{"id":29908,"date":"2018-01-05T00:08:48","date_gmt":"2018-01-04T16:08:48","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=29908"},"modified":"2018-07-29T15:28:10","modified_gmt":"2018-07-29T07:28:10","slug":"%e4%b8%89%e4%ba%ba%e8%a1%8c%e5%bf%85%e6%9c%89%e6%88%91%e5%b8%ab%e7%84%89%ef%bc%9a%e5%be%9e%e7%99%8c%e7%97%87%e8%ba%ab%e4%b8%8a%e6%89%be%e9%a3%9f%e6%85%be%e6%8e%a7%e5%88%b6%e8%97%a5%e7%89%a9%e6%96%b0","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=29908","title":{"rendered":"\u4e09\u4eba\u884c\u5fc5\u6709\u6211\u5e2b\u7109\uff1a\u5f9e\u764c\u75c7\u8eab\u4e0a\u627e\u98df\u617e\u63a7\u5236\u85e5\u7269\u65b0\u9748\u611f"},"content":{"rendered":"

\u25a0\u53e4\u4eba\u8aaa\uff0c\u300c\u4e09\u4eba\u884c\uff0c\u5fc5\u6709\u6211\u5e2b\u7109\u3002\u300d\u90a3\u50cf\u662f\u764c\u75c7\u9019\u7a2e\u5728\u53f0\u7063\u8207\u4e16\u754c\u5341\u5927\u6b7b\u56e0\u88e1\u4e45\u4e45\u90fd\u540d\u5217\u524d\u8305\u7684\u982d\u597d\u5927\u9ebb\u7169\uff0c\u4e5f\u6709\u6211\u5011\u53ef\u300c\u5e2b\u300d\u7684\u9577\u8655\u55ce\uff1fYes! \u79d1\u5b78\u5bb6\u5728\u764c\u75c7\u8eab\u4e0a\uff0c\u627e\u5230\u4e86\u5982\u4f55\u63a7\u5236\u98df\u617e\u7684\u65b0\u9748\u611f\uff01<\/strong><\/span><\/p>\n

\"\"\u64b0\u6587\uff5c\u99f1\u5b9b\u7433<\/strong><\/p>\n

\u5728\u8ad6\u6587\u671f\u520a\u767c\u8868\u4e0a\uff0c\u5076\u723e\u53ef\u4ee5\u770b\u5230\u5169\u7bc7\u8ad6\u6587\u5728\u540c\u4e00\u672c\u671f\u520a\u4e0a\uff0c\u9b5a\u5e6b\u6c34\u3001\u6c34\u5e6b\u9b5a\u7684\u624b\u727d\u624b\u4e00\u8d77\u806f\u5408\u767c\u8868\u3002\u4f46\u5341\u6708\uff0c\u537b\u6709\u4f86\u81ea\u56db\u5927\u85e5\u5ee0\u7814\u7a76\u54e1\u7684\u56db\u7bc7\u6587\u7ae0\u540c\u6642\u767c\u8868\u3002\u5176\u4e2d\u4e09\u7bc7\u520a\u5728\u00a0Nature Medicine\u00a0<\/em>\u4e0a\uff0c\u53e6\u4e00\u7bc7\u520a\u8f09\u65bc\u00a0Nature<\/em>\u3002\u662f\u4ec0\u9ebc\u9818\u57df\u7684\u7814\u7a76\u9019\u9ebc\u53b2\u5bb3\uff1f\u4e0d\u50c5\u8b93\u5404\u5927\u85e5\u5ee0\u8da8\u4e4b\u82e5\u9da9\uff0c\u505a\u51fa\u4f86\u7684\u7814\u7a76\u4e5f\u5982\u6b64\u64f2\u5730\u6709\u8072\uff1f<\/p>\n

\u9019\u56db\u7bc7\u7814\u7a76\uff0c\u90fd\u628a\u7126\u9ede\u653e\u5728 GDF15 \u8eab\u4e0a\u2014\u2014 GDF15 \u662f\u500b\u5728\u5be6\u9a57\u5c0f\u9f20\u3001\u5927\u9f20\uff0c\u8207\u7334\u5b50\u8eab\u4e0a\uff0c\u90fd\u6709\u660e\u986f\u6e1b\u91cd\u6548\u679c\u537b\u6c92\u6709\u89c0\u5bdf\u5230\u526f\u4f5c\u7528\u7684\u86cb\u767d\u8cea\u3002<\/p>\n

