{"id":30129,"date":"2018-02-02T00:16:41","date_gmt":"2018-02-01T16:16:41","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=30129"},"modified":"2018-08-29T17:05:01","modified_gmt":"2018-08-29T09:05:01","slug":"%e7%95%b6%e5%bf%83%e7%97%9b%e8%ae%8a%e6%88%90%e7%9c%9f%e7%97%9b%ef%bc%9a%e8%97%a5%e8%b2%b4%e4%b8%80%e5%b0%ba%ef%bc%8c%e5%89%af%e4%bd%9c%e7%94%a8%e6%9c%83%e4%b8%8d%e6%9c%83%e4%b9%9f%e9%ab%98%e4%b8%80","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=30129","title":{"rendered":"\u7576\u5fc3\u75db\u8b8a\u6210\u771f\u75db\uff1a\u85e5\u8cb4\u4e00\u5c3a\uff0c\u526f\u4f5c\u7528\u6703\u4e0d\u6703\u4e5f\u9ad8\u4e00\u4e08\uff1f"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u6108\u8cb4\u7684\u85e5\uff0c\u771f\u6703\u8b93\u6211\u5011\u5728\u6f5b\u610f\u8b58\u88e1\u89ba\u5f97\u6108\u6709\u6548\u55ce\uff1f\u5982\u679c\u6709\u300c\u5fc3\u60f3\u300e\u85e5\u6548\u300f\u6210\u300d\u7684\u5b89\u6170\u5291\u6548\u61c9\uff08placebo effect\uff09\uff0c\u6bd4\u8f03\u8cb4\u7684\u85e5\u6703\u4e0d\u6703\u8b93\u75c5\u60a3\u89ba\u5f97\uff0c\u56e0\u70ba\u85e5\u6548\u5f37\uff0c\u526f\u4f5c\u7528\u4e5f\u6bd4\u8f03\u9ad8\uff0c\u800c\u8b93\u9019\u4e9b\u9ad8\u50f9\u85e5\u7269\u88ab\u300c\u8166\u5167\u5c0f\u5287\u5834\u300d\u53cd\u5c07\u4e00\u8ecd\uff0c\u4ee5\u81f3\u65bc\u526f\u4f5c\u7528\u767c\u751f\u7684\u6a5f\u7387\u4e5f\u6bd4\u8f03\u9ad8\u5462\uff1f<\/strong><\/span><\/p>\n<figure id=\"attachment_30130\" aria-describedby=\"caption-attachment-30130\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-30130\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/12\/a-research-study-revealed-the-top-five-most-expensive-drugs-in-the-world.jpg\" alt=\"\" width=\"450\" height=\"312\" \/><figcaption id=\"caption-attachment-30130\" class=\"wp-caption-text\">High cost of healthcare<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c\u99f1\u5b9b\u7433<\/strong><\/p>\n<p>\u5200\u6709\u5169\u5203\uff0c\u786c\u5e63\u6709\u5169\u9762\uff0c\u6bcf\u4ef6\u4e8b\u60c5\u4f3c\u4e4e\u7e3d\u6709\u6b63\u53cd\u9762\uff1b\u90a3\u5b89\u6170\u5291\u6548\u61c9\uff08placebo