{"id":30997,"date":"2018-06-18T00:19:47","date_gmt":"2018-06-17T16:19:47","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=30997"},"modified":"2018-06-15T11:21:33","modified_gmt":"2018-06-15T03:21:33","slug":"%e3%80%8c%e6%88%91%e7%9a%84%e3%80%8d%e5%9f%ba%e5%9b%a0%ef%bc%9f%e5%a5%87%e5%a6%99%e7%9a%84%e9%91%b2%e5%b5%8c%e7%8f%be%e8%b1%a1%ef%bc%88mosaicism%ef%bc%89","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=30997","title":{"rendered":"\u300c\u6211\u7684\u300d\u57fa\u56e0\uff1f\u5947\u5999\u7684\u9472\u5d4c\u73fe\u8c61\uff08mosaicism\uff09"},"content":{"rendered":"

\u25a0Priest\u91ab\u5e2b\u7121\u6cd5\u7406\u89e3\u81ea\u5df1\u6240\u770b\u5230\u7684\u4e00\u5207\u3002\u4ed6\u6b63\u5728\u70ba\u4e00\u4f4d\u91cd\u75c7\u5b30\u5152\u6aa2\u67e5DNA\uff0c\u8a66\u8457\u627e\u51fa\u5a01\u8105\u5979\u5fc3\u8df3\u7684\u57fa\u56e0\u7a81\u8b8a\u3002\u7136\u800c\uff0c\u6839\u64da\u6aa2\u67e5\u7d50\u679c\uff0c\u9019\u4e9b\u57fa\u56e0\u5f77\u5f7f\u662f\u5f9e\u53e6\u4e00\u500b\u5b8c\u5168\u4e0d\u540c\u7684\u5b30\u5152\u8eab\u4e0a\u6240\u53d6\u5f97\u7684\u3002<\/strong><\/span><\/p>\n

\"\"
\uff08Photo credit: Rebekah D. Wallace, University of Georgia, Bugwood.org\uff09<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c\u838a\u5b87\u771f<\/strong><\/p>\n

\u6839\u64da\u904e\u53bb\u6211\u5011\u5728\u751f\u7269\u8ab2\u6240\u5b78\uff0c\u6253\u5f9e\u6211\u5011\u9084\u662f\u53d7\u7cbe\u5375\u958b\u59cb\uff0c\u7d30\u80de\u4f9d\u898f\u5f8b\u9032\u884c\u5206\u88c2\uff0c\u5fe0\u5be6\u5730\u5c07\u67d3\u8272\u9ad4\u8907\u88fd\u5230\u5b50\u4ee3\u7684\u7d30\u80de\u88e1\uff0c\u6700\u7d42\u7d44\u6210\u6211\u5011\u7684\u8eab\u9ad4\u3002\u56e0\u6b64\uff0c\u6211\u5011\u6703\u8a8d\u70ba\uff0c\u300c\u57fa\u56e0\u7d44\u300d\uff08Genome\uff09\u662f\u4e00\u9805\u5c08\u5c6c\u65bc\u81ea\u5df1\u7684\u7a69\u5b9a\u7279\u5fb5\uff0c\u50cf\u662f\u6307\u7d0b\u4e00\u822c\u3002<\/p>\n

\u7136\u800c\uff0c\u6700\u8fd1\u6578\u5341\u5e74\u4f86\uff0c\u6709\u8d8a\u4f86\u8d8a\u591a\u7814\u7a76\u767c\u73fe\uff0c\u57fa\u56e0\u7d44\u4e26\u4e0d\u53ea\u662f\u5728\u4eba\u8207\u4eba\u4e4b\u9593\u6709\u5dee\u7570\uff0c\u5b83\u4e5f\u53ef\u80fd\u5728\u540c\u4e00\u500b\u8eab\u9ad4\u88e1\u3001\u7d30\u80de\u8207\u7d30\u80de\u4e4b\u9593\u7522\u751f\u3002\u7c21\u55ae\u4f86\u8aaa\uff0c\u5728\u6211\u5011\u7684\u8eab\u9ad4\u88e1\uff0c\u53ef\u80fd\u5728\u5fc3\u81df\u7d30\u80de\u8207\u80ba\u81df\u7d30\u80de\u4e4b\u9593\uff0c\u5206\u6790\u51fa\u4e0d\u540c\u7684\u57fa\u56e0\u8a0a\u606f\u3002<\/p>\n

