{"id":29334,"date":"2017-08-24T00:46:51","date_gmt":"2017-08-23T16:46:51","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=29334"},"modified":"2018-07-29T11:13:37","modified_gmt":"2018-07-29T03:13:37","slug":"%e9%87%91%e9%ad%9a%e5%a6%82%e4%bd%95%e5%8f%af%e4%bb%a5%e5%9c%a8%e7%bc%ba%e6%b0%a7%e7%9a%84%e7%92%b0%e5%a2%83%e4%b8%8b%e6%b4%bb%e4%ba%94%e5%80%8b%e6%9c%88%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=29334","title":{"rendered":"\u91d1\u9b5a\u5982\u4f55\u53ef\u4ee5\u5728\u7f3a\u6c27\u7684\u74b0\u5883\u4e0b\u6d3b\u4e94\u500b\u6708\uff1f"},"content":{"rendered":"<figure id=\"attachment_29336\" aria-describedby=\"caption-attachment-29336\" style=\"width: 400px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-29336\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/08\/Goldfish3.jpg\" alt=\"\" width=\"400\" height=\"429\" \/><figcaption id=\"caption-attachment-29336\" class=\"wp-caption-text\">\u91d1\u9b5a\u3002\u5716\u7247\u4f86\u6e90\uff1aWiki<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n<p>\u7d55\u5927\u90e8\u5206\u7684\u810a\u690e\u52d5\u7269\uff08vertebrate\uff09\u90fd\u662f\u597d\u6c27\u751f\u7269\uff0c\u7f3a\u6c27\u6642\u9802\u591a\u6490\u5e7e\u5206\u9418\u5c31\u639b\u4e86\uff1b\u6709\u4e9b\u9b5a\uff08\u5982\u9bc9\u9b5a<em>Cyprinus carpio<\/em>\uff09\u53ef\u4ee5\u6490\u5e7e\u5c0f\u6642\u3002\u4f46\u6709\u6975\u5c11\u6578\u7684\u786c\u9aa8\u9b5a\uff0c\u53ef\u4ee5\u71ac\u597d\u5e7e\u500b\u6708\uff01\u7260\u5011\u767c\u5c55\u51fa\u9019\u500b\u80fd\u529b\uff0c\u4e3b\u8981\u70ba\u4e86\u8981\u71ac\u904e\u51ac\u5929\u7684\u6642\u5019\u6e56\u6cca\u51b0\u5c01\u7f3a\u6c27\u7684\u554f\u984c\u3002\u5230\u5e95\u7260\u5011\u662f\u5982\u4f55\u80fd\u5728\u7f3a\u6c27\u7684\u72c0\u6cc1\u4e0b\u6d3b\u597d\u5e7e\u500b\u6708\u5462\uff1f<\/p>\n<p>\u8b93\u6211\u5011\u5148\u4f86\u77ad\u89e3\u4e00\u4e0b\uff0c\u4e00\u822c\u7684\u810a\u690e\u52d5\u7269\u7f3a\u6c27\u6642\u767c\u751f\u4ec0\u9ebc\u4e8b\u3002<\/p>\n<p>\u4e00\u822c\u7684\u810a\u690e\u52d5\u7269\uff08\u5982\u4f60\u3001\u6211\uff09\uff0c\u6211\u5011\u7522\u751f\u80fd\u91cf\u7684\u9014\u5f91\u4e3b\u8981\u662f\u4f9d\u9760\u91a3\u89e3\u4f5c\u7528\uff08glycolysis\uff09\u5148\u628a\u8461\u8404\u7cd6\u7b49\u5c0f\u5206\u5b50\u5206\u89e3\u70ba\u4e19\u916e\u9178\uff08pyruvate\uff09\uff0c\u518d\u628a\u4e19\u916e\u9178\u904b\u5165\u7c92\u7dda\u9ad4\uff08mitochondria\uff09\uff1b\u5728\u7c92\u7dda\u9ad4\u4e2d\uff0c\u4e19\u916e\u9178\u6703\u5148\u88ab\u4e19\u916e\u9178\u812b\u6c2b\u9176\u8907\u5408\u9ad4\uff08PDH\uff0cpyruvate