{"id":29969,"date":"2018-01-19T00:04:11","date_gmt":"2018-01-18T16:04:11","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=29969"},"modified":"2018-07-29T15:19:28","modified_gmt":"2018-07-29T07:19:28","slug":"%e5%a6%82%e6%9e%9c%e5%90%b8%e8%a1%80%e9%ac%bc%e4%b9%9f%e6%8c%91%e9%a3%9f%e4%b9%8b%e3%80%8c%e5%b9%b4%e8%bc%95%e4%ba%ba%e7%9a%84%e8%a1%80%e8%83%bd%e5%b9%ab%e5%8a%a9%e6%8a%97%e8%80%81%e5%8c%96%e5%97%8e","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=29969","title":{"rendered":"\u5982\u679c\u5438\u8840\u9b3c\u4e5f\u6311\u98df\u4e4b\u300c\u5e74\u8f15\u4eba\u7684\u8840\u80fd\u5e6b\u52a9\u6297\u8001\u5316\u55ce\uff1f\u300d"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u5e74\u8f15\u4eba\u7684\u8840\u6f3f\u6703\u662f\u9752\u6625\u4e0d\u8001\u6cc9\u7684\u79d8\u5bc6\u55ce\uff1f\u6700\u8fd1\u4e00\u8d77\u81e8\u5e8a\u7814\u7a76\u7684\u521d\u6b65\u7d50\u679c\uff0c\u4f3c\u4e4e\u70ba\u9019\u500b\u5047\u8aaa\uff0c\u6f86\u4e86\u4e00\u76c6\u51b7\u6c34\u3002<\/strong><\/span><\/p>\n<p><strong><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft wp-image-30011\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/01\/134760638.jpg\" alt=\"\" width=\"450\" height=\"312\" \/>\u64b0\u6587\uff5c\u99f1\u5b9b\u7433<\/strong><\/p>\n<p>\u5341\u4e00\u6708\u521d\uff0c\u5728\u7f8e\u570b\u6ce2\u58eb\u9813\u8209\u884c\u7684\u7b2c\u5341\u5c46\u963f\u8332\u6d77\u9ed8\u75c7\u81e8\u5e8a\u8a66\u9a57\u5e74\u6703\u4e0a\uff0c\u6709\u7bc7\u5e38\u88ab\u5a92\u9ad4\u8207\u671f\u520a\u66b1\u7a31\u70ba\u300c\u5438\u8840\u9b3c\u300d\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u767c\u8868\u4e86\u521d\u6b65\u7d50\u679c\u3002\u9019\u8d77\u81e8\u5e8a\u8a66\u9a57\u7531\u7f8e\u570b Stanford University\u3001Tony Wyss-Coray \u535a\u58eb\u5be6\u9a57\u5ba4\u6240\u4e3b\u5c0e\uff0c\u60f3\u8981\u77e5\u9053\u5e74\u8f15\u4eba\u7684\u8840\u6db2\u5c0d\u8001\u5e74\u4eba\u4f86\u8aaa\uff0c\u662f\u4e0d\u662f\u5177\u6709\u300c\u6297\u8001\u5316\u300d\u7684\u529f\u6548\u3002\u81e8\u5e8a\u8a66\u9a57\u88e1\u9996\u5148\u6536\u4e86\u4e5d\u4f4d\u60a3\u6709\u8f15\u5ea6\u81f3\u4e2d\u5ea6\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u75c5\u4eba\uff0c\u628a\u4ed6\u5011\u96a8\u6a5f\u5206\u70ba\u5169\u7d44\uff0c\u6bcf\u500b\u79ae\u62dc\u63a5\u53d7\u4e00\u6b21 18 \u5230 30 \u6b72\u5e74\u8f15\u4eba\u8840\u6f3f\u7684\u8f38\u8840\uff08\u6216\u662f\u751f\u7406\u98df\u9e7d\u6c34\uff09\uff0c\u4e00\u6b21\u7d04 250 \u6beb\u5347\uff0c\u9023\u7e8c\u56db\u500b\u79ae\u62dc\u3002\u7136\u5f8c\uff0c\u4f11\u606f\u516d\u500b\u79ae\u62dc\u4e4b\u5f8c\uff0c\u5169\u7d44\u7684\u8f38\u6db2\u5c0d\u8abf\uff1b\u539f\u4f86\u8f38\u8840\u6f3f\u7684\u6539\u70ba\u8f38\u5165\u751f\u7406\u98df\u9e7d\u6c34\uff0c\u539f\u4f86\u8f38\u5165\u751f\u7406\u98df\u9e7d\u6c34\u7684\u63a7\u5236\u7d44\uff0c\u5247\u63a5\u53d7\u5e74\u8f15\u4eba\u8840\u6f3f\u8f38\u6db2\u56db\u500b\u79ae\u62dc\u3002\u9019\u4e00\u7d44\u81e8\u5e8a\u8a66\u9a57\u88e1\u9762\u9075\u5faa\u96d9\u76f2\u7814\u7a76\u7684\u898f\u77e9\uff0c\u4e0d\u8ad6\u662f\u53c3\u8207\u7684\u53d7\u8a66\u8005\u3001\u9084\u662f\u8a66\u9a57\u4eba\u54e1\uff0c\u90fd\u4e0d\u77e5\u9053\u8a72\u75c5\u4eba\u88ab\u96a8\u6a5f\u5206\u5230\u4e86\u54ea\u4e00\u7d44\uff0c\u8981\u4e00\u76f4\u7b49\u5230\u6240\u6709\u8a66\u9a57\u968e\u6bb5\u90fd\u5b8c\u6210\u4e86\u624d\u6703\u77e5\u9053\u6bcf\u500b\u53d7\u8a66\u8005\u863f\u8514\u8a72\u843d\u54ea\u500b\u5751\u3002<!--more--><\/p>\n<p>\u540c\u6642\uff0c\u81e8\u5e8a\u8a66\u9a57\u4e5f\u6536\u4e86\u53e6\u5916\u4e5d\u4f4d\u8f15\u5ea6\u5230\u4e2d\u5ea6\u60a3\u6709\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u53d7\u8a66\u8005\uff0c\u660e\u78ba\u544a\u77e5\u4ed6\u5011\u6703\u63a5\u53d7\u5e74\u8f15\u4eba\u8840\u6f3f\u7684\u8f38\u8840\uff1b\u4e00\u9031\u4e00\u6b21\uff0c\u9023\u7e8c\u56db\u500b\u79ae\u62dc\u3002\u4e4b\u5f8c\uff0c\u5169\u7d44\u53d7\u8a66\u8005\u90fd\u6703\u63a5\u53d7\u8a31\u591a\u795e\u7d93\u8a8d\u77e5\u76f8\u95dc\u7684\u6e2c\u9a57\uff0c\u7167\u9867\u9019\u4e9b\u963f\u8332\u6d77\u9ed8\u75c7\u53d7\u8a66\u8005\u7684\u770b\u8b77\u6216\u7167\u9867\u4eba\u54e1\u4e5f\u6703\u63a5\u53d7\u554f\u5377\u8abf\u67e5\u3002\u9019\u500b\u5c0f\u898f\u6a21\u7684\u81e8\u5e8a\u8a66\u9a57\u4e3b\u8981\u60f3\u8981\u77e5\u9053\u5169\u500b\u554f\u984c\uff1a\u5176\u4e00\uff0c\u9019\u6a23\u7684\u6cbb\u7642\u65b9\u6848\u5b89\u5168\u4e5f\u53ef\u884c\u55ce\uff1f\u5176\u4e8c\uff0c\u5e74\u8f15\u4eba\u7684\u8840\uff0c\u771f\u662f\u6297\u8001\u5316\u9748\u4e39\u55ce\uff1f<\/p>\n<p>\u9019\u500b\u81e8\u5e8a\u8a66\u9a57\u770b\u8d77\u4f86\u5929\u99ac\u884c\u7a7a\uff0c\u4f46\u5728\u79d1\u5b78\u7814\u7a76\u754c\u5012\u662f\u722d\u8ad6\u4e0d\u4f11\u4e86\u597d\u4e00\u9663\u5b50\u3002\u5c24\u5176\u5728 2016 \u5e74\u590f\u5929\u7684\u6642\u5019\uff0c\u7f8e\u570b\u52a0\u5dde\u6709\u5bb6\u516c\u53f8\uff0c\u7c4c\u5283\u4e00\u8d77\u81e8\u5e8a\u8a66\u9a57\u662f\u9810\u5099\u6536\u516d\u767e\u500b\u75c5\u4eba\uff0c\u5728\u70ba\u671f\u5169\u5929\u5167\uff0c\u7d66\u4e88\u6bcf\u4eba\u7d04 1500 \u6beb\u5347\u3001\u5c0f\u65bc\u4e8c\u5341\u4e94\u6b72\u5e74\u8f15\u4eba\u7684\u8840\u6f3f\u8f38\u6db2\u3002\u5728\u9019\u81e8\u5e8a\u8a66\u9a57\u88e1\uff0c\u53d7\u8a66\u8005\u53ea\u8981\u5e74\u904e\u4e09\u5341\u4e94\u5c31\u53ef\u4ee5\uff1b\u4f46\u9019\u516c\u53f8\uff0c\u5c07\u5c0d\u6bcf\u500b\u53d7\u8a66\u8005\u6536\u8cbb\u516b\u5343\u7f8e\u5143\u3002\u9019\u6a23\u7684\u81e8\u5e8a\u8a66\u9a57\u8a2d\u5b9a\uff0c\u81ea\u7136\u5728\u502b\u7406\u9053\u7fa9\u4e0a\u6380\u8d77\u5404\u65b9\u8cea\u7591\u3002<\/p>\n<p>\u5e74\u8f15\u4eba\u7684\u8840\uff0c\u5230\u5e95\u6709\u4ec0\u9ebc\u7279\u5225\uff1f\u7e31\u7136\u6c92\u6709\u5438\u8840\u9b3c\u53ef\u4ee5\u8a62\u554f\uff0c\u9019\u554f\u984c\u5012\u662f\u53ef\u4ee5\u5f9e\u8001\u9f20\u8eab\u4e0a\u4e00\u7aba\u7a76\u7adf\u3002<\/p>\n<p>\u65e9\u5728 1864 \u5e74\uff0c\u7576\u7f8e\u570b\u6b63\u5fd9\u8457\u6253\u5357\u5317\u6230\u722d\uff0c\u6cd5\u570b\u6709\u4f4d\u751f\u7406\u5b78\u5bb6 Paul Bert\uff0c\u5c07\u5169\u96bb\u8001\u9f20\u80a9\u9760\u80a9\uff0c\u5229\u7528\u5916\u79d1\u624b\u8853\u6280\u8853\u8b93\u5169\u96bb\u8001\u9f20\u7684\u76ae\u819a\u7e2b\u5408\u5728\u4e00\u8d77\uff0c\u300c\u8089\u8ec0\u300d\u7dca\u7dca\u76f8\u9023\u3002\u65bc\u662f\uff0c\u7576\u50b7\u53e3\u7652\u5408\u5f8c\uff0c\u5169\u96bb\u8001\u9f20\u5404\u81ea\u7684\u5fae\u8840\u7ba1\u6703\u50cf\u7570\u5f62\u7684\u89f8\u624b\u4e00\u6a23\uff0c\u6df1\u5165\u53e6\u4e00\u96bb\u8001\u9f20\u7684\u7d44\u7e54\u88e1\uff1b\u65bc\u662f\uff0c\u9019\u5169\u96bb\u8001\u9f20\u9664\u4e86\u505a\u4ec0\u9ebc\u4e8b\u90fd\u5f97\u9f4a\u982d\u4e26\u884c\u4e4b\u5916\uff0c\u9084\u300c\u5171\u4eab\u300d\u4e86\u4e00\u5957\u5faa\u74b0\u7cfb\u7d71\u3002\u79d1\u5b78\u5bb6\u628a\u9019\u500b\u807d\u8d77\u4f86\u50cf\u79d1\u5e7b\u5c0f\u8aaa\u60c5\u7bc0\u7684\u53e4\u8001\u6280\u8853\uff0c\u5b89\u4e0a\u4e86\u500b\u540d\u5b57\u53eb\u505a\u7570\u7a2e\u5171\u751f\uff08parabiosis\uff09\u3002<\/p>\n<p>1950 \u5e74\u6642\uff0c \u5728\u7f8e\u570b Cornell University \u4efb\u8077\uff0c\u7b2c\u4e00\u500b\u63d0\u51fa\u300c\u71b1\u91cf\u5c11\u4e00\u9ede\u3001\u58fd\u547d\u4e45\u4e00\u9ede\u300d\u7684\u79d1\u5b78\u5bb6 Clive McCay\uff0c\u767c\u73fe\u5982\u679c\u5c07\u4e00\u96bb\u5e74\u8f15\u7684\u8001\u9f20\u548c\u4e00\u96bb\u5e74\u8001\u7684\u8001\u9f20\uff0c\u5229\u7528\u7570\u7a2e\u5171\u751f\u6280\u8853\u7e2b\u5408\u5728\u4e00\u8d77\uff0c\u6703\u8b93\u8001\u5316\u4e2d\u7684\u8001\u9f20\u50cf\u662f\u63a5\u4e0a\u4e00\u5ea7\u4e0d\u8001\u6cc9\u4f3c\u7684\uff0c\u80fd\u5920\u9006\u8f49\u8001\u5316\u3002McCay \u7684\u90a3\u500b\u5e74\u4ee3\uff0c\u5206\u5b50\u751f\u7269\u5b78\u8207\u7d30\u80de\u751f\u7269\u5b78\u7684\u76f8\u95dc\u5be6\u9a57\u6280\u8853\u4e0d\u5982\u73fe\u4eca\u5f37\u608d\uff0cMcCay \u96d6\u6709\u4e86\u6709\u8da3\u7684\u767c\u73fe\uff0c\u537b\u4e5f\u5de7\u5a66\u96e3\u65bc\u7121\u7c73\u4e4b\u708a\u3002<\/p>\n<p>2005 \u5e74\uff0cStanford University \u7684 Thomas Rando \u5be6\u9a57\u5ba4\u548c Irving Weissman \u5be6\u9a57\u5ba4\u5408\u4f5c\uff0c\u5728 <em>Nature<\/em> \u671f\u520a\u4e0a\u518d\u6b21\u8b49\u5be6 McCay \u6240\u89c0\u5bdf\u5230\u7684\u73fe\u8c61\u4e0d\u662f\u7121\u4e2d\u751f\u6709\uff0c\u66f4\u975e\u66c7\u82b1\u4e00\u73fe\u3002\u5728\u5f8c\u7e7c\u7814\u7a76\u88e1\uff0c\u5148\u5f8c\u6709\u5be6\u9a57\u5ba4\u767c\u73fe\u5e74\u8f15\u8001\u9f20\u7684\u8840\u6db2\uff0c\u53ef\u4ee5\u5ef6\u7de9\u5e74\u8001\u8001\u9f20\u7684\u8001\u5316\u73fe\u8c61\uff1a\u50cf\u662f\u6e1b\u5c11\u5fc3\u81df\u5fc3\u58c1\u808c\u8089\u80a5\u539a\u3001\u589e\u52a0\u9aa8\u9abc\u808c\u4fee\u5fa9\u529f\u80fd\uff0c\u751a\u81f3\u4fc3\u9032\u795e\u7d93\u5143\u5e79\u7d30\u80de\u7684\u589e\u751f\uff0c\u8207\u589e\u52a0\u8166\u5167\u8840\u6db2\u6d41\u91cf\u8207\u529f\u80fd\u7b49\u3002\u800c\u9019\u6ce2\u7814\u7a76\u6210\u679c\uff0c\u4e5f\u8b93\u8a31\u591a\u5be6\u9a57\u5ba4\u958b\u59cb\u722d\u76f8\u8ffd\u9010\u627e\u51fa\u5e74\u8f15\u8001\u9f20\u8840\u6db2\u88e1\uff0c\u662f\u4ec0\u9ebc\u795e\u5947\u5206\u5b50\u6709\u6297\u8001\u5316\u529f\u80fd\u3002<\/p>\n<p>\u5341\u5e74\u4f86\uff0c\u6700\u53d7\u77da\u76ee\u7684\u5206\u5b50\u6709\u5169\u500b\uff1a\u5176\u4e00\u662f GDF11\uff0c\u7531\u7f8e\u570b Harvard University \u7684 Amy Wagers \u535a\u58eb\u5be6\u9a57\u5ba4\u6240\u767c\u73fe\u3002\u5728\u6700\u521d 2005 \u5e74 <em>Nature <\/em>\u7814\u7a76\u9032\u884c\u7684\u6642\u5019\uff0cWagers \u9084\u662f Weissman \u5be6\u9a57\u5ba4\u7684\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u3002\u5f8c\u4f86\uff0cWager \u5728 Harvard University \u91ab\u5b78\u9662\u627e\u5230\u6559\u8077\uff0c\u4e00\u958b\u59cb\u7d93\u71df\u81ea\u5df1\u5be6\u9a57\u5ba4\uff0c\u5c31\u628a\u5168\u526f\u7cbe\u795e\u6295\u5165\u627e\u5c0b\u6297\u8001\u5316\u5206\u5b50\u7684\u4efb\u52d9\u3002\u6700\u5f8c\uff0c\u767c\u73fe\u8840\u6db2\u88e1 GDF11 \u7684\u6fc3\u5ea6\u6703\u96a8\u8457\u8001\u5316\u800c\u9010\u6f38\u905e\u6e1b\uff1b\u5982\u679c\u9069\u6642\u7d66\u4e88\u5e74\u8001\u7684\u8001\u9f20\u88dc\u5145 