\u9019\u7a2e\u5728\u540c\u4e00\u500b\u751f\u7269\u9ad4\u8eab\u4e0a\uff0c\u540c\u6642\u64c1\u6709\u5169\u7a2e\u6216\u66f4\u591a\u5177\u6709\u4e0d\u540c\u57fa\u56e0\u578b\u7d30\u80de\u7684\u73fe\u50cf\uff0c\u88ab\u7a31\u70ba\u300c\u9472\u5d4c\u73fe\u8c61<\/a>\u300d\uff08mosaicism\uff09\u3002\u5728\u4eba\u985e\uff0c\u7576\u9472\u5d4c\u73fe\u8c61\u767c\u751f\u5728\u672c\u8eab\u5177\u6709\u67d3\u8272\u9ad4\u6578\u76ee\u7570\u5e38\u6216\u5176\u4ed6\u907a\u50b3\u75be\u75c5\u6642\uff0c\u53ef\u80fd\u6703\u4f7f\u75c7\u72c0\u8f03\u8f15\u5fae\uff0c\u56e0\u70ba\u9472\u5d4c\u73fe\u8c61\u610f\u5473\u8457\u8eab\u9ad4\u88e1\u6709\u4e00\u90e8\u5206\u7684\u7d30\u80de\u662f\u5e36\u6709\u672a\u7a81\u8b8a\u57fa\u56e0\u7684\u3002\u4f8b\u5982<\/a>\uff1a\u6027\u67d3\u8272\u9ad4\u7f3a\u5c11\u4e00\u500bX\u7684\u5973\u6027\u900f\u7d0d\u6c0f\u75c7\uff08Turner's syndrome\uff09\uff0c\u82e5\u662f\u5728\u9472\u5d4c\u67d3\u8272\u9ad4\u7684\u75c5\u4eba\u8eab\u4e0a\uff0c\u75c5\u4eba\u53ef\u80fd\u75c7\u72c0\u4e0d\u660e\u986f\u3001\u6216\u4ecd\u64c1\u6709\u6b63\u5e38\u7684\u5973\u6027\u751f\u7406\u9031\u671f\uff08\u56e0\u70ba\u8eab\u9ad4\u88e1\u6709\u7684\u7d30\u80de\u662fXO\u3001\u6709\u7684\u662fXX\uff09\u3002<\/p>\n

\u25cf\u9472\u5d4c\u73fe\u8c61\u5728\u690d\u7269\u754c~<\/strong>\u7121\u5fc3\u63d2\u67f3<\/strong><\/span><\/p>\n

\u5728\u4e2d\u4e16\u7d00\u7684\u6b50\u6d32\uff0c\u65c5\u4eba\u9577\u9014\u8dcb\u6d89\uff0c\u7a7f\u8d8a\u68ee\u6797\u7684\u9014\u4e2d\uff0c\u6709\u6642\u6703\u9047\u898b\u4e00\u7a2e\u4ee4\u4eba\u6bdb\u9aa8\u609a\u7136\u7684\u6a39\u3002\u6a39\u5e79\u4e0a\u5192\u51fa\u4e86\u53e6\u4e00\u7a2e\u4e0d\u540c\u7684\u690d\u7269\uff0c\u5bc6\u96c6\u5730\u5f62\u6210\u4e00\u7d91\u679d\u689d\uff0c\u50cf\u662f\u4eba\u5011\u6240\u88fd\u9020\u7684\u6383\u5e1a\u3002\u5fb7\u570b\u4eba\u5c07\u5b83\u7a31\u70ba\u300c\u5973\u5deb\u6383\u5e1a\u300d\uff08Hexenbesen\uff09\u3002<\/p>\n

19\u4e16\u7d00\uff0c\u690d\u7269\u80b2\u7a2e\u4eba\u767c\u73fe\uff0c\u7576\u4ed6\u5011\u5c07\u300c\u5973\u5deb\u6383\u5e1a\u300d\u780d\u4e0b\u3001\u5ac1\u63a5\u5230\u53e6\u4e00\u68f5\u6a39\u4e0a\u6642\uff0c\u9019\u500b\u300c\u6383\u5e1a\u300d\u5c07\u6703\u65e2\u7e8c\u751f\u9577\u4e14\u7d50\u7a2e\u5b50\uff0c\u800c\u9019\u4e9b\u7a2e\u5b50\u4e5f\u6703\u9577\u51fa\u5973\u5deb\u6383\u5e1a\u3002<\/p>\n

