{"id":29618,"date":"2017-10-13T00:36:57","date_gmt":"2017-10-12T16:36:57","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=29618"},"modified":"2018-07-29T12:19:01","modified_gmt":"2018-07-29T04:19:01","slug":"%e5%af%b6%e8%b2%9d%e3%80%81%e5%af%b6%e8%b2%9d%ef%bc%8c%e7%b5%a6%e4%bd%a0%e4%b8%80%e9%bb%9e%e7%94%9c%e7%94%9c%ef%bc%8c%e8%ae%93%e5%85%8d%e7%96%ab%e7%b3%bb%e7%b5%b1%e4%b8%8d%e5%86%8d%e6%83%b9%e9%ba%bb","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=29618","title":{"rendered":"\u5bf6\u8c9d\u3001\u5bf6\u8c9d\uff0c\u7d66\u4f60\u4e00\u9ede\u751c\u751c\uff0c\u8b93\u514d\u75ab\u7cfb\u7d71\u4e0d\u518d\u60f9\u9ebb\u7169\uff01"},"content":{"rendered":"<p><span style=\"color: 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\u9031\u5927\u7684\u6642\u5019\uff0c\u9084\u662f\u4e00\u76f4\u90fd\u5065\u5065\u5eb7\u5eb7\uff0c\u7d72\u6beb\u6c92\u6709\u7cd6\u5c3f\u75c5\u75c7\u72c0\u3002\u9019\u4e9b\u5c0f\u8001\u9f20\u8840\u7cd6\u6b63\u5e38\uff0c\u9ad4\u5167\u8abf\u7bc0\u578b T \u7d30\u80de\u7684\u6bd4\u4f8b\uff0c\u8ddf\u7121\u7cd6\u7d44\u5c0f\u9f20\u4e00\u6bd4\uff0c\u66f4\u662f\u986f\u8457\u589e\u52a0\u3002\u800c\u88ab\u8a8d\u70ba\u9020\u6210\u7cd6\u5c3f\u75c5\u75c5\u7406\u7684\u7b2c\u4e00\u578b\u8207\u7b2c\u4e8c\u578b\u8f14\u52a9\u578b T \u7d30\u80de\uff0c\u7d30\u80de\u6bd4\u4f8b\u8207\u6240\u5206\u6ccc\u6703\u523a\u6fc0\u514d\u75ab\u53cd\u61c9\u7684\u7d30\u80de\u6fc0\u7d20\uff0c\u5728\u751c\u4e86\u5634\u7684\u5c0f\u8001\u9f20\u4e5f\u90fd\u986f\u8457\u964d\u4f4e\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u54e1\u9084\u8a66\u9a57\u4e86\u53e6\u4e00\u7d44\u56e0\u70ba T \u7d30\u80de\u6d3b\u5316\u800c\u5f15\u8d77\u547c\u5438\u9053\u767c\u708e\u7684\u52d5\u7269\u5be6\u9a57\u6a21\u578b\uff0c\u4e5f\u89c0\u5bdf\u5230\u4e86\u985e\u4f3c\u7684\u7d50\u679c\u3002\u5728\u98f2\u6c34\u88e1\u647b\u4e86\u7518\u9732\u7cd6\u7684\u5be6\u9a57\u8001\u9f20\u7d44\u88e1\uff0c\u8f03\u9ad8\u6bd4\u7387\u7684\u8abf\u7bc0\u578b T \u7d30\u80de\u4e5f\u80fd\u5920\u6291\u5236\u547c\u5438\u9053\u767c\u708e\uff0c\u800c\u4fdd\u8b77\u5be6\u9a57\u7d44\u8001\u9f20\u3002Chen \u535a\u58eb\u5be6\u9a57\u5ba4\u63a5\u8457\u767c\u73fe\uff0c\u7518\u9732\u7cd6\u80fd\u5920\u555f\u52d5\u5206\u5316\u6210\u8abf\u7bc0\u578b T \u7d30\u80de\u6240\u7d55\u5c0d\u9700\u8981\u7684\u8f49\u5316\u751f\u9577\u56e0\u5b50\u03b2\uff08TGF-\u03b2\uff09\u8a0a\u606f\u50b3\u905e\u8def\u5f91\uff0c\u6240\u4ee5\u8b93\u8f14\u52a9\u578b T 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D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017 Sep;23(9):1036-1045. doi: 10.1038\/nm.4375. Epub 2017 Jul 24.<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Schneider, A. et al. Successful prenatal mannose treatment for congenital disorder of glycosylation-Ia in mice. Nat. Med. 18, 71\u201373 (2011).<\/li>\n<li>Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity. 2013 Apr 18;38(4):633-43. doi: 10.1016\/j.immuni.2013.04.005. Review.<\/li>\n<li>Wang R, Green DR. Metabolic checkpoints in activated T cells. Nat Immunol. 2012 Oct;13(10):907-15. doi: 10.1038\/ni.2386. Epub 2012 Sep 18. Review.<\/li>\n<li>Sharma V, et al. Mannose metabolism: more than meets the eye. Biochem Biophys Res Commun. 2015 Oct 17.<\/li>\n<\/ol>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br \/>\n<span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u5403\u7cd6\uff1f\u4e0d\u597d\u3002\u7d66\u7cd6\uff1f\u4e0d\u8981\u3002\u81ea\u5f9e\u81e8\u5e8a\u4e0a\u8207\u7814\u7a76\u754c\u5f97\u5230\u4e00\u81f4\u5171\u8b58\uff0c\u5403\u592a\u591a\u7684\u7cd6\uff0c\u9664\u4e86\u8b93\u8170\u570d\u5927\uff0c\u66f4\u662f\u5c0e\u81f4\u4ee3\u8b1d\u578b\u75be\u75c5\u7684\u9ad8\u5371\u96aa\u56e0\u5b50\u4e4b\u5f8c\uff0c\u98f2\u98df\u4e0a\u9664\u4e86\u300c\u5c11\u6cb9\u3001\u5c11\u9e7d\u300d\uff0c\u7acb\u523b\u53c8\u591a\u4e86\u300c\u5c11\u7cd6\u300d\u3002 \u4f46\u5982\u679c\u4e00\u7aff\u5b50\u6253\u7ffb\u6240\u6709\u7cd6\uff0c\u771f\u7684\u597d\u55ce\uff1f\u6700\u8fd1\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\uff0c\u5728\u8001\u9f20\u8eab\u4e0a\u7518\u9732\u7cd6\u53ef\u4ee5\u6709\u6548\u9810\u9632\u81ea\u9ad4\u514d\u75ab\u6027\u7b2c\u4e00\u578b\u7cd6\u5c3f\u75c5 \u3002<\/p>\n","protected":false},"author":20,"featured_media":29619,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/09\/Cranberries.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29618"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29618"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29618\/revisions"}],"predecessor-version":[{"id":31864,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29618\/revisions\/31864"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/29619"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29618"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29618"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}