{"id":30944,"date":"2018-05-14T08:48:41","date_gmt":"2018-05-14T00:48:41","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=30944"},"modified":"2018-07-29T19:34:13","modified_gmt":"2018-07-29T11:34:13","slug":"%e3%80%90%e4%ba%ba%e7%89%a9%e5%b0%88%e8%a8%aa%e3%80%91%e5%b0%8b%e5%af%b6%ef%bc%8c%e6%8f%ad%e9%96%8b%e7%94%9f%e5%91%bd%e7%9a%84%e9%9d%a2%e7%b4%97%e2%94%80%e2%94%80%e2%94%80%e2%94%80%e8%a8%aa%e9%98%ae-2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=30944","title":{"rendered":"\u3010\u4eba\u7269\u5c08\u8a2a\u3011\u5c0b\u5bf6\uff0c\u63ed\u958b\u751f\u547d\u7684\u9762\u7d17\u2500\u2500\u2500\u2500\u8a2a\u962e\u9e97\u84c9\u8001\u5e2b"},"content":{"rendered":"<p><span style=\"color: #008080;\"><strong>\u25cf5\/26 \u962e\u9e97\u84c9\u8001\u5e2b\u4e3b\u8b1b\uff1a\u300c\u6f14\u594fDNA\u751f\u547d\u6a02\u8b5c\u7684\u4ea4\u97ff\u6a02\u5718\uff1a\u8868\u89c0\u907a\u50b3\u300d<a style=\"color: #008080;\" 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Workman\u3002\u7576\u962e\u8001\u5e2b\u5411Workman\u6559\u6388\u8a00\u53ca\u5979\u60f3\u8981\u77ad\u89e3\u7684\u662f\u300c\u63a7\u5236\u751f\u547d\u7684\u57fa\u672c\u751f\u547d\u6cd5\u5247\u300d\u6642\uff0cWorkman\u6559\u6388\u6b23\u7136\u5c0d\u8001\u5e2b\u8aaa:\u300c\u5982\u679c\u9019\u662f\u59b3\u7684\u76ee\u6a19\uff0c\u90a3\u9ebc\u59b3\u5c31\u4f86\u5c0d\u4e86!\u6211\u7684\u5be6\u9a57\u5ba4\u7814\u7a76\u7684\u6b63\u662f\u300e\u88ab\u7d44\u86cb\u767d\u5305\u88f9\u7684DNA\u7a76\u7adf\u5982\u4f55\u88ab\u8f49\u9304\u6210RNA\u300f\uff0c\u5c31\u9019\u9ebc\u7c21\u55ae\uff0c\u6240\u6709\u771f\u6838\u751f\u547d\u90fd\u5fc5\u9808\u9075\u5faa\u7684\u6cd5\u5247\uff0c\u662f\u653e\u8af8\u5929\u4e0b\u7686\u6e96\u7684\u751f\u547d\u6cd5\u5247\u3002\u300d\u9019\u53e5\u8a71\uff0c\u81f3\u4eca\u4ecd\u8b93\u8001\u5e2b\u5370\u8c61\u6df1\u523b\uff0c\u4e5f\u662f\u9019\u9ebc\u4e00\u500b\u57fa\u672c\u537b\u53c8\u95dc\u9375\u7684\u7814\u7a76\u4e3b\u984c\uff0c\u8b93\u962e\u8001\u5e2b\u770b\u898b\u4e86\u751f\u547d\u7b54\u6848\u7684\u66d9\u5149\u3002<\/p>\n<p><span 