\u6700\u5148\u767c\u73fe GDF15 \u6709\u8457\u63a7\u5236\u9ad4\u91cd\u6f5b\u529b\u7684\u300c\u4f2f\u6a02\u300d\uff0c\u662f\u6fb3\u6d32\u96ea\u68a8\u8056\u6587\u68ee\u91ab\u9662\u7684Samuel Breit \u535a\u58eb\u3002Breit \u535a\u58eb\u662f\u91ab\u751f\uff0c\u4f46\u540c\u6642\u4e5f\u662f\u500b\u514d\u75ab\u5b78\u5bb6\u3002\u4ed6\u5c0d\u81e8\u5e8a\u514d\u75ab\u5b78\u7684\u8208\u8da3\uff0c\u9396\u5b9a\u5728\u70ba\u4ec0\u9ebc\u764c\u75c7\u5f8c\u671f\u75c5\u4eba\u5e38\u5e38\u4f34\u96a8\u8457\u53ad\u98df\u75c7(anorexia)\uff0c\u800c\u6700\u7d42\u5c0e\u81f4\u764c\u75c7\u60e1\u75c5\u9ad4\u8cea\u75c7\u5019\u7fa4(cachexia)\u3001\u56b4\u91cd\u71df\u990a\u4e0d\u826f\u7684\u72c0\u6cc1\u3002\u5728\u90a3\u6642\u5019\uff0c\u79d1\u5b78\u7814\u7a76\u754c\u666e\u904d\u8a8d\u70ba\u4f34\u96a8\u764c\u75c7\u5f8c\u671f\u6240\u51fa\u73fe\u7684\u53ad\u98df\u75c7\uff0c\u4e3b\u8981\u7531\u7d30\u80de\u6fc0\u7d20(cytokines)\u6240\u5c0e\u81f4\uff1b\u800c\u7f6a\u9b41\u798d\u9996\u7684\u5927\u5e3d\u5b50\uff0c\u5c31\u6263\u5728\u6703\u4fc3\u9032\u767c\u708e\u53cd\u61c9\u7684\u7d30\u80de\u6fc0\u7d20 IL-6\u3001IL-1\uff0c\u8207 TNF \u8eab\u4e0a\u3002\u800c\u5f9e\u764c\u75c7\u75c5\u4eba\u6240\u6536\u96c6\u5230\u7684\u8840\u6db2\u6aa2\u9ad4\u88e1\uff0c\u9019\u4e09\u7a2e\u7d30\u80de\u6fc0\u7d20\u4e5f\u7684\u78ba\u8ddf\u53ad\u98df\u75c7\u75c5\u72c0\u986f\u8457\u76f8\u95dc\u3002<\/p>\n