effect\uff09\u5462\uff1f\u7576\u6709\u4e00\u7a2e\u85e5\u6548\uff0c\u53eb\u505a\u300c\u6211\u89ba\u5f97\u5f88\u6709\u6548\u300d\uff0c\u6703\u4e0d\u6703\u6709\u4e00\u7a2e\u85e5\u7269\u526f\u4f5c\u7528\uff0c\u4e5f\u540c\u6642\u662f\u8087\u56e0\u65bc\u5fc3\u7406\u5f71\u97ff\u751f\u7406\uff0c\u662f\u300c\u6211\u89ba\u5f97\u9019\u90fd\u662f\u526f\u4f5c\u7528\u300d\u800c\u60f9\u7684\u798d\uff1f\u81e8\u5e8a\u5be6\u9a57\u88e1\uff0c\u7814\u7a76\u4eba\u54e1\u5f97\u4ed4\u7d30\u8a55\u4f30\u85e5\u7269\u5be6\u9a57\u8a2d\u8a08\uff0c\u907f\u514d\u7f8e\u597d\u7684\u5047\u8c61\u5e72\u64fe\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\uff1b\u4f46\u540c\u6642\u9593\uff0c\u9084\u6709\u300c\u53cd\u5b89\u6170\u5291\u6548\u61c9\u300d\u8981\u7169\u60f1\uff1a\u4e5f\u5c31\u662f\u6240\u8b02\u7684nocebo effect\u3002<!--more--><\/p>\n<p>\u300cNocebo\u300d\u8ddf\u300cplacebo\u300d\u4e00\u6a23\uff0c\u90fd\u6e90\u81ea\u62c9\u4e01\u6587\u3002\u65e2\u7136 placebo \u8a00\u50b3\u4e86\u5c0d\u826f\u85e5\u82e6\u53e3\u3001\u85e5\u5230\u75c5\u9664\u7684\u4fe1\u5fc3\uff0c\u90a3\u5927\u6982\u4e5f\u4e0d\u96e3\u610f\u6703 nocebo \u63cf\u8ff0\u4e86\u300c\u4e0d~~~~\u300d\uff0c\u5c0d\u85e5\u7269\u90fd\u662f\u6bd2\u85e5\u3001\u5929\u4e0b\u6c92\u6709\u767d\u5403\u5348\u9910\u7684\u64d4\u6182\u3002\u5f9e\u6f14\u5316\u7684\u89d2\u5ea6\u4f86\u8aaa\uff0c\u4e0d\u8ad6\u662f placebo effect \u9084\u662f nocebo effect\uff0c\u5169\u8005\u90fd\u80fd\u8b93\u5927\u8166\u5728\u77e5\u89ba\u4e0a\uff0c\u5c0d\u65bc\u672a\u4f86\u53ef\u80fd\u767c\u751f\u7684\u6f5b\u5728\u5a01\u8105\u6709\u6240\u8b66\u89ba\uff0c\u597d\u8b93\u500b\u9ad4\u80fd\u5920\u5f37\u5316\u6709\u6f5b\u5728\u76ca\u8655\u7684\u884c\u70ba\uff0c\u7b97\u662f\u6f14\u5316\u9001\u4e0a\u9580\uff0c\u80fd\u5920\u8da8\u5409\u907f\u51f6\u7684\u5e73\u5b89\u7b26\u3002\u4f46\u5728\u81e8\u5e8a\u85e5\u7269\u5be6\u9a57\u4e0a\uff0c\u9019\u5169\u500b\u6548\u61c9\u537b\u8b93\u4eba\u982d\u5927\u3002\u85e5\u7269\u8a66\u9a57\u8a2d\u8a08\u5e38\u5e38\u6703\u96a8\u6a5f\u5206\u914d\u53d7\u8a66\u8005\u5230\u5be6\u9a57\u85e5\u7269\u7d44\uff0c\u6216\u662f\u53ea\u7d66\u5b89\u6170\u5291\u7684\u63a7\u5236\u7d44\uff1b\u800c\u5b89\u6170\u5291\u7d44\u7684\u75c5\u4eba\uff0c\u6709\u6642\u5019\u4e5f\u6703\u51fa\u73fe\u5be6\u9a57\u85e5\u7269\u6240\u53ef\u80fd\u6703\u5c0e\u81f4\u7684\u526f\u4f5c\u7528\uff0c\u800c\u4e14\u9019\u4e9b\u75c5\u4eba\u53d7\u526f\u4f5c\u7528\u6240\u56f0\u64fe\u7684\u7a0b\u5ea6\u8207\u771f\u5be6\u5ea6\uff0c\u53ef\u80fd\u8ddf\u670d\u7528\u4e86\u5be6\u9a57\u85e5\u7269\u7684\u75c5\u4eba\u4e0d\u76f8\u4e0a\u4e0b\u3002<\/p>\n<p>2017 \u5e74\u516d\u6708\u7684\u6642\u5019\uff0c\u6709\u500b\u6709\u8da3\u7684\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u767c\u8868\u5728 <em>Lancet<\/em> \u671f\u520a\u4e0a\u3002Statin \u985e\u85e5\u7269\u53ef\u4ee5\u6709\u6548\u964d\u4f4e\u8840\u8102\uff0c\u9810\u9632\u9ad8\u8840\u8102\u60a3\u8005\u767c\u751f\u51a0\u72c0\u52d5\u8108\u731d\u6b7b\u3001\u7f3a\u8840\u6027\u8166\u4e2d\u98a8\u7b49\u91cd\u5927\u5fc3\u8840\u7ba1\u75be\u75c5\u610f\u5916\u3002\u4f46\u5947\u602a\u7684\u662f\uff0c\u5728\u96d9\u76f2\u8a2d\u8a08\u7684\u85e5\u7269\u8a66\u9a57\u7814\u7a76\u6642\uff0c\u7576\u91ab\u7642\u4eba\u54e1\u8207\u53d7\u8a66\u8005\u90fd\u4e0d\u77e5\u9053\u6240\u670d\u7528\u7684\u85e5\u7269\u662f statin \u985e\u85e5\u7269\u9084\u662f\u5b89\u6170\u5291\u7684\u6642\u5019\uff0c\u670d\u7528 statin \u985e\u85e5\u7269\u75c5\u60a3\u51fa\u73fe\u7684\u526f\u4f5c\u7528\u75c7\u72c0\uff0c\u8ddf\u63a7\u5236\u7d44\u76f8\u5dee\u7121\u5e7e\u3002\u4f46\u5728\u85e5\u7269\u4e0a\u5e02\u4e4b\u5f8c\uff0c\u5982\u679c\u5206\u6790\u5404\u570b\u7684\u91ab\u7642\u4fdd\u5065\u8cc7\u6599\u5eab\uff0c\u537b\u986f\u793a\u670d\u85e5\u5f8c\uff0c\u4e0d\u5c11\u75c5\u60a3\u62b1\u6028\u808c\u8089\u75e0\u75db\u7121\u529b\uff0c\u800c\u9019\u526f\u4f5c\u7528\u4e5f\u5c0e\u81f4\u7d04\u6709\u4e94\u5206\u4e4b\u4e00\u7684\u75c5\u4eba\u7121\u6cd5\u7e7c\u7e8c\u670d\u7528 statin \u985e\u85e5\u7269\u3002<\/p>\n<p>\u70ba\u4ec0\u9ebc\uff1f\u6709\u4e00\u731c\u60f3\u662f\u300cnocebo effect\u300d\u5728\u5176\u4e2d\u6417\u9b3c\u3002<\/p>\n<p>\u82f1\u570b\u5728 2000 \u5e74\u5de6\u53f3\u7684\u6642\u5019\uff0c\u66fe\u7d93\u505a\u904e\u4e00\u8d77\u5927\u898f\u6a21\u7684 statin \u985e\u85e5\u7269\uff08atorvastatin\uff09\u81e8\u5e8a\u5be6\u9a57\uff0c\u800c\u4e14\u5be6\u9a57\u8a2d\u8a08\u975e\u5e38\u6709\u8da3\uff0c\u525b\u597d\u5f88\u9069\u5408\u62ff\u4f86\u63a2\u8a0e nocebo effect\u3002\u4ed6\u5011\u6536\u4e86\u4e0a\u842c\u500b\u5e74\u904e\u56db\u5341\u3001\u4f46\u672a\u6eff\u516b\u5341\u6b72\u7684\u9ad8\u8840\u58d3\u75c5\u4eba\uff0c\u4e26\u5c07\u81e8\u5e8a\u5be6\u9a57\u5206\u6210\u5169\u968e\u6bb5\u3002\u7b2c\u4e00\u968e\u6bb5\u6642\uff0c\u4ed6\u5011\u5c07\u75c5\u4eba\u96a8\u6a5f\u5206\u6210\u5169\u7d44\uff0c\u4e00\u7d44\u670d\u7528 statin \u985e\u85e5\u7269\uff08atorvastatin\uff09\uff0c\u53e6\u4e00\u7d44\u670d\u7528\u5b89\u6170\u5291\uff0c\u5e73\u5747\u5927\u7d04 