\u5b83\u7684\u751f\u6d3b\u53f2\u4e2d\uff0c\u6b63\u5e38\u6210\u87f2\u7684\u58fd\u547d\u7d04\u70ba18\uff5e21\u5929\uff1b\u4f46\u662f\u5982\u679c\u906d\u9022\u300c\u98e2\u9949\u300d\uff0c\u521d\u5b75\u5316\u7684\u5e7c\u87f2\u6703\u9032\u5165\u300c\u51ac\u7720\u300d\u3002\u51ac\u7720\u7684\u5e7c\u87f2\u58fd\u547d\u53ef\u9577\u9054\u4e00\u5e74\uff0c\u4e00\u65e6\u98df\u7269\u4f9b\u61c9\u7121\u865e\uff0c\u5b83\u53c8\u6703\u56de\u5fa9\u6b63\u5e38\uff0c\u767c\u80b2\u6210\u53ea\u80fd\u6d3b\u4e09\u661f\u671f\u7684\u7dda\u87f2\u3002\u904e\u53bb\u5c0d\u300c\u51ac\u7720\u300d\u63a7\u5236\u5df2\u4f5c\u4e86\u4e0d\u5c11\u7814\u7a76\u3002\u300c\u51ac\u7720\u300d\u7684\u9032\u884c\u8207\u6062\u5fa9\uff0c\u662f\u7531\u4e00\u4e9b\u57fa\u56e0\u5728\u63a7\u5236\uff0c\u5176\u4e2d\u4e00\u500b\u53ebdaf2\u7684\u57fa\u56e0\u3002\u5e73\u6642daf2\u662f\u6301\u7e8c\u8868\u73fe\uff0c\u4f46\u5728\u74b0\u5883\u60e1\u52a3\u4e0b\uff0c daf2\u57fa\u56e0\u6703\u95dc\u9589\uff0c\u8a98\u767c\u53e6\u4e00\u500bdaf16\u57fa\u56e0\u7684\u958b\u555f\uff0c\u96a8\u5373\u5c55\u958b\u300c\u51ac\u7720\u300d\u7684\u5be6\u65bd\u3002<\/p>\n<p>\u52a0\u5dde\u5927\u5b78\u820a\u91d1\u5c71\u5206\u6821\u7684\u80af\u63da\uff08Kenyon\uff09\u6559\u6388\u60f3\u5230\uff0c\u6211\u5011\u5982\u679c\u8b93\u5e7c\u87f2\u767c\u80b2\u5230\u6210\u87f2\uff0c\u518d\u767c\u52d5\u300c\u51ac\u7720\u8a08\u756b\u300d\uff0c\u770b\u770b\u7576\u9019\u4e9b\u63a7\u5236\u300c\u51ac\u7720\u300d\u7684\u57fa\u56e0\u5c0d\u6210\u87f2\u7684\u58fd\u547d\u6709\u4ec0\u9ebc\u6a23\u7684\u5f71\u97ff\u3002\u80af\u63da\u6559\u6388\u8b93\u7dda\u87f2\u5148\u767c\u80b2\u5230\u6210\u87f2\u968e\u6bb5\u518d\u4f7fdaf2\u5931\u53bb\u6d3b\u6027\uff0c\u800cdaf16\u5247\u88ab\u8a98\u767c\u3002\u9019\u4e00\u4f86\uff0c\u7dda\u87f2\u7684\u58fd\u547d\u5e7e\u4e4e\u5ef6\u9577\u4e86\u4e00\u500d\uff01\u4f46\u53e6\u4e00\u65b9\u9762\uff0c\u7576\u80af\u63da\u6559\u6388\u540c\u6642\u7834\u58dedaf2\u53cadaf16\u9019\u4e8c\u500b\u57fa\u56e0\uff0c\u5247\u767c\u73fe\u7dda\u87f2\u4ecd\u7136\u53ea\u80fd\u6d3b\u4e09\u661f\u671f\u3002\u9019\u500b\u5be6\u9a57\u7d50\u679c\u8868\u793a\uff0cdaf2\u9019\u500b\u57fa\u56e0\u7684\u6b63\u5e38\u529f\u80fd\u662f\u6703\u6e1b\u77ed\u7dda\u87f2\u7684\u58fd\u547d\uff0c\u800c\u7834\u58dedaf2\u57fa\u56e0\u6240\u5c0e\u81f4\u5ef6\u7de9\u8001\u5316\u7684\u904e\u7a0b\u5247\u7684\u78ba\u5f97\u4ef0\u8cf4daf16\u7684\u6d3b\u6027\u3002\u90a3\u9ebcdaf16\u4e0d\u5c31\u6210\u4e86\u300c\u9577\u9752\u57fa\u56e0\u300d\uff1f<\/p>\n<p><span