{"id":31357,"date":"2018-07-24T00:06:09","date_gmt":"2018-07-23T16:06:09","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=31357"},"modified":"2019-09-17T13:09:51","modified_gmt":"2019-09-17T05:09:51","slug":"%e3%80%90%e6%8e%a2%e7%b4%a219-7%e3%80%91%e7%bf%bb%e6%a1%88%e6%8b%89%e9%a6%ac%e5%85%8b%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=31357","title":{"rendered":"\u3010\u63a2\u7d2219-7\u3011\u7ffb\u6848\u62c9\u99ac\u514b\uff1f"},"content":{"rendered":"
\"\"
\u62c9\u99ac\u514b<\/figcaption><\/figure>\n

\u8b1b\u5e2b\uff5c\u4e2d\u7814\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u7814\u7a76\u54e1 \u6c88\u54f2\u9be4<\/strong>
\n\u5f59\u6574\u64b0\u6587\uff5c\u6c88\u541b\u5b9c<\/strong><\/p>\n

\u9054\u723e\u6587\u65e9\u662f\u500b\u5bb6\u55bb\u6236\u66c9\u7684\u540d\u5b57\uff0c\u800c\u6f14\u5316\u8ad6\u66f4\u662f\u9023\u79d1\u5b78\u7684\u9580\u5916\u6f22\u4e5f\u7565\u901a\u4e00\u4e8c\u3002\u7136\u800c\uff0c\u5728\u4ed6\u4e4b\u524d\u6709\u500b\u5149\u8292\u76e1\u5931\u7684\u89d2\u8272\uff1a\u63d0\u51fa\u300c\u7528\u9032\u5ee2\u9000\u300d\u5b78\u8aaa\u7684\u6cd5\u570b\u79d1\u5b78\u5bb6\uff0c\u62c9\u99ac\u514b\u3002\u62c9\u99ac\u514b\u8a8d\u70ba\uff0c\u751f\u7269\u5728\u5f8c\u5929\u6240\u7372\u5f97\u4e4b\u884c\u70ba\u6216\u751f\u7406\u4e4b\u8b8a\u5316\uff0c\u80fd\u5920\u907a\u50b3\u7d66\u5b50\u4ee3\u3002\u6709\u8da3\u800c\u8af7\u523a\u7684\u662f\uff0c\u4ed6\u63d0\u51fa\u6b64\u8aaa\u76841809\u5e74\uff0c\u6070\u662f\u9054\u723e\u6587\u51fa\u751f\u7684\u5e74\u4efd\u3002\u62c9\u99ac\u514b\u7684\u5b78\u8aaa\u752b\u4e00\u63d0\u51fa\u4fbf\u98fd\u53d7\u6279\u8a55\uff0c\u7d42\u7a76\u57281959\u5e74\u9054\u723e\u6587\u63d0\u51fa\u6f14\u5316\u8ad6\u5f8c\uff0c\u5e7e\u4e4e\u5931\u53bb\u4e86\u821e\u53f0\u3002\u800c\u5f8c\uff0c\u5b5f\u5fb7\u723e\u7684\u8c4c\u8c46\u5be6\u9a57\uff0c\u66f4\u5960\u5b9a\u4e86\u57fa\u56e0\u8b8a\u7570\u662f\u6f14\u5316\u57fa\u790e\u7684\u6982\u5ff5\u3002<\/p>\n

\u62c9\u99ac\u514b\u771f\u7684\u932f\u4e86\u55ce\uff1f\u7d30\u770b\u7528\u9032\u5ee2\u9000\u8aaa\uff0c\u5be6\u5247\u5305\u542b\u5169\u500b\u90e8\u5206\uff1a\u300c\u7528\u9032\u5ee2\u9000\u300d\u8207\u300c\u7372\u5f97\u6027\u907a\u50b3\u300d\u3002\u524d\u8005\u5012\u662f\u9817\u53d7\u8a8d\u53ef\u7684\uff0c\u7531\u4eba\u5011\u5c0d\u5065\u8eab\u623f\u8da8\u4e4b\u82e5\u9da9\u4fbf\u53ef\u898b\u4e00\u6591\u3002\u5f8c\u4f86\u7684\u5b78\u8aaa\u4e3b\u8981\u662f\u5426\u5b9a\u4e86\u5f8c\u5929\u7372\u5f97\u7684\u7279\u6027\u5f97\u4ee5\u907a\u50b3\u7d66\u5b50\u4ee3\u7684\u8aaa\u6cd5\u2014\u2014<\/strong>\u4eca\u5929\u6240\u898b\u7684\u9577\u9838\u9e7f\uff0c\u8116\u5b50\u4e4b\u6240\u4ee5\u9577\uff0c\u4e26\u4e0d\u662f\u56e0\u70ba\u9838\u5b50\u4f38\u9577\u5f8c\u50b3\u4e0b\u6b64\u4e00\u7279\u6027\u7d66\u5b50\u4ee3\uff1b\u800c\u662f\u5e36\u6709\u9577\u8116\u5b50\u57fa\u56e0\u7684\u9577\u9838\u9e7f\uff0c\u5728\u5929\u64c7\u5f8c\u4fdd\u7559\u4e86\u4e0b\u4f86\u3002<\/p>\n