dehydrogenase complex\uff09\u8f49\u63db\u70ba\u4e59\u91af\u8f14\u9176 A\uff08acetyl-CoA\uff09\uff0c\u518d\u9001\u5165\u6ab8\u6aac\u9178\u5faa\u74b0\uff08Citric acid cycle\uff09\u5b8c\u5168\u6c27\u5316\u3002<!--more--><\/p>\n<p>\u7f3a\u6c27\u7684\u6642\u5019\u56e0\u70ba\u7c92\u7dda\u9ad4\u7121\u6cd5\u4f5c\u7528\uff0c\u53ea\u5269\u4e0b\u91a3\u89e3\u4f5c\u7528\u7368\u6311\u5927\u6a11\uff1b\u4f46\u662f\u91a3\u89e3\u4f5c\u7528\u9700\u8981\u4e0d\u65b7\u7684\u6709\u83f8\u9e7c\u91af\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff08Nicotinamide adenine dinucleotide\uff0c\u4ee5\u4e0b\u7c21\u7a31 NAD<sup>+<\/sup>\uff09\u5c07\u5b83\u7522\u751f\u7684\u96fb\u5b50\u5e36\u8d70\u3002\u539f\u672c\u9019\u500b\u5de5\u4f5c\u662f\u4ea4\u7d66\u7c92\u7dda\u9ad4\u8655\u7406\u7684\uff0c\u4f46\u7f3a\u6c27\u6642\u7c92\u7dda\u9ad4\u7121\u6cd5\u5de5\u4f5c\uff0c\u65bc\u662f\u96fb\u5b50\u4fbf\u4ee5 NADH \u7684\u578b\u614b\u7d2f\u7a4d\uff0c\u9020\u6210\u91a3\u89e3\u4f5c\u7528\u56e0\u70ba\u7f3a\u5c11 NAD<sup>+\u00a0<\/sup>\u800c\u7121\u6cd5\u5de5\u4f5c\u3002<\/p>\n<p>\u9019\u6642\u5019\u6211\u5011\u7684\u7d30\u80de\u6703\u5148\u9032\u884c\u767c\u9175\u4f5c\u7528\uff08fermentation\uff09\uff0c\u6d88\u8017\u6389\u4e00\u90e8\u4efd\u7684 NADH\uff0c\u4f7f\u91a3\u89e3\u4f5c\u7528\u53ef\u4ee5\u7e7c\u7e8c\u904b\u884c\uff1b\u4f46\u662f\u767c\u9175\u4f5c\u7528\u6703\u7522\u751f\u4e73\u9178\uff08lactic acid\uff09\uff0c\u4e73\u9178\u5e36\u6709\u8f15\u5fae\u7684\u6bd2\u6027\uff0c\u4e0d\u80fd\u5132\u5b58\u5728\u9ad4\u5167\uff0c\u5fc5\u9808\u8981\u76e1\u5feb\u4ee3\u8b1d\u6389\uff0c\u5426\u5247\u5c31\u6703\u767c\u751f\u4e73\u9178\u4e2d\u6bd2\uff08lactic acidosis\uff09\uff1b\u56e0\u6b64\uff0c\u810a\u690e\u52d5\u7269\u4e0d\u80fd\u5728\u7f3a\u6c27\u7684\u72c0\u6cc1\u4e0b\u300c\u6490\u300d\u5f88\u4e45\u3002<\/p>\n<p>\u90a3\u9ebc\u9019\u4e9b\u53b2\u5bb3\u7684\u9b5a\uff08\u5982\u9ed1\u9bfd\u00a0<em>Carassius carassius<\/em>\u6216\u91d1\u9b5a\u00a0<em>Carassius auratus<\/em>\uff09\u662f\u600e\u9ebc\u6490\u597d\u5e7e\u500b\u6708\u5462\uff1f<\/p>\n<p>\u904e\u53bb\u7684\u7814\u7a76\u767c\u73fe\uff0c\u7260\u5011\u7adf\u7136\u53ef\u4ee5\u628a\u4e73\u9178\u8f49\u70ba\u9152\u7cbe\uff0c\u7136\u5f8c\u518d\u7d93\u7531\u9c13\u6392\u5230\u6c34\u4e2d\uff01\u4e4b\u524d\u7684\u7814\u7a76\u5718\u968a\u8a8d\u70ba\uff0c\u53ef\u80fd\u662f