style=\"color: #003366;\"><strong>\u5c0b\u627e\u5ef6\u7de9\u8001\u5316\u57fa\u56e0<\/strong><\/span><\/p>\n<p>\u5f9e\u7dda\u87f2\u7684\u4f8b\u5b50\uff0c\u6211\u5011\u5f88\u6e05\u695a\u770b\u5230\u751f\u7269\u58fd\u547d\u7684\u9577\u77ed\uff0c\u7684\u78ba\u53d7\u5230\u4e00\u4e9b\u57fa\u56e0\u7684\u63a7\u5236\u3002\u9019\u662f\u4e0d\u662f\u771f\u7684\u8868\u793a\u6709\u6240\u8b02\u7684\u300c\u8001\u5316\u7a0b\u5f0f\u300d\u6216\u662f\u300c\u8001\u5316\u6642\u9418\u300d\u5b58\u5728\u5462\uff1f\u51ac\u7720\u662f\u7dda\u87f2\u70ba\u61c9\u4ed8\u60e1\u52a3\u74b0\u5883\u6240\u6f14\u5316\u51fa\u7684\u4e00\u5957\u907a\u50b3\u7a0b\u5f0f\u3002\u7576daf2\u57fa\u56e0\u7684\u6d3b\u6027\u5931\u53bb\u6642\uff0c\u96d6\u7136\u751f\u5b58\u74b0\u5883\u826f\u597d\uff0c\u4f46\u7dda\u87f2\u4ecd\u6703\u555f\u52d5\u51ac\u7720\u7a0b\u5f0f\u800c\u958b\u59cb\u51ac\u7720\u3002Daf2\u57fa\u56e0\u7684\u7522\u7269\u76f8\u7576\u65bc\u4eba\u985e\u7684\u80f0\u5cf6\u7d20\u53d7\u9ad4\uff0c\u5c08\u53f8\u63a5\u53d7\u80f0\u5cf6\u7d20\u6216\u662f\u80f0\u5cf6\u7d20\u751f\u9577\u56e0\u5b50\u7684\u6307\u4ee4\u3002\u7576\u98df\u7269\u5145\u88d5\u7684\u6642\u5019\uff0c\u80f0\u5cf6\u7d20\u6703\u547d\u4ee4\u7d30\u80de\u628a\u990a\u5206\u5132\u5b58\u8d77\u4f86\uff0c\u540c\u6642\u6539\u5584\u91a3\u4efd\u71c3\u71d2\u7684\u6548\u7387\u7b49\u7b49\u3002\u7576\u5e7c\u87f2\u78b0\u5230\u98df\u7269\u4e0d\u8db3\uff0c\u80f0\u5cf6\u7d20\u53d7\u9ad4\u81ea\u7136\u5c31\u6703\u4fdd\u6301\u975c\u9ed8\uff0c\u9019\u500b\u975c\u9ed8\u7684\u8a0a\u865f\u6d3b\u5316\u4e86daf16\u57fa\u56e0\uff0c\u9032\u800c\u555f\u52d5\u5e7c\u87f2\u7576\u7684\u51ac\u7720\u7a0b\u5f0f\u3002\u56e0\u6b64daf2 \u548cdaf16\u5c0d\u7dda\u87f2\u6b63\u5e38\u7684\u751f\u7406\u8abf\u63a7\u5404\u6709\u5176\u529f\u80fd\u3002\u800c\u5b83\u5011\u5c0d\u7dda\u87f2\u58fd\u547d\u7684\u5f71\u97ff\uff0c\u53ea\u80fd\u770b\u4f5c\u662f\u5be6\u9a57\u5ba4\u57f9\u990a\u689d\u4ef6\u4e0b\u7684\u526f\u7522\u54c1\u7f77\u4e86\u3002<\/p>\n<p>\u53e6\u5916\u9084\u6709\u4e00\u500b\u6709\u8da3\u7684\u554f\u984c\u662f\uff1adaf16\u662f\u5426\u70ba\u552f\u4e00\u53ef\u4ee5\u5ef6\u7de9\u8001\u5316\u7684\u57fa\u56e0\uff1f\u7b54\u6848\u7576\u7136\u662f\u5426\u5b9a\u7684\u3002\u80af\u63da\u6559\u6388\u57282006\u5e74 \u4f5c\u4e86\u4e00\u500b\u5927\u898f\u6a21\u7684\u57fa\u56e0\u7be9\u6aa2\uff0c\u5979\u628a\u4e00\u842c\u591a\u500b\u7dda\u87f2\u7684\u57fa\u56e0\u4e00\u4e00\u7834\u58de\uff0c\u770b\u770b\u90a3\u4e9b\u57fa\u56e0\u88ab\u7834\u58de\u4e4b\u5f8c\u7dda\u87f2\u7684\u58fd\u547d\u6703\u56e0\u6b64\u800c\u5ef6\u9577\u3002\u7d50\u679c\u5979\u53c8\u627e\u5230\u6578\u5341\u500b\u57fa\u56e0\u6703\u5f71\u97ff\u7dda\u87f2\u7684\u58fd\u547d\u3002 \u9019\u7576\u7136\u9084\u4e0d\u662f\u6545\u4e8b\u7684\u5168\u90e8\uff0c\u672a\u4f86\u9084\u53ef\u80fd\u6703\u767c\u73fe\u8981\u4e8c\u6216\u751a\u81f3\u4e09\u500b\u7279\u5b9a\u57fa\u56e0\u7684\u5408\u4f5c\u6216\u62ee\u6297\u624d\u6703\u5f97\u5230\u5f71\u97ff\u7dda\u87f2\u58fd\u547d\u7684\u8a0a\u865f\u3002\u672a\u4f86\u7dda\u87f2\u8001\u5316\u7684\u7814\u7a76\u7d42\u5c07\u5e36\u9818\u6211\u5011\u8d70\u5165\u7cfb\u7d71\u751f\u7269\u5b78\u7684\u6bbf\u5802\u3002<\/p>\n<p>\u5982\u679c\u591a\u7d30\u80de\u751f\u7269\u6703\u8001\uff0c\u90a3\u9ebc\u55ae\u7d30\u80de\u7684\u7d30\u83cc\u5462\uff1f\u6211\u5011\u4e5f\u5f88\u96e3\u53bb\u8a08\u7b97\u7d30\u83cc\u7684\u5e74\u7d00\u3002\u56e0\u70ba\u7576\u4e00\u500b\u7d30\u83cc\u5206\u88c2\u6210\u4e8c\u500b\u5927\u5c0f\u76f8\u540c\u7684\u5b50\u4ee3\u6642\uff0c\u6211\u5011\u641e\u4e0d\u6e05\u695a\u8ab0\u662f\u300c\u5abd\u5abd\u300d\uff0c\u8ab0\u662f\u300c\u5973\u5152\u300d\u3002\u9019\u6a23\u6c92\u6709\u8fa6\u6cd5\u8ffd\u8e64\u55ae\u4e00\u7d30\u83cc\uff0c\u770b\u5b83\u7a76\u7adf\u80fd\u5206\u88c2\u591a\u5c11\u6b21\u548c\u6d3b\u591a\u4e45\uff01\u56e0\u6b64\u904e\u53bb\u7684\u8001\u5316\u7814\u7a76\u4e2d\uff0c\u55ae\u7d30\u80de\u751f\u7269\u4e0d\u662f\u88ab\u770b\u597d\u7684\u7814\u7a76\u6a21\u5f0f\uff01<\/p>\n<p>\u4e0d\u904e\u65e9\u57281959\u5e74\uff0c\u7f8e\u570b\u52a0\u5dde\u5927\u5b78\u67cf\u514b\u840a\u5206\u6821\u7684Johnston\u6559\u6388\u5c31\u60f3\u51fa\u4e00\u500b\u300c\u5947\u7b28\u7121\u6bd4\u300d\u7684\u65b9\u6cd5\u53bb\u6aa2\u9a57\u9175\u6bcd\u83cc\u7684\u58fd\u547d\u3002\u6211\u5011\u5e73\u6642\u4f5c\u9eb5\u5305\u7684\u9175\u6bcd\u83cc\uff08Saccharomyces