\u25cf\u4e92\u52d5\u7684\u57fa\u56e0\u578b\u8207\u8868\u73fe\u578b\u2014\u2014\u8868\u89c0\u907a\u50b3\u5b78<\/strong><\/span><\/p>\n

DNA\u5e8f\u5217\u7d93\u7531\u8f49\u9304\u5f62\u6210mRNA\uff0c\u518d\u8f49\u8b6f\u6210\u86cb\u767d\u8cea\uff0c\u5f9e\u800c\u5f62\u5851\u4e86\u751f\u7269\u7684\u8868\u5fb5\u3002\u6b64\u4e00\u57fa\u56e0\u578b\uff08genotype\uff09\u6c7a\u5b9a\u8868\u73fe\u578b\uff08phenotype\uff09\u7684\u89c0\u5ff5\uff0c\u5373\u662f\u907a\u50b3\u5b78\u7684\u4e2d\u5fc3\u601d\u60f3\uff08central dogma\uff09\u3002\u95dc\u65bc\u62c9\u99ac\u514b\u7406\u8ad6\u7684\u7b2c\u4e00\u500b\u722d\u8b70\uff0c\u5728\u65bc\u5916\u986f\u8868\u5fb5\u7684\u6539\u8b8a\uff0c\u662f\u5426\u4e5f\u80fd\u5f71\u97ff\u57fa\u56e0\u578b\uff0c\u9032\u800c\u4ee3\u4ee3\u76f8\u50b3\uff1f<\/p>\n

\u57fa\u56e0\u7684\u7a81\u8b8a\u6216\u91cd\u7d44\uff0c\u662f\u6f14\u5316\u7684\u57fa\u672c\u52d5\u529b\u3002\u7136\u800c\u751f\u7269\u7684\u8868\u5fb5\u7d55\u975e\u5982\u6b64\u55ae\u7d14\uff0c\u300c\u8868\u89c0\u907a\u50b3\u5b78\uff08epigenetics\uff09\u300d\u7e3d\u6709\u8fa6\u6cd5\u5f9e\u4e2d\u4f5c\u6897\uff0c\u8abf\u63a7\u8f49\u9304\u8207\u8f49\u8b6f\u7684\u9032\u884c\uff0c\u5f80\u5f80\u4f7f\u751f\u7269\u7684\u8868\u73fe\u578b\u8207\u57fa\u56e0\u578b\u6709\u6240\u51fa\u5165\u3002\u8f03\u65e9\u5148\u7684\u7814\u7a76\u767c\u73fe\u7684\u8868\u89c0\u907a\u50b3\u65b9\u5f0f\uff0c\u662f\u85c9\u7531DNA\u7e5e\u5728\u7d44\u86cb\u767d(histone)\u4e0a\u6240\u5f62\u6210\u4e4b\u6838\u5c0f\u9ad4(nucleosome)\u7dca\u5bc6\u8207\u5426\uff0c\u4f86\u63a7\u5236\u8f49\u9304\u7684\u96e3\u6613\u3002\u8ab0\u4f86\u6c7a\u5b9a\u6838\u5c0f\u9ad4\u7e8f\u7e5e\u7684\u9b06\u7dca\u5462\uff1f\u4e00\u500b\u6a5f\u5236\u5247\u662f\u900f\u904e\u7d44\u86cb\u767d\u4e0a\u7684\u4fee\u98fe\uff0c\u5c07\u5b83\u4e59\u91af\u5316(acetylation)\ufe54\u53e6\u4e00\u500b\u5247\u91dd\u5c0dDNA\u5e8f\u5217\u7684\u80de\u5627\u5576C(cytosine)\uff0c\u5c07\u5176\u7532\u57fa\u5316(methylation)\u3002<\/p>\n

\u8fd1\u5e74\u4f86\uff0c\u53c8\u767c\u73fe\u4e86\u53e6\u5169\u7a2e\u8868\u89c0\u907a\u50b3\u7684\u6a5f\u5236\uff0c\u4e00\u300c\u9577\u300d\u4e00\u300c\u77ed\u300d\u3002<\/p>\n