PDH \u628a\u4e19\u916e\u9178\u8f49\u70ba\u4e59\u919b\uff0c\u518d\u7531\u4e00\u500b\u7279\u5225\u7684\u9152\u7cbe\u53bb\u6c2b\u9176\uff08ADH\uff0calcohol dehydrogenase\uff09\u5c07\u4e59\u919b\u8f49\u70ba\u9152\u7cbe\u3002<\/p>\n<p>PDH \u662f\u771f\u6838\u751f\u7269\u4e2d\u6700\u5927\u7684\u86cb\u767d\u8cea\u8907\u5408\u9ad4\uff08protein complex\uff09\uff0c\u7531\u4e09\u500b\u9175\u7d20 E1, E2, E3 \u69cb\u6210\u3002\u5176\u4e2d\u6700\u91cd\u8981\u7684\u662f E1\uff0c\u7531\u5169\u500b\u03b1\u8207\u5169\u500b\u03b2\u6b21\u55ae\u5143\uff08subunit\uff09\u69cb\u6210\uff0c\u5176\u529f\u80fd\u70ba\u5c07\u4e19\u916e\u9178\u5148\u812b\u78b3\u3001\u9084\u539f\u5f8c\u518d\u5c07\u4e59\u91af\u57fa\uff08acetyl group\uff09\u8f49\u5230 E2\uff1b\u5982\u679c\u91d1\u9b5a\u7684 PDH \u4e0d\u518d\u5c07\u4e19\u916e\u9178\u812b\u78b3\u3001\u9084\u539f\uff0c\u800c\u662f\u5c07\u4e19\u916e\u9178\u8f49\u70ba\u4e59\u919b\uff0c\u662f\u5426\u610f\u5473\u8457 E1 \u7522\u751f\u4e86\u8b8a\u5316\u5462\uff1f<\/p>\n<p>\u70ba\u4e86\u89e3\u958b\u9019\u500b\u8b0e\u984c\uff0c\u632a\u5a01\u7684\u79d1\u5b78\u5bb6\u7d44\u6210\u7684\u7814\u7a76\u5718\u968a\u6bd4\u8f03\u4e86\u9bc9\u79d1\u9b5a\u985e\uff08\u9bc9\u9b5a\u3001\u9ed1\u9bfd\u3001\u91d1\u9b5a\uff09\u7684 PDH \u8207 ADH \u7684\u4fe1\u606f\u6838\u91a3\u6838\u9178\uff08mRNA\uff0cmessenger RNA\uff09\u7684\u5e8f\u5217\uff0c\u4ee5\u53ca\u9019\u4e9b\u57fa\u56e0\u5728\u6b63\u5e38\u72c0\u6cc1\u3001\u7f3a\u6c27\u4e00\u5929\u3001\u7f3a\u6c27\u4e03\u5929\u3001\u7f3a\u6c27\u4e03\u5929\u5f8c\u518d\u653e\u56de\u6b63\u5e38\u72c0\u6cc1\u516d\u5929\u5728\u4e0d\u540c\u7d44\u7e54\u88e1\u7684\u8868\u73fe\u72c0\u6cc1\u3002<\/p>\n<p>\u7d50\u679c\u767c\u73fe\uff0c\u5728\u9bc9\u9b5a\u7684\u4e0d\u540c\u7d44\u7e54\u88e1\uff0c\u4e0d\u8ad6\u4ec0\u9ebc\u72c0\u6cc1\uff0c\u7260\u7684 E1, E2, E3 \u7684\u8868\u73fe\u91cf\u90fd\u5dee\u4e0d\u591a\uff1b\u4f46\u662f\u5728\u9ed1\u9bfd\u7684\u9aa8\u9abc\u808c\u4e2d\uff0c\u5176 E1\u03b1 \u8207 E1\u03b2 \u7684 mRNA \u6574\u9ad4\u8868\u73fe\u91cf\u662f\u5fc3\u3001\u809d\u3001\u8166\u7684\u5341\u500d\u5230\u4e00\u767e\u500d\u3002\u86cb\u767d\u8cea\u7684\u8868\u73fe\u91cf\u4e5f\u547c\u61c9 mRNA \u7684\u91cf\u3002<\/p>\n<p>\u9019\u9ebc\u591a