\u4f46\u5728 2007 \u5e74\u6642\uff0c\u5728\u00a0\u00a0Nature Medicine\u00a0\u00a0<\/em>\u671f\u520a\u4e0a\uff0cBreit \u535a\u58eb\u7684\u7814\u7a76\u5718\u968a\u537b\u7368\u6392\u773e\u8b70\u7684\u6307\u51fa\uff0c\u5176\u5be6\u764c\u75c7\u75c5\u4eba\u8eab\u4e0a\u6240\u51fa\u73fe\u7684\u53ad\u98df\u75c7\u5e55\u5f8c\u85cf\u93e1\u4eba\u662f GDF15\u3002\u90a3\u6642\u5019\uff0c\u4ed6\u5011\u7528 GDF15 \u7684\u53e6\u4e00\u500b\u5225\u540d\uff1aMIC-1\uff0c\u662f\u5de8\u566c\u7d30\u80de\u6291\u5236\u56e0\u5b50\u7684\u7e2e\u5beb(macrophage inhibitory cytokine-1)\u3002\u4ed6\u5011\u5728\u7814\u7a76\u524d\u5217\u817a\u764c\u75c7\u5f8c\u671f\u75c5\u4eba\u7684\u8840\u6db2\u6aa2\u9ad4\u7684\u6642\u5019\uff0c\u767c\u73fe\u552f\u4e00\u548c\u75c5\u4eba\u534a\u5e74\u5167\u9ad4\u91cd\u5982\u81ea\u7531\u843d\u9ad4\u822c\u76f4\u7dda\u4e0b\u964d\uff0c\u6709\u5f37\u70c8\u6b63\u76f8\u95dc\u7684\u86cb\u767d\u8cea\uff0c\u662f GDF15\u3002\u6709\u8da3\u7684\u662f\uff0c\u96d6\u7136\u5728\u53e6\u4e00\u7d44\u524d\u5217\u817a\u764c\u5f8c\u671f\u75c5\u4eba\u7684\u8840\u6db2\u6aa2\u9ad4\uff0c\u8207\u6162\u6027\u814e\u8870\u7aed\u75c5\u4eba\u8eab\u4e0a\u4e5f\u8b49\u5be6\u4e86 GDF15 \u8207\u53ad\u98df\u75c7\u7684\u95dc\u806f\uff0c\u5728\u8178\u80c3\u9053\u76f8\u95dc\u764c\u75c7\u4e0a\uff0c\u4e26\u6c92\u6709\u89c0\u5bdf\u5230\u985e\u4f3c\u7684\u95dc\u806f\uff0c\u800c\u9019\u53ef\u80fd\u56e0\u70ba\u8178\u80c3\u9053\u5df2\u7d93\u88ab\u764c\u75c7\u6298\u78e8\u7684\u9ad4\u7121\u5b8c\u819a\u3002\u5728\u90a3\u7bc7\u7814\u7a76\u88e1\uff0cBreit \u5be6\u9a57\u5ba4\u63a5\u8457\u8b49\u5be6\uff0c\u96d6\u7136\u764c\u75c7\u7d30\u80de\u6703\u5927\u8086\u88fd\u9020 GDF15\uff0c\u800c\u4f7f\u5be6\u9a57\u5c0f\u9f20\u5931\u53bb\u98df\u617e\uff0c\u4f46\u6574\u500b\u904e\u7a0b\u4e5f\u4e0d\u662f\u764c\u75c7\u7d30\u80de\u5927\u6416\u5927\u64fa\u7684\u8aaa\u4e86\u5c31\u7b97\u3002\u5982\u679c\u7d66\u5be6\u9a57\u5c0f\u9f20\u80fd\u5920\u4e2d\u548c\u6389 GDF15 \u7684\u6297\u9ad4\uff0c\u5c31\u80fd\u8b93\u5c0f\u9f20\u91cd\u65b0\u898b\u300c\u98df\u300d\u80c3\u53e3\u5927\u958b\u3002\u540c\u7406\uff0c\u5982\u679c\u7d66\u4e88\u5065\u5eb7\u5c0f\u9f20 GDF15 \u7684\u91cd\u7d44\u86cb\u767d\uff0c\u4e5f\u80fd\u8b93\u6210\u5929\u5403\u5403\u5403\u7684\u5c0f\u9f20\uff0c\u5931\u53bb\u98df\u617e\u800c\u9ad4\u91cd\u76f4\u76f4\u843d\u3002<\/p>\n

GDF15 \u5230\u5e95\u662f\u4f55\u65b9\u795e\u8056\uff1fGDF15 \u662f\u8f49\u5316\u751f\u9577\u56e0\u5b50 \u03b2 \u5bb6\u65cf\u88e1\u7684\u4e00\u54e1(TGF\u03b2 superfamily)\uff0c\u5305\u62ec\u524d\u5217\u817a\u764c\u3001\u5927\u8178\u764c\u3001\u80f0\u81df\u764c\u8207\u4e73\u764c\u75c5\u4eba\u8eab\u4e0a\uff0c\u90fd\u53ef\u4ee5\u5075\u6e2c\u5230 GDF15 \u88ab\u7570\u5e38\u5730\u5927\u91cf\u8868\u73fe\u3002\u5728\u764c\u75c7\u5f8c\u671f\u75c5\u4eba\u9ad4\u5167\u7684 GDF15 \u6fc3\u5ea6\uff0c\u53ef\u4ee5\u5f9e 0.45 ng\/ml \u907d\u589e\u5230 5 ng\/ml \u5230 50 ng\/ml\uff0c\u5927\u6982\u662f\u4e00\u767e\u500d\u7684\u589e\u5e45\u3002\u5728\u5065\u5eb7\u4eba\u8eab\u4e0a\uff0cGDF15 \u4e3b\u8981\u8868\u73fe\u65bc\u809d\u81df\uff0c\u4e0d\u904e\u5728\u8178\u9053\u3001\u814e\u4e0a\u817a\u8207\u814e\u81df\u7d30\u80de\u88e1\uff0c\u4e5f\u6709\u5c11\u91cf\u7684 GDF15 \u8e64\u8de1\u3002<\/p>\n

