{"id":31233,"date":"2018-07-12T00:39:35","date_gmt":"2018-07-11T16:39:35","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=31233"},"modified":"2022-10-11T13:17:46","modified_gmt":"2022-10-11T05:17:46","slug":"%e7%b6%ad%e7%94%9f%e7%b4%a0a%e8%a1%8d%e7%94%9f%e7%89%a9-%e8%ae%93%e8%82%9d%e7%99%8c%e4%b8%8d%e5%86%8d%e5%9b%82%e5%bc%b5","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=31233","title":{"rendered":"\u7dad\u751f\u7d20A\u884d\u751f\u7269\u2014\u2014\u8b93\u809d\u764c\u4e0d\u518d\u56c2\u5f35"},"content":{"rendered":"<p><span style=\"color: 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height=\"312\">\u7de8\u8b6f\uff5c\u8d99\u63da\u5149\u3001\u9673\u96c5\u5a77<\/strong><\/p>\n<p>\u505a\u70ba\u4e00\u7a2e\u81f4\u547d\u6027\u9ad8\u7684\u764c\u75c7\uff0c\u809d\u7d30\u80de\u764c(HCC)\u6bcf\u5e74\u5728\u5168\u7403\u7d04\u9020\u621060\u842c\u4eba\u6b7b\u4ea1\uff0c\u5176\u9ad8\u81f4\u6b7b\u7387\u7684\u539f\u56e0\u4e4b\u4e00\u662f\u5fa9\u767c\u7387\u6975\u9ad8\u3002\u82e5\u5728\u4eba\u9ad4\u767c\u73feHCC\uff0c\u521d\u671f\u900f\u904e\u624b\u8853\u548c\u5176\u4ed6\u6cbb\u7642\u662f\u6709\u6548\u7684\uff0c\u4e0d\u904e\u764c\u7d30\u80de\u5f80\u5f80\u6703\u5728\u4e00\u6bb5\u6642\u9593\u5f8c\u5fa9\u767c\u3002\u56e0\u6b64\u9632\u6b62\u764c\u7d30\u80de\u5fa9\u767c\uff0c\u4e00\u76f4\u90fd\u662f\u91ab\u5b78\u754c\u7684\u7814\u7a76\u91cd\u9ede\u30022018\u5e74\uff0c\u65e5\u672c\u7406\u5316\u5b78\u7814\u7a76\u6240(RIKEN)\u7684\u7814\u7a76\u5718\u968a\u5728\u300a\u7f8e\u570b\u570b\u5bb6\u79d1\u5b78\u9662\u9662\u520a(<em>Proceedings of the National Academy of 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Cancer Genome Atlas, TCGA)\u7684\u6578\u64da\uff0c\u4ea6\u767c\u73feMYCN\u7684\u7570\u5e38\u64f4\u589e\u8207\u9810\u5f8c\u4e0d\u826f\u5448\u73fe\u6b63\u76f8\u95dc\u3002\u81f3\u6b64\uff0c\u6211\u5011\u6216\u8a31\u53ef\u4ee5\u9019\u9ebc\u8aaa\uff0c\u7121\u74b0\u985e\u7dad\u751f\u7d20A\u5c0d\u65bc\u67d0\u985e\u7684\u764c\u75c7\u5e79\u7d30\u80de\u6709\u6291\u5236\u529f\u6548\uff0c\u4e5f\u70ba\u91ab\u5b78\u754c\u81f4\u529b\u964d\u4f4e\u764c\u75c7\u5fa9\u767c\u6a5f\u7387\u548c\u771f\u6b63\u6cbb\u7652\u764c\u75c7\u75c5\u60a3\uff0c\u63d0\u4f9b\u4e86\u4e00\u689d\u91cd\u8981\u7684\u767c\u5c55\u65b9\u5411\uff01<\/p>\n<p>\u76ee\u524d\uff0c\u5305\u542b\u81fa\u7063\u3001\u97d3\u570b\u548c\u65b0\u52a0\u5761\u7b49\u5730\uff0c\u4e5f\u9010\u6b65\u9032\u884c\u5176\u4ed6\u7121\u74b0\u985e\u7dad\u751f\u7d20A (\u5982Peretinoin)\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u6291\u5236HCC\u5fa9\u767c\u7684\u6709\u6548\u6027\u3002\u6216\u8a31\u5728\u4e0d\u4e45\u7684\u5c07\u4f86\uff0c\u764c\u75c7\u80fd\u5920\u4e0d\u518d\u8b93\u4eba\u5011\u56f0\u64fe\u8207\u5bb3\u6015\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u539f\u6587\u7814\u7a76\uff1a<a href=\"http:\/\/www.riken.jp\/en\/pr\/press\/2018\/20180424_1\/\">Vitamin A derivative selectively kills liver cancer stem cells<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u4ee4\u4eba\u805e\u8072\u8272\u8b8a\u7684\u764c\u75c7\uff0c\u5c0d\u4eba\u5011\u751f\u547d\u7684\u5a01\u8105\u7121\u9808\u8a00\u660e\uff1b\u5728\u81fa\u7063\uff0c\u764c\u75c7\u75c5\u60a3\u7684\u6b7b\u4ea1\u7387\u4e5f\u9577\u671f\u5c45\u9ad8\u4e0d\u4e0b\uff01\u4ee5\u809d\u7d30\u80de\u764c(HCC)\u4f86\u8aaa\uff0c\u9577\u671f\u5c45\u65bc\u81fa\u7063\u5341\u5927\u764c\u75c7\u6b7b\u56e0\u4e4b\u9996\uff0c\u4e14HCC\u4ecd\u7121\u6709\u6548\u7684\u6839\u6cbb\u65b9\u5f0f\u3002\u73fe\u5728\uff0c\u79d1\u5b78\u5bb6\u5011\u767c\u73fe\u4e86\u4e00\u7a2e\u7dad\u751f\u7d20A\u7684\u884d\u751f\u5316\u5408\u7269\uff0c\u53ef\u4ee5\u9632\u6b62\u6700\u5e38\u898b\u7684HCC\u5fa9\u767c\u3002<\/p>\n","protected":false},"author":20,"featured_media":31234,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,6512,2977,1025],"tags":[3903,3904,3902,3905,877],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/06\/cells-500.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/31233"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=31233"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/31233\/revisions"}],"predecessor-version":[{"id":40865,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/31233\/revisions\/40865"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/31234"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=31233"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=31233"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=31233"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}