\u9577\u7684\u662flong non-coding RNA (\u9577\u93c8\u975e\u7de8\u78bc\u6838\u7cd6\u6838\u9178)\uff0c\u5927\u7d04\u9577\u9054\u5e7e\u767e\u5230\u5e7e\u5343\u500b\u9e7c\u57fa\u3002\u9019\u4e9bRNA\u4e0d\u6703\u88ab\u8f49\u8b6f\u51fa\u86cb\u767d\uff0c\u5b83\u5011\u85c9\u7531\u548c\u8f49\u9304\u56e0\u5b50\u5408\u5925\uff0c\u8abf\u63a7\u8f49\u9304\u7684\u767c\u751f\uff1a\u6709\u4e9b\u8f49\u9304\u56e0\u5b50\u5c6c\u65bc\u6d3b\u5316\u56e0\u5b50(transcriptional activator)\uff0c\u9700\u548c long non-coding RNA \u7d50\u5408\u65b9\u53ef\u5de5\u4f5c\uff0c\u9644\u8457\u4e0aDNA\uff0c\u958b\u59cb\u8f49\u9304\u3002\u6709\u4e9b\u8f49\u9304\u56e0\u5b50\u5c6c\u65bc\u6291\u5236\u56e0\u5b50(transcriptional repressor)\uff0c\u9738\u8457DNA\u5e8f\u5217\u4e0d\u51c6\u8a31\u8f49\u9304\u7684\u767c\u751f\ufe54\u53ea\u6709\u5728 long non-coding RNA \u7d50\u5408\u5f8c\uff0c\u624d\u9858\u610f\u653e\u884c\u3002<\/p>\n

\u77ed\u7684\u7a31\u4f5c micro-RNA (\u5c0f\u5206\u5b50\u6838\u7cd6\u6838\u9178)\u3002\u6709\u4e9b micro-RNA\u5c08\u641e\u7834\u58de\uff0c\u5b83\u5011\u53ef\u4ee5\u8207mRNA (\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178)\u63a5\u8fd1\u5b8c\u7f8e\u5730\u4e92\u88dc\u7d50\u5408\uff0c\u5f8c\u679c\u537b\u662f\u5f15\u4f86\u9175\u7d20\u5206\u5b50\u5206\u89e3\u6389mRNA\u3002\u5982\u6b64\u4e00\u4f86\uff0c\u8f49\u8b6f\u51fa\u7684\u86cb\u767d\u81ea\u7136\u5c11\u4e86\u3002\u53e6\u4e00\u689d\u8def\u5f91\u4e2dmicro-RNA\u8207mRNA\u53ea\u6709\u90e8\u5206\u4e92\u88dc\uff0c\u4e0d\u6703\u5f15\u4f86\u9175\u7d20\u7684\u653b\u64ca\uff0c\u4f46\u7e8f\u5f97mRNA\u7d81\u624b\u7d81\u8173\uff0c\u4e5f\u7121\u6cd5\u8f49\u8b6f\u51fa\u4e0b\u6e38\u7684\u80fa\u57fa\u9178\u4e86\u3002Micro-RNA\u7684\u8abf\u63a7\u904e\u7a0b\u767c\u751f\u5728DNA\u5df2\u7d93\u8f49\u9304\u70bamRNA\u4e4b\u5f8c\uff0c\u6545\u88ab\u7a31\u4f5c\u300c\u8f49\u9304\u5f8c\u4fee\u98fe\u300d\u3002<\/p>\n

\u25cf\u51e1\u8d70\u904e\u5fc5\u7559\u4e0b\u75d5\u8de1\uff1f\u8868\u89c0\u907a\u50b3\u7684\u53ef\u611b\u53ef\u6068<\/strong><\/span><\/p>\n

\u4eba\u7684\u4e00\u751f\uff0c\u98f2\u98df\u3001\u904b\u52d5\u3001\u4eba\u969b\u4e92\u52d5\u3001\u58d3\u529b\u3001\u85e5\u7269\uff0c\u6216\u591a\u6216\u5c11\u7684\u5728\u8eab\u4e0a\u7559\u4e0b\u523b\u7d0b\u3002\u9019\u4e9b\u5f8c\u5929\u7684\u74b0\u5883\u523a\u6fc0\u6240\u9020\u6210\u8868\u73fe\u578b\u7684\u6539\u8b8a\uff0c\u7d55\u5927\u591a\u6578\u4e26\u4e0d\u5f71\u97ffDNA\u5e8f\u5217\uff0c\u5c6c\u65bc\u8868\u89c0\u907a\u50b3\u7684\u7bc4\u7587\u3002\u7406\u8ad6\u4e0a\uff0c\u5176\u5f71\u97ff\u61c9\u7576\u6b62\u65bc\u81ea\u8eab\uff0c\u800c\u4e0d\u6703\u50b3\u7d66\u5b50\u4ee3\u3002\u5982\u679c\u60f3\u8981\u70ba\u62c9\u99ac\u514b\u5e73\u53cd\u4e00\u4e8c\uff0c\u53ea\u5f97\u63a2\u7a76\u8868\u89c0\u907a\u50b3\u7684\u8a0a\u606f\uff0c\u662f\u5426\u53ef\u80fd\u70ba\u5b50\u4ee3\u6240\u63a5\u6536\u4e86\u3002<\/p>\n

