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\u90ed\u6587\u83ef\u6559\u6388<\/strong><br \/>\n<strong>\u6574\u7406\u64b0\u6587\uff5c\u9ad8\u82f1\u54f2<\/strong><\/p>\n<p>\u7cd6\u5c3f\u75c5\u65e9\u5728\u897f\u5143 2 \u4e16\u7d00\u5c31\u6709\u8a18\u8f09\uff0c\u4e0d\u904e\u76f4\u5230 1889 \u5e74\uff0c\u4eba\u5011\u624d\u767c\u73fe\u80f0\u817a\u8207\u7cd6\u5c3f\u75c5\u4e4b\u9593\u7684\u95dc\u4fc2\u3002 1922 \u5e74\u6210\u529f\u5206\u96e2\u80f0\u5cf6\u7d20\uff0c\u7528\u65bc\u9032\u884c\u7cd6\u5c3f\u75c5\u6cbb\u7642\uff0c\u4e4b\u5f8c\u53c8\u5c07\u7cd6\u5c3f\u75c5\u5340\u5206\u70ba\u907a\u50b3\u6027\u7684\u4e00\u578b\u8ddf\u904e\u91cd\u7684\u4e8c\u578b\uff0c\u9032\u884c\u66f4\u7cbe\u6e96\u7684\u6cbb\u7642\u3002<\/p>\n<p>\u78fa\u91af\u8132\u985e (sulfonylurea) \u662f\u5728 1950 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\u85e5\u7269\u51fa\u73fe\u4e4b\u5f8c\uff0c\u624d\u53c8\u91cd\u8fd4\u81e8\u5e8a\u7528\u85e5\u3002\u66fe\u7d93\u5099\u53d7\u671f\u5f85\u7684\u964d\u8840\u7cd6\u96d9\u80cd\u985e\u85e5\u7269\u964d\u7cd6\u9748 (phenformin) \uff0c\u56e0\u70ba\u53ef\u80fd\u5c0e\u81f4\u4e73\u9178\u8840\u75c7\uff0c\u5728 1978 \u5e74\u5728\u7f8e\u570b\u906d\u5230\u7981\u7528\u3002\u5982\u4eca\u4e3b\u5c0e\u7cd6\u5c3f\u75c5\u85e5\u7269\u5e02\u5834\u7684\u5eab\u9b6f\u5316 (metformin) \uff0c\u50f9\u683c\u4fbf\u5b9c\u6548\u679c\u53c8\u597d\uff0c\u662f\u76ee\u524d\u6cbb\u7642\u4e8c\u578b\u7cd6\u5c3f\u75c5\u7684\u9996\u9078\u85e5\u7269\u3002<!--more--><\/p>\n<p>\u5eab\u9b6f\u5316\u7684\u7528\u85e5\u53f2\u76f8\u7576\u6709\u610f\u601d\u3002\u5b83\u5728 1950 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