\u4eca\u5929\uff0c\u4f60\u53ef\u4ee5\u5728\u5c0b\u5e38\u5e02\u90ca\u7684\u8349\u576a\u4e0a\u770b\u5230\u5973\u5deb\u6383\u5e1a\u7684\u4f8b\u5b50\u3002\u77ee\u7a2e\u767d\u96f2\u6749\uff08dwarf Alberta spruce\uff09\u662f\u4f86\u81ea\u52a0\u62ff\u5927\u7684\u666f\u89c0\u690d\u7269\uff08\u50cf\u662f\u5c0f\u9846\u7684\u8056\u8a95\u6a39\uff09\uff0c\u6700\u9ad8\u53ef\u9577\u5230300\u516c\u5206\u5de6\u53f3\u30021903\u5e74\uff0c\u690d\u7269\u5b78\u5bb6\u7b2c\u4e00\u6b21\u767c\u73fe\u5b83\u6642\uff0c\u5b83\u6b63\u7dca\u7dca\u4f9d\u9644\u5728\u4e00\u68f5\u767d\u96f2\u6749\u4e0a\uff1b\u767d\u96f2\u6749\u672c\u8eab\u662f\u53ef\u9577\u5230\u5c07\u8fd110\u5c64\u6a13\u9ad8\u7684\u5de8\u5927\u6749\u6728\u3002<\/p>\n

\u7c89\u7d05\u8461\u8404\u67da\uff08pink grapefruit\uff09\u4e5f\u662f\u5728\u985e\u4f3c\u72c0\u6cc1\u4e0b<\/a>\u88ab\u767c\u73fe\u7684\u3002\u4e00\u500b\u4f5b\u7f85\u91cc\u9054\u5dde\u8fb2\u592b\u6ce8\u610f\u5230\uff0cWalters\u8461\u8404\u67da\u6a39\u4e0a\u9577\u51fa\u5947\u602a\u7684\u5206\u679d\uff1bWalters\u8461\u8404\u67da\u901a\u5e38\u7522\u51fa\u7684\u662f\u767d\u67da\uff0c\u7136\u800c\u9019\u500b\u5206\u679d\u537b\u9577\u51fa\u6709\u7c89\u7d05\u679c\u8089\u7684\u8461\u8404\u67da\u3002\u5f9e\u90a3\u4ee5\u5f8c\uff0c\u9019\u4e9b\u7a2e\u5b50\u5c31\u88ab\u62ff\u4f86\u76f4\u63a5\u7a2e\u690d\u51fa\u7c89\u7d05\u8461\u8404\u67da\u6a39\u3002<\/p>\n

\u5c07\u8fd1160\u5e74\u524d\uff0c\u4ee5\u300a\u7269\u7a2e\u8d77\u6e90\u300b\u4e00\u66f8\u64bc\u52d5\u6f14\u5316\u7406\u8ad6\u7684\u9054\u723e\u6587\uff08Charles Darwin, 1809-1882\uff09\u6df1\u6df1\u53d7\u5230\u9019\u985e\u5947\u7279\u666f\u50cf\u7684\u5438\u5f15\u3002\u4ed6\u5c0d\u65bc\u5728\u958b\u82b1\u690d\u7269\u6240\u767c\u751f\u7684\u300c\u82bd\u8b8a\u300d\uff08bud sport; bud mutation; bud variation\uff09\u73fe\u8c61\uff0c\u4e5f\u5c31\u662f\u5728\u540c\u4e00\u7a2e\u690d\u7269\u4e2d\uff0c\u7522\u751f\u975e\u5178\u578b\u3001\u5947\u7279\u7684\u82b1\uff0c\u611f\u5230\u5341\u5206\u597d\u5947\u3002\u9054\u723e\u6587\u731c\u60f3\u9019\u6216\u8a31\u662f\u80fd\u89e3\u958b\u907a\u50b3\u79d8\u5bc6\u7684\u7dda\u7d22\u3002<\/p>\n

\u7d93\u904e\u7d2f\u7a4d\u7121\u6578\u7684\u7814\u7a76\u5f8c\u7d42\u65bc\u77ad\u89e3\uff0c\u300c\u5973\u5deb\u6383\u5e1a\u300d\u8207\u300c\u82bd\u8b8a\u300d\u90fd\u662f\u9472\u5d4c\u9ad4\u7684\u4f8b\u5b50\u3002\u5927\u81ea\u7136\u7528\u7d30\u80de\u5275\u9020\u4e86\u5b83\uff0c\u5c07\u4e0d\u540c\u7684\u57fa\u56e0\u6a23\u8c8c\u878d\u5408\u5728\u9019\u7247\u8996\u89ba\u9957\u5bb4\u88e1\u3002<\/p>\n

\u25cf\u9472\u5d4c\u73fe\u8c61\u7121\u6240\u4e0d\u5728<\/strong><\/span><\/p>\n

\u7f8e\u570b\u54c8\u4f5b\u5927\u5b78\u7684\u57fa\u56e0\u5b78\u5bb6Christopher Walsh\u8207\u5176\u7814\u7a76\u5718\u968a\u5728\u4e00\u500b\u610f\u60f3\u4e0d\u5230\u7684\u5730\u65b9\u767c\u73fe\u4e86\u9472\u5d4c\u73fe\u8c61\u7684\u8b49\u64da\u3002<\/p>\n