\u601d\u8003\u9019\u500b\u554f\u984c\u524d\uff0c\u6211\u5011\u9996\u5148\u5b9a\u7fa9\u300c\u8de8\u4ee3\u7e7c\u627f (transgenerational inheritence)\u300d\u3002\u82e5\u74b0\u5883\u523a\u6fc0\u767c\u751f\u5728\u975e\u61f7\u5b55\u671f\uff0c\u53ef\u80fd\u76f4\u63a5\u5f71\u97ff\u7684\u662f\u7b2c\u4e00\u500b\u4e16\u4ee3(F0)\u548c\u5176\u914d\u5b50\uff0c\u6545\u914d\u5b50\u6240\u9577\u6210\u7684\u4e0b\u4e00\u500b\u4e16\u4ee3(F1)\u4e5f\u53ef\u80fd\u70ba\u76f4\u63a5\u53d7\u5f71\u97ff\u8005\u3002\u5247\u300c\u8de8\u4ee3\u7e7c\u627f\u300d\u7684\u767c\u751f\uff0c\u5b9a\u7fa9\u5728\u4e0b\u4e0b\u4e16\u4ee3(F2)\uff0c\u4e5f\u5c31\u662f\u4fd7\u7a31\u7684\u300c\u5b6b\u5b50\u8f29\u300d\u4e5f\u51fa\u73fe\u74b0\u5883\u523a\u6fc0\u6240\u5f15\u767c\u7684\u6027\u72c0\ufe54\u5176\u610f\u7fa9\u662f\uff0cF1\u7522\u751f\u7684\u914d\u5b50\u4e2d\uff0c\u4ea6\u651c\u5e36\u4e86\u6b64\u4e00\u6027\u72c0\u7684\u907a\u50b3\u5bc6\u78bc\uff01\u64da\u6b64\u9053\u7406\uff0c\u82e5\u74b0\u5883\u523a\u6fc0\u767c\u751f\u5728\u61f7\u5b55\u671f\uff0c\u523a\u6fc0\u767c\u751f\u7576\u4e0b\u5728\u5834\u7684\u662fF0\u3001\u8179\u4e2d\u7684F1\uff0c\u4ee5\u53caF1\u9ad4\u5167\u3001\u5c07\u4f86\u6703\u9577\u6210F2\u7684\u914d\u5b50\u3002\u300c\u8de8\u4ee3\u7e7c\u627f\u300d\u662f\u4ee5\u61c9\u8a72\u5b9a\u7fa9\u70baF3\u51fa\u73fe\u8a72\u6027\u72c0\uff0c\u8868\u793a\u4e8b\u767c\u7576\u4e0b\u5c1a\u672a\u5b58\u5728\u73fe\u5834\u7684F2\u7684\u914d\u5b50\uff0c\u4e5f\u651c\u5e36\u4e86\u6b64\u4e00\u907a\u50b3\u4fe1\u606f\u3002<\/p>\n

\u61f7\u5b55\u5973\u6027\u5438\u83f8\u6216\u53ef\u6210\u70ba\u5176\u4e2d\u4e00\u500b\u4f8b\u5b50\u3002\u5c3c\u53e4\u4e01\u76f8\u95dc\u7684\u6c23\u5598\u6216\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5 (Chronic obstructive pulmonary disease, COPD)\uff0c\u4e0d\u55ae\u5728\u4e0b\u4e00\u4ee3 (F1\uff0c\u4e5f\u5c31\u662f\u7576\u6642\u5728\u5b50\u5bae\u4e2d\u7684\u5bf6\u5bf6)\u7684\u76db\u884c\u7387\u4e0a\u5347\uff0c\u4ea6\u4f7f\u518d\u4e0b\u4e00\u4ee3(F2)\u60a3\u75c5\u7684\u6bd4\u7387\u63d0\u5347\u3002\u8001\u9f20\u5be6\u9a57\u4e5f\u767c\u73fe\uff0c\u5c3c\u53e4\u4e01\u5728\u80ba\u90e8\u7d30\u80de\u4e2d\uff0c\u6703\u589e\u52a0\u7b2c\u4e09\u500b\u7d44\u86cb\u767d(H3)\u7684\u4e59\u91af\u5316\u3001\u6e1b\u5c11\u7b2c\u56db\u500b\u7d44\u86cb\u767d(H4)\u7684\u4e59\u91af\u5316\u3002\u776a\u4e38\u4e2d\uff0cDNA\u7532\u57fa\u5316\u5728\u5c3c\u53e4\u4e01\u66b4\u9732\u5f8c\u589e\u52a0\u4e86\uff0cH3\u8207H4\u7684\u4e59\u91af\u5316\u5247\u6e1b\u5c11\u3002\u5375\u5de2\u4e2d\uff0cDNA\u7532\u57fa\u5316\u6e1b\u5c11\uff0cH4\u7684\u4e59\u91af\u5316\u5247\u589e\u52a0\u3002\u795e\u7955\u7684\u907a\u50b3\u6a5f\u5236\u4fdd\u7559\u4e86\u5c3c\u53e4\u4e01\u7684\u4e0d\u826f\u5f71\u97ff\uff0c\u7adf\u6709\u4e86\u4e00\u7a2e\u798d\u5ef6\u5b50\u5b6b\u7684\u5473\u9053\u3002<\/p>\n