E1\u03b1 \u8207 E1\u03b2\uff0c\u662f\u4e0d\u662f\u90fd\u662f\u540c\u4e00\u500b\u57fa\u56e0\u7684\u7522\u7269\u5462\uff1f\u904e\u53bb\u5df2\u77e5\u9b5a\u985e\u5728\u4e00\u81f3\u4e8c\u5104\u5e74\u524d\u66fe\u767c\u751f\u904e\u4e00\u6b21\u57fa\u56e0\u9ad4\u91cd\u8907\uff0c\u9020\u6210 E1\u03b1 \u6709\u5169\u500b\u57fa\u56e0\uff08\u4ee5E1\u03b1<sub>1<\/sub>\u3001E1\u03b1<sub>2<\/sub>\u8868\u793a\uff09\uff0cE2 \u8207 E3 \u4e5f\u5404\u6709\u5169\u500b\uff08\u4ee5 E2a\u3001E2b\u3001E3a\u3001E3b \u8868\u793a\uff09\uff1b\u800c E1\u03b2 \u53ea\u6709\u4e00\u500b\u3002\u7814\u7a76\u5718\u968a\u5206\u6790\u5e8f\u5217\u7684\u7d50\u679c\u767c\u73fe\uff0c\u5728\u9ed1\u9bfd\u8207\u91d1\u9b5a\u7684\u9aa8\u9abc\u808c\u4e2d\uff0c\u9664\u4e86\u672c\u4f86\u7684\u5169\u500b E1\u03b1 \u8207\u4e00\u500b E1\u03b2 \u4ee5\u5916\uff0c\u9084\u591a\u4e86\u4e00\u500b E1\u03b1 \u8207 E1\u03b2\uff08\u4ee5 E1\u03b1<sub>3\u00a0<\/sub>\u8207 E1\u03b2<sub>2\u00a0<\/sub>\u8868\u793a\uff09\u3002\u9019\u5169\u500bE1\u7684\u6b21\u55ae\u5143\u5728\u9aa8\u9abc\u808c\u7684\u7d05\u808c\uff08red muscle\uff09\u4e2d\u70ba\u4e3b\u8981\u8868\u73fe\u65cf\u7fa4\uff0c\u4f54\u6574\u9ad4 E1\u03b1 \u8207 E1\u03b2 \u7684 95% \u4ee5\u4e0a\uff08E1\u03b1<sub>3\u00a0<\/sub>95.7%\uff0cE1\u03b2<sub>2<\/sub>\u00a097.1%\uff09\uff1b\u4f46\u662f\u5728\u8166\u3001\u5fc3\u3001\u809d\u88e1\uff0c\u9019\u5169\u500b E1 \u7684\u6b21\u55ae\u5143\u7684\u8868\u73fe\u91cf\u90fd\u5f88\u4f4e\u3002<\/p>\n<p>\u591a\u51fa\u4f86\u7684 E1\u03b1 \u8207 E1\u03b2 \u662f\u54ea\u88e1\u4f86\u7684\u5462\uff1f\u7814\u7a76\u5718\u968a\u8a8d\u70ba\uff0c\u9019\u5169\u500b\u65b0\u7684\u57fa\u56e0\u61c9\u8a72\u4f86\u81ea\u65bc 820 \u842c\u5e74\u524d\u7684\u9bc9\u79d1\u9b5a\u985e\u57fa\u56e0\u9ad4\u91cd\u8907\u4e8b\u4ef6\u3002\u5f9e\u6591\u99ac\u9b5a\uff08<em>Danio rerio<\/em>\uff09\u7684\u57fa\u56e0\u9ad4\u4e5f\u5370\u8b49\u4e86\u9019\u9ede\u3002\u6591\u99ac\u9b5a\u5728\u9bc9\u79d1\u9b5a\u985e\u57fa\u56e0\u9ad4\u91cd\u8907\u767c\u751f\u4e4b\u524d\uff0c\u5c31\u8207\u7260\u5011\u5206\u9053\u63da\u9463\uff1b\u5206\u6790\u7260\u7684\u57fa\u56e0\u9ad4\u4e5f\u53ea\u80fd\u770b\u5230\u5169\u500b E1\u03b1 \u8207\u4e00\u500b