{"id":29302,"date":"2017-09-15T00:28:18","date_gmt":"2017-09-14T16:28:18","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=29302"},"modified":"2018-07-29T11:26:28","modified_gmt":"2018-07-29T03:26:28","slug":"%e7%99%8c%e7%97%87%e6%96%b0%e7%99%82%e6%b3%95%e7%9a%84%e5%b0%8b%e5%b0%8b%e8%a6%93%e8%a6%93-%e8%ae%93%e5%85%8d%e7%96%ab%e7%b3%bb%e7%b5%b1%e5%b9%ab%e4%bd%a0%e9%87%8f%e8%ba%ab%e8%a8%82%e4%bd%9c-2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=29302","title":{"rendered":"\u764c\u75c7\u65b0\u7642\u6cd5\u7684\u5c0b\u5c0b\u8993\u8993\u2014\u8b93\u514d\u75ab\u7cfb\u7d71\u5e6b\u4f60\u91cf\u8eab\u8a02\u4f5c\uff01 \uff08\u4e0b\uff09"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0PD-1 \u8207 CTLA-4 \u6a19\u9776\u6cbb\u7642\u6240\u4f34\u96a8\u7684\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u76f8\u95dc\u526f\u4f5c\u7528\uff0c\u8b93\u91ab\u85e5\u7814\u7a76\u754c\u60f3\u8981\u627e\u51fa\u4e00\u500b\u66f4\u70ba\u5c08\u4e00\u6027\u7684\u764c\u75c7\u6cbb\u7642\u7b56\u7565\u3002\u5728\u7f8e\u570b\u7684 Catherine Wu \u535a\u58eb\u5718\u968a\uff0c\u548c\u5fb7\u570b\u7684 Carmen Loquai \u53ca Ozlem Tureci \u535a\u58eb\u5718\u968a\uff0c\u5404\u81ea\u5b8c\u6210\u4e86\u4ee5\u76ae\u819a\u764c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u70ba\u4e3b\u7684\u7b2c\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u91dd\u5c0d\u500b\u5225\u60a3\u8005\u91cf\u8eab\u8a02\u505a\u4e00\u5957\u514d\u75ab\u7cfb\u7d71\u4f5c\u6230\u7b56\u7565\uff0c\u8b93\u514d\u75ab\u7cfb\u7d71\u767c\u52d5\u53ea\u91dd\u5c0d\u764c\u75c7\u7d30\u80de\u70ba\u4e3b\u7684\u653b\u64ca\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_29307\" aria-describedby=\"caption-attachment-29307\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-29307\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/08\/cancer.jpg\" alt=\"\" width=\"450\" height=\"312\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/08\/cancer.jpg 980w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/08\/cancer-600x416.jpg 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/08\/cancer-800x555.jpg 800w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-29307\" class=\"wp-caption-text\">CC BY-SA 3.0 Nick Youngson<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n<p>\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u7684\u597d\u6210\u7e3e\uff0c\u8b93\u5927\u5bb6\u90fd\u5c0d\u5229\u7528\u514d\u75ab\u7d30\u80de\u4f86\u5c0d\u6297\u764c\u75c7\u7684\u6cbb\u7642\u65b9\u6cd5\u5bc4\u4e88\u539a\u671b\uff0c\u671f\u76fc\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u80fd\u5920\u6210\u70ba\u8b93\u764c\u75c7\u4e0d\u518d\u8b93\u91ab\u85e5\u754c\u60f3\u4f86\u5c31\u982d\u75db\u7684\u7d42\u6975\u6b66\u5668\u3002\u4ee5\u300cPD-1\u300d\u6216\u300cCTLA-4\u300d\u70ba\u9776\u9ede\u7684\u6cbb\u7642\u7b56\u7565\u800c\u8a00\uff0c\u85c9\u7531\u6295\u8207\u60a3\u8005\u80fd\u7d50\u5408\u4e0a PD-1 \u6216 CTLA-4 \u7684\u6297\u9ad4\uff0c\u4f86\u963b\u65b7\u514d\u75ab\u7d30\u80de\u5167\u7684\u6291\u5236\u578b\u8a0a\u606f\u50b3\u5c0e\u8ff4\u8def\u3002\u65bc\u662f\uff0c\u7e31\u7136\u816b\u7624\u5167\u8207\u816b\u7624\u5468\u570d\u7684\u74b0\u5883\u90fd\u4e0d\u5229\u65bc\u514d\u75ab\u53cd\u61c9\uff0c\u514d\u75ab T \u7d30\u80de\u5728\u6291\u5236\u8a0a\u865f\u56e0\u70ba\u6295\u85e5\u800c\u88ab\u8abf\u5f31\u7684\u72c0\u614b\u4e0b\uff0c\u4ecd\u7136\u53ef\u4ee5\u6709\u6548\u7684\u57f7\u884c\u529f\u80fd\uff0c\u5c07\u764c\u75c7\u7d30\u80de\u4e00\u4e00\u8fa8\u8a8d\u51fa\u800c\u6bba\u7d55\u3002<!