\u7f79\u60a3\u300c\u534a\u908a\u5de8\u8166\u75c7<\/a>\u300d\uff08hemimegalencephaly\uff09\u7684\u75c5\u4eba\u6703\u6709\u534a\u908a\u5927\u8166\u904e\u5ea6\u751f\u9577\u7684\u60c5\u5f62\uff0c\u901a\u5e38\u4f34\u96a8\u96e3\u4ee5\u63a7\u5236\u7684\u7672\u7647\u91dd\u5c0d\u7121\u6cd5\u4ee5\u85e5\u7269\u63a7\u5236\u7684\u75c5\u4eba\uff0c\u53ef\u80fd\u6703\u900f\u904e\u5927\u8166\u534a\u7403\u5207\u9664\u8853\uff08hemispherectomy\uff09\u4f86\u9032\u884c\u6cbb\u7642\u3002\u7814\u7a76\u5718\u968a\u65bc\u662f\u4f7f\u7528\u624b\u8853\u5207\u9664\u7684\u7d44\u7e54\u9032\u884c\u6aa2\u9a57<\/a>\u3002\u5728\u75c5\u4eba\u7684\u8166\u90e8\u7d30\u80de\u88e1\uff0c\u7814\u7a76\u8005\u767c\u73fe\u6709\u4e00\u90e8\u5206\u7d30\u80de\u5177\u6709\u76f8\u540c\u7a81\u8b8a\u57fa\u56e0\u3002\u53ef\u80fd\u7684\u63a8\u6e2c\u662f\uff0c\u9019\u4e9b\u7a81\u8b8a\u7684\u795e\u7d93\u7d30\u80de\u5206\u88c2\u901f\u5ea6\u6bd4\u6b63\u5e38\u8166\u90e8\u7d30\u80de\u66f4\u5feb\uff0c\u56e0\u6b64\u4fc3\u6210\u55ae\u5074\u5927\u8166\u5de8\u5927\u7684\u60c5\u5f62\u3002<\/p>\n

Dr. Walsh\u548c\u7814\u7a76\u5718\u968a\u5f8c\u7e8c\u9032\u4e00\u6b65\u5728\u5065\u5eb7\u4eba\u5927\u8166\u4e2d\u767c\u73fe\u4e86\u8907\u96dc\u7684\u9472\u5d4c\u73fe\u50cf\u3002\u7814\u7a76\u4eba\u54e1\u5f9e\u4e00\u540d\u610f\u5916\u6b7b\u65bc\u8eca\u798d\u768417\u6b72\u7537\u5b69\u8166\u4e2d\uff0c\u53d6\u51fa\u795e\u7d93\u7d30\u80de\u9032\u884cDNA\u5b9a\u5e8f\uff0c\u4e26\u8207\u7537\u5b69\u809d\u81df\u3001\u5fc3\u81df\u3001\u8207\u80ba\u81df\u7d30\u80de\u88e1\u7684DNA\u9032\u884c\u6bd4\u8f03\u3002\u7814\u7a76\u767c\u73fe\uff0c\u6bcf\u500b\u795e\u7d93\u5143\u90fd\u6709\u4e0a\u767e\u500b\u8eab\u9ad4\u5176\u4ed6\u5668\u5b98\u7d30\u80de\u6c92\u6709\u7684\u7a81\u8b8a\u3002\u7136\u800c\uff0c\u8a31\u591a\u7a81\u8b8a\u50c5\u5728\u90e8\u5206\u795e\u7d93\u7d30\u80de\u4e4b\u9593\u662f\u76f8\u540c\u7684\u3002<\/p>\n

Dr. Walsh\u56e0\u6b64\u6709\u4e86\u9748\u611f\uff0c\u4ed6\u5617\u8a66\u85c9\u7531\u9019\u4e9b\u7a81\u8b8a\u4f86\u91cd\u5efa\u7d30\u80de\u4e16\u7cfb\uff08cell lineages\uff09 \u2013 \u4e5f\u5c31\u662f\u77ad\u89e3\u5b83\u5011\u662f\u5f9e\u4f55\u767c\u6e90\u7684\u3002\u7814\u7a76\u4eba\u54e1\u5c07\u6bcf\u500b\u795e\u7d93\u7d30\u80de\u4f9d\u5176\u89aa\u758f\u9060\u8fd1\u9023\u7d50\u8d77\u4f86\uff0c\u6839\u64da\u5b8c\u6210\u7684\u7e6a\u88fd\u7d50\u679c\uff0c\u53ef\u6b78\u7d0d\u51fa5\u500b\u4e3b\u8981\u4e16\u7cfb\u3002\u6bcf\u500b\u4e16\u7cfb\u88e1\u7684\u7d30\u80de\u7686\u907a\u50b3\u6709\u76f8\u540c\u7684\u3001\u7368\u7279\u7684\u9472\u5d4c\u8a18\u865f\u3002<\/p>\n