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\u8a31\u591a\u5be6\u9a57\u5ba4\u90fd\u60f3\u8ffd\u6839\u7a76\u5e95 GDF15 \u7684\u5e95\u7d30\uff1b\u7b2c\u4e00\u6ce2\u7814\u7a76\u6240\u5efa\u69cb\u7684 GDF15 \u6a21\u578b\uff0c\u8a8d\u70ba GDF15 \u85c9\u7531\u7d50\u5408\u4e0a\u662f\u8f49\u5316\u751f\u9577\u56e0\u5b50 \u03b2 \u5bb6\u65cf\u88e1\u53d7\u5668\u88e1\u7684\u4e00\u54e1 TGF\u03b2RII\uff0c\u800c\u65bd\u5c55\u5176\u9b54\u529b\u3002\u4f46\u9019\u6a23\u7684\u5047\u8aaa\uff0c\u4e0d\u50c5\u7121\u6cd5\u88ab\u5f8c\u7e7c\u7814\u7a76\u6240\u8b49\u5be6\uff0c\u4e5f\u6709\u9ede\u50cf\u662f\u770b\u5230\u7d05\u773c\u775b\u5c31\u76f4\u558a\u5c0f\u5154\u5b50\uff0c\u800c\u5f88\u53ef\u60dc GDF15 \u7684\u4f5c\u7528\u6a5f\u8f49\u4e26\u6c92\u6709\u9019\u9ebc\u76f4\u89c0\u3002\u6700\u8fd1\u9019\u56db\u7bc7\u7814\u7a76\uff0c\u5247\u6709\u5fd7\u4e00\u540c\u7684\u627e\u5230 GDF15 \u7684\u4f5c\u7528\u6a19\u9776\uff0c\u662f\u900f\u904e GFRAL\u53d7\u5668\u3002GFRAL \u53d7\u5668\u7b97\u662f\u8f49\u5316\u751f\u9577\u56e0\u5b50\u03b2 \u53d7\u5668\u7684\u9060\u89aa\uff0c\u5728\u9019\u56db\u7bc7\u7814\u7a76\u767c\u8868\u524d\uff0cGFRAL \u7684\u5e95\u7d30\u4ecd\u7136\u591a\u534a\u662f\u8b0e\u3002<\/p>\n

\u9019\u56db\u7bc7\u7814\u7a76\u90fd\u501f\u93e1\u524d\u4eba\u7684\u6559\u8a13\uff0c\u800c\u5c07\u641c\u5c0b\u7bc4\u570d\u986f\u8457\u64f4\u5927\uff0c\u4e0d\u505a\u904e\u591a\u7684\u9810\u8a2d\u3002\u5728 GDF15 \u5230\u5e95\u7d50\u5408\u4e0a\u54ea\u500b\u53d7\u5668\u7684\u6349\u8ff7\u85cf\u88e1\uff0c\u5404\u500b\u5be6\u9a57\u5ba4\u6709\u5404\u81ea\u8b93\u8a72\u53d7\u5668\u73fe\u5f62\u7684\u6cd5\u5bf6\uff0c\u4f46\u7814\u64ec\u7b56\u7565\u7684\u908f\u8f2f\u5927\u81f4\u985e\u4f3c\u3002\u5229\u7528\u884d\u751f\u81ea\u4eba\u985e\u80da\u80ce\u814e\u7d30\u80de\u7684 HEK293 \u7d30\u80de\u682a\uff0c\u8868\u73fe\u6240\u6709\u4e0a\u5343\u7a2e\u4e0d\u540c\u7684\u7d30\u80de\u819c\u86cb\u767d\u8cea\uff0c\u5efa\u7acb\u51fa\u4e00\u7d44\u8cc7\u6599\u5eab\u3002\u7136\u5f8c\u5229\u7528\u6297\u9ad4\u5de5\u7a0b\u6280\u8853\uff0c\u5c07 GDF15 \u91cd\u7d44\u86cb\u767d\u63a5\u4e0a\u6297\u9ad4\u7684\u57fa\u5ea7\u300cFc\u300d\u5340\u6bb5\uff0c\u7136\u5f8c\u5229\u7528\u5730\u6bef\u5f0f\u641c\u5c0b\uff0c\u770b\u770b\u8868\u73fe\u4e86\u54ea\u4e00\u500b\u7279\u5b9a\u7d30\u80de\u819c\u86cb\u767d\u8cea\u7684 HEK293 \u7d30\u80de\uff0c\u53ef\u4ee5\u7d50\u5408\u4e0a GDF15-Fc \u91cd\u7d44\u86cb\u767d\u3002\u800c\u63a5\u4e0a\u6297\u9ad4\u57fa\u5ea7 Fc \u5340\u6bb5\u7684 GDF15\uff0c\u5c31\u50cf\u662f\u5728\u982d\u4e0a\u5857\u4e86\u8702\u871c\u4e00\u6a23\uff0c\u8b93\u7814\u7a76\u4eba\u54e1\u53ef\u4ee5\u8f15\u800c\u6613\u8209\u7684\u5229\u7528\u5176\u4ed6\u5e36\u6709\u87a2\u5149\u86cb\u767d\u7684\u6297\u9ad4\u4f86\u8b93 GDF15 \u7684\u8e64\u8de1\u5b8c\u5168\u73fe\u5f62\u3002<\/p>\n