GDF11\uff0c\u4e0d\u8ad6\u662f\u8001\u5316\u4e2d\u7684\u9aa8\u9abc\u808c\u3001\u5fc3\u808c\uff0c\u751a\u81f3\u662f\u8166\u5167\u7684\u8840\u7ba1\u7d44\u7e54\u8207\u795e\u7d93\u5143\uff0c\u529f\u80fd\u4e0a\u90fd\u80fd\u5920\u300c\u8b8a\u5e74\u8f15\u300d\u3002<\/p>\n<p>\u4f46\uff0cGDF11 \u6240\u6380\u8d77\u7684\u5404\u65b9\u8ad6\u6230\u5012\u662f\u4e0d\u66fe\u548c\u89e3\uff0c\u539f\u56e0\u662f GDF11 \u8eab\u5c6c TGF\u03b2\u9019\u500b\u5927\u5bb6\u65cf\uff0c\u800c\u4e0d\u5de7\u8ddf\u540c\u4e00\u500b\u5bb6\u65cf\u7684 GDF8 \u6709\u9ad8\u9054 90% \u7684\u76f8\u4f3c\u5ea6\u3002GDP8 \u53c8\u540d myostatin\uff0c\u4e2d\u6587\u540d\u300c\u808c\u8089\u751f\u9577\u6291\u5236\u7d20\u300d\u540d\u6b63\u8a00\u9806\u7684\u4e00\u8a9e\u9053\u76e1 GDF8 \u5728\u9aa8\u9abc\u808c\u751f\u9577\u8abf\u7bc0\u88e1\uff0c\u5982\u4f55\u626e\u6f14\u8457\u81f3\u95dc\u91cd\u5927\u7684\u89d2\u8272\u3002\u800c\u4e5f\u56e0\u70ba\u9019\u5169\u500b\u86cb\u767d\u8cea\u5be6\u5728\u662f\u592a\u76f8\u8fd1\u4e86\uff0c\u7531\u7f8e\u570b Novartis \u85e5\u5ee0\u6240\u4e3b\u5c0e\u7684\u7814\u7a76\u767c\u73fe\uff0cWagers \u5be6\u9a57\u5ba4\u6240\u4f7f\u7528\u7528\u4f86\u5075\u6e2c GDF11 \u7684\u6297\u9ad4\uff0c\u4e5f\u6703\u8aa4\u8a8d GDF8\u3002Novartis \u85e5\u5ee0\u7814\u767c\u51fa\u5c08\u9580\u91dd\u5c0d GDF11 \u7684\u6297\u9ad4\uff0c\u91cd\u8907\u5be6\u9a57\uff0c\u537b\u767c\u73fe GDF11 \u4e0d\u50c5\u96a8\u8457\u8001\u5316\u5728\u8840\u6db2\u4e2d\u6fc3\u5ea6\u65e5\u6f38\u589e\u52a0\uff1b\u6ce8\u5c04 GDF11 \u5230\u8001\u9f20\u9ad4\u5167\uff0c\u751a\u81f3\u6703\u6291\u5236\u5e74\u8f15\u8001\u9f20\u9aa8\u9abc\u808c\u8089\u7684\u518d\u751f\u4fee\u5fa9\u3002<\/p>\n<p>\u4f46\u96a8\u5f8c\uff0cWagers \u5be6\u9a57\u5ba4\u537b\u767c\u73fe Novartis \u7814\u767c\u51fa\u4f86\u865f\u7a31\u80fd\u5920\u5c08\u4e00\u6027\u5075\u6e2c GDF11 \u7684\u6297\u9ad4\uff0c\u624d\u662f\u500b\u5b8c\u5168\u8a8d\u932f\u86cb\u767d\u8cea\u7684\u300c\u5927\u81c9\u76f2\u300d\uff1a\u8a72\u682a\u6297\u9ad4\u6240\u8fa8\u8b58\u7684\u86cb\u767d\u8cea\uff0c\u5176\u5be6\u662f\u514d\u75ab\u7403\u86cb\u767d\uff08immunoglobulin\uff09\uff0c\u662f\u53e6\u4e00\u500b\u96a8\u8457\u5e74\u9f61\u8001\u5316\uff0c\u6703\u5728\u8840\u6db2\u4e2d\u6fc3\u5ea6\u905e\u589e\u7684\u86cb\u767d\u8cea\u3002\u4ed6\u5011\u540c\u6642\u4e5f\u53cd\u99c1\u53e6\u4e00\u7bc7\u767c\u73fe GDF11 \u5c0d\u5e74\u9081\u8001\u9f20\u5fc3\u81df\u80a5\u539a\u7121\u7de9\u548c\u6548\u679c\u7684\u7814\u7a76\uff0c\u8a8d\u70ba\u7b87\u4e2d\u539f\u56e0\u6709\u53ef\u80fd\u662f\u751f\u6280\u5ee0\u5546\u6240\u88fd\u9020\u8ca9\u552e\u7684 