\u66f4\u5947\u602a\u7684\u662f\uff0c\u79d1\u5b78\u5bb6\u5728\u7537\u5b69\u7684\u5fc3\u81df\u7d30\u80de\u767c\u73fe\u4e86\u8207\u5927\u8166\u795e\u7d93\u7d30\u80de\u76f8\u540c\u7684\u7a81\u8b8a\u8a18\u865f\u3002\u5176\u4ed6\u4e16\u7cfb\u4e5f\u5206\u5225\u6709\u8207\u5176\u4ed6\u5668\u5b98\u76f8\u540c\u7684\u60c5\u5f62\u3002\u6839\u64da\u6b64\u7d50\u679c\uff0c\u7814\u7a76\u4eba\u54e1\u70ba\u7537\u5b69\u7684\u5927\u8166\u62fc\u51fa\u5b83\u7684\u4e00\u751f<\/a>\u3002\u7576\u7537\u5b69\u9084\u662f\u5b50\u5bae\u88e1\u7684\u80da\u80ce\u6642\uff0c5\u500b\u7d30\u80de\u4e16\u7cfb\u8a95\u751f\u4e86\uff0c\u6bcf\u500b\u4e16\u7cfb\u4e5f\u5206\u5225\u5e36\u6709\u5176\u7368\u7279\u7684\u7a81\u8b8a\u3002\u63a5\u4e0b\u4f86\uff0c\u4e0d\u540c\u4e16\u7cfb\u7684\u7d30\u80de\u5f80\u4e0d\u540c\u7684\u65b9\u5411\u9077\u79fb\uff0c\u6700\u5f8c\u767c\u5c55\u6210\u4e0d\u540c\u7684\u5668\u5b98 \u2013 \u5305\u62ec\u5927\u8166\u3002<\/p>\n

\u7f8e\u570b\u5967\u52d2\u5ca1\u5065\u5eb7\u8207\u79d1\u5b78\u5927\u5b78\uff08Oregon Health & Science University\uff09\u7684\u751f\u7269\u5b78\u5bb6Markus Grompe\u8207\u4ed6\u7684\u540c\u4e8b\uff0c\u5c0d\u65bc\u6c92\u6709\u809d\u81df\u75be\u75c5\u7684\u5152\u7ae5\u53ca\u6210\u4eba\uff0c\u89c0\u5bdf\u4ed6\u5011\u7684\u809d\u81df\u7d30\u80de\u3002\u5176\u4e2d\u7d04\u67091\/4\u81f3\u4e00\u534a\u7684\u7d30\u80de\u67d3\u8272\u9ad4\u662f\u975e\u6574\u500d\u9ad4\uff08aneuploids\uff09<\/a>\uff0c\u591a\u6578\u662f\u7f3a\u5931\u4e86\u4e00\u5957\u67d3\u8272\u9ad4\u3002<\/p>\n

2017\u5e74\uff0c\u82f1\u570b\u7dad\u5eb7\u6851\u683c\u7814\u7a76\u6240\uff08Wellcome Trust Sanger Institute\uff09\u7684\u7814\u7a76\u8005\u6aa2\u9a57\u4e86241\u540d\u5973\u6027\u7684\u767d\u8840\u7403DNA\u5e8f\u5217\u3002\u6bcf\u4f4d\u5973\u6027\u7686\u6709\u7d04160\u500b\u65b0\u7684\u7a81\u8b8a<\/a>\uff0c\u6bcf\u500b\u7a81\u8b8a\u7686\u5728\u5176\u7d30\u80de\u4e2d\u4f54\u6709\u4e00\u5b9a\u7684\u6bd4\u4f8b\u3002<\/p>\n

\u65e9\u671f\u7814\u7a76\u63a8\u6e2c\uff0c\u9472\u5d4c\u73fe\u8c61\u5f88\u53ef\u80fd\u662f\u8a31\u591a\u75be\u75c5\u7684\u8087\u56e0<\/a>\u30022017\u5e74\uff0cDr. Walsh\u8207\u5176\u7814\u7a76\u5718\u968a\u767c\u8868\u65bcNature Neuroscience<\/a>\uff0c\u91dd\u5c0d\u300c\u6cdb\u81ea\u9589\u75c7\u969c\u7919\u300d\uff08autism spectrum disorder, ASD\uff09\u7684\u75c5\u56e0\uff0c\u8a66\u5716\u5f9e\u9472\u5d4c\u7a81\u8b8a\u627e\u51fa\u7dda\u7d22\u3002<\/p>\n