ceravisiae\uff09\u662f\u4ee5\u51fa\u82bd\u5206\u88c2\u7684\u65b9\u5f0f\u7e41\u6b96\u5f8c\u4ee3\u3002\u6240\u4ee5\u5728\u986f\u5fae\u93e1\u4e0b\u5f88\u5bb9\u6613\u770b\u51fa\u8ab0\u662f\u300c\u5abd\u5abd\u300d\u8ab0\u662f\u300c\u5973\u5152\u300d\u3002Johnston\u6559\u6388\u628a\u55ae\u4e00\u525b\u300c\u51fa\u751f\u300d\u7684\u9175\u6bcd\u83cc\u9644\u8457\u5728\u6d0b\u83dc\u81a0\u4e0a\uff0c\u7d66\u4e88\u5145\u5206\u7684\u71df\u990a\u4e4b\u5f8c\uff0c\u9175\u6bcd\u83cc\u5c31\u958b\u59cb\u884c\u51fa\u82bd\u5206\u88c2\u3002\u4ed6\u5728\u986f\u5fae\u93e1\u4e0b\u9023\u7e8c\u89c0\u5bdf\uff0c\u6bcf\u7576\u65b0\u82bd\u8ff8\u51fa\uff0c\u5c31\u7528\u4e00\u7a2e\u8d85\u7d30\u5fae\u7684\u9257\u5b50\u628a\u9019\u500b\u525b\u51fa\u751f\u7684\u300c\u5973\u5152\u300d\u9257\u8d70\uff0c\u7136\u5f8c\u7b97\u300c\u5abd\u5abd\u300d\u7d30\u80de\u8907\u88fd\u4e86\u4e00\u6b21\u3002<\/p>\n<p>\u9019\u6a23\u5468\u800c\u5fa9\u59cb\uff0c\u770b\u4e86\u8a31\u591a\u9175\u6bcd\u83cc\u5f8c\uff0cJohnston\u6559\u6388\u4e0b\u4e86\u4e00\u500b\u7d50\u8ad6\uff1a\u9175\u6bcd\u83cc\u4e5f\u6703\u8001\u6b7b\uff01\u56e0\u70ba\u6bcf\u4e00\u500b\u65b0\u51fa\u751f\u7684\u5b50\u7d30\u80de\u90fd\u6709\u4e00\u5b9a\u7684\u5206\u88c2\u6f5b\u80fd\uff0c\u6700\u591a\u5927\u7d04\u80fd\u5206\u88c2\u56db\u5341\u6b21\u5de6\u53f3\u3002\u4ed6\u767c\u73fe\u9175\u6bcd\u83cc\u548c\u4eba\u985e\u76f8\u4eff\uff0c\u6b7b\u4ea1\u7387\u6703\u96a8\u8457\u5e74\u9f61 \uff08\u9175\u6bcd\u83cc\u7684\u5e74\u9f61\u662f\u7528\u5206\u88c2\u4ee3\u6578\u4f86\u754c\u5b9a\u7684\uff09\u5448\u6307\u6578\u589e\u52a0\u3002\u63db\u53e5\u8a71\u8aaa\uff0c\u5c0d\u9175\u6bcd\u83cc\u8001\u5316\u3001\u6b7b\u4ea1\uff0c\u4e00\u65b9\u9762\u662f\u6a5f\u7387\u554f\u984c\uff0c\u53e6\u4e00\u65b9\u9762\u5b83\u53c8\u6709\u5176\u4e0d\u53ef\u8d85\u8d8a\u7684\u6975\u9650\u3002\u9019\u500b\u6975\u9650\u8207\u6a5f\u7387\u53c8 \u6703\u96a8\u8457\u300c\u7269\u7a2e\u300d\uff08species\uff09\u7684\u4e0d\u540c\u800c\u6709\u6240\u4e0d\u540c\uff0c\u986f\u793a\u5b83\u5011\u662f\u7531\u907a\u50b3\u57fa\u56e0\u4f86\u6c7a\u5b9a\u7684\u3002<\/p>\n<p><span style=\"color: #003366;\"><strong>\u767d\u85dc\u8606\u9187\u662f\u9752\u6625\u4e4b\u6cc9\uff1f<\/strong><\/span><\/p>\n<figure style=\"width: 316px\" class=\"wp-caption alignleft\"><img decoding=\"async\" title=\"\u8461\u8404(by