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Workman\u6307\u51fa\uff0c\u7576DNA\u88ab\u7d44\u86cb\u767d\u5305\u88f9\u6642\u4e0d\u5bb9\u6613\u88ab\u8f49\u9304\u3002\u66f4\u9032\u4e00\u6b65\u7684\uff0c\u79d1\u5b78\u5bb6\u9010\u6f38\u77ad\u89e3\uff0c\u751f\u7269\u9ad4\u53ef\u4ee5\u5728\u7d44\u86cb\u767d\u53caDNA\u4e0a\u52a0\u4e0a\u4e0d\u540c\u7684\u5316\u5b78\u5b98\u80fd\u57fa\uff0c\u4f7fDNA\u5728\u4e0d\u6539\u8b8a\u5176\u9e7c\u57fa\u7d44\u6210\u5e8f\u5217\u7684\u60c5\u6cc1\u4e0b\uff0c\u8abf\u63a7\u7279\u5b9a\u57fa\u56e0\u7247\u6bb5\u7684\u8868\u73fe\uff0c\u4f7f\u8a72\u57fa\u56e0\u5728\u5408\u9069\u7684\u6642\u6a5f\u3001\u5408\u9069\u7684\u7d30\u80de\u4e2d\u88ab\u8f49\u9304\u6210RNA\uff0c\u518d\u88ab\u8f49\u8b6f\u70ba\u86cb\u767d\u8cea\uff0c\u57f7\u884c\u5404\u6a23\u7d30\u80de\u529f\u80fd\u3002\u9019\u500b\u8f49\u9304\u8abf\u63a7\u5f9e\u751f\u547d\u4e4b\u521d\uff0c\u4e00\u500b\u53d7\u7cbe\u5375\u958b\u59cb\u5206\u88c2\u6210\u5169\u500b\u3001\u56db\u500b\u7d30\u80de\u6642\uff0c\u4e00\u76f4\u5230\u6210\u5343\u4e0a\u842c\u500b\u7d30\u80de\u7684\u6210\u9ad4\uff0c\u5747\u626e\u6f14\u975e\u5e38\u91cd\u8981\u7684\u89d2\u8272\u3002<\/p>\n<p>\u65e9\u671f\u79d1\u5b78\u5bb6\u89c0\u5bdf\u5230\u7d44\u86cb\u767d\u548cDNA\u4e0a\u6709\u5316\u5b78\u57fa\u4fee\u98fe\uff0c\u53ea\u80fd\u63a8\u6e2c\u9019\u4e9b\u5316\u5b78\u4fee\u98fe\u7684\u529f\u80fd\uff0c\u4f46\u7121\u6cd5\u660e\u767d\u78ba\u5207\u7684\u6a5f\u5236\u3002\u96a8\u8457\u6642\u4ee3\u3001\u79d1\u6280\u7684\u9032\u6b65\uff0c\u5e7e\u4f4d\u5091\u51fa\u7684\u79d1\u5b78\u5bb6\u627e\u5230\u4e86\u5728\u7d44\u86cb\u767d\u4e0a\u63d2\u4e0a\u5404\u5f0f\u5404\u6a23\u5316\u5b78\u6a19\u7c64\u7684\u95dc\u9375\u9175\u7d20(\u9176)\uff0c\u9019\u500b\u9818\u57df\u9813\u6642\u958b\u59cb\u84ec\u52c3\u767c\u5c55\u3002\u79d1\u5b78\u5bb6\u627e\u51fa\u662f\u54ea\u4e00\u4e9b\u57fa\u56e0\u88fd\u9020\u51fa\u9019\u4e9b\u9176\uff0c\u7e7c\u800c\u900f\u904e\u751f\u7269\u6280\u8853\u628a\u9019\u6bb5\u57fa\u56e0\u5254\u9664\uff0c\u8b93\u7d30\u80de\u5931\u53bb\u9019\u7a2e\u9175\u7d20\uff0c\u7121\u6cd5\u5728\u7d44\u86cb\u767d\u548cDNA\u4e0a\u63d2\u4e0a\u7279\u5b9a\u6a19\u7c64\uff0c\u518d\u89c0\u5bdf\u7d30\u80de\u767c\u751f\u4e86\u4ec0\u9ebc\u8b8a\u5316\u3002\u4e4b\u5f8c\uff0c\u79d1\u5b78\u5bb6\u56de\u63a8\u9