\u4e0d\u904e\uff0c\u79d1\u5b78\u5bb6\u540c\u6642\u4e5f\u767c\u73fe\u5230\uff0c\u9472\u5d4c\u73fe\u8c61\u4e0d\u5fc5\u7136\u7b49\u65bc\u6709\u75be\u75c5\u3002\u4e8b\u5be6\u4e0a\uff0c\u901a\u5e38\u662f\u6c92\u6709\u75be\u75c5\u7684\u3002\u7576\u4e00\u500b\u53d7\u7cbe\u5375\uff08\u5408\u5b50\uff09\u958b\u59cb\u65bc\u5b50\u5bae\u5167\u5206\u88c2\uff0c\u8a31\u591a\u65e9\u671f\u5206\u88c2\u51fa\u4f86\u7684\u5b50\u4ee3\u7d30\u80de\uff0c\u662f\u5177\u6709\u932f\u8aa4\u67d3\u8272\u9ad4\u6578\u91cf\u7684\u7d30\u80de\u3002\u591a\u6578\u9019\u4e9b\u7d30\u80de\u6703\u56e0\u6b64\u5206\u88c2\u7de9\u6162\u4e14\u6b7b\u4ea1\uff1b\u4e0d\u904e\uff0c\u5728\u5e36\u6709\u4e0d\u540c\u67d3\u8272\u9ad4\u72c0\u6cc1\u7684\u524d\u63d0\u4e0b\uff0c\u9084\u662f\u6709\u76f8\u7576\u9ad8\u6bd4\u4f8b\u7684\u80da\u80ce\u662f\u53ef\u4ee5\u5b58\u6d3b\u7684\u3002<\/p>\n

\u25cf\u6d88\u5931\u7684\u7a81\u8b8a~<\/strong>\u5fc3\u81df\u79d1\u7684\u5c0f\u5c0f\u75c5\u4eba<\/strong><\/span><\/p>\n

Astrea Li\uff0c\u5728\u5979\u525b\u51fa\u751f\u90a3\u5929\u5c31\u767c\u751f\u5fc3\u8df3\u505c\u6b62\u3002\u5979\u7684\u4e3b\u6cbb\u91ab\u5e2b\u6c7a\u5b9a\u9032\u884c\u690d\u5165\u53bb\u986b\u5668\uff08defibrillator\uff09\u7684\u624b\u8853\uff0c\u4f7fAstrea\u7684\u5fc3\u5f8b\u80fd\u56de\u5fa9\u6b63\u5e38\u3002<\/p>\n

\u7f8e\u570b\u53f2\u4e39\u4f5b\u5927\u5b78\u7684\u5c0f\u5152\u5fc3\u81df\u79d1James Priest\u91ab\u5e2b\u5c0dAstrea\u7684\u57fa\u56e0\u7d44\u9032\u884c\u5b9a\u5e8f\uff0c\u8a66\u5716\u627e\u51fa\u9020\u6210\u6b64\u75be\u75c5\u7684\u539f\u56e0\u3002\u4ed6\u5728\u5176\u4e2d\u4e00\u5957\u57fa\u56e0\u627e\u5230\u4e86SCN5A\u7a81\u8b8a\uff0c\u800c\u9019\u500b\u57fa\u56e0\u6240\u8f49\u8b6f\u7684\u86cb\u767d\uff0c\u539f\u672c\u662f\u8ca0\u8cac\u5354\u52a9\u5fc3\u8df3\u7684\u8d77\u52d5\u3002\u4f46\u7576Dr. Priest\u8a66\u5716\u7528\u53e6\u4e00\u7a2e\u6aa2\u6e2c\u65b9\u6cd5\u6642\uff0c\u9019\u500b\u7a81\u8b8a\u5c31\u9019\u6a23\u6d88\u5931\u4e86\u3002<\/p>\n

Dr. Priest\u4e0d\u6562\u76f8\u4fe1\uff0c\u70ba\u8ffd\u6839\u7a76\u5e95\uff0c\u4ed6\u627e\u4e86\u5b78\u6821\u88e1\u5c08\u9577\u65bc\u7d30\u80de\u57fa\u56e0\u7d44\u5b9a\u5e8f\u7684\u751f\u7269\u5b78\u5bb6Steven Quake\u4e00\u584a\u4f86\u5e6b\u5fd9\u3002\u4ed6\u5011\u5f9e\u5bf6\u5bf6\u8840\u6db2\u4e2d\u62bd\u51fa36\u500b\u767d\u8840\u7403\uff0c\u7136\u5f8c\u5c0d\u6bcf\u4e00\u500b\u7d30\u80de\u9032\u884c\u5b8c\u6574\u57fa\u56e0\u7d44\u7684\u5b9a\u5e8f\u3002\u5728\u5176\u4e2d33\u500b\u7d30\u80de\uff0c\u5169\u5957\u57fa\u56e0\u88e1\u7684SCN5A\u90fd\u662f\u6b63\u5e38\u7684\u3002\u7136\u800c\uff0c\u5728\u5269\u4e0b\u76843\u500b\u7d30\u80de\u88e1\uff0c\u7814\u7a76\u4eba\u54e1\u5728\u5176\u4e2d\u4e00\u5957\u57fa\u56e0\u627e\u5230\u4e86\u7a81\u8b8a\u3002\u539f\u4f86\uff0c\u9472\u5d4c\u7d30\u80de\u5b58\u5728Astrea\u7684\u8840\u6db2\u88e1\u3002<\/p>\n