3.3 \u5e74\u3002\u4e26\u4e14\u5728\u96d9\u76f2\u8a66\u9a57\u7684\u8a2d\u8a08\u4e0b\uff0c\u6c92\u6709\u4eba\u77e5\u9053\u75c5\u60a3\u662f\u5c6c\u65bc\u54ea\u4e00\u7d44\u3002\u7136\u5f8c\uff0c\u7576\u7b2c\u4e00\u968e\u6bb5\u7d50\u675f\u4e4b\u5f8c\uff0c\u7dca\u63a5\u8457\u8b93\u9019\u4e9b\u53d7\u8a66\u8005\u9032\u5165\u300c\u77e5\u60c5\u300d\u7684\u7b2c\u4e8c\u968e\u6bb5\uff0c\u4e4b\u524d\u670d\u7528 statin \u985e\u85e5\u7269\u7684\u75c5\u4eba\u518d\u62c6\u6210\u5169\u7d44\uff0c\u4e00\u5c0f\u7d44\u6301\u7e8c\u670d\u7528\uff0c\u53e6\u4e00\u5c0f\u7d44\u5247\u6539\u7528\u5b89\u6170\u5291\uff1b\u800c\u7b2c\u4e00\u968e\u6bb5\u7684\u5b89\u6170\u5291\u7d44\u4e5f\u540c\u6a23\u62c6\u6210\u670d\u85e5\u3001\u6216\u5b89\u6170\u5291\u7684\u5169\u5c0f\u7d44\u3002\u7b2c\u4e8c\u968e\u6bb5\u5e73\u5747\u662f 2.3 \u5e74\u3002\u7576\u91cd\u65b0\u5206\u6790\u90a3\u6642\u5019\u7684\u8cc7\u6599\u767c\u73fe\uff0c\u300c\u77e5\u60c5\u300d\u9019\u4ef6\u4e8b\u5728\u75c5\u60a3\u8eab\u4e0a\u660e\u986f\u589e\u52a0\u4e86\u526f\u4f5c\u7528\u7684\u6bd4\u7387\u3002\u5f88\u591a\u5728\u7b2c\u4e00\u968e\u6bb5\u670d\u85e5\u6c92\u6709\u51fa\u73fe\u526f\u4f5c\u7528\u56f0\u64fe\u7684\u75c5\u4eba\uff0c\u7576\u7b2c\u4e8c\u968e\u6bb5\u9084\u6301\u7e8c\u670d\u85e5\u6642\uff0c\u7a81\u7136\u958b\u59cb\u51fa\u73fe\u808c\u8089\u75bc\u75db\u7684\u526f\u4f5c\u7528\u3002<\/p>\n<p>\u986f\u7136\uff0c\u5176\u4e2d\u6709\u53ef\u80fd\u662f\u300cnocebo effect\u300d\uff0c\u4e5f\u5c31\u662f\u75c5\u60a3\u7684\u300c\u9810\u671f\u5fc3\u614b\u300d\u5728\u6697\u4e2d\u6417\u86cb\u3002<\/p>\n<p>\u4e0d\u8ad6\u662f\u300cplacebo effect\u300d\u6216\u662f\u300cnocebo effect\u300d\uff0c\u90fd\u4e0d\u53ea\u662f\u8166\u5167\u5c0f\u5287\u5834\u88e1\u7684\u6d77\u5e02\u8703\u6a13\uff0c\u800c\u662f\u5728\u7d30\u80de\u5c64\u7d1a\u4e0a\uff0c\u53ef\u4ee5\u660e\u78ba\u89c0\u5bdf\u5230\u7d30\u80de\u529f\u80fd\u6539\u8b8a\u7684\u5177\u9ad4\u5b58\u5728\u3002\u8a31\u591a\u56e0\u7d20\u90fd\u53ef\u80fd\u4fc3\u4f7f placebo effect \u6216 nocebo effect \u767c\u751f\uff0c\u50cf\u662f\u91ab\u7642\u74b0\u5883\u3001\u75c5\u60a3\u60c5\u7dd2\uff0c\u6216\u662f\u91ab\u75c5\u4e4b\u9593\u6e9d\u901a\u7684\u65b9\u5f0f\uff0c\u4ee5\u53ca\u5728\u91ab\u7642\u671f\u9593\u7684\u8aee\u8a62\u8207\u885b\u6559\u3001\u6216\u662f\u81e8\u5e8a\u8a66\u9a57\u9032\u884c\u524d\u8b93\u53d7\u8a66\u8005\u5c0d\u6574\u500b\u8a66\u9a57\u6d41\u7a0b\u6709\u5b8c\u6574\u8a8d\u8b58\u7684\u8aaa\u660e\u544a\u77e5\u968e\u6bb5\u3002\u66f4\u751a\u8005\uff0c\u50cf\u662f\u85e5\u54c1\u5916\u89c0\u3001\u50f9\u683c\uff0c\u9019\u4e9b\u770b\u4f3c\u5f88\u300c\u5916\u8cbf\u5354\u6703\u300d\u7684\u7709\u89d2\uff0c\u90fd\u53ef\u80fd\u7121\u610f\u8b58\u5730\u5fae\u8abf\u4e86\u75c5\u60a3\u5c0d\u85e5\u54c1\u7684\u300c\u671f\u5f85\u300d\uff0c\u800c\u5f71\u97ff\u5230\u85e5\u54c1\u7684\u7642\u6548\u8207\u526f\u4f5c\u7528\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u54e1\u5df2\u7d93\u767c\u73fe\u91ab\u7642\u884c\u70ba\u7684\u300c\u50f9\u78bc\u300d\uff0c\u53ef\u4ee5\u5de6\u53f3placebo effect\u3002\u6240\u8b02\u4e00\u5206\u9322\u3001\u4e00\u5206\u8ca8\uff0c\u6a19\u50f9\u6108\u9ad8\u7684\u85e5\uff0cplacebo effect \u5c31\u6108\u986f\u8457\u3002\u4f46\u9b5a\u8207\u718a\u638c\uff0c\u4e0d\u53ef\u517c\u5f97\uff1b\u6a19\u50f9\u9ad8\u7684\u85e5\u7269\uff0c\u6703\u4e0d\u6703\u4e5f\u540c\u6642\u8b93 nocebo effect \u767c\u751f\u7684\u6a5f\u7387\u4e5f\u589e\u52a0\u5462\uff1f<\/p>\n<p>\u5fb7\u570b\u6f22\u5821\u827e\u672c\u591a\u592b\u5927\u5b78\u91ab\u7642\u4e2d\u5fc3\u7684 Christian Buchel \u535a\u58eb\u5be6\u9a57\u5ba4\u7684\u535a\u58eb\u751f Alexandra Tinnermann \u5c0d\u9019\u500b\u554f\u984c\u5f88\u611f\u8208\u8da3\uff0c\u4ed6\u60f3\u8981\u77e5\u9053\u6108\u8cb4\u7684\u85e5\u6703\u4e0d\u6703\u900f\u904e nocebo effect\uff0c\u800c\u8b93\u526f\u4f5c\u7528\u7684\u767c\u751f\u7387\u8ddf\u4fbf\u5b9c\u7684\u85e5\u6bd4\u8d77\u4f86\uff0c\u4e5f\u5927\u5e45\u4e0a\u5347\u3002\u70ba\u4e86\u8981\u8b93\u53d7\u8a66\u8005\u66f4\u300c\u8eab\u6b77\u5176\u5883\u300d\uff0cAlexandra \u9996\u5148\u8a2d\u8a08\u4e86\u5169\u6b3e\u6cbb\u7642\u76ae\u819a\u7662\u7684\u5916\u7528\u85e5\u76d2\u5b50\uff0c\u4e00\u500b\u770b\u8d77\u4f86\u5f88\u4fbf\u5b9c\uff0c\u53ea\u662f\u7c21\u55ae\u7684\u6a58\u8272\uff1b\u53e6\u4e00\u6b3e\u5247\u6bd4\u8f03\u6709\u8a2d\u8a08\u611f\uff0c\u662f\u6f02\u4eae\u7684\u85cd\u8272\u3002\u4ed6\u9996\u5148\u627e\u4f86 66 \u4f4d\u53d7\u8a66\u8005\uff0c\u6e2c\u8a66\u4ed6\u6240\u8a2d\u8a08\u3001\u4ee3\u8868\u4fbf\u5b9c\u8207\u6602\u8cb4\u6b62\u7662\u85e5\u7684\u76ae\u819a\u5916\u7528\u85e5\u76d2\uff0c\u6709\u6c92\u6709\u8aaa\u670d\u529b\u3002\u901a\u904e\u8abf\u67e5\u7b2c\u4e00\u968e\u6bb5\u53d7\u8a66\u8005\u7684\u610f\u898b\uff0cAlexandra \u78ba\u8a8d\u300c\u85e5\u76d2\u5916\u89c0\u300d\u7684\u78ba\u80fd\u5920\u50b3\u9054\u67d0\u4e9b\u5148\u5165\u70ba\u4e3b\u7684\u8a55\u50f9\u4e4b\u5f8c\uff0c\u4ed6\u62db\u4f86\u4e86 49 \u4f4d\u5065\u5eb7\u53d7\u8a66\u8005\uff0c\u8ddf\u4ed6\u5011\u8aaa\uff0c\u9019\u5169\u6b3e\u85e5\u818f\u90fd\u80fd\u6709\u6548\u6b62\u7662\uff0c\u4f46\u540c\u6642\u4e5f\u6703\u8b93\u5857\u62b9\u85e5\u818f\u7684\u76ae\u819a\u8b8a\u5f97\u5c0d\u75db\u89ba\u66f4\u70ba\u654f\u611f\u3002\u4f46\u5176\u5be6\uff0c\u5169\u6b3e\u85e5\u818f\u4e00\u6a21\u4e00\u6a23\uff0c\u4e5f\u6c92\u6709\u4efb\u4f55\u85e5\u7269\u6210\u5206\u3002\u7136\u5f8c\uff0c\u4ed6\u8b93\u53d7\u8a66\u8005\u63a5\u53d7\u75db\u89ba\u6e2c\u8a66\uff0c\u4e26\u4e14\u5229\u7528\u529f\u80fd\u6027\u78c1\u632f\u9020\u5f71\u6280\u8853\uff0c\u89c0\u5bdf\u53d7\u8a66\u8005\u8166\u90e8\u8207\u810a\u690e\u8655\u8ddf\u75db\u89ba\u50b3\u905e\u6709\u95dc\u7684\u795e\u7d93\u6d3b\u52d5\u3002<\/p>\n<p>Alexandra \u7684\u7814\u7a76\u767c\u73fe\uff0c\u6bd4\u8f03\u8cb4\u7684\u6b62\u7662\u76ae\u819a\u85e5\uff0c\u771f\u7684\u6703\u8b93\u53d7\u8a66\u8005\u56e0\u70ba\u300c\u9810\u671f\u300d\u85e5\u6548\u5f37\u7684\u85e5\u6bd4\u8f03\u5bb9\u6613\u5f15\u8d77\u526f\u4f5c\u7528\uff0c\u800c\u8b93\u53d7\u8a66\u8005\u5728\u75db\u89ba\u6e2c\u8a66\u4e0a\u6bd4\u8f03\u654f\u611f\u3002\u800c\u85e5\u50f9\u4e0a\u7684\u5dee\u7570\uff0c\u9664\u4e86\u53cd\u61c9\u5728\u526f\u4f5c\u7528\u5f37\u5ea6\u4e0a\uff0c\u66f4\u5728\u53d7\u8a66\u8005\u7684\u8166\u90e8\u8207\u810a\u690e\u8655\u529f\u80fd\u6027\u78c1\u632f\u9020\u5f71\u4e0a\u53ef\u4ee5\u770b\u51fa\u7aef\u502a\u3002\u7576\u53d7\u8a66\u8005\u9810\u671f\u85e5\u50f9\u9ad8\u3001\u526f\u4f5c\u7528\u4e5f\u9ad8\uff0c\u800c\u5728\u8a66\u9a57\u4e0a\u8b8a\u5f97\u5c0d\u75db\u89ba\u7279\u5225\u654f\u611f\u6642\uff0c\u4ed6\u89c0\u5bdf\u5230\u53d7\u8a66\u8005\u5927\u8166\u524d\u5599\u6263\u5e36\u76ae\u8cea\uff08rACC\uff0crostral anterior cingulate cortex\uff09\u7684\u6d3b\u6027\u88ab\u6291\u5236\u3002\u524d\u5599\u6263\u5e36\u76ae\u8cea\u662f\u4f4d\u5728\u6263\u5e36\u76ae\u5c64\u4e00\u584a\u5927\u7d04\u5341\u584a\u786c\u5e63\u5927\u5c0f\u7684\u5340\u57df\uff0c\u5c0d\u75bc\u75db\u7684\u77e5\u89ba\u8207\u8abf\u7bc0\u626e\u6f14\u8457\u95dc\u9375\u89d2\u8272\u3002\u50cf\u662f\u5b89\u6170\u5291\u3001\u6216\u662f\u51a5\u60f3\u975c\u5750\u7b49\u53ef\u4ee5\u8