{"id":31174,"date":"2018-07-13T00:51:29","date_gmt":"2018-07-12T16:51:29","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=31174"},"modified":"2019-09-17T13:09:56","modified_gmt":"2019-09-17T05:09:56","slug":"%e3%80%90%e6%8e%a2%e7%b4%a219-6%e3%80%91%e6%bc%94%e5%a5%8fdna%e7%94%9f%e5%91%bd%e6%a8%82%e8%ad%9c%e7%9a%84%e4%ba%a4%e9%9f%bf%e6%a8%82%e5%9c%98%ef%bc%9a%e8%a1%a8%e8%a7%80%e9%81%ba%e5%82%b3","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=31174","title":{"rendered":"\u3010\u63a2\u7d2219-6\u3011\u6f14\u594fDNA\u751f\u547d\u6a02\u8b5c\u7684\u4ea4\u97ff\u6a02\u5718\uff1a\u8868\u89c0\u907a\u50b3"},"content":{"rendered":"

\"\"\u8b1b\u5e2b\uff5c\u4e2d\u592e\u7814\u7a76\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u7814\u7a76\u54e1 \u962e\u9e97\u84c9
\n\u5f59\u6574\u64b0\u6587\uff5c\u8b1d\u5b63\u6046
\n<\/strong><\/p>\n

\u25cf\u300c\u5927\u8e8d\u9032\u300d\u7684\u4e00\u7532\u5b50<\/strong><\/span><\/p>\n

2016\u5e7411\u6708\u7f8e\u570b\u8077\u68d2\u829d\u52a0\u54e5\u5c0f\u718a\u968a\u7d42\u65bc\u5728\u777d\u905571\u5e74\u4e4b\u5f8c\u518d\u6b21\u7372\u5f97\u4e16\u754c\u5927\u8cfd\u51a0\u8ecd\uff0c\u9019\u4ef6\u4e8b\u88ab Science<\/em> \u671f\u520a\u7279\u5225\u5beb\u6210\u5c08\u6587\uff0c\u56de\u9867\u4e0a\u4e00\u6b21\u829d\u52a0\u54e5\u5c0f\u718a\u968a\u57281945\u5e74\u7372\u5f97\u51a0\u8ecd\u4e4b\u6642\uff0c\u7576\u6642\u7684\u5b78\u754c\u9084\u6c92\u6709\u89e3\u958bDNA\u9019\u4ee4\u4eba\u9a5a\u8277\u7684\u9ec3\u91d1\u96d9\u87ba\u65cb\u7d50\u69cb\u3002\u5728\u904e\u53bb\u7684\u4e00\u7532\u5b50\u4e2d\uff0c\u96a8\u8457DNA\u7d50\u69cb\u7684\u89e3\u6790\uff0c\u751f\u547d\u79d1\u5b78\u9818\u57df\u7684\u7814\u7a76\u6210\u679c\u53ef\u4ee5\u8aaa\u662f\u5f9e\u300c\u8778\u725b\u6162\u722c\u300d\u5230\u642d\u4e0a\u4e86\u300c\u592a\u7a7a\u68ad\u300d\uff0c\u5728\u4e00\u8f49\u773c\u9593\u4f86\u5230\u7576\u5e74\u59cb\u6599\u672a\u53ca\u7684\u9ad8\u5ea6\u3002<\/p>\n