\u7e7c\u83f8\u4ee5\u5f8c\uff0c\u9152\u7cbe\u540c\u88ab\u9ede\u540d\uff0c\u4e5f\u975e\u51fa\u4eba\u610f\u8868\u4e4b\u4e8b\u3002\u6211\u5011\u7d93\u5e38\u5c07\u559d\u9152\u8207\u8aa4\u4e8b\u505a\u806f\u60f3\uff0c\u5728\u57fa\u56e0\u7684\u89c0\u9ede\u4e0a\u662f\u5426\u6709\u6839\u64da\u5462\uff1f\u5176\u5be6\u82e5\u8ad6\u300c\u9152\u7cbe\u5728\u4eba\u7684\u5f71\u97ff\u662f\u5426\u53ef\u8de8\u4ee3\u907a\u50b3\u300d\u7684\u89c0\u5bdf\u6027\u7814\u7a76\uff0c\u9084\u771f\u662f\u6c92\u5c11\u904e\uff0c\u53ef\u60dc\u5f80\u5f80\u96e3\u4ee5\u9054\u5230\u7d71\u8a08\u4e0a\u7684\u610f\u7fa9\u3002\u4f46\u82e5\u5c0d\u61f7\u5b55\u6bcd\u9f20\u704c\u9152\uff0c\u80fd\u89c0\u5bdf\u5230\u5176\u5f8c\u4ee3\u795e\u7d93\u5167\u5206\u6ccc\u7cfb\u7d71\u7684\u5931\u8abf\u3002\u9019\u4e9b\u88ab\u704c\u9189\u7684\u8001\u9f20\u672c\u8eab\uff0c\u8166\u4e2d\u8207\u751f\u6b96\u7d30\u80de\u4e2dDNA\u7684\u7532\u57fa\u5316\u548c\u7d44\u86cb\u767d\u7684\u4fee\u98fe\u5747\u6709\u6240\u8b8a\u5316\u3002\u5176\u4e2d\u814e\u4e0a\u817a\u7684\u555f\u52d5\u5b50\u57fa\u56e0\u7532\u57fa\u5316\uff0c\u800c\u7121\u6cd5\u6b63\u5e38\u904b\u4f5c\u3002\u82e5\u61f7\u5b55\u6bcd\u9f20\u7684\u5f8c\u4ee3\u662f\u96c4\u6027\uff0c\u5247\u5176\u7cbe\u5b50\u4e2d\uff0c\u4e5f\u53ef\u898b\u5230\u76f8\u61c9\u7684\u8868\u89c0\u907a\u50b3\u6539\u8b8a\u3002<\/p>\n

\u25cf\u7d93\u9a57\u8207\u8a18\u61b6\u7684\u8840\u8108\u76f8\u627f<\/strong><\/span><\/p>\n