\u5c07\u8fd1\u4e94\u5343\u7a2e\u4e0d\u540c\u7684\u7d30\u80de\u819c\u86cb\u767d\u88ab\u6e2c\u8a66\uff0c\u800c\u56db\u500b\u5be6\u9a57\u5ba4\u90fd\u53ea\u767c\u73fe\u4e00\u500b\u7d30\u80de\u819c\u53d7\u5668\u3001GFRAL\u88ab GDF15 \u9752\u775e\u3002\u78ba\u8a8d GDF15 \u7684\u5fc3\u982d\u597d\u4e4b\u5f8c\uff0c\u4e0b\u4e00\u500b\u6311\u6230\u5c31\u662f\u627e\u51fa GFRAL \u5728\u751f\u7269\u9ad4\u5167\u7684\u85cf\u533f\u8655\u3002\u6709\u8da3\u7684\u662f\uff0cGFRAL \u986f\u7136\u5c0d\u5176\u300c\u5c45\u6240\u300d\u4e5f\u5f88\u6311\u60d5\uff0c\u56db\u7bc7\u7814\u7a76\u90fd\u767c\u73fe GFRAL \u53ea\u5728\u8166\u5167\u5169\u500b\u5340\u57df\u8868\u73fe\uff1a\u4f4d\u65bc\u5f8c\u8166(hindbrain)\u7684\u8166\u6975\u5f8c\u5340(area postrema)\uff0c\u4ee5\u53ca\u5b64\u675f\u6838(nucleus of the tractus solitaries)\u3002\u800c\u9019\u540c\u6642\u662f\u500b\u597d\u6d88\u606f\uff0c\u4e5f\u662f\u500b\u58de\u6d88\u606f\u3002\u70ba\u4ec0\u9ebc\uff1f<\/p>\n