DNA(\u53bb\u6c27\u6838\u91a3\u6838\u9178\uff0cdeoxyribonucleic acid)\uff0c\u7c21\u55ae\u7528\u4e00\u53e5\u8a71\u5f62\u5bb9\u5c31\u662f\u300c\u4e00\u7a2e\u7531\u773e\u751f\u547d\u9ad4\u6240\u5171\u540c\u64c1\u6709\uff0c\u4e58\u8f09\u57fa\u56e0\u5373\u907a\u50b3\u5bc6\u78bc\u7684\u5316\u5b78\u5de8\u5206\u5b50\u300d\u800c\u300c\u57fa\u56e0\u300d\uff0c\u5247\u662f\u5176\u4e0a\u80fd\u8868\u73fe\u529f\u80fd\u7684\u6700\u5c0f\u55ae\u4f4d\u3002\u7e7c1953\u5e74\uff0cDNA\u96d9\u80a1\u87ba\u65cb\u7d50\u69cb\u7684\u767c\u8868\u540c\u6642\u9707\u64bc\u5b78\u754c\u53ca\u4e16\u754c\u8d77\uff1b1972\u5e74\uff0c\u6211\u5011\u501f\u9451\u7d30\u83cc\uff0c\u5b78\u6703\u4e86\u300c\u57fa\u56e0\u5de5\u7a0b\u300d\uff1b1990\u52302003\uff0c13\u5e74\u7684\u671f\u9593\u88e1\u6211\u5011\u5b8c\u6210\u4eba\u985e\u7684\u5168\u57fa\u56e0\u9ad4\u5b9a\u5e8f(Whole-genome sequencing, WGS)\u8a08\u756b\uff0c\u6210\u529f\u89e3\u78bc\u9577\u905430\u5104\u9e7c\u57fa\u7684\u751f\u547d\u4e4b\u66f8\uff1b1995\u5e74\uff0c\u300c\u8868\u89c0\u907a\u50b3\u300d\u7684\u5d1b\u8d77\u5247\u5c07\u5206\u5b50\u751f\u7269\u5b78\u63a8\u5411\u4e00\u500b\u5d84\u65b0\u7684\u5bec\u95ca\u5883\u754c\u3002<\/p>\n

\u25cf\u8868\u89c0\u907a\u50b3\u7684\u751f\u547d\u610f\u7fa9<\/strong><\/span><\/p>\n