019\u7a2e\u5728\u7d44\u86cb\u767d\u4e0a\u7684\u6a19\u7c64\u5230\u5e95\u4ee3\u8868\u8457\u54ea\u4e9b\u542b\u610f\uff0c\u66f4\u9032\u4e00\u6b65\u5728\u8907\u96dc\u7684\u5c0f\u9f20\uff0c\u4e43\u81f3\u65bc\u4eba\u985e\uff0c\u77ad\u89e3\u9019\u4e9b\u5316\u5b78\u6a19\u7c64\u7684\u529f\u80fd\uff0c\u5f9e\u800c\u9084\u539f\u51fa\u66f4\u8cbc\u8fd1\u4e8b\u5be6\u7684\u771f\u76f8\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u63a8\u7a97\u800c\u5f8c\u80fd\u671b\u6708<\/strong><\/span><\/p>\n<p>\u5230\u4e86\u4eba\u985e\u968e\u6bb5\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\uff0c\u5f88\u591a\u75be\u75c5\u7684\u767c\u751f\uff0c\u90fd\u548c\u8868\u89c0\u907a\u50b3\u56e0\u5b50\u767c\u751f\u7a81\u8b8a\u6709\u95dc\u3002\u6bd4\u5982\uff0c\u7576\u6291\u5236\u816b\u7624\u767c\u751f\u7684\u57fa\u56e0\u88ab\u904e\u5ea6\u7532\u57fa\u5316\u800c\u6291\u5236\u8868\u73fe\u91cf\u6642\uff0c\u7d30\u80de\u5c31\u5bb9\u6613\u812b\u5e8f\uff0c\u5f62\u6210\u764c\u75c7\u3002\u962e\u8001\u5e2b\u7684\u7814\u7a76\u4e3b\u984c\uff0c\u4e3b\u8981\u63a2\u8a0e\u8868\u89c0\u907a\u50b3\u548c\u767c\u80b2\u53ca\u75be\u75c5\u4e4b\u9593\u7684\u95dc\u806f\u3002\u65e9\u671f\u7684\u7814\u7a76\u63a2\u8a0e\u4e00\u7a2e\u611f\u67d3\u7d30\u80de\u7684\u75c5\u6bd2(\u4eba\u985e\u5de8\u7d30\u80de\u75c5\u6bd2)\u5982\u4f55\u63a7\u5236\u5bbf\u4e3b\u7684\u8868\u89c0\u907a\u50b3\u6a5f\u5236\u3002\u9019\u7a2e\u75c5\u6bd2\u572870-80%\u7684\u4eba\u8eab\u4e0a\u7d30\u80de\u6f5b\u4f0f\uff0c\u7576\u5bbf\u4e3b\u56e0\u70ba\u7f79\u60a3\u611b\u6ecb\u75c5\uff0c\u6216\u63a5\u53d7\u9aa8\u9ad3\u79fb\u690d\uff0c\u670d\u7528\u964d\u4f4e\u514d\u75ab\u529b\u907f\u514d\u6392\u65a5\u4f5c\u7528\u7684\u85e5\u7269\u7b49\u56e0\u7d20\uff0c\u800c\u514d\u75ab\u529b\u4f4e\u843d\u6642\uff0c\u4fbf\u300c\u9192\u300d\u904e\u4f86\u5927\u8086\u4f5c\u602a\uff0c\u6700\u56b4\u91cd\u6642\u53ef\u9020\u6210\u75c5\u4eba\u6b7b\u4ea1\u3002\u962e\u8001\u5e2b\u767c\u73fe\uff0c\u9019\u7a2e\u75c5\u6bd2\u975e\u5e38\u300c\u8070\u660e\u300d\uff0c\u5b83\u6703\u63a7\u5236\u5bbf\u4e3b\u7d30\u80de\u7684\u8868\u89c0\u907a\u50b3\u56e0\u5b50\uff0c\u4e26\u85c9\u6b64\u7671\u7613\u816b\u7624\u6291\u5236\u57fa\u56e0p53\u3