GDF11\uff0c\u5728\u5404\u6279\u7522\u54c1\u88e1\uff0c\u6709\u6d3b\u6027\u7684 GDF11 \u6bd4\u4f8b\u6709\u6240\u5dee\u7570\u3002\u7576\u7136\uff0c\u5404\u5bb6\u5be6\u9a57\u5ba4\u7528\u4ee5\u8a98\u4f7f\u808c\u8089\u640d\u50b7\u7684\u5be6\u9a57\u65b9\u6cd5\u4e5f\u90fd\u4e0d\u4e00\u6a23\uff0c\u800c\u9019\u4e5f\u6709\u53ef\u80fd\u662f\u9020\u6210\u7d50\u679c\u83ab\u8877\u4e00\u662f\u7684\u5e55\u5f8c\u9ed1\u624b\u3002<\/p>\n<p>\u4f46\u9664\u4e86 GDF11\uff0c\u4f4d\u65bc Stanford University \u7684Wyss-Coray \u535a\u58eb\uff0c\u4e5f\u5c31\u662f\u4e3b\u5c0e\u9019\u7bc7\u5728\u7b2c\u5341\u5c46\u963f\u8332\u6d77\u9ed8\u75c7\u81e8\u5e8a\u8a66\u9a57\u5e74\u6703\u4e0a\u767c\u8868\u8a66\u9a57\u7d50\u679c\u7684\u5be6\u9a57\u5ba4\uff0c\u5247\u5c07\u7c4c\u78bc\u653e\u4e0a\u4e86 TIMP2 \u9019\u500b\u86cb\u767d\u8cea\u3002\u4ed6\u5011\u767c\u73fe\u5982\u679c\u7d66\u4e88\u5e74\u8001\u8001\u9f20 TIMP2\uff0c\u80fd\u5920\u8b93\u8001\u9f20\u5728\u8a18\u61b6\u6e2c\u9a57\u4e0a\u5927\u5e45\u9032\u6b65\uff0c\u5e7e\u4e4e\u53ef\u4ee5\u8868\u73fe\u5f97\u8ddf\u7d66\u4e88\u81cd\u5e36\u8840\u6ce8\u5c04\u7684\u5e74\u8001\u8001\u9f20\u4e00\u6a23\u597d\uff1b\u800c\u5982\u679c\u5c07\u81cd\u5e36\u8840\u88e1\u7684 TIMP2 \u86cb\u767d\u8cea\u53bb\u9664\uff0c\u5247\u6ce8\u5c04\u81cd\u5e36\u8840\u7684\u8001\u9f20\uff0c\u5c31\u4e0d\u518d\u6709\u8a18\u61b6\u529b\u9032\u6b65\u7684\u8868\u73fe\u3002\u800c\u4e14\uff0c\u5982\u679c\u5728\u5e74\u8f15\u8001\u9f20\u9ad4\u5167\u963b\u65b7 TIMP2\uff0c\u5e74\u8f15\u8001\u9f20\u4e5f\u6703\u51fa\u73fe\u8a18\u61b6\u529b\u8870\u9000\u7684\u8001\u5316\u73fe\u8c61\u3002<\/p>\n<p>Wyss-Coray \u535a\u58eb\u5c0d\u300c\u5e74\u8f15\u300d\u8840\u6db2\u80fd\u5920\u6297\u8001\u5316\u7684\u6f5b\u529b\uff0c\u4e00\u76f4\u662f\u5145\u6eff\u71b1\u5ff1\u4e5f\u4fe1\u5fc3\u52c3\u52c3\u3002\u4f46\uff0c\u79d1\u5b78\u754c\u88e1\uff0c\u5c0d\u9019\u5047\u8aaa\u7684\u8cea\u7591\u8072\u6d6a\u4e5f\u4e00\u76f4\u5b58\u5728\u3002\u9996\u5148\uff0c\u5728\u5e74\u8f15\u8001\u9f20\u8207\u5e74\u8001\u8001\u9f20\u7570\u9ad4\u5171\u751f\u7684\u5be6\u9a57\u88e1\uff0c\u5169\u96bb\u8001\u9f20\u4e0d\u55ae\u55ae\u662f\u5171\u4eab\u4e86\u8840\u6db2\u5faa\u74b0\u7cfb\u7d71\uff0c\u8a31\u591a\u9ad4\u5167\u4ee3\u8b1d\u7cfb\u7d71\u4e5f\u53ef\u80fd\u5728\u7570\u9ad4\u5171\u751f\u6642\uff0c\u8b93\u5e74\u8f15\u8001\u9f20\u7684\u7cfb\u7d71\u5668\u5b98\u505a\u8457\u5169\u96bb\u8001\u9f20\u7684\u6d3b\u3002\u518d\u8005\uff0c\u662f\u4e0d\u662f\u4e5f\u6709\u53ef\u80fd\u662f\u5e74\u8001\u8001\u9f20\u7684\u8840\u6db2\u5167\u300c\u4fc3\u8001\u300