{"id":30746,"date":"2018-04-26T01:03:51","date_gmt":"2018-04-25T17:03:51","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=30746"},"modified":"2018-07-12T20:16:00","modified_gmt":"2018-07-12T12:16:00","slug":"%e3%80%90dna65%e9%80%b1%e5%b9%b4%e3%80%91%e5%b9%95%e5%be%8c%e8%8a%b1%e7%b5%ae-%e6%8f%92%e5%9c%96%e7%9a%84%e4%bd%9c%e8%80%85","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=30746","title":{"rendered":"\u3010DNA65\u9031\u5e74\u3011\u5e55\u5f8c\u82b1\u7d6e\u2014\u2014\u63d2\u5716\u7684\u4f5c\u8005"},"content":{"rendered":"<figure id=\"attachment_30747\" aria-describedby=\"caption-attachment-30747\" style=\"width: 126px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-30747\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/04\/1523329819859.jpg\" alt=\"\" width=\"126\" height=\"400\" \/><figcaption id=\"caption-attachment-30747\" class=\"wp-caption-text\">\u8ad6\u6587\u7684\u63d2\u5716<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c\u8449\u7da0\u8212<\/strong><\/p>\n<p>\u4e0d\u77e5\u9053DNA\u96d9\u87ba\u65cb\u7d50\u69cb\u662f\u7531\u83ef\u751f\uff08James D. Watson\uff0c1928-\uff09\u8207\u514b\u91cc\u514b\uff08Francis Crick\uff0c1916-2004\uff09\u5169\u4eba\u89e3\u51fa\u7684\u4eba\uff0c\u61c9\u8a72\u5f88\u5c11\uff1b\u4f46\u662f\u6709\u591a\u5c11\u4eba\u8b80\u904e1953\u5e74\u56db\u6708\u520a\u767b\u5728\u300a\u81ea\u7136\u300b\uff08Nature\uff09\u671f\u520a\u4e0a\u7684\u90a3\u7bc7\u8ad6\u6587\u5462\uff1f\u96d6\u7136\u520a\u767b\u5728\u300a\u81ea\u7136\u300b\u8207\u300a\u79d1\u5b78\u300b\uff08Science\uff09\u5169\u5927\u671f\u520a\u4e0a\u7684\u8ad6\u6587\u4e00\u822c\u90fd\u5f88\u77ed\uff0c\u4f46\u9019\u7bc7\u8ad6\u6587\u66f4\u662f\u77ed\u4e2d\u4e4b\u77ed\uff0c\u53ea\u6709\u4e00\u9801\u591a\u4e00\u9ede\u9ede\uff08842\u500b\u5b57\uff09\u8207\u4e00\u500b\u63d2\u5716\u3002\uff08<a href=\"http:\/\/www.sns.ias.edu\/~tlusty\/courses\/landmark\/WatsonCrick1953.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">\u8ad6\u6587\u9ede\u6b64<\/a>\uff09<\/p>\n<p>\u63d2\u5716\u4ee5\u4e00\u7a2e\u5beb\u610f\u7684\u65b9\u5f0f\uff0c\u5c07DNA\u7684\u96d9\u87ba\u65cb\u512a\u96c5\u5730\u63cf\u7e6a\u51fa\u4f86\uff1b\u4e2d\u9593\u7684\u6a6b\u69d3\u4ee3\u8868\u4e86\u817a\u560c\u5464\u8207\u80f8\u817a\u5627\u5576\u3001\u9ce5\u7cde\u560c\u5464\u8207\u80de\u5627\u5576\u4ee5\u6c2b\u9375\u7d50\u5408\u7684\u578b\u614b\uff1b\u5169\u500b\u5c0f\u5c0f\u7684\u53cd\u5411\u7bad\u982d\u8aaa\u660e\u4e86\u9019\u87ba\u65cb\u7684\u96d9\u80a1\u7684\u8d70\u5411