\u6211\u5011\u77e5\u9053\uff0c\u6211\u5011\u9ad4\u5167\u7684\u6bcf\u4e00\u500b\u7d30\u80de(\u751f\u6b96\u7d30\u80de\u9664\u5916)\u7684\u7d30\u80de\u6838\u5167\u90fd\u85cf\u670923\u5c0d\u67d3\u8272\u9ad4\uff0c\u800c\u5176\u4e2d\u768423\u689d\u4f86\u81ea\u7236\u89aa\uff0c\u53e6\u5916\u768423\u689d\u5247\u6e90\u81ea\u65bc\u6bcd\u89aa\uff0c\u5982\u679c\u5c07\u9019\u4e9b\u67d3\u8272\u9ad4\u5b8c\u5168\u6524\u958b\uff0c\u5176\u9577\u5ea6\u53ef\u9577\u90542\u516c\u5c3a\u591a\uff0c\u800c\u4eca\u5b83\u5011\u537b\u80fd\u88ab\u6fc3\u7e2e\u5728\u76f4\u5f91\u53ea\u6709\u5e7e\u5fae\u7c73\u7684\u7d30\u80de\u6838\u5167\uff0c\u53ef\u77e5DNA\u5305\u88f9\u7684\u91cd\u8981\u6027\u3002\u5982\u679c\u6211\u5011\u5c07\u67d3\u8272\u9ad4\u7684\u5305\u88dd\u9010\u5c64\u89e3\u958b\uff0c\u6700\u5f8c\u6211\u5011\u6703\u5f97\u5230\u4e00\u6bb5\u7e8f\u6eff\u7d44\u86cb\u767d(Histone)\u7684\u96d9\u80a1\u87ba\u65cb\uff0c\u4e5f\u6b63\u662f\u9019\u4e9b\u7d44\u86cb\u767d\u548cDNA\u4e4b\u9593\u7684\u4e92\u52d5\uff0c\u5176\u4e0a\u4e0d\u540c\u7684\u5316\u5b78\u4fee\u98fe\u6c7a\u5b9a\u4e86\u88ab\u5b83\u5011\u6240\u5305\u88f9\u7684\u57fa\u56e0\u80fd\u5426\u9806\u5229\u8868\u73fe\u3002\u9019\u7a2e\u5728\u4e0d\u5f71\u97ffDNA\u9e7c\u57fa\u7d44\u6210\u7684\u524d\u63d0\u4e0b\uff0c\u7531\u7d44\u86cb\u767d\u4fee\u98fe\u6216\u9e7c\u57fa\u4fee\u98fe\u6c7a\u5b9a\u8a72\u6bb5\u57fa\u56e0\u80fd\u5426\u8868\u9054\uff0c\u7e7c\u800c\u900f\u904e\u907a\u50b3\u5f71\u97ff\u4e0b\u4e00\u4ee3\u7684\u73fe\u8c61\u5c31\u7a31\u4e4b\u70ba\u300c\u8868\u89c0\u907a\u50b3\u300d\u3002\u7d9c\u89c0\u4eba\u985e\u5168\u57fa\u56e0\u9ad4\u5b9a\u5e8f\u6240\u89e3\u51fa\u768430\u5104\u500b\u9e7c\u57fa\u6240\u7d44\u6210\u7684\u7c97\u4f302\u842c3\u5343\u591a\u500b\u57fa\u56e0\uff0c\u4e8b\u5be6\u4e0a\uff0c\u5728\u4eba\u9ad4\u7684\u6bcf\u4e00\u500b\u7d30\u80de\u4e2d\u6240\u8868\u73fe\u7684\u57fa\u56e0\u53ea\u6709\u7d043%\uff0c\u5176\u4ed6\u7684\u57fa\u56e0\u5247\u900f\u904e\u4fee\u98fe\u9677\u5165\u6c89\u7761\uff0c\u4e5f\u56e0\u70ba\u5982\u6b64\uff0c\u6211\u5011\u7684\u773c\u775b\u7d30\u80de\u624d\u6703\u53ea\u8868\u73fe\u8996\u89ba\u76f8\u95dc\u7684\u57fa\u56e0\uff0c\u5fc3\u81df\u808c\u8089\u7d30\u80de\u5247\u8868\u73fe\u5176\u76f8\u95dc\u57fa\u56e0\u800c\u80fd\u64d4\u8d77\u8eab\u9ad4\u8840\u6db2\u5faa\u74b0\u6cf5\u7684\u91cd\u8cac\u5927\u4efb\u3002<\/p>\n

\u25cf\u6a02\u8b5c\u4e0a\u7684\u300c\u6ce8\u91cb\u300d\u8a18\u865f<\/strong><\/span><\/p>\n

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CG\u5cf6\u300d\uff0c\u5373\u5728\u4e00\u6bb5\u57fa\u56e0\u7684\u9e7c\u57fa\u5e8f\u5217\u4e2d\u6703\u7a81\u7136\u51fa\u73fe\u4e00\u6bb5\u5bcc\u542bC\u3001G\u9e7c\u57fa\u7684\u7247\u6bb5\uff0c\u9019\u4e9bC\u3001G\u7247\u6bb5\u4e0a\u7684C\u9e7c\u57fa\u7279\u5225\u5bb9\u6613\u88ab\u52a0\u4e0a\u300c\u7532\u57fa(-CH3<\/sub>)\u300d\uff0c\u7576\u5b83\u5011\u88ab\u63a5\u4e0a\u7532\u57fa\u6642\uff0c\u9019\u6bb5\u57fa\u56e0\u5c31\u5982\u540c\u88ab\u4e0b\u4e86\u300c\u7981\u8a9e\u4ee4\u300d\u822c\uff0c\u5931\u53bb\u8f49\u9304\u8868\u9054\u7684\u80fd\u529b\u3002<\/p>\n