E1\u03b2\u3002<\/p>\n<p>\u4ee5\u4e0a\u9019\u4e9b\u767c\u73fe\u8b93\u7814\u7a76\u5718\u968a\u8a8d\u70ba\uff1a\u91d1\u9b5a\u8207\u9ed1\u9bfd\u5c07\u4e19\u916e\u9178\u8f49\u5316\u70ba\u4e59\u919b\u7684\u80fd\u529b\uff0c\u53ef\u80fd\u5c31\u662f\u4f86\u81ea\u65bc\u9019\u5169\u500b\u591a\u51fa\u4f86\u7684\u57fa\u56e0\uff1b\u4e5f\u5c31\u662f\u8aaa\uff0cE1\u03b1<sub>3\u00a0<\/sub>\u8207 E1\u03b2<sub>2\u00a0<\/sub>\u7d44\u6210\u4e00\u500b\u7279\u5225\u7684 PDH-E1\uff0c\u5c07\u4e19\u916e\u9178\u8f49\u5316\u70ba\u4e59\u919b\u3002<\/p>\n<p>\u662f\u5426\u9019\u7279\u5225\u7684 PDH-E1\uff0c\u771f\u7684\u53ef\u4ee5\u7368\u7acb\u4f5c\u6230\u5462\uff1f\u9996\u5148\u7814\u7a76\u5718\u968a\u5206\u6790\u4e86\u9019\u5169\u500bE1\u6b21\u55ae\u5143\u7684\u8868\u73fe\u91cf\uff0c\u767c\u73fe\u5728\u5fc3\u3001\u809d\u3001\u8166\u4e2d\u7684 E1:E2:E3 \u7684\u6bd4\u4f8b\u90fd\u5dee\u4e0d\u591a\uff1b\u4f46\u662f\u5728\u7d05\u808c\u8089\u8207\u767d\u808c\u8089\u4e2d\u4e0d\u8ad6\u662f E1:E2 \u6216 E1:E3 \u90fd\u51fa\u73fe\u516d\u5341\u500d\u7684\u5dee\u8ddd\u3002<\/p>\n<p>\u9019\u9ebc\u591a\u7684 E1\uff0c\u7576\u7136\u6709\u53ef\u80fd\u6709\u4e00\u4e9bE1\u662f\u7368\u7acb\u4f5c\u6230\u8005\uff1b\u4f46\u662f\u7814\u7a76\u5718\u968a\u63a5\u8457\u5206\u6790 E1\u03b1<sub>3\u00a0<\/sub>\u8207 E1\u03b2<sub>2\u00a0<\/sub>\u7684\u5e8f\u5217\uff0c\u767c\u73fe E1\u03b2<sub>2\u00a0<\/sub>\u7684\u57fa\u56e0\u6709\u500b\u7a81\u8b8a\uff0c\u4f7f\u5b83\u7684\u7b2c 319 \u865f\u6c28\u57fa\u9178\u7531\u5e36\u96fb\u7684\u5929\u51ac\u80fa\u9178\uff08aspartic acid\uff0cD\uff09\u8b8a\u6210\u4e0d\u5e36\u96fb\u7684\u5929\u51ac\u9170\u80fa\uff08asparagine\uff0cN\uff09\u3002\u904e\u53bb\u5728\u4eba\u985e\u7684 E1\u03b2 \u4e2d\u66fe\u767c\u73fe\u985e\u4f3c\u7684\u7a81\u8b8a\uff0c\u9020\u6210 E1 \u8207 E2 \u5206\u96e2\uff0c\u5f71\u97ff PDH \u7684\u529f\u80fd\u3002\u9019\u6a23\u7684\u7a81\u8b8a\u5c0d\u4e00\u822c\u7684 PDH \u662f\u6709\u5bb3\u7684\uff0c\u4f46\u5c0d\u65bc\u91d1\u9b5a\u8207\u9ed1\u9bfd\u7684 PDH-E1 \u4f86\u8aaa\uff0c\u537b\u662f\u6b63\u4e2d\u4e0b\u61f7\uff01\u8ddf\u5176\u4ed6 PDH \u7684 E1 \u985e\u4f3c\u7684\u662f\uff0c\u9019\u500b PDH-E1 \u4e5f\u662f\u900f\u904e\u8abf\u7bc0 \u03b1 \u6b21\u55ae\u5143\u7684\u6d3b\u6027\u4f86\u8abf\u7bc0\u6574\u500b\u9175\u7d20\u7684\u6d3b\u6027\u3002\u5728\u7f3a\u6c27\u6642\uff0c\u5b83\u7684 E1\u03b1 \u6703\u88ab\u53bb\u78f7\u9178\u5316\u800c\u6d3b\u5316\uff1b\u7576\u6c27\u6c23\u91cf\u6062\u5fa9\u6b63\u5e38\u5f8c\uff0c\u5b83\u53c8\u6703\u88ab\u78f7\u9178\u5316\u800c\u5931\u53bb\u6d3b\u6027\u4e86\u3002<\/p>\n<p>\u6240\u4ee5\uff0c\u5728\u91d1\u9b5a\u8207\u9ed1\u9bfd\u4e2d\u591a\u51fa\u4f86\u7684\u9019\u500b