\u6578\u6708\u5f8c\uff0cAstrea\u518d\u6b21\u56de\u5230\u91ab\u9662\u63a5\u53d7\u5fc3\u81df\u79fb\u690d\u624b\u8853\uff0c\u5f8c\u7e8c\u5fa9\u539f\u826f\u597d\uff0c\u8fd4\u5bb6\u4eab\u53d7\u5979\u61c9\u6709\u7684\u5feb\u6a02\u7ae5\u5e74\u751f\u6d3b\u3002\u9019\u500b\u79fb\u690d\u624b\u8853\u4e0d\u53ea\u8b93Astrea\u7372\u5f97\u4e86\u65b0\u751f\uff0c\u540c\u6642\u4e5f\u8b93Dr. Priest\u6709\u6a5f\u6703\u77ad\u89e3\u5fc3\u81df\u7684\u9472\u5d4c\u57fa\u56e0\u3002Dr. Priest\u8207\u540c\u4e8b\u5247\u5206\u5225\u5f9eAstrea\u5fc3\u81df\u4e0d\u540c\u90e8\u4f4d\u7684\u808c\u8089\u7d30\u80de\u8403\u53d6\u51faSCN5A\u57fa\u56e0\uff0c\u5206\u6790\u5f8c\u767c\u73fe\uff1a\u5728\u5fc3\u81df\u53f3\u5074\uff0c\u8d85\u904e5%\u7684\u7d30\u80de\u6709\u7a81\u8b8a\uff1b\u5de6\u5074\u5247\u6709\u5c07\u8fd112%\u7684\u7d30\u80de\u6709\u6b64\u7a81\u8b8a\u3002<\/p>\n

\u25cf\u9472\u5d4c\u8457\u672a\u77e5\u7684\u672a\u4f86<\/strong><\/span><\/p>\n

\u5728\u5c0f\u5c0f\u75c5\u4ebaAstrea\u63d0\u4f9b\u4e86\u5982\u6b64\u73cd\u8cb4\u7684\u7814\u7a76\u7d93\u9a57\u4e4b\u5f8c\uff0cDr. Priest\u4e0d\u7981\u601d\u7d22\uff0c\u6709\u591a\u5c11\u4eba\u6b63\u56e0\u70ba\u9019\u7a2e\u9472\u5d4c\u6f5b\u85cf\u7684\u7a81\u8b8a\u800c\u8655\u65bc\u98a8\u96aa\u4e4b\u4e2d\uff1f\u7136\u800c\uff0c\u5728\u4e0b\u500bAstrea\u8d70\u5165\u79d1\u5b78\u6bbf\u5802\u4e4b\u524d\uff0c\u9019\u500b\u7b54\u6848\u5f88\u53ef\u80fd\u59cb\u7d42\u662f\u672a\u77e5\u7684\u3002<\/p>\n

\u9762\u5c0d\u6211\u5011\u8eab\u9ad4\u88e1\u53ef\u80fd\u5b58\u5728\u8457\u7684\u300c\u9472\u5d4c\u73fe\u8c61\u300d\uff0c\u76ee\u524d\u4ecd\u5f88\u96e3\u53bb\u8ad6\u65b7\uff0c\u9019\u5c0d\u6211\u5011\u7684\u751f\u547d\u5c07\u6709\u4f55\u5f71\u97ff\u3002\u4f46\u6211\u5011\u53ef\u4ee5\u78ba\u77e5\u7684\u662f\uff0c\u9472\u5d4c\u73fe\u8c61\u70ba\u751f\u7269\u9ad4\u7684\u767c\u5c55\u5e36\u4f86\u4e86\u300c\u4e0d\u53ef\u9810\u6e2c\u6027\u300d\uff08randomness\uff09\u3002\u6b63\u5982\u540c\u7a81\u8b8a\uff0c\u539f\u672c\u5c31\u662f\u4f86\u81ea\u96a8\u6a5f\u7684\u73fe\u8c61\uff0c\u5728\u6bcf\u500b\u4eba\u8eab\u4e0a\u90fd\u6703\u5e36\u4f86\u4e0d\u540c\u7684\u5448\u73fe\u3002<\/p>\n