b93\u75bc\u75db\u300c\u53bb\u53bb\u8d70\u300d\u7684\u504f\u65b9\uff0c\u5f88\u591a\u90fd\u662f\u9760\u8abf\u7bc0\u524d\u5599\u6263\u5e36\u76ae\u8cea\u7684\u529f\u80fd\u3002\u7576\u524d\u5599\u6263\u5e36\u76ae\u8cea\u7684\u529f\u80fd\u88ab\u6291\u5236\uff0c\u4e2d\u8166\u5c0e\u6c34\u7ba1\u5468\u570d\u7070\u8cea\u8207\u810a\u9ad3\u8655\u8ddf\u75db\u89ba\u50b3\u905e\u6709\u95dc\u7684\u795e\u7d93\u5143\uff0c\u5c31\u6703\u518d\u4e0b\u4e00\u6b21\u75db\u89ba\u523a\u6fc0\u6642\u66f4\u5bb9\u6613\u88ab\u6d3b\u5316\uff0c\u53d7\u8a66\u8005\u4e5f\u5c31\u6703\u56e0\u6b64\u611f\u89ba\u5230\u66f4\u75db\u4e86\u3002\u800c\u85e5\u50f9\u9ad8\u4f4e\u5c31\u53ef\u4ee5\u900f\u904e\u300c\u5927\u8166\u524d\u5599\u6263\u5e36\u76ae\u8cea\u2014\u5c0e\u6c34\u7ba1\u5468\u570d\u7070\u8cea\u2014\u810a\u9ad3\u300d\u9019\u689d\u50b3\u5c0e\u8ff4\u8def\uff0c\u5f71\u97ff\u5230\u53d7\u8a66\u8005\u5c0d\u65bc\u75db\u89ba\u7684\u611f\u53d7\u4e86\uff01<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u539f\u59cb\u8ad6\u6587\uff1a<\/strong><\/p>\n<p>\u95dc\u65bc\u82f1\u570b\u81e8\u5e8a\u7814\u7a76\u5206\u6790 nocebo effect \u5c0d statin \u985e\u85e5\u7269\u526f\u4f5c\u7528\u7684\u5f71\u97ff\uff1a<\/p>\n<ol>\n<li>Gupta A, Thompson D, Whitehouse A, Collier T, Dahlof B, Poulter N, Collins R, Sever P; ASCOT Investigators. Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase.<\/li>\n<li>Lancet. 2017 Jun 24;389(10088):2473-2481. doi: 10.1016\/S0140-6736(17)31075-9. Epub 2017 May 2.PMID: 28476288<\/li>\n<\/ol>\n<p>\u95dc\u65bc\u85e5\u50f9\u9ad8\u4f4e\u5c0d nocebo effect \u7684\u5f71\u97ff\uff1a<\/p>\n<ol>\n<li>Tinnermann A, Geuter S, Sprenger C, Finsterbusch J, B\u00fcchel C. Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia. Science. 2017 Oct 6;358(6359):105-108. doi: 10.1126\/science.aan1221.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Carlino E, et al. Pain and the context. Nat Rev Rheumatol. 2014 Jun;10(6):348-55. doi: 10.1038\/nrrheum.2014.17. Epub 2014 Feb 25.<\/li>\n<li>Colloca L, et al. The nocebo effect and its relevance for clinical practice. Psychosom Med. 2011 Sep;73(7):598-603. doi: 10.1097\/PSY.0b013e3182294a50. Epub 2011 Aug 23.<\/li>\n<li>Colloca L. Nocebo effects can make you feel pain. Science. 