002\u66f4\u6709\u8da3\u7684\u662f\uff0c\u4eba\u985e\u5de8\u7d30\u80de\u75c5\u6bd2\u7684\u8907\u88fd\u9700\u8981\u4ef0\u8cf4\u5bbf\u4e3b\u7d30\u80de\u4f5c\u70ba\u5de5\u5ee0\uff0c\u5b83\u6703\u53bb\u7d81\u67b6\u539f\u4f86\u5354\u52a9\u5bbf\u4e3b\u7d30\u80de\u7d44\u86cb\u767d\u5305\u88f9DNA\u7684\u4e00\u7fa4\u67d3\u8272\u8cea\u86cb\u767d\u5230\u81ea\u5df1\u7684\u8907\u88fd\u4e2d\u5fc3\uff0c\u4f7f\u5bbf\u4e3b\u7d30\u80de\u7684DNA\u8907\u88fd\u505c\u64fa\uff0c\u75c5\u6bd2\u81ea\u5df1\u5247\u6301\u7e8c\u8907\u88fd\u3002<\/p>\n<p>\u4e4b\u5f8c\uff0c\u962e\u8001\u5e2b\u5728\u7814\u7a76\u764c\u75c7\u548c\u8868\u89c0\u907a\u50b3\u7684\u95dc\u4fc2\u6642\uff0c\u767c\u73fe\u4e00\u7a2e\u7279\u5225\u7684\u9175\u7d20N-\u03b1-acetyltransferase 10 protein (Naa10p)\u5728\u4eba\u985e\u7684\u80ba\u764c\u7d30\u80de\u4e2d\u6703\u5927\u91cf\u8868\u73fe\uff0c\u4e26\u4e14\u8868\u73fe\u5f97\u8d8a\u591a\uff0c\u75c5\u4eba\u7684\u7652\u5f8c\u60c5\u5f62\u8d8a\u5dee\u3002\u79d1\u5b78\u5bb6\u539f\u672c\u53ea\u77e5\u9053\u9019\u500b\u9175\u7d20\u5728\u7d30\u80de\u8cea\u4e2d\u7684\u6838\u7cd6\u9ad4\u66ff\u8f49\u8b6f\u51fa\u7684\u7b2c\u4e00\u500b\u80fa\u57fa\u9178\u52a0\u4e0a\u4e00\u500b\u4e59\u91af\u57fa\uff0c2010\u5e74\uff0c\u962e\u8001\u5e2b\u7684\u7814\u7a76\u767c\u73fe\uff0c\u5b83\u4e5f\u6703\u9032\u5165\u7d30\u80de\u6838\u4e2d\uff0c\u8abf\u63a7\u6291\u764c\u57fa\u56e0\u7684\u7532\u57fa\u5316\u30022011\u5e74\u4e4b\u5f8c\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\uff0cNaa10p\u7684\u91cd\u8981\u4f4d\u7f6e\u4e0a\u767c\u751f\u4e0d\u540c\u4f4d\u7f6e\u7684\u9ede\u7a81\u8b8a\uff0c\u6539\u8b8a\u55ae\u4e00\u500b\u80fa\u57fa\u9178\uff0c\u53ef\u9020\u6210\u56b4\u91cd\u767c\u80b2\u9072\u7de9\uff0c\u5176\u4e2d\u4e00\u7a2e\u9ede\u7a81\u8b8a\u5c0e\u81f4\u7684\u767c\u80b2\u9072\u7de9\u7a31\u70ba\u5967\u683c\u767b\u75c7\u5019\u7fa4(Ogden syndrome) \u3002\u7f79\u60a3\u5967\u683c\u767b\u75c7\u5019\u7684\u75c5\u4eba\u6d3b\u4e0d\u904e\u4e00\u6b72\u534a\uff0c\u800c\u5e36\u6709\u5176\u4ed6\u9ede\u7a81\u8b8a\u50e5\u5016\u5b58\u6d3b\u7684\u75c5\u4eba\u5247\u90fd\u6709\u667a\u80fd\u969c\u7919\u7684\u554f\u984c\u3002\u962e\u8001\u5e2b\u900f\u904e\u88fd\u9020\u8a72\u57fa\u56e0\u7684\u57fa\u56e0\u5254\u9664\u9f20(knockout