\u8a0e\u8ad6\u4e86\u7269\u8cea\u6feb\u7528\u9020\u6210\u7684\u8b8a\u5316\uff0c\u90a3\u5c08\u5c6c\u65bc\u751f\u7269\u9ad4\u672c\u8eab\u7684\u300c\u7d93\u9a57\u300d\u8207\u300c\u8a18\u61b6\u300d\uff0c\u7e3d\u4e0d\u6703\u518d\u50b3\u7d66\u5b50\u4ee3\u4e86\u5427\uff1f\u5f14\u8a6d\u7684\u662f\uff0c\u6050\u61fc\u8a18\u61b6\u537b\u4f3c\u4e4e\u5728\u8840\u8108\u4e2d\u6d41\u50b3\u8457\u3002\u5be6\u9a57\u4f7f\u7528\u5236\u7d04\u53cd\u61c9\u4f7f\u8001\u9f20\u9023\u7d50\u300c\u53d7\u96fb\u64ca\u300d\u7684\u9a5a\u5687\u8207\u67d0\u7a2e\u7279\u6b8a\u7684\u6c23\u5473\uff0c\u96a8\u5f8c\u767c\u73fe\u53d7\u904e\u9a5a\u5687\u7684\u516c\u9f20\uff0c\u5176\u7cbe\u5b50\u4e0a\u638c\u7ba1\u6b64\u4e00\u6c23\u5473\u7684\u53d7\u9ad4\u57fa\u56e0\u524d\u7aef\u5c11\u4e86\u4e00\u500b\u7532\u57fa\u3002\u800c\u53ef\u6190\u7684\u5b50\u4ee3\u8001\u9f20\uff0c\u55ae\u662f\u55c5\u5230\u9019\u7a2e\u7368\u7279\u6c23\u5473\uff0c\u5c31\u6703\u611f\u5230\u9a5a\u5687\u8207\u6050\u61fc\u3002\u70ba\u4e86\u907f\u514d\u5176\u4ed6\u56e0\u5b50\u7684\u5e72\u64fe\uff0c\u79d1\u5b78\u5bb6\u751a\u81f3\u4f7f\u7528\u4eba\u5de5\u53d7\u5b55\uff0c\u5c07\u7cbe\u5b50\u53d6\u51fa\u3001\u5728\u8a66\u7ba1\u4e2d\u53d7\u7cbe\uff0c\u7d50\u679c\u4e5f\u5982\u51fa\u4e00\u8f4d\u3002\u8868\u89c0\u907a\u50b3\u7684\u5f71\u97ff\u5c64\u9762\uff0c\u751a\u81f3\u64f4\u53ca\u4e86\u6211\u5011\u4ee5\u70ba\u5f88\u300c\u79c1\u4eba\u300d\u7684\u60c5\u7dd2\u8a18\u61b6\u3002<\/p>\n

\u73fe\u4ee3\u4eba\u6700\u95dc\u5fc3\u7684\u58d3\u529b\u554f\u984c\uff0c\u5f9e\u8868\u89c0\u907a\u50b3\u7684\u89c0\u9ede\u4ea6\u6709\u8de1\u53ef\u5faa\u3002\u5be6\u9a57\u767c\u73fe\uff0c\u5fc3\u7406\u58d3\u529b\u9020\u6210\u516c\u9f20\u7684\u7cd6\u76ae\u8cea\u6fc0\u7d20\u589e\u52a0\uff1b\u540c\u6642\uff0c\u751f\u6b96\u7d30\u80de\u4e2dSfmbt2\u57fa\u56e0\u7684\u555f\u52d5\u5b50\uff0c\u4ea6\u6703\u589e\u52a0\u7532\u57fa\u5316\uff1b\u6b64\u4e00\u555f\u52d5\u5b50\u4e0d\u4f46\u8207\u57fa\u56e0\u672c\u8eab\u7522\u751f\u7684mRNA\u76f8\u95dc\uff0c\u4ea6\u95dc\u4fc2\u5230\u4e0b\u6e38micro-RNA\u7684\u88fd\u9020\u3002\u5176\u4e2d\u4e00\u7a2emicro-RNA\u96a8\u4e4b\u4e0b\u964d\uff0c\u4f7f\u5f97\u539f\u5148\u548cPEPCK\u9019\u7a2emRNA\u7684\u7d50\u5408\u4e0b\u964d\u4e86\uff0c\u4e5f\u6e1b\u5c11\u4e86\u5b83\u88ab\u6291\u5236\u7684\u6548\u679c\u3002\u800cPEPCK\u6b63\u662f\u7cd6\u8cea\u65b0\u751f\u7684\u76f8\u95dc\u57fa\u56e0\uff0c\u4e00\u65e6\u8868\u73fe\u904e\u91cf\uff0c\u5c31\u53ef\u80fd\u9020\u6210\u9ad8\u8840\u7cd6\u3002\u9019\u6a23\u7684\u8b8a\u5316\u4e0d\u55ae\u767c\u751f\u5728\u809d\u81df\u4e2d\uff0c\u4e5f\u6703\u85c9\u7531\u7cbe\u5b50\u4fdd\u7559\u7d66\u4e0b\u4e00\u4ee3\u3002\u7f8e\u4e2d\u4e0d\u8db3\u7684\u662f\uff0c\u672c\u5be6\u9a57\u53ea\u8ffd\u8e64\u5230F1\uff0c\u66ab\u7121\u4e0b\u4e0b\u4e00\u4ee3\u7684\u6578\u64da\u4e86\u3002<\/p>\n

