{"id":31375,"date":"2018-07-09T09:25:28","date_gmt":"2018-07-09T01:25:28","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=31375"},"modified":"2018-08-29T17:08:47","modified_gmt":"2018-08-29T09:08:47","slug":"%e9%ad%9a%e6%9c%83%e4%b8%8d%e6%9c%83%e8%a6%ba%e5%be%97%e7%99%a2%e5%91%a2%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=31375","title":{"rendered":"\u9b5a\u6703\u4e0d\u6703\u89ba\u5f97\u7662\u5462\uff1f"},"content":{"rendered":"

\u25a0\u9b5a\u6703\u4e0d\u6703\u89ba\u5f97\u7662\u5462\uff1f\u6c92\u932f\uff01\u9019\u662f\u4e00\u500b\u6709\u6b63\u78ba\u7b54\u6848\u7684\u554f\u984c\uff0c\u6839\u64da\u4eca\u5e74\u516d\u6708\u4e00\u7bc7\u767c\u8868\u5728 eLife \u671f\u520a\u7684\u7814\u7a76\uff0c\u6591\u99ac\u9b5a\u662f\u6703\u89ba\u5f97\u7662\u7684\u3002<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u4f86\u6e90By Azul - Own work, Copyrighted free use, wikimedia<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c\u9ec3\u4f73\u6b23<\/strong><\/p>\n

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\u9019\u4e9b\u7279\u5316\u7684\u795e\u7d93\u7d30\u80de\u8868\u9762\u5e36\u6709\u8a31\u591a\u4e0d\u540c\u7684\u86cb\u767d\u8cea\u53d7\u5668\uff0c\u7576\u7279\u5b9a\u7684\u53d7\u5668\u88ab\u523a\u6fc0\u6642\uff0c\u795e\u7d93\u5143\u7d30\u80de\u5c31\u6703\u50b3\u905e\u8a0a\u606f\u5230\u5927\u8166\u3002\u9019\u985e\u86cb\u767d\u8cea\u53d7\u5668\u5c31\u50cf\u5b89\u63d2\u5728\u795e\u7d93\u5143\u7d30\u80de\u819c\u4e0a\u7684\u7ba1\u9053\uff0c\u7576\u7279\u5b9a\u7684\u96e2\u5b50\u901a\u904e\u7ba1\u9053\u4fbf\u6703\u8b93\u7d30\u80de\u7522\u751f\u96fb\u4f4d\u8b8a\u5316\u800c\u50b3\u905e\u8a0a\u606f\u51fa\u53bb\u3002\u5728\u54fa\u4e73\u52d5\u7269\u4e2d\uff0c\u7662\u89ba\u8ddf\u75db\u89ba\u4f7f\u7528\u5169\u7fa4\u4e0d\u540c\u7684\u53d7\u5668\uff0c\u800c\u5176\u4e2d\u4e00\u985e\u7a31\u4f5c TRP \uff08\u77ac\u614b\u96fb\u58d3\u611f\u53d7\u5668\u65cf\uff09\u96e2\u5b50\u901a\u9053\uff0c\u5b83\u5c0d\u65bc\u75db\u89ba\u8207\u7662\u89ba\u7686\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002\u4f8b\u5982\uff0c\u76f4\u63a5\u53bb\u523a\u6fc0\u52d5\u7269\u8eab\u4e0a\u7684 TRP \u96e2\u5b50\u901a\u9053\u5c31\u6703\u5f15\u767c\u75bc\u75db\u611f\u3002\u7136\u800c\uff0c\u7576\u63a5\u6536\u300c\u7662\u300d\u7684\u7279\u5b9a\u611f\u89ba\u53d7\u5668\u88ab\u6fc0\u6d3b\u5f8c\uff0c\u540c\u6642\u4e5f\u6703\u63a5\u8457\u53bb\u6fc0\u6d3b TRP \u53d7\u5668\u3002\u96d6\u7136\u9019\u4e9b\u611f\u89ba\u53cd\u61c9\u7684\u904e\u7a0b\u5728\u54fa\u4e73\u52d5\u7269\u5df2\u7d93\u5f97\u5230\u5145\u5206\u7684\u7814\u7a76\uff0c\u4f46\u6211\u5011\u5c0d\u65bc\u5176\u4ed6\u52d5\u7269\u662f\u5426\u6703\u6709\u7662\u7684\u611f\u89ba\u537b\u662f\u77e5\u4e4b\u751a\u5c11\u3002<\/p>\n