mice)\u9032\u884c\u7814\u7a76\uff0c\u767c\u73fe\u670930%\u7684\u5c0f\u9f20\u5728\u80da\u80ce\u6642\u671f\u6b7b\u4ea1\uff0c\u5269\u4e0b\u7684\u5247\u5bb9\u6613\u7f79\u60a3\u6c34\u8166\u6b7b\u4ea1\uff0c\u5b58\u6d3b\u4e0b\u4f86\u7684\u7d04\u53ea\u6709\u4e00\u534a\u7684\u5c0f\u9f20\u5247\u6709\u9ad4\u91cd\u6e1b\u8f15\u3001\u8166\u795e\u7d93\u7570\u5e38\u3001\u667a\u80fd\u4e0d\u8db3\u7b49\u767c\u80b2\u9072\u7de9\u3001\u4e0d\u5168\u7684\u554f\u984c\u3002\u66f4\u7279\u5225\u7684\u662f\uff0c\u5982\u679c\u4ee5knockout\u5c0f\u9f20\u4f5c\u70ba\u6bcd\u89aa\uff0c\u5247\u65b0\u751f\u7684\u5c0f\u9f20\u572824\u5c0f\u6642\u5167\u6703\u592d\u6298\uff0c\u53cd\u4e4b\uff0c\u6c92\u6709Naa10p\u57fa\u56e0\u7684\u7238\u7238\u4ea4\u914d\u7522\u4e0b\u7684\u5c0f\u9f20\u5247\u6c92\u6709\u76f8\u95dc\u554f\u984c\u3002\u962e\u8001\u5e2b\u5be6\u9a57\u5ba4\u6700\u5f8c\u767c\u73fe\uff0cNaa10p\u5728\u80da\u80ce\u53ca\u5e79\u7d30\u80de\u4e2d\u8abf\u63a7DNA\u7532\u57fa\u5316\u53ca\u5370\u8a18\u57fa\u56e0(imprint)\u7684\u8868\u73fe\u3002DNA\u7532\u57fa\u5316\u53ca\u5370\u8a18\u57fa\u56e0\u7b49\u8868\u89c0\u907a\u50b3\u6a5f\u5236\u5931\u8abf\uff0c\u5f88\u53ef\u80fd\u662fNaa10p\u7a81\u8b8a\u9020\u6210\u4eba\u985e\u75be\u75c5\u7684\u91cd\u8981\u539f\u56e0\u3002\u5370\u8a18\u57fa\u56e0\u4e5f\u662f\u8868\u89c0\u907a\u50b3\u8a0e\u8ad6\u7684\u4e00\u500b\u6709\u8da3\u8b70\u984c\uff0c\u4e5f\u5c31\u662f\u8aaa\uff0c\u6709\u90e8\u5206\u5206\u5225\u4f86\u81ea\u65bc\u7238\u7238\u548c\u5abd\u5abd\u7684\u5c0d\u5076\u57fa\u56e0\uff0c\u6703\u9078\u64c7\u6027\u7684\u53ea\u8868\u73fe\u5176\u4e2d\u4f86\u81ea\u7238\u7238\u6216\u5abd\u5abd\u7684\u7279\u5b9a\u5c0d\u5076\u57fa\u56e0\uff0c\u53e6\u4e00\u500b\u5247\u900f\u904e\u8868\u89c0\u907a\u50b3\u7684\u65b9\u5f0f\u6291\u5236\u5176\u8868\u73fe\uff0c\u986f\u793a\u9019\u985e\u57fa\u56e0\u7684\u8868\u73fe\u91cf\u591a\u5be1\u5c0d\u751f\u7269\u9ad4\u7684\u751f\u5b58\u5f71\u97ff\u81f3\u95dc\u91cd\u5927\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u4e0b\u4e00\u7ad9<\/strong><strong>:<\/strong><strong>\u9ec3\u91d1\u7480\u74a8<\/strong><\/span><\/p>\n<