\u662f\u76f8\u53cd\u7684\uff08\u53cd\u5e73\u884c\uff0canti-parallel\uff09\u3002<\/p>\n<p>\u9019\u5f35\u5716\u662f\u8ab0\u756b\u7684\u5462\uff1f\u96d6\u7136\u7d55\u5927\u90e8\u5206\u671f\u520a\u8ad6\u6587\u7684\u5716\u90fd\u662f\u7814\u7a76\u8005\u81ea\u884c\u7e6a\u88fd\u3001\u6216\u662f\u5be6\u9a57\u5ba4\u88e1\u9762\u7684\u540c\u4ec1\u4ee3\u70ba\u6349\u5200\u7e6a\u88fd\uff08\u4e0d\u53ef\u5426\u8a8d\u7684\uff0c\u6703\u4f5c\u5be6\u9a57\u7684\u4eba\u4e0d\u4e00\u5b9a\u6703\u756b\u5716\uff09\uff0c\u4f46\u9019\u7bc7\u8ad6\u6587\u88e1\u7684\u5716\uff0c\u662f\u7531\u4e00\u4f4d\u79d1\u5b78\u7814\u7a76\u5b8c\u5168\u5916\u884c\u7684\u4eba\u2014\u514b\u91cc\u514b\u7684\u592a\u592a\u5967\u8482\u5152\u2027\u53f2\u7562\u5fb7\uff08Odile Speed\uff0c1920-2007\uff09\u3002<!--more--><\/p>\n<p>\u5967\u8482\u5152\u8207\u514b\u91cc\u514b\u57281945\u5e74\u5728\u502b\u6566\u7684\u6d77\u8ecd\u90e8\u8fa6\u516c\u5ba4\u76f8\u9047\uff0c\u7576\u6642\u514b\u91cc\u514b\u5df2\u8207\u7b2c\u4e00\u4efb\u592a\u592a\u5206\u5c45\uff1b\u96d6\u7136\u514b\u91cc\u514b\u7b2c\u4e00\u6b21\u7d04\u5979\u51fa\u53bb\u88ab\u62d2\u7d55\u4e86\uff0c\u4e0d\u904e\u7b2c\u4e8c\u6b21\u7684\u5348\u9910\u9080\u7d04\u5f97\u5230\u5141\u8a31\u3002\u5967\u8482\u5152\u4f86\u81ea\u73e0\u5bf6\u5546\u5bb6\u5ead\uff0c\u6bcd\u89aa\u662f\u6cd5\u570b\u4eba\uff0c\u82e5\u4e0d\u662f\u4e8c\u6b21\u4e16\u754c\u5927\u6230\u7206\u767c\uff0c\u5979\u539f\u672c\u8981\u53bb\u5df4\u9ece\u8b80\u85dd\u8853\u5b78\u6821\u7684\u3002\u7b49\u52301947\u5e74\u514b\u91cc\u514b\u548c\u7b2c\u4e00\u4efb\u59bb\u5b50\u96e2\u5a5a\u5f8c\uff0c\u5169\u4eba\u57281949\u5e74\u516b\u6708\u7d50\u5a5a\u3002<\/p>\n<figure id=\"attachment_30748\" aria-describedby=\"caption-attachment-30748\" style=\"width: 490px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-30748\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/04\/F4.large_.jpg\" alt=\"\" width=\"490\" height=\"340\" \/><figcaption id=\"caption-attachment-30748\" class=\"wp-caption-text\">\u5169\u4eba\u65bc1949\u5e74\u7d50\u5a5a<\/figcaption><\/figure>\n<p>1953\u5e74\u4e09\u6708\u5341\u4e8c\u65e5\uff0c\u5728\u5a01\u723e\u91d1\u65af\uff08Maurice H. F. Wilkins\uff0c1916-2004\uff09\u3001\u5bcc\u862d\u514b\u6797\uff08Rosalind E. Franklin\uff0c1920-1958\uff09\u7b49\u4eba\u770b\u904e\u9019\u500b\u6a21\u578b\u5f8c\uff0c\u85cd\u5fb7\u723e\uff08John