\u4e00\u822c\u800c\u8a00\uff0c\u5927\u8166\u88ab\u8840\u8166\u969c\u853d\u6240\u7dca\u7dca\u4fdd\u8b77\u8457\uff0c\u53ea\u5141\u8a31\u67d0\u90e8\u5206\u7269\u8cea\u901a\u904e\uff0c\u85c9\u4ee5\u4fdd\u8b77\u8166\u5167\u74b0\u5883\u7684\u6046\u5b9a\u6027\uff0c\u4e0d\u53d7\u8eab\u9ad4\u5faa\u74b0\u5167\u5176\u4ed6\u7269\u8cea\u7684\u5f71\u97ff\uff0c\u66f4\u4fdd\u8b77\u5927\u8166\u4e0d\u53d7\u6bd2\u7d20\u3001\u5fae\u751f\u7269\u7b49\u7684\u5165\u4fb5\u3002\u4f46\u8840\u8166\u969c\u853d\u4e5f\u9020\u6210\u85e5\u7269\u8a2d\u8a08\u4e0a\u7684\u56f0\u96e3\uff0c\u8981\u8b93\u85e5\u7269\u80fd\u5920\u901a\u904e\u8840\u8166\u969c\u853d\u7684\u6aa2\u67e5\u54e8\uff0c\u4e0d\u662f\u4e00\u4ef6\u5bb9\u6613\u7684\u4e8b\u3002\u4e0d\u904e\uff0cGFRAL \u6240\u8868\u73fe\u7684\u5340\u57df\uff0c\u6070\u6070\u662f\u8840\u8166\u969c\u853d\u9632\u885b\u6700\u8584\u5f31\u7684\u5340\u57df\u3002\u4ee5\u8166\u6975\u5f8c\u5340\u4f86\u8aaa\uff0c\u4e5f\u540c\u6642\u662f\u300c\u5614\u5410\u4e2d\u5fc3\u300d\uff0c\u8b93\u751f\u7269\u5982\u679c\u4e0d\u5c0f\u5fc3\u8aa4\u98df\u6709\u6bd2\u98df\u7269\uff0c\u5728\u6bd2\u7d20\u5230\u9054\u8166\u6975\u5f8c\u5340\u6642\uff0c\u80fd\u5920\u8a98\u767c\u5614\u5410\u53cd\u61c9\uff0c\u597d\u8b93\u6bd2\u7d20\u5c0d\u751f\u7269\u9ad4\u7684\u50b7\u5bb3\u7a0b\u5ea6\u6e1b\u5230\u6700\u4f4e\u3002\u56e0\u6b64\uff0c\u56e0\u70ba GFRAL \u5728\u8166\u5167\u7684\u8868\u73fe\u5340\u57df\u4e0d\u53d7\u8840\u8166\u969c\u853d\u56b4\u683c\u63a7\u7ba1\uff0c\u5c0d\u65bc\u85e5\u54c1\u958b\u767c\u4f86\u8aaa\uff0c\u4e0d\u557b\u662f\u500b\u597d\u6d88\u606f\u3002<\/p>\n

\u4f46\uff0c\u9019\u4e5f\u540c\u6642\u662f\u500b\u5169\u9762\u5203\u3002\u5982\u679c\u85e5\u7269\u7684\u9776\u9ede\u6070\u6070\u4f4d\u5728\u5614\u5410\u4e2d\u5fc3\uff0c\u611f\u89ba\u5c31\u7b97\u7ad9\u4e0a\u9ad4\u91cd\u8a08\u7684\u90a3\u5e7e\u79d2\u5f88\u958b\u5fc3\uff0c\u4e5f\u4e0d\u662f\u500b\u5bb9\u6613\u8b93\u75c5\u60a3\u670d\u7528\u85e5\u7269\u7684\u7d93\u9a57\u592a\u904e\u6109\u6085\u7684\u7b56\u7565\u3002\u4e0d\u904e\uff0c\u5176\u4e2d\u4e00\u7d44\u7814\u7a76\u5718\u968a\uff0c\u5229\u7528\u86cb\u767d\u8cea\u5de5\u7a0b\u6280\u8853\uff0c\u5c07 GDF15 \u91cd\u7d44\u86cb\u767d\u6539\u9020\u70ba\u534a\u8870\u671f\u6bd4\u8f03\u9577\u7684\u9032\u5316\u7248\uff0c\u7136\u5f8c\u5c07\u9032\u5316\u7248\u7684 GDF15 \u7d66\u4e86\u7334\u5b50\u3002\u5728\u7334\u5b50\u8eab\u4e0a\uff0c\u7814\u7a76\u4eba\u54e1\u6c92\u6709\u89c0\u5bdf\u5230\u985e\u4f3c\u5614\u5410\u3001\u5641\u5fc3\uff0c\u6216\u662f\u4e0d\u8212\u670d\u7684\u526f\u4f5c\u7528\uff0c\u800c\u7334\u5b50\u7684\u9ad4\u91cd\u4e5f\u7684\u78ba\u5982\u9810\u671f\u822c\u4e0b\u964d\u3002\u4e0d\u904e\uff0c\u4e5f\u6709\u7814\u7a76\u52d5\u7269\u884c\u70ba\u7684\u795e\u7d93\u79d1\u5b78\u5bb6\u6307\u51fa\uff0c\u56e0\u70ba\u7814\u7a76\u4eba\u54e1\u7121\u6cd5\u76f4\u63a5\u4e86\u7576\u7684\u554f\u7334\u5b50\u651d\u53d6\u85e5\u7269\u5f8c\u611f\u89ba\u5982\u4f55\uff0cGDF15 \u7684\u4f5c\u7528\u9776\u9ede\u9084\u662f\u6709\u53ef\u80fd\u8b93\u9019\u6b3e\u85e5\u7269\u7814\u767c\u6709\u4e00\u5b9a\u7684\u8ced\u6ce8\u98a8\u96aa\u3002<\/p>\n