2017 Oct 6;358(6359):44. doi: 10.1126\/science.aap8488. No abstract available. PMID: 28983038<\/li>\n<li>Blasini M, et al. Nocebo and pain: An overview of the psychoneurobiological mechanisms. Pain Rep. 2017 Mar-Apr;2(2). pii: e585. doi: 10.1097\/PR9.0000000000000585. PMID: 28971165<\/li>\n<li>Tracey I. Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans. Nat Med. 2010 Nov;16(11):1277-83. doi: 10.1038\/nm.2229. Epub 2010 Oct 14.<\/li>\n<li>Wager TD, et al. The neuroscience of placebo effects: connecting context, learning and health. Nat Rev Neurosci. 2015 Jul;16(7):403-18. doi: 10.1038\/nrn3976.<\/li>\n<li>Wiech K. Deconstructing the sensation of pain: The influence of cognitive processes on pain perception. Science. 2016 Nov 4;354(6312):584-587.<\/li>\n<\/ol>\n<p><strong>--<\/strong><br \/>\n<span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u6108\u8cb4\u7684\u85e5\uff0c\u771f\u6703\u8b93\u6211\u5011\u5728\u6f5b\u610f\u8b58\u88e1\u89ba\u5f97\u6108\u6709\u6548\u55ce\uff1f\u5982\u679c\u6709\u300c\u5fc3\u60f3\u300e\u85e5\u6548\u300f\u6210\u300d\u7684\u5b89\u6170\u5291\u6548\u61c9\uff08placebo effect\uff09\uff0c\u6bd4\u8f03\u8cb4\u7684\u85e5\u6703\u4e0d\u6703\u8b93\u75c5\u60a3\u89ba\u5f97\uff0c\u56e0\u70ba\u85e5\u6548\u5f37\uff0c\u526f\u4f5c\u7528\u4e5f\u6bd4\u8f03\u9ad8\uff0c\u800c\u8b93\u9019\u4e9b\u9ad8\u50f9\u85e5\u7269\u88ab\u300c\u8166\u5167\u5c0f\u5287\u5834\u300d\u53cd\u5c07\u4e00\u8ecd\uff0c\u4ee5\u81f3\u65bc\u526f\u4f5c\u7528\u767c\u751f\u7684\u6a5f\u7387\u4e5f\u6bd4\u8f03\u9ad8\u5462\uff1f<\/p>\n","protected":false},"author":20,"featured_media":30130,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[3695,3694,2987,3696],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/12\/a-research-study-revealed-the-top-five-most-expensive-drugs-in-the-world.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/30129"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=30129"}],"version-history":[{"count":2,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/30129\/revisions"}],"predecessor-version":[{"id":31956,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/30129\/revisions\/31956"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/30130"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=30129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=30129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=30129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}