\u80a5\u80d6\u4ea6\u662f\u7576\u4ee3\u7684\u8ab2\u984c\u4e4b\u4e00\u3002\u98f2\u98df\u7fd2\u6163\u8207\u672c\u8eab\u7684\u80a5\u80d6\uff0c\u5176\u95dc\u806f\u6027\u53ef\u60f3\u800c\u77e5\uff1b\u6bd4\u8f03\u96e3\u9810\u6599\u7684\u662f\uff0c\u5f8c\u5929\u98f2\u98df\u7fd2\u6163\u9020\u6210\u80a5\u80d6\u7684\u516c\u9f20\uff0c\u4e5f\u6bd4\u8f03\u5bb9\u6613\u64c1\u6709\u904e\u91cd\u7684\u5b50\u4ee3\uff01\u897f\u5316\u98f2\u98df\u7684\u80a5\u80d6\u516c\u9f20\uff0c\u5373\u4fbf\u8207\u6a19\u6e96\u9ad4\u578b\u7684\u6bcd\u9f20\u4ea4\u914d\uff0c\u5f8c\u4ee3\u80a5\u80d6\u8207\u7f79\u60a3\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u7684\u6bd4\u4f8b\u5747\u63d0\u9ad8\u3002\u6b64\u6a5f\u5236\u900f\u904e\u897f\u5316\u98f2\u98df\uff0c\u4fc3\u4f7fmicro-RNA\u7684\u589e\u52a0\uff0c\u5f71\u97ff\u4e86\u8a31\u591a\u7d44\u7e54\u4e2d\u7684\u57fa\u56e0\u8868\u73fe\uff0c\u7cbe\u5b50\u4e5f\u672a\u80fd\u5016\u514d\u3002\u5149\u662f\u53d6\u51fa\u9019\u4e9b\u7cbe\u5b50\u88e1\u7684micro-RNA\uff0c\u690d\u5165\u89aa\u4ee3\u5c6c\u65bc\u6a19\u6e96\u9ad4\u578b\u7684\u80da\u80ce\u4e2d\uff0c\u4e5f\u80fd\u4f7f\u6b64\u80da\u80ce\u7522\u751f\u80a5\u80d6\u8207\u7cd6\u5c3f\u75c5\u3002\u6709\u8da3\u7684\u662f\uff0c\u5f8c\u5929\u80a5\u80d6\u7684\u6bcd\u9f20\u4f3c\u4e4e\u4e0d\u6703\u628a\u80a5\u80d6\u7684\u6027\u5fb5\u5f80\u4e0b\u50b3\u3002<\/p>\n

\u25cf\u62c9\u99ac\u514b\u7684\u9006\u8972\uff1f\u5c40\u52e2\u672a\u660e<\/strong><\/span><\/p>\n

\u8868\u89c0\u907a\u50b3\u7121\u6cd5\u89e3\u91cb\u6240\u6709\u50b3\u905e\u7d66\u5b50\u4ee3\u7684\u8b8a\u7570\u3002\u6709\u90e8\u5206\u4ee3\u4ee3\u76f8\u50b3\u7684\u8b8a\u7570\u9084\u662f\u5f97\u56de\u6b78\u57fa\u672c\u7684\u907a\u50b3\u5b78\uff1a\u6bd4\u5982\u5316\u5b78\u7269\u8cea\u8207\u6bd2\u7269\uff0c\u672c\u8eab\u5373\u53ef\u80fd\u5f71\u97ffDNA\u672c\u8eab\u7684\u6392\u5217\uff0c\u800c\u74b0\u5883\u58d3\u529b\u4e5f\u53ef\u80fd\u5f15\u767cDNA\u7684\u91cd\u7d44\u3002\u53e6\u4e00\u90e8\u5206\uff0c\u66f4\u6709\u5176\u4ed6\u8907\u96dc\u7684\u6a5f\u5236\u3002\u5176\u4e2d\u4e00\u7a2e\u8fd1\u5e74\u5ee3\u70ba\u8a0e\u8ad6\u7684\u7576\u5c6c\u300c\u8df3\u52d5\u5b50 (transposon)\u300d\u3002<\/p>\n