\u70ba\u4e86\u63a2\u7d22\u9019\u4ef6\u4e8b\uff0c\u7531 Ajay Dhaka \u5e36\u9818\u7684\u5718\u968a\u5229\u7528\u6703\u8b93\u54fa\u4e73\u52d5\u7269\u7522\u751f\u7662\u89ba\u7684\u85e5\u7269\u65bd\u7528\u5728\u6591\u99ac\u9b5a\u4e0a\u4f86\u9032\u884c\u7814\u7a76\u3002\u4ed6\u5011\u767c\u73fe\u7528\u65bc\u6cbb\u7642\u67d0\u985e\u76ae\u819a\u75be\u75c5\u7684\u85e5\u7269 imiquimod (\u54aa\u55b9\u83ab\u7279) \u6703\u5f15\u767c\u6591\u99ac\u9b5a\u7522\u751f\u7662\u89ba \uff08\u5716\u4e00\uff09\u3002\u7576\u9019\u7a2e\u5316\u5b78\u7269\u8cea\u6ce8\u5c04\u5230\u9b5a\u7684\u5634\u5507\u4e0a\u6642\uff0c\u6591\u99ac\u9b5a\u6703\u4e0d\u65b7\u5730\u53bb\u6469\u64e6\u6c34\u7f38\u58c1\uff0c\u985e\u4f3c\u65bc\u6293\u7662\u7684\u884c\u70ba\u7522\u751f\u3002\u9032\u4e00\u6b65\u7684\u5be6\u9a57\u8b49\u5be6\u9019\u7a2e\u5316\u5b78\u7269\u8cea\u662f\u76f4\u63a5\u6fc0\u6d3b\u6591\u99ac\u9b5a\u7684\u75db\u89ba\u53d7\u5668 TRPA1\u3002\u800c\u7576\u7814\u7a76\u4eba\u54e1\u5c07 TRPA1 \u9019\u500b\u53d7\u5668\u57fa\u56e0\u5254\u9664\u4e4b\u5f8c\uff0c\u9019\u7a2e\u5316\u5b78\u7269\u8cea\u5c31\u4e0d\u6703\u5f15\u767c\u6591\u99ac\u9b5a\u6469\u64e6\u6c34\u7f38\u58c1\u7684\u884c\u70ba\u3002\u56e0\u6b64\uff0c TRPA1\u53d7\u5668\u5c0d\u65bc\u6591\u99ac\u9b5a\u7522\u751f\u300c\u6293\u7662\u300d\u7684\u884c\u70ba\u662f\u5fc5\u9808\u7684\u3002<\/p>\n

\"\"
\u5716\u4e00 \uff5c\u7d05\u7dda\u4ee3\u8868\u8ffd\u8e64\u6591\u99ac\u9b5a\u6e38\u6cf3\u884c\u70ba\u8ecc\u8de1\u3002\u5de6\u5716\u662f\u6591\u99ac\u9b5a\u6b63\u5e38\u7684\u6e38\u6cf3\u884c\u70ba\u3002\u4e2d\u9593\u662f\u6ce8\u5c04 10 \u00b5M AITC (allyl isothiocyanate, \u7570\u786b\u6c30\u9178\u70ef\u4e19\u916f\u70ba\u82a5\u672b\u5167\u523a\u6fc0\u6027\u7269\u8cea) \u5728\u6591\u99ac\u9b5a\u4e0a\u5507\u4e4b\u5f8c\uff0c\u9b5a\u7522\u751f\u75db\u89ba\u53cd\u61c9\u7684\u884c\u70ba\uff0c\u6d3b\u52d5\u529b\u660e\u986f\u5730\u964d\u4f4e\uff0c\u53f3\u5716\u662f\u6ce8\u5c04100 \u03bcM IMQ \uff08imiquimod, \u54aa\u55b9\u83ab\u7279\u662f\u6703\u5f15\u767c\u7662\u89ba\u7684\u85e5\u7269\uff09\u5728\u6591\u99ac\u9b5a\u4e0a\u5507\u4e4b\u5f8c\uff0c\u9b5a\u6703\u4e0d\u65b7\u5730\u6469\u64e6\u6c34\u7f38\u58c1\uff0c\u985e\u4f3c\u6293\u7662\u7684\u884c\u70ba\u8868\u73fe\u3002\u5716\u7247\u4f86\u6e90: Fig. 1k in Esancy et al. (2018) eLife 7:e32036\u3002<\/figcaption><\/figure>\n