PDH-E1\uff0c\u5b83\u5e36\u6709 D319N \u7a81\u8b8a\u4f7f\u5b83\u7121\u6cd5\u8207 E2 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ADH8a\uff1b\u5176\u4e2d\u7684 ADH8a3 \u4f54\u91d1\u9b5a\u8207\u9ed1\u9bfd\u7e3d\u9ad4 ADH8a \u8868\u73fe\u91cf\u7684 96%\uff0c\u800c\u4e14\u9019\u500b ADH \u4e26\u4e0d\u8868\u73fe\u5728\u809d\u81df\u4e2d\uff01\u7576\u7136\u809d\u81df\u88e1\u9084\u662f\u6709 ADH\uff0c\u662fADH8a1\uff1b\u4f46\u662f\u7d05\u808c\u8089\u88e1\u9762\u7684 ADH\uff08ADH8a3\uff09\u662f\u767d\u808c\u8089\u8207\u809d\u81df\u7684\u56db\u500d\u3002ADH8a3 \u4e5f\u5b58\u5728\u8457\u4e00\u500b\u7a81\u8b8a\uff0c\u5c07\u5b83\u7684\u7b2c 122 \u865f\u80fa\u57fa\u9178\u7531\u812f\u80fa\u9178\uff08proline\uff0cP\uff09\u8b8a\u6210\u7d44\u80fa\u9178\uff08histidine\uff0cH\uff09\u3002\u7531\u65bc\u9019\u500b\u4f4d\u7f6e\u6b63\u597d\u5728\u6d3b\u5316\u4f4d\u5740\u7684\u9644\u8fd1\uff0c\u7814\u7a76\u5718\u968a\u8a8d\u70ba\u9019\u500b\u7a81\u8b8a\u6216\u8a31\u6703\u8b93 ADH8a3 \u5c0d\u4e59\u919b\u89aa\u548c\u529b\u4e0a\u5347\uff0c\u9020\u6210\u66f4\u50be\u5411\u65bc\u5f9e\u4e59\u919b\u5408\u6210\u9152\u7cbe\uff0c\u800c\u4e0d\u662f\u7531\u9152\u7cbe\u7522\u751f\u4e59\u919b\u02ca\uff1b\u4e0d\u904e\u9019\u5c31\u6709\u5f85\u5f8c\u7e8c\u518d\u7814\u7a76\u4e86\u3002<\/p>\n<p>\u6574\u9ad4\u770b\u4f86\uff0c\u5728\u91d1\u9b5a\u8207\u9ed1\u9bfd\u4e2d\uff0c\u7531\u65bc\u57fa\u56e0\u9ad4\u91cd\u8907\u7522\u751f\u4e86\u984d\u5916\u7684 E1 \u6b21\u55ae\u5143\u3002\u56e0\u70ba\u6709\u5169\u7d44 E1\uff0c\u4f7f\u5176\u4e2d\u4e00\u7d44 E1 \u53ef\u4ee5\u6709\u7a7a\u9593\u7522\u751f\u4e00\u4e9b\u8b8a\u5316\uff0c\u9032\u800c\u8b93\u91d1\u9b5a\u8207\u9ed1\u9bfd\u7372\u53d6\u4e86\u66f4\u5f37\u7684\u751f\u5b58\u6280\u80fd\u3002<\/p>\n<p>\u7b46\u8005\u4ee5\u524d\u5728\u570b\u5916\u5e38\u807d\u5230\u670b\u53cb\u8aaa\uff1a\u91d1\u9b5a\u7684\u751f\u547d\u529b\u5f88\u5f37\uff0c\u5373\u4f7f\u4f60\u4e0d\u60f3\u990a\u4e86\u3001\u628a\u7260\u6c96\u5230\u4e0b\u6c34\u9053\u88e1\u9762\u53bb\uff0c\u7260\u4e5f\u9084\u53ef\u4ee5\u6d3b\u5f97\u597d\u597d\u7684\uff1b\u9019\u9ede\u65e9\u5df2\u7372\u5f97\u8b49\u5be6\u3002<a href=\"http:\/\/e-info.org.tw\/node\/202930\">\u6709\u4eba<\/a>\u572820\u5e74\u524d\u628a\u4e00\u7f38\u91d1\u9b5a\u5012\u5165\u74e6\u745f\u6cb3\uff08Vasse