Zest-pk@flicker, CC)\" src=\"http:\/\/farm2.static.flickr.com\/1259\/923930277_3ee185ea40.jpg\" alt=\"\u8461\u8404\u4e2d\u542b\u6709\u8c50\u5bcc\u7684\u767d\u85dc\u8606\u9187\" width=\"316\" height=\"480\" \/><figcaption class=\"wp-caption-text\">\u8461\u8404\u4e2d\u542b\u6709\u8c50\u5bcc\u7684\u767d\u85dc\u8606\u9187<\/figcaption><\/figure>\n<p>\u65e2\u7136\u9175\u6bcd\u83cc\u6703\u8001\uff0c\u90a3\u9ebc\u662f\u90a3\u4e9b\u57fa\u56e0\u5728\u5f71\u97ff\u9175\u6bcd\u83cc\u7684\u58fd\u547d\uff1f\u9019\u500b\u554f\u984c\u4e00\u76f4\u62d6\u5230\u4e5d\u25cb\u5e74\u4ee3\u624d\u6709\u4e86\u7a81\u7834\u6027\u7684\u767c\u5c55\u3002\u5176\u4e2d\u6700\u91cd\u8981\u7684\u79d1\u5b78\u5bb6\u662f\u9ebb\u7701\u7406\u5de5\u5b78\u9662\u7684Guarente\u6559\u6388\u3002Guarente \u6559\u6388\u4e00\u958b\u59cb\u5206\u6790\u4e86\u5e7e\u500b\u4e0d\u540c\u54c1\u7cfb\u9175\u6bcd\u83cc\u7684\u58fd\u547d\uff0c\u767c\u73fe\u5b83\u5011\u9577\u77ed\u4e0d\u4e00\uff0c\u4f46\u4e0d\u77e5\u9053\u662f\u4ec0\u9ebc\u57fa\u56e0\u5728\u8abf\u63a7\u3002\u5c0f\u5fc3\u89c0\u5bdf\u6c38\u9060\u662f\u8b93\u610f\u5916\u6210\u70ba\u7a81\u7834\u7684\u95dc\u9375\uff0c\u6709\u4e00\u6b21\u7576\u4ed6\u628a\u51b7\u85cf\u5728\u51b0\u7bb1\u4e2d 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u4ea1\u7387\u589e\u52a0\u5e7e\u4e4e\u53ef\u5b8c\u5168\u88ab\u767d\u85dc\u8606\u9187\u6240\u9006\u8f49\uff0c\u6b7b\u4ea1\u7387\u53cd\u5012\u964d\u4f4e\uff0c\u4e14\u9ad4\u91cd\u4e26\u672a\u964d\u4f4e\uff0c\u8001\u9f20\u540a\u55ae\u69d3\u3001\u8dd1\u6b65\u7684\u9ad4\u529b\u9577\u671f\u4f86\u770b\u4e26\u6c92\u6709\u6e1b\u9000\u3002<\/p>\n<p>\u767d\u85dc\u8606\u9187\u6700\u65e9\u662f\u5728\u4e2d\u85e5\u864e\u6756\uff08\u53c8\u540d\u300e\u7d05\u5ddd\u4e03\u300f\uff09\u4e2d\u5206\u96e2\u51fa\u4f86\u7684\uff0c\u4e4b\u5f8c\u79d1\u5b78\u5bb6\u767c\u73fe\u5b83\u53ef\u5ef6\u9577\u9175\u6bcd\u83cc\u7684\u58fd\u547d\uff0c\u800c\u5728\u7d05\u8461\u8404\u3001\u7279\u5225\u662f\u8461\u8404\u76ae\u4e2d\u7684\u542b\u91cf\u975e\u5e38\u8c50\u5bcc\u3002\u6cd5\u570b\u4eba\u8207\u7f8e\u570b\u4eba\u4e00\u6a23\u651d\u53d6\u9ad8\u8102\u80aa\u98df\u7269\uff0c\u4f46\u767c\u751f\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u6a5f\u7387\u660e\u986f\u8f03\u7f8e\u570b\u4eba\u5c1140%\uff0c\u662f\u5426\u8207\u7d93\u5e38\u98f2\u7528\u8461\u8404\u9152\uff0c\u800c\u5176\u4e2d\u542b\u8c50\u5bcc\u300c\u767d\u85dc\u8606\u9187\u300d\u6709\u95dc\uff0c\u662f\u500b\u503c\u5f97\u63a2\u8a0e\u7684\u554f\u984c\u30022008\u5e74\u516b\u6708\uff0c\u7f8e\u570b\u570b\u5bb6\u8001\u5e74\u7814\u7a76\u6240\u7684\u5831\u544a\u51fa\u7210\uff0c\u4ed6\u5011\u767c\u73fe\u96d6\u7136\u300c\u767d\u85dc\u8606\u9187\u300d\u53ef\u4ee5\u6e1b\u5c11\u8001\u9f20\u5e74\u8001\u6642\u5fc3\u81df\u8840\u7ba1\u7684\u75c5\u8b8a\uff0c\u4f46\u662f\u5c0d\u6574\u9ad4\u58fd\u547d\u7684\u5ef6\u9577\u4e26\u6c92\u6709\u5e6b\u52a9\u3002\u9019\u4e9b\u5927\u91cf\u670d\u7528\u300c\u767d\u85dc\u8606\u9187\u300d\u7684\u8001\u9f20\u6700\u5f8c\u548c\u63a7\u5236\u7d44\u7684\u8001\u9f20\u4e00\u6a23\uff0c\u5927\u591a\u6b7b\u65bc\u6dcb\u5df4\u7624\u3002\u770b\u4f86\u5728\u5c0b\u627e\u300c\u9752\u6625\u4e4b\u6cc9\u300d\u7684\u8def\u4e0a\uff0c\u6211\u5011\u9084\u6709\u4e00\u6bb5\u6f2b\u9577\u7684\u8def\u8981\u8d70\u3002<\/p>\n<p><span style=\"color: #003366;\"><strong>\u95dc\u65bc\u8001\u5316 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\u8ac7\u904e\u7684\u6c27\u5316\u58d3\u529b\u3002\u5728\u9019\u6a23\u4e00\u500b\u57fa\u56e0\u7684\u6642\u4ee3\u88e1\u9762\uff0c\u7a76\u7adf\u8a72\u600e\u9ebc\u6a23\u9762\u5c0d\u8001\u5316\u7684\u6311\u6230\uff1f\u6211\u5011\u6c92\u6709\u4efb\u4f55\u6e05\u695a\u7684\u7b54\u6848\u3002\u4f46\u662f\u5c0d\u751f\u547d\u3001\u5c0d\u8001\u5316\u7684\u73fe\u8c61\uff0c\u73fe\u5728\u6211\u5011\u81f3\u5c11\u6709\u4e00\u4e9b\u77ad\u89e3\uff1b\u6211\u5011\u9084\u9700\u8981\u6709\u66f4\u591a\u7684\u667a\u6167\u3002<\/p>\n<p><strong> <\/strong><\/p>\n<p><span style=\"color: #003366;\"><strong> <\/strong><\/span><\/p>\n<p><strong><br \/>\n<span style=\"color: #003366;\">\u8cac\u4efb\u7de8\u8f2f\uff1aMissZoe<\/span><\/strong><\/p>\n<pre><span style=\"color: #800000;\"><strong>\u5099\u8a3b\uff1a\u672c\u7cfb\u5217\u6587\u7ae0\u6539\u5beb\u81ea\u5468\u6210\u529f\u6559\u6388\u57282009\u5e746\u670827\u65e5\u70ba\u300c\u63a2\u7d22\u8b1b\u5ea7\uff1a\u9054\u723e\u6587\u7684\u5947\u5e7b\u65c5\u7a0b\u300d\u6240\u505a\u7684\u6f14\u8b1b\u3002<\/strong><\/span><\/pre>\n<p><strong><br \/>\n<\/strong><strong> <\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>How we age\uff1f 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