d\u7269\u8cea\uff0c\u5728\u7570\u9ad4\u5171\u751f\u6642\u88ab\u7a00\u91cb\u6389\u4e86\u5462\uff1f\u76f8\u95dc\u7684\u7814\u7a76\u9023\u5e36\u5ef6\u4f38\u51fa\u8a31\u591a\u672a\u89e3\u8b0e\u984c\uff0c\u800c\u8a31\u591a\u5be6\u9a57\u5ba4\u4e5f\u5728\u5162\u5162\u696d\u696d\u627e\u8457\u7b54\u6848\u3002<\/p>\n<p>\u90a3\uff0cWyss-Coray\u535a\u58eb\u5728\u7b2c\u5341\u5c46\u963f\u8332\u6d77\u9ed8\u75c7\u81e8\u5e8a\u8a66\u9a57\u5e74\u6703\u4e0a\u767c\u8868\u7684\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u5982\u4f55\u5462\uff1f\u5728\u4ed6\u5011\u898f\u6a21\u5c0f\u5c0f\u7684\u81e8\u5e8a\u7814\u7a76\u88e1\uff0c\u6700\u7d42\u7d50\u679c\u767c\u73fe\u5e74\u8f15\u4eba\u7684\u8840\u6db2\u5c0d\u5ef6\u7de9\u963f\u8332\u6d77\u9ed8\u75c7\u75c5\u4eba\u7684\u75c5\u7a0b\uff0c\u6c92\u6709\u986f\u8457\u5e6b\u52a9\u3002\u4f46\u75c5\u4eba\u6c92\u6709\u51fa\u73fe\u660e\u986f\u7684\u56b4\u91cd\u526f\u4f5c\u7528\uff0c\u8b93\u4ed6\u5011\u5c0d\u7642\u7a0b\u8a2d\u8a08\u6709\u4e86\u4fe1\u5fc3\uff0c\u800c\u5728\u770b\u8b77\u8207\u7167\u8b77\u4eba\u54e1\u7684\u554f\u5377\u8abf\u67e5\u88e1\uff0c\u5e74\u8f15\u4eba\u7684\u8840\u6db2\u4f3c\u4e4e\u5c0d\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u65e5\u5fa9\u4e00\u65e5\u7684\u65e5\u5e38\u8d77\u5c45\u529f\u80fd\uff0c\u6709\u4e9b\u9032\u6b65\u3002\u81f3\u5c11\uff0cWyss-Coray \u535a\u58eb\u5728\u6297\u8001\u5316\u7684\u7814\u7a76\u8def\u4e0a\uff0c\u4f9d\u7136\u662f\u71b1\u60c5\u6eff\u6eff\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u539f\u59cb\u8cc7\u6599\uff1a<\/strong>Wyss-Coray \u535a\u58eb\u5be6\u9a57\u5ba4\u5728\u5e74\u6703\u4e0a\u7684\u8ad6\u6587\u6458\u8981\uff1aSha S, et al. The Plasma for Alzhemer sympton Amelioration (PLASMA) Study. 10<sup>th<\/sup> Clinical Trials on Alzheimer\u2019s Disease Conference, Boston, MA, USA, Nov 2017. Abstract # LBP34.<br \/>\nWyss-Coray \u535a\u58eb\u4e3b\u5c0e\u7684\u81e8\u5e8a\u8a66\u9a57\uff08# NCT02256306\uff09\uff1a<br \/>\nThe PLasma for Alzheimer SymptoM Amelioration (PLASMA) Study (PLASMA): <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02256306\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02256306<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Kaiser J. Blood from young people does little to reverse Alzheimer\u2019s in first test. Science. Nov 1, 2017.<\/li>\n<li>Hall SS. Young blood. Science. 2014 Sep 12;345(6202):1234-7. doi: 10.1126\/science.345.6202.1234. PMID: 25214587<\/li>\n<li>Brun CE, Rudnicki MA. GDF11 and the Mythical Fountain of Youth. Cell Metab. 2015 Jul 7;22(1):54-6. doi: 10.1016\/j.cmet.2015.05.009. Epub 2015 May 20.<\/li>\n<li>Walker RG, et al. Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Circ Res. 2016 Apr 1;118(7):1125-41; discussion 1142. doi: 10.1161\/CIRCRESAHA.116.308391<\/li>\n<li>Wyss-Coray T. Ageing, neurodegeneration and brain rejuvenation. Nature. 2016 Nov 10;539(7628):180-186. doi: 10.1038\/nature20411.<\/li>\n<li>Kaiser J. BIOMEDICINE. Antiaging trial using young blood stirs concerns. Science. 2016 Aug 5;353(6299):527-8. doi: 10.1126\/science.353.6299.527. PMID: 27493159<\/li>\n<li>Kaiser J. Regenerative medicine. 'Rejuvenating' protein doubted. Science. 2015 May 22;348(6237):849. doi: 10.1126\/science.348.6237.849. PMID: 25999487<\/li>\n<\/ol>\n<p><strong>--<\/strong><br \/>\n<span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u5e74\u8f15\u4eba\u7684\u8840\u6f3f\u6703\u662f\u9752\u6625\u4e0d\u8001\u6cc9\u7684\u79d8\u5bc6\u55ce\uff1f\u5341\u4e00\u6708\u521d\uff0c\u5728\u7f8e\u570b\u6ce2\u58eb\u9813\u8209\u884c\u7684\u7b2c\u5341\u5c46\u963f\u8332\u6d77\u9ed8\u75c7\u81e8\u5e8a\u8a66\u9a57\u5e74\u6703\u4e0a\uff0c\u6709\u7bc7\u5e38\u88ab\u5a92\u9ad4\u8207\u671f\u520a\u66b1\u7a31\u70ba\u300c\u5438\u8840\u9b3c\u300d\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u767c\u8868\u4e86\u521d\u6b65\u7d50\u679c\u3002\u9019\u8d77\u81e8\u5e8a\u8a66\u9a57\u7531\u7f8e\u570b Stanford University\u3001Tony Wyss-Coray \u535a\u58eb\u5be6\u9a57\u5ba4\u6240\u4e3b\u5c0e\uff0c\u60f3\u8981\u77e5\u9053\u5e74\u8f15\u4eba\u7684\u8840\u6db2\u5c0d\u8001\u5e74\u4eba\u4f86\u8aaa\uff0c\u662f\u4e0d\u662f\u5177\u6709\u300c\u6297\u8001\u5316\u300d\u7684\u529f\u6548\u3002<\/p>\n","protected":false},"author":20,"featured_media":30011,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,2977,1025],"tags":[3679,3680,2044,3677,3678],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2018\/01\/134760638.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29969"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29969"}],"version-history":[{"count":6,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29969\/revisions"}],"predecessor-version":[{"id":31927,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29969\/revisions\/31927"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/30011"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29969"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29969"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}