\u53e6\u5916\uff0c\u90a3\u4e9b\u8ca0\u8cac\u5305\u88f9DNA\u7684\u7d44\u86cb\u767d\u4e0a\u4e5f\u6709\u88ab\u5beb\u4e0a\u300c\u6ce8\u91cb\u8a18\u865f\u300d\u7684\u53ef\u80fd\u6027\u3002\u56e0\u70ba\u7d44\u86cb\u767d\u4e0a\u5e36\u6709\u6b63\u96fb\u8377\uff0c\u6b63\u597d\u53ef\u4ee5\u548cDNA\u6838\u82f7\u9178\u4e0a\u7684\u8ca0\u96fb\u8377\u5f7c\u6b64\u6b63\u8ca0\u76f8\u5438\uff0c\u6240\u4ee5\u53ef\u4ee5\u7dca\u5bc6\u7684\u5305\u88f9DNA\uff0c\u7576DNA\u88ab\u7dca\u5bc6\u5305\u8986\u6642\uff0c\u8ca0\u8cac\u8f49\u9304\u7684\u9175\u7d20\u548c\u90a3\u4e9b\u5354\u52a9\u8f49\u9304\u7684\u9175\u7d20\u5c31\u5f88\u96e3\u9644\u8457\u4e0a\u53bb\uff0c\u4e5f\u56e0\u6b64\u4f7f\u9019\u6bb5DNA\u4e0d\u8868\u73fe\uff1b\u76f8\u5c0d\u7684\uff0c\u7576\u7d44\u86cb\u767d\u88ab\u4e59\u91af\u57fa(-Ac)\u4fee\u98fe\u6642\uff0c\u7531\u65bc\u7d44\u86cb\u767d\u4e0a\u7684\u6b63\u96fb\u8377\u88ab\u4e2d\u548c\uff0c\u800c\u7a0d\u5fae\u9b06\u958b\u548cDNA\u9593\u7684\u9023\u7d50\uff0c\u4e5f\u5c31\u662f\u9019\u500b\u9b06\u958b\u7684\u9593\u9699\u4f7f\u8a72\u6bb5\u57fa\u56e0\u6709\u4e86\u88ab\u8f49\u9304\u56e0\u5b50\u7d50\u5408\u7e7c\u800c\u8868\u9054\u57fa\u56e0\u7522\u7269\u7684\u6a5f\u6703\u3002<\/p>\n

\u25cf\u7cbe\u5bc6\u7684\u8abf\u63a7<\/strong><\/span><\/p>\n

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\u25cf\u5c0f\u6a19\u8a18\uff0c\u5927\u5b78\u554f<\/strong><\/span><\/p>\n

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\u8868\u89c0\u907a\u50b3\u4f5c\u70ba\u65b0\u8208\u7684\u79d1\u5b78\u7814\u7a76\u9818\u57df\uff0c\u5c1a\u5b58\u5728\u8457\u8a31\u591a\u672a\u89e3\u4e4b\u8b0e\uff0c\u962e\u9e97\u84c9\u8001\u5e2b\u9f13\u52f5\u672a\u4f86\u7684\u5b78\u5b50\u5011\u5728\u5b78\u7fd2\u6642\u591a\u52a0\u7559\u610f\u8ab2\u672c\u6240\u8b1b\u8ff0\u7684\u5df2\u7d93\u89e3\u6c7a\u7684\u554f\u984c\u7684\u6642\u9593\u548c\u6b77\u53f2\u80cc\u666f\u4ee5\u53ca\u73fe\u5728\u6975\u6b32\u89e3\u51fa\u7684\u71c3\u7709\u4e4b\u6025\uff0c\u5982\u6b64\u4e0d\u53ea\u53ef\u4ee5\u5728\u79d1\u5b78\u7814\u7a76\u7684\u6b77\u53f2\u9577\u6cb3\u4e2d\u5b9a\u4f4d\u81ea\u5df1\u7684\u4f4d\u7f6e\uff0c\u66f4\u53ef\u4ee5\u5f9e\u4e2d\u767c\u6398\u8a31\u591a\u79d8\u5bc6\uff0c\u6216\u8a31\u7576\u6642\u7684\u554f\u984c\u7121\u6cd5\u89e3\u958b\u53ea\u662f\u6280\u8853\u672a\u5230\uff0c\u540c\u6a23\u7684\u554f\u984c\u4f7f\u7528\u73fe\u5728\u7684\u5100\u5668\u8aaa\u4e0d\u5b9a\u4fbf\u80fd\u8fce\u5203\u800c\u89e3\u5462!<\/p>\n