GDF15 \u795e\u5947\u55ce\uff1f\u8aaa\u5230\u5e95\uff0c\u5c31\u662f\u6709\u6548\u7684\u63a7\u5236\u9032\u98df\u98df\u617e\u3002\u5982\u679c\u7814\u7a76\u4eba\u54e1\u4f9d\u7167\u7d66\u4e86 GDF15 \u7684\u5c0f\u9f20\u9032\u98df\u91cf\uff0c\u4f86\u9650\u5236\u666e\u901a\u63a7\u5236\u7d44\u8001\u9f20\u9019\u4e00\u5929\u53ef\u4ee5\u5403\u591a\u5c11\u98df\u7269\uff0c\u90a3\u63a7\u5236\u7d44\u8001\u9f20\u4e5f\u80fd\u5920\u50cf GDF15 \u5c0f\u9f20\u4e00\u6a23\u7e96\u7d30\u82d7\u689d\u3002\u4f46\uff0c\u5982\u679c GDF15 \u80fd\u5920\u548c\u5176\u4ed6\u5df2\u7d93\u88ab\u6838\u51c6\u7684\u9ad4\u91cd\u63a7\u5236\u85e5\u7269\u4e00\u8d77\u6295\u4e88\uff0c\u6216\u8a31\u5c31\u80fd\u767c\u63ee\u4e00\u52a0\u4e00\u5927\u65bc\u4e8c\u7684\u6548\u7528\uff0c\u8b93\u904e\u65bc\u80a5\u80d6\u7684\u75c5\u60a3\u80fd\u5920\u9577\u671f\u7684\u6709\u6548\u63a7\u5236\u4f4f\u9ad4\u91cd\u4e86\uff0c\u800c\u9019\uff0c\u4e5f\u662f\u9019\u5e7e\u5927\u85e5\u5ee0\u52aa\u529b\u7684\u76ee\u6a19\u3002<\/p>\n

 <\/p>\n

\u539f\u59cb\u8ad6\u6587\uff1a<\/strong><\/p>\n

    \n
  1. Hsu JY, et al. Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature. 2017 Oct 12;550(7675):255-259. doi: 10.1038\/nature24042. Epub 2017 Sep 27. PMID: 28953886<\/li>\n
  2. Yang L, et al. GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. Nat Med. 2017 Oct;23(10):1158-1166. doi: 10.1038\/nm.4394. Epub 2017 Aug 28. PMID: 28846099<\/li>\n
  3. Emmerson PJ, et al. The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL. Nat Med. 2017 Oct;23(10):1215-1219. doi: 10.1038\/nm.4393. Epub 2017 Aug 28. PMID: 28846098<\/li>\n
  4. Mullican SE, et al. GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates. Nat Med. 2017 Oct;23(10):1150-1157. doi: 10.1038\/nm.4392. Epub 2017 Aug 28. PMID: 28846097<\/li>\n<\/ol>\n

    --<\/strong><\/span>
    \n\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    \u25a0\u53e4\u4eba\u8aaa\uff0c\u300c\u4e09\u4eba\u884c\uff0c\u5fc5\u6709\u6211\u5e2b\u7109\u3002\u300d\u90a3\u50cf\u662f\u764c\u75c7\u9019\u7a2e\u5728\u53f0\u7063\u8207\u4e16\u754c\u5341\u5927\u6b7b\u56e0\u88e1\u4e45\u4e45\u90fd\u540d\u5217\u524d\u8305\u7684\u982d\u597d\u5927\u9ebb\u7169\uff0c\u4e5f\u6709\u6211\u5011\u53ef\u300c\u5e2b\u300d\u7684\u9577\u8655\u55ce\uff1fYes! \u79d1\u5b78\u5bb6\u5728\u764c\u75c7\u8eab\u4e0a\uff0c\u627e\u5230\u4e86\u5982\u4f55\u63a7\u5236\u98df\u617e\u7684\u65b0\u9748\u611f\uff01<\/p>\n","protected":false},"author":20,"featured_media":29909,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[3660,3661,378],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/11\/fig.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29908"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29908"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29908\/revisions"}],"predecessor-version":[{"id":31935,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29908\/revisions\/31935"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/29909"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}