River\uff09\uff0c\u73fe\u5728\u6574\u689d\u6cb3\u90fd\u662f\u91d1\u9b5a\u3002\u9019\u7bc7\u7814\u7a76\u544a\u8a34\u6211\u5011\uff0c\u5c31\u7b97\u662f\u6c96\u5230\u4e0b\u6c34\u9053\u88e1\uff0c\u91d1\u9b5a\u7d55\u5c0d\u9084\u662f\u53ef\u4ee5\u6d3b\u5f97\u597d\u597d\u7684\u5594\uff01<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u6587\u737b\uff1a<\/strong>Cathrine E. Fagernes et. al., 2017.\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41598-017-07385-4\">Extreme anoxia tolerance in crucian carp and goldfish through neofunctionalization of duplicated genes creating a new ethanol-producing pyruvate decarboxylase pathway<\/a>. Scientific Reports 7. doi:10.1038\/s41598-017-07385-4<\/p>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br \/>\n<span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7d55\u5927\u90e8\u5206\u7684\u810a\u690e\u52d5\u7269\uff08vertebrate\uff09\u90fd\u662f\u597d\u6c27\u751f\u7269\uff0c\u7f3a\u6c27\u6642\u9802\u591a\u6490\u5e7e\u5206\u9418\u5c31\u639b\u4e86\uff1b\u6709\u4e9b\u9b5a\uff08\u5982\u9bc9\u9b5aCyprinus carpio\uff09\u53ef\u4ee5\u6490\u5e7e\u5c0f\u6642\u3002\u4f46\u6709\u6975\u5c11\u6578\u7684\u786c\u9aa8\u9b5a\uff0c\u53ef\u4ee5\u71ac\u597d\u5e7e\u500b\u6708\uff01\u7260\u5011\u767c\u5c55\u51fa\u9019\u500b\u80fd\u529b\uff0c\u4e3b\u8981\u70ba\u4e86\u8981\u71ac\u904e\u51ac\u5929\u7684\u6642\u5019\u6e56\u6cca\u51b0\u5c01\u7f3a\u6c27\u7684\u554f\u984c\u3002\u5230\u5e95\u7260\u5011\u662f\u5982\u4f55\u80fd\u5728\u7f3a\u6c27\u7684\u72c0\u6cc1\u4e0b\u6d3b\u597d\u5e7e\u500b\u6708\u5462\uff1f<\/p>\n","protected":false},"author":20,"featured_media":29335,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,26],"tags":[3537,3539,3536,1865,3538,124,3535],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/08\/fish-881161_1280.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29334"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29334"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29334\/revisions"}],"predecessor-version":[{"id":31816,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29334\/revisions\/31816"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/29335"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29334"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29334"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}