Randall\uff0c1905-1984\uff09\u8207\u300a\u81ea\u7136\u300b\u7684\u7de8\u8f2f\u9054\u6210\u5354\u8b70\uff0c\u8b93\u4e09\u7bc7\u8ad6\u6587\u540c\u6642\u520a\u767b\u3002\u7b2c\u4e00\u7bc7\u5c31\u662f\u83ef\u751f\u8207\u514b\u91cc\u514b\u7684\u300c\u53bb\u6c27\u6838\u7cd6\u6838\u9178\u7684\u7d50\u69cb\u300d\uff08Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid\uff09\uff0c\u6587\u7a3f\u7531\u514b\u91cc\u514b\u8d77\u8349\uff0c\u83ef\u751f\u7684\u59b9\u59b9\u8c9d\u8482\u5e6b\u5fd9\u6253\u5b57\uff0c\u5716\u5247\u7531\u5967\u8482\u5152\u7e6a\u88fd\u3002<\/p>\n<p>\u96d6\u7136\u5967\u8482\u5152\u66fe\u77ed\u66ab\u5730\u7576\u904e\u4e00\u9663\u5b50\u7684\u6559\u5e2b\uff0c\u4e0d\u904e\u5728\u5979\u8207\u514b\u91cc\u514b\u7684\u5973\u5152\u5011\u63a5\u9023\u51fa\u751f\u5f8c\uff0c\u5979\u4fbf\u5c08\u5fc3\u5728\u5bb6\u5e36\u5b69\u5b50\uff0c\u6c92\u6709\u518d\u51fa\u53bb\u5de5\u4f5c\u4e86\u3002<\/p>\n<p>\u8981\u5728\u77ed\u6642\u9593\uff08\u4e09\u6708\u5341\u516b\u65e5\u8ad6\u6587\u8349\u7a3f\u5b8c\u5de5\u3001\u5bc4\u5230\u570b\u738b\u5b78\u9662\uff09\u756b\u51fa\u5982\u6b64\u7c21\u6f54\u53c8\u5beb\u610f\u7684\u69cb\u9020\u5716\uff0c\u975e\u5967\u8482\u5152\u7684\u85dd\u8853\u5929\u8ce6\u83ab\u8fa6\uff1b\u5728\u5979\u8207\u514b\u91cc\u514b\u516d\u5341\u5e74\u7684\u5a5a\u59fb\u751f\u6d3b\u4e2d\uff0c\u5979\u4e5f\u4e00\u76f4\u4ee5\u79d1\u5b78\u7684\u5c40\u5916\u4eba\u7684\u89d2\u8272\uff0c\u9069\u5ea6\u5730\u8abf\u548c\u514b\u91cc\u514b\u7684\u751f\u6d3b\u3002\u4ed6\u5011\u7684\u5bb6\u4e2d\u5e38\u6709\u85dd\u8853\u65b9\u9762\u7684\u6d3e\u5c0d\uff0c\u800c\u5728\u7b2c\u4e8c\u500b\u5973\u5152\u51fa\u751f\u524d\uff0c\u7576\u6642\uff081954\uff09\u6eff\u8166\u5b50\u90fd\u662fDNA\u7684\u514b\u91cc\u514b\u7adf\u7136\u63d0\u8b70\u8981\u628a\u5973\u5152\u547d\u540d\u70ba\u300cAdenine\u300d\uff08\u817a\u560c\u5464\uff09\uff0c\u4e5f\u88ab\u5979\u62d2\u7d55\u4e86\uff08\u9019\u500b\u5e78\u904b\u7684\u5c0f\u670b\u53cb\u5f8c\u4f86\u53eb\u505a\u8cc8\u6842\u7433\uff0cJacqueline\uff09\u3002\u60f3\u60f3\u4e00\u500b\u540d\u53ebAdenine\u7684\u5c0f\u5973\u751f\u5728\u5b78\u6821\u6703\u600e\u6a23\u88ab\u6b3a\u8ca0\u2026\u6211\u89ba\u5f97\u5979\u61c9\u8a72\u7531\u8877\u611f\u6fc0\u5979\u7684\u6bcd\u89aa\u7684\u777f\u667a\u3002<\/p>\n<p>\u9019\u7bc7\u53ea\u6709\u5169\u500b\u4f5c\u8005\uff08\u96d6\u7136\u5a01\u723e\u91d1\u65af\u8207\u5bcc\u862d\u514b\u6797\u7684\u540d\u5b57\u61c9\u8a72\u8981\u5728\u4e0a\u9762\uff09\u8207\u4e00\u5f35\u5716\u7684\u8d85\u77ed\u8ad6\u6587\uff0c\u5169\u4f4d\u4f5c\u8005\u7684\u8ca2\u737b\u5ea6\u5176\u5be6\u5dee\u4e0d\u591a\uff1b\u4f46\u6700\u5f8c\u7684\u6392\u5e8f\u662f\u83ef\u751f\u7b2c\u4e00\u3001