\u89aa\u4ee3\u5c0d\u65bc\u5b69\u5b50\u7684\u7167\u9867\uff0c\u5c0d\u4ed6\u5011\u65e5\u5f8c\u7684\u767c\u5c55\uff0c\u4e00\u76f4\u662f\u6b77\u4e45\u4e0d\u8870\u7684\u8b70\u984c\u3002\u6709\u500b\u5176\u5be6\u9817\u70ba\u6b98\u5fcd\u7684\u5be6\u9a57\uff0c\u85c9\u7531\u6253\u65b7\u6bcd\u9f20\u5c0d\u5b50\u4ee3\u7684\u7167\u9867 (maternal care)\uff0c\u89c0\u5bdf\u5c0f\u9f20\u7684\u767c\u5c55\u3002\u4e00\u822c\u7684\u60c5\u6cc1\u4e0b\uff0c\u82e5\u662f\u6bcd\u9f20\u672a\u5f97\u4ee5\u6089\u5fc3\u7167\u6599\u5c0f\u9f20\uff0c\u5f8c\u8005\u8166\u4e2d\u8ca0\u8cac\u884c\u7532\u57fa\u5316\u7684DNMT3A\u9175\u7d20\u7684\u542b\u91cf\u5373\u6703\u4e0b\u964d\uff0c\u9032\u800c\u8b93L1\u57fa\u56e0\u8df3\u52d5\u5b50\u7684\u7532\u57fa\u5316\u6e1b\u5c11\u3002\u539f\u5148\u8a72\u4e56\u4e56\u5f85\u5728\u539f\u8655\u7684L1\u57fa\u56e0\u8df3\u52d5\u5b50\uff0c\u4fbf\u7522\u751f\u4e86\u300c\u8df3\u52d5\u300d\uff0c\u4f7fL1\u7684\u4efd\u6578(copy number)\u589e\u52a0\u4e86\u3002\u6b64\u8b8a\u5316\u5c24\u4ee5\u6d77\u99ac\u8ff4\u4e2d\u6700\u70ba\u986f\u8457\uff0c\u884c\u70ba\u4e0a\u5247\u53ef\u89c0\u5bdf\u5230\u5c0f\u9f20\u8b8a\u5f97\u7126\u8e81\u4e0d\u5b89\uff0c\u751a\u6216\u5728\u6210\u5e74\u671f\u4ea6\u662f\u5982\u6b64\u3002\u89c0\u5bdf\u4eba\u985e\u793e\u6703\uff0c\u9019\u7a2e\u6545\u4e8b\u4f3c\u66fe\u76f8\u8b58\uff0c\u552f\u96e3\u4ee5\u9032\u884c\u5982\u6b64\u4e0d\u4eba\u9053\u7684\u8a66\u9a57\u3002<\/p>\n

\u5f8c\u5929\u7d93\u9a57\u80fd\u5426\u88ab\u7e7c\u627f\uff1f\u7d9c\u89c0\u6c88\u54f2\u9be4\u7814\u7a76\u54e1\u63d0\u53ca\u7684\u751f\u7269\u754c\u8af8\u591a\u6848\u4f8b\uff0c\u4f3c\u4e4e\u662d\u7136\u82e5\u63ed\u3002\u53ea\u662f\uff0c\u62c9\u99ac\u514b\u7684\u5b78\u8aaa\u5c31\u6b64\u7ffb\u6848\u6210\u529f\u4e86\u55ce\uff1f\u5012\u662f\u672a\u5fc5\u3002\u4e0d\u8ad6\u83f8\u9152\u3001\u58d3\u529b\u3001\u6050\u61fc\u8a18\u61b6\u3001\u897f\u5316\u98f2\u98df\u3001\u758f\u65bc\u7167\u9867\u7684\u89aa\u4ee3\uff0c\u9020\u6210\u7684\u5f71\u97ff\u591a\u504f\u8ca0\u9762\uff0c\u8207\u6f14\u5316\u4e0a\u7269\u7a2e\u6108\u4f86\u6108\u9069\u61c9\u74b0\u5883\u7684\u65b9\u5411\uff0c\u4f3c\u4e4e\u80cc\u9053\u800c\u99b3\u3002\u7136\u57fa\u56e0\u79d1\u5b78\u9084\u6709\u591a\u5c11\u5967\u79d8\uff1f\u4f3c\u4e4e\u503c\u5f97\u6211\u5011\u62fe\u56de\u62c9\u99ac\u514b\u7684\u5b78\u8aaa\uff0c\u53d6\u7d93\u4e00\u4e8c\u3002<\/p>\n

 <\/p>\n

--
\n\u672c\u6587\u6574\u7406\u81ea\uff1a107\/06\/02\u7531\u6c88\u54f2\u9be4\u8001\u5e2b\u5728\u81fa\u5927\u601d\u4eae\u9928\u570b\u969b\u6703\u8b70\u5ef3\u6240\u4e3b\u8b1b\u4e4b\u300c\u8868\u89c0\u907a\u50b3\u5b78\u7684\u91cd\u8981\u89d2\u8272\uff1a\u5e73\u53cd\u62c9\u99ac\u514b\uff1f<\/a>\u300d\u6f14\u8b1b\u5167\u5bb9\u3002<\/strong><\/p>\n

 <\/p>\n

\"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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