p>\u81ea\u83ef\u751f\u548c\u514b\u91cc\u514b\u57281953\u5e74\u767c\u73feDNA\u96d9\u80a1\u87ba\u65cb\u7d50\u69cb\u8d77\uff0c\u5230\u4eca\u5929\uff0c65\u5e74\u88e1\uff0c\u6211\u5011\u6709\u4e86\u751f\u7269\u6280\u8853\uff0c\u53ef\u4ee5\u5b9a\u5e8f\u3001\u89e3\u8b80\u7684\u751f\u7269\u5929\u66f8\uff0c\u751a\u81f3\u6709\u4e86\u57fa\u56e0\u7de8\u8f2f\u7684\u5de5\u5177\u53ef\u4ee5\u81ea\u7531\u6539\u5beb\u5929\u66f8\u4e2d\u7684\u6587\u5b57\u5bc6\u78bc\u3002\u6bd4\u8d77\u904e\u53bb\uff0c\u751f\u7269\u5b78\u7684\u9032\u5c55\u53ef\u4ee5\u8aaa\u662f\u5f9e\u4e00\u89c0\u5bdf\u4e00\u73fe\u8c61\u7684\u8778\u725b\u6162\u722c\uff0c\u5230\u4e00\u53e3\u6c23\u7531\u6839\u57fa\u8457\u624b\u89e3\u78bc\uff0c\u5982\u540c\u642d\u4e58\u592a\u7a7a\u68ad\u822c\u6025\u901f\u800c\u884c\u3002<\/p>\n<p>\u4e0b\u4e00\u6b65\uff0c\u4eba\u985e\u6703\u5728\u90a3\u5152\uff1f\u962e\u9e97\u84c9\u8001\u5e2b\u7279\u5225\u5f37\u8abf\uff0c\u5728\u9019\u500b\u9818\u57df\u88e1\uff0c\u300c\u597d\u5947\u5fc3\u300d\u5c31\u662f\u4e00\u5207\u7684\u539f\u52d5\u529b\u3002\u56e0\u70ba\u60f3\u77e5\u9053\uff0c\u6240\u4ee5\u6703\u53bb\u6316\u6398\uff0c\u6240\u4ee5\u80fd\u5f97\u5230\u767c\u73fe\uff0c\u8aaa\u6709\u8da3\u7684\u6545\u4e8b\u3002\u962e\u8001\u5e2b\u76ee\u524d\u6b63\u7a4d\u6975\u63a2\u8a0eNaa10p\u548c\u8868\u89c0\u907a\u50b3\u56e0\u5b50\u5982\u4f55\u8abf\u63a7\u8166\u529f\u80fd\u53ca\u8166\u76f8\u95dc\u9000\u5316\u75be\u75c5\uff0c\u975e\u5e38\u671f\u5f85\u597d\u5947\u5bf6\u5bf6\u5011\u52a0\u5165\u5718\u968a\u3002\u751f\u547d\u5230\u5e95\u662f\u4ec0\u9ebc\uff0c\u5b83\u662f\u5982\u4f55\u767c\u751f\u53c8\u662f\u5982\u4f55\u7cbe\u6e96\u8abf\u63a7\u51fa\u591a\u8b8a\u7684\u7dba\u9e97\u4e16\u754c\uff1f\u9019\u4e9b\u554f\u984c\u7684\u7b54\u6848\u76ee\u524d\u96d6\u4ecd\u672a\u88ab\u5b8c\u5168\u89e3\u958b\uff0c\u4f46\u63ed\u958b\u7684\u4e00\u89d2\u5df2\u900f\u9732\u51fa\u751f\u547d\u7684\u6df5\u535a\u548c\u7cbe\u7dfb\u3002\u7121\u8ad6\u7b54\u6848\u662f\u4ec0\u9ebc\uff0c\u8868\u89c0\u907a\u50b3\u90fd\u5c07\u5728\u89e3\u7b54\u7684\u821e\u53f0\u4e0a\u6f14\u51fa\u76db\u5927\u7684\u5287\u5e55\u3002<\/p>\n<p><iframe 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