\u300c\u7e31\u4f7f\u662f\u4f86\u81ea\u540c\u4e00\u500b\u5408\u5b50\uff08zygote\uff09\uff0c\u4e5f\u6c38\u9060\u4e0d\u53ef\u80fd\u767c\u5c55\u6210\u540c\u4e00\u6a23\u5b50\u7b2c\u4e8c\u6b21\u3002\u300dDr. Walsh\u5982\u662f\u8aaa\u3002<\/p>\n

 <\/p>\n

\u5831\u5c0e\u51fa\u8655\uff1a<\/strong>Carl Zimmer (May 21, 2018). Every Cell in Your Body Has the Same DNA. Except It Doesn\u2019t<\/a>. The New York Times.<\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/strong><\/p>\n

    \n
  1. \u201cMosaicism\u201d (Nature.com). https:\/\/www.nature.com\/subjects\/mosaicism<\/a><\/li>\n
  2. \u8cf4\u82f1\u660e\uff081.8\uff09\u3002\u67d3\u8272\u9ad4\u9472\u5d4c\u73fe\u8c61 ( Mosaicism )\u3002\u53d6\u81ea\uff1ahttp:\/\/www.pansivf.com.tw\/know\/detail\/50<\/a><\/li>\n
  3. Graca JVD, Louzada E, Sauls JW. 2004. The Origins of Red Pigmented Grapefruits and the Development of New Varieties<\/a>. Conference: Proceedings, International Society of Citriculture, At Agadir, Morocco, Volume: 1 Pages 369-374.<\/li>\n
  4. \u9673\u8679\u6f54\u3001\u90ed\u842c\u7950\uff082009\uff09\u3002\u534a\u908a\u5de8\u8166\u75c7(Hemimegalencephaly)\u3002\u81e8\u5e8a\u91ab\u5b78 63: 317-20\u3002<\/li>\n
  5. Poduri A, Evrony GD, Cai X, Walsh CA. 2013. Somatic Mutation, Genomic Variation, and Neurological Disease. Science 341(6141), 1237758.<\/li>\n
  6. Lodato MA, Woodworth MB, Lee S, Evrony GD, Mehta BK, Karger A,\u2026Walsh CA. 2015. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science 350(6256), 94-8.<\/li>\n
  7. Duncan AW, Hanlon Newell AE, Smith L, Wilson EM, Olson SB, Thayer MJ, Strom SC, Grompe M. 2012. Frequent Aneuploidy Among Normal Human Hepatocytes. Gastroenterology 142(1), 25-28.<\/li>\n
  8. Ju YS, Martincorena I,\u2026Stratton MR. 2017. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo. Nature 543, 714-8.<\/li>\n
  9. McConnell MJ,\u2026& Brain Somatic Mosaicism Network. 2017. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science 356(6336), eaal1641.<\/li>\n
  10. Lim ET, Uddin M,\u2026Walsh CA. 2017. Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nature Neuroscience 20, 1217-24.<\/li>\n<\/ol>\n

     <\/p>\n

    --
    \n<\/strong>\u4f5c\u8005\uff1a\u838a\u5b87\u771f\uff0c\u7562\u696d\u65bc\u4ea4\u901a\u5927\u5b78\u79d1\u6280\u6cd5\u5f8b\u7814\u7a76\u6240\uff0c\u73fe\u4efb\u751f\u7269\u91ab\u5b78\u502b\u7406\u9818\u57df\u5c08\u4efb\u7814\u7a76\u52a9\u7406\u3002\u4eba\u751f\u6700\u6a02\u4e4b\u4e8b\u83ab\u904e\u65bc\u627e\u5230\u81ea\u5df1\u7684\u5fd7\u696d\uff0c\u5beb\u4f5c\u4e4b\u65bc\u6211\u6b63\u662f\u5982\u6b64\u3002\u70ba\u57ce\u90a6\u90e8\u843d\u683c\u300a\u5065\u5eb7\u77e5\u5fc3\u300b\u4e4b\u683c\u4e3b\uff0c\u64d4\u4efb\u570b\u5167\u300a\u719f\u5e74\u8a8c\u300b\u96dc\u8a8c\u91ab\u85e5\u65b0\u77e5\u7279\u7d04\u4f5c\u8005\u3002\u77e5\u8b58\u662f\u89f8\u89d2\uff0c\u8b93\u4eba\u638c\u63e1\u4e16\u754c\uff1b\u5065\u5eb7\u662f\u8ca1\u5bcc\uff0c\u8b93\u4eba\u4eab\u53d7\u4eba\u751f\u3002<\/strong><\/p>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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