Dhaka\u7684\u5718\u968a\u9084\u61c9\u7528\u57fa\u56e0\u5de5\u7a0b\u6280\u8853\u900f\u904e\u87a2\u5149\u86cb\u767d\u4f86\u8ffd\u8e64\u5177\u5099\u75db\u89ba\u53d7\u5668\u7684\u795e\u7d93\u5143\u7d30\u80de\uff0c\u89c0\u5bdf\u54ea\u4e9b\u795e\u7d93\u5143\u5c0d\u9019\u7a2e\u5316\u5b78\u7269\u8cea\u7522\u751f\u53cd\u61c9\u800c\u767c\u51fa\u7d05\u8272\u87a2\u5149\u3002\u9019\u500b\u6280\u8853\u9032\u4e00\u6b65\u767c\u73fe\u5728\u6591\u99ac\u9b5a\u7684\u76ae\u819a\u4e2d\uff0c\u81f3\u5c11\u6709\u5169\u7fa4\u529f\u80fd\u4e0a\u622a\u7136\u4e0d\u540c\u7684\u795e\u7d93\u5143\u7d30\u80de\u3002\u9019\u5169\u7fa4\u795e\u7d93\u5143\u7d30\u80de\u90fd\u6709\u8868\u73fe TRPA1 \u57fa\u56e0\uff0c\u5176\u4e2d\u4e00\u7fa4\u795e\u7d93\u5143\u4e3b\u8981\u8ddf\u5f15\u767c\u6591\u99ac\u9b5a\u300c\u6293\u7662\u300d\u884c\u70ba\u6709\u95dc\u806f\uff0c\u5b83\u5011\u7684 TRPA1\u53d7\u5668\u5728\u4f4e\u6fc3\u5ea6\u523a\u6fc0\u6642\u5c31\u6703\u7522\u751f\u53cd\u61c9\u3002\u53e6\u4e00\u7fa4\u795e\u7d93\u5143\u5247\u76f8\u5c0d\u8f03\u4e0d\u654f\u611f\uff0c\u53ea\u5c0d\u65bc\u9ad8\u5f37\u5ea6\u7684\u523a\u6fc0\u7522\u751f\u53cd\u61c9\uff0c\u800c\u4e14\u8ddf\u52d5\u7269\u7522\u751f\u75db\u89ba\u53cd\u61c9\u7684\u884c\u70ba\u4f8b\u5982\u505c\u6b62\u4e0d\u52d5\u6216\u884c\u70ba\u7de9\u6162\u6709\u95dc\u3002\u53e6\u5916\uff0c\u7814\u7a76\u4eba\u54e1\u4e5f\u5728\u5c0f\u9f20\u7684\u5be6\u9a57\u4e2d\u89c0\u5bdf\u5230\u76f8\u540c\u7684\u7d50\u8ad6\uff0c\u8868\u793a\u985e\u4f3c\u7684\u611f\u89ba\u63a7\u5236\u6a5f\u5236\u4e5f\u5b58\u5728\u65bc\u54fa\u4e73\u52d5\u7269\u4e2d\u3002\u9019\u500b\u7814\u7a76\u6307\u51fa\u52d5\u7269\u7684\u76ae\u819a\u5229\u7528\u5169\u7fa4\u4e0d\u540c\u795e\u7d93\u5143\u4e0a\u7684\u53d7\u5668\u5c0d\u65bc\u76f8\u540c\u523a\u6fc0\u7269\u5177\u5099\u4e0d\u540c\u7684\u53cd\u61c9\u95a5\u503c\uff0c\u7e7c\u800c\u5340\u5206\u7d93\u6b77\u7662\u89ba\u8207\u75db\u89ba\u7684\u7de8\u78bc\u7b56\u7565\u3002<\/p>\n

\u7814\u7a76\u9b5a\u9019\u985e\u52d5\u7269\u5982\u4f55\u611f\u89ba\u5230\u7662\uff0c\u4e0d\u50c5\u53ef\u4ee5\u6df1\u5165\u4e86\u89e3\u63a2\u8a0e\u9019\u4e9b\u611f\u89ba\u7cfb\u7d71\u662f\u5982\u4f55\u5728\u52d5\u7269\u985e\u7fa4\u4e2d\u6f14\u8b8a\u3002\u751a\u81f3\uff0c\u900f\u904e\u5728\u5206\u5b50\u8207\u7d30\u80de\u5c64\u6b21\u4e0a\u66f4\u52a0\u4e86\u89e3\u9019\u7a2e\u6a5f\u5236\uff0c\u5c07\u6709\u52a9\u65bc\u6539\u5584\u6216\u662f\u8a2d\u8a08\u51fa\u6e1b\u8f15\u6414\u7662\u8207\u75bc\u75db\u66f4\u597d\u7684\u6cbb\u7642\u65b9\u6cd5\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Esancy K, Condon L, Feng J, Kimball C, Curtright A, Dhaka A (2018). A zebrafish and mouse model for selective pruritus via direct activation of TRPA1. eLife 7:e32036. DOI: 10.7554\/eLife.32036<\/a><\/li>\n
  2. Ross SE (2011). Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease. Current Opinion in Neurobiology 21:880\u2013887. https:\/\/doi.org\/10.1016\/j.conb.2011.10.012<\/a><\/li>\n<\/ol>\n

    --<\/strong>
    \n\u4f5c\u8005\uff1a<\/strong>\u9ec3\u4f73\u6b23<\/strong> \uff0c\u53f0\u7063\u5927\u5b78\u6606\u87f2\u5b78\u535a\u58eb\u3002\u73fe\u70ba\u4e2d\u592e\u7814\u7a76\u9662\u8cc7\u8a0a\u79d1\u5b78\u6240\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u3002\u904e\u53bb\u4ee5\u6606\u87f2\u751f\u7406\u53ca\u8178\u9053\u83cc\u5171\u751f\u95dc\u4fc2\u70ba\u7814\u7a76\u4e3b\u984c\uff0c\u76ee\u524d\u805a\u7126\u65bc\u751f\u7269\u8cc7\u8a0a\u8207\u529f\u80fd\u6027\u57fa\u56e0\u9ad4\u5b78\u3002<\/strong><\/p>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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