--
\n\u672c\u6587\u6574\u7406\u81ea\uff1a107\/5\/26\u7531\u962e\u9e97\u84c9\u8001\u5e2b\u5728\u81fa\u5927\u601d\u4eae\u9928\u570b\u969b\u6703\u8b70\u5ef3\u6240\u4e3b\u8b1b\u4e4b\u300c\u6f14\u594fDNA\u751f\u547d\u6a02\u8b5c\u7684\u4ea4\u97ff\u6a02\u5718\uff1a\u8868\u89c0\u907a\u50b3<\/a>\u300d\u6f14\u8b1b\u5167\u5bb9\u3002<\/strong><\/p>\n

 <\/p>\n

\"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u25a0DNA(\u53bb\u6c27\u6838\u91a3\u6838\u9178\uff0cdeoxyribonucleic acid)\uff0c\u7c21\u55ae\u7528\u4e00\u53e5\u8a71\u5f62\u5bb9\u5c31\u662f\u300c\u4e00\u7a2e\u7531\u773e\u751f\u547d\u9ad4\u6240\u5171\u540c\u64c1\u6709\uff0c\u4e58\u8f09\u57fa\u56e0\u5373\u907a\u50b3\u5bc6\u78bc\u7684\u5316\u5b78\u5de8\u5206\u5b50\u300d\u800c\u300c\u57fa\u56e0\u300d\uff0c\u5247\u662f\u5176\u4e0a\u80fd\u8868\u73fe\u529f\u80fd\u7684\u6700\u5c0f\u55ae\u4f4d\u3002\u7e7c1953\u5e74\uff0cDNA\u96d9\u80a1\u87ba\u65cb\u7d50\u69cb\u7684\u767c\u8868\u540c\u6642\u9707\u64bc\u5b78\u754c\u53ca\u4e16\u754c\u8d77\uff1b1972\u5e74\uff0c\u6211\u5011\u501f\u9451\u7d30\u83cc\uff0c\u5b78\u6703\u4e86\u300c\u57fa\u56e0\u5de5\u7a0b\u300d\uff1b1990\u52302003\uff0c13\u5e74\u7684\u671f\u9593\u88e1\u6211\u5011\u5b8c\u6210\u4eba\u985e\u7684\u5168\u57fa\u56e0\u9ad4\u5b9a\u5e8f(Whole-genome sequencing, WGS)\u8a08\u756b\uff0c\u6210\u529f\u89e3\u78bc\u9577\u905430\u5104\u9e7c\u57fa\u7684\u751f\u547d\u4e4b\u66f8\uff1b1995\u5e74\uff0c\u300c\u8868\u89c0\u907a\u50b3\u300d\u7684\u5d1b\u8d77\u5247\u5c07\u5206\u5b50\u751f\u7269\u5b78\u63a8\u5411\u4e00\u500b\u5d84\u65b0\u7684\u5bec\u95ca\u5883\u754c\u3002<\/p>\n","protected":false},"author":20,"featured_media":31327,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,3749],"tags":[37,1809,29,3918],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/07\/19-6-Nucleosome-WIKI.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/31174"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=31174"}],"version-history":[{"count":9,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/31174\/revisions"}],"predecessor-version":[{"id":31556,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/31174\/revisions\/31556"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/31327"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=31174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=31174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=31174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}