\u514b\u91cc\u514b\u7b2c\u4e8c\uff1b\u9019\u500b\u6392\u5e8f\u53c8\u662f\u600e\u9ebc\u6c7a\u5b9a\u7684\u5462\uff1f\u662f\u4e1f\u9285\u677f\u6c7a\u5b9a\u7684\uff01\u60f3\u4e0d\u5230\u5427\uff01\u4f46\u4e5f\u56e0\u6b64\uff0c\u6211\u5011\u63d0\u5230DNA\u7d50\u69cb\uff0c\u6c38\u9060\u90fd\u662f\u300c\u83ef\u751f-\u514b\u91cc\u514b\u300d\u9019\u6a23\u8b1b\uff0c\u751a\u81f3\u9020\u6210\u6709\u4f4d\u79d1\u5b78\u5bb6\u7b2c\u4e00\u6b21\u770b\u5230\u514b\u91cc\u514b\u672c\u5c0a\u6642\uff0c\u5f88\u9a5a\u8a1d\u5730\u8aaa\uff1a\u539f\u4f86\u4f60\u59d3\u514b\u91cc\u514b\u800c\u5df2\u5594\uff1f<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u4e0d\u77e5\u9053DNA\u96d9\u87ba\u65cb\u7d50\u69cb\u662f\u7531\u83ef\u751f\uff08James D. Watson\uff0c1928-\uff09\u8207\u514b\u91cc\u514b\uff08Francis Crick\uff0c1916-2004\uff09\u5169\u4eba\u89e3\u51fa\u7684\u4eba\uff0c\u61c9\u8a72\u5f88\u5c11\uff1b\u4f46\u662f\u6709\u591a\u5c11\u4eba\u8b80\u904e1953\u5e74\u56db\u6708\u520a\u767b\u5728\u300a\u81ea\u7136\u300b\uff08Nature\uff09\u671f\u520a\u4e0a\u7684\u90a3\u7bc7\u8ad6\u6587\u5462\uff1f\u96d6\u7136\u520a\u767b\u5728\u300a\u81ea\u7136\u300b\u8207\u300a\u79d1\u5b78\u300b\uff08Science\uff09\u5169\u5927\u671f\u520a\u4e0a\u7684\u8ad6\u6587\u4e00\u822c\u90fd\u5f88\u77ed\uff0c\u4f46\u9019\u7bc7\u8ad6\u6587\u66f4\u662f\u77ed\u4e2d\u4e4b\u77ed\uff0c\u53ea\u6709\u4e00\u9801\u591a\u4e00\u9ede\u9ede\uff08842\u500b\u5b57\uff09\u8207\u4e00\u500b\u63d2\u5716\u3002<br \/>\n\u63d2\u5716\u4ee5\u4e00\u7a2e\u5beb\u610f\u7684\u65b9\u5f0f\uff0c\u5c07DNA\u7684\u96d9\u87ba\u65cb\u512a\u96c5\u5730\u63cf\u7e6a\u51fa\u4f86\u3002\u90a3\uff0c\u7e6a\u8005\u7a76\u7adf\u662f\u8ab0\u5462\uff1f<\/p>\n","protected":false},"author":20,"featured_media":30748,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1042,3100],"tags":[3775,3776,3804],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/04\/F4.large_.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/30746"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=30746"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/30746\/revisions"}],"predecessor-version":[{"id":31455,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/30746\/revisions\/31455"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/30748"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=30746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=30746"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=30746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}