--more--><\/p>\n<p>\u4f46 PD-1 \u8207 CTLA-4 \u6a19\u9776\u6cbb\u7642\u6240\u4f34\u96a8\u7684\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u76f8\u95dc\u526f\u4f5c\u7528\uff0c\u537b\u4e5f\u8b93\u91ab\u85e5\u7814\u7a76\u754c\u60f3\u8981\u627e\u51fa\u4e00\u500b\u66f4\u70ba\u5c08\u4e00\u6027\u7684\u764c\u75c7\u6cbb\u7642\u7b56\u7565\u3002<\/p>\n<p>T\u7d30\u80de\u7684\u5947\u5999\u8655\u5728\u65bc\u6bcf\u4e00\u500b\u7d30\u80de\u6240\u8868\u73fe\u7684 T \u7d30\u80de\u53d7\u9ad4\uff08T cell receptors\uff09\u90fd\u64c1\u6709\u4e0d\u540c\u7684\u5c08\u4e00\u6027\u3002\u6bcf\u4e00\u500bT\u7d30\u80de\u90fd\u6b7b\u5fc3\u584c\u5730\u7684\u53ea\u8fa8\u8a8d\u4e00\u7a2e\u6297\u539f\uff0c\u800c\u4e14\u6bcf\u4e00\u500bT\u7d30\u80de\u6240\u80fd\u5920\u8fa8\u8a8d\u7684\u6297\u539f\u90fd\u4e0d\u4e00\u6a23\u3002\u64da\u4f30\u8a08\uff0c\u4e00\u500b\u6210\u5e74\u4eba\u5927\u7d04\u6709 4\u00d710<sup>11 <\/sup>\u500b T \u7d30\u80de\u5728\u8840\u6db2\u5167\u5954\u6d41\uff0c\u800c\u4e00\u500b\u7279\u5b9a\u6297\u539f\u64da\u4f30\u8a08\u5927\u6982\u53ef\u4ee5\u523a\u6fc0\u5341\u500b\u4e0a\u4e0b\u7684 T \u7d30\u80de\uff0c\u8b93\u514d\u75ab\u7cfb\u7d71\u8b66\u9234\u5927\u97ff\u3002\u65bc\u662f\uff0c\u53ea\u8981\u4e00\u9ede\u9ede\u7c21\u55ae\u6578\u5b78\u7684\u60f3\u50cf\uff0c\u5927\u6982\u5c31\u80fd\u7406\u89e3\u300cPD-1\u300d\u8207\u300cCTLA-4\u300d\u514d\u75ab\u9776\u9ede\u6cbb\u7642\u9019\u9802\u91d1\u9418\u7f69\u7684\u5f31\u9ede\uff1a\u7576\u6beb\u7121\u5dee\u5225\u7684\u8b93\u6240\u6709T\u7d30\u80de\u6291\u5236\u8a0a\u606f\u50b3\u5c0e\u9014\u5f91\u90fd\u88ab\u963b\u65b7\uff0c\u53ea\u70ba\u4e86\u8b93\u6975\u3001\u6975\u3001\u6975\u5176\u5c11\u6578\u80fd\u8fa8\u8a8d\u764c\u75c7\u7d30\u80de\u7684T\u7d30\u80de\u88ab\u6d3b\u5316\uff0c\u9019\u7b56\u7565\u662f\u500b\u5371\u96aa\u7684\u5169\u9762\u5203\u3002\u800c\u6b66\u5668\u7684\u53e6\u4e00\u5203\uff0c\u5c31\u662f\u8a98\u767c\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u7684\u96b1\u6182\u3002\u75c5\u60a3\u9ad4\u5167\u7684 T \u7d30\u80de\u4e0d\u8ad6\u662f\u5426\u64c1\u6709\u80fd\u5920\u8fa8\u8a8d\u51fa\u764c\u75c7\u7d30\u80de\u7684T\u7d30\u80de\u53d7\u9ad4\uff0c\u90fd\u6703\u56e0\u70ba PD-1 \u8207 CTLA-4 \u6297\u9ad4\uff0c\u800c\u66f4\u52a0\u5bb9\u6613\u88ab\u523a\u6fc0\u800c\u6d3b\u5316\u3002<\/p>\n<p>\u90a3\u8981\u5982\u4f55\u627e\u5230\u9019\u4e9b\u5c08\u9580\u80fd\u5920\u8fa8\u8a8d\u51fa\u764c\u75c7\u7d30\u80de\u7684T\u7d30\u80de\u5462\uff1f\u79d1\u5b78\u7814\u7a76\u754c\u4e00\u76f4\u60f3\u8981\u505a\u7684\u4e8b\uff0c\u5c31\u662f\u627e\u5230\u90a3\u4e9b\u53ea\u5728\u764c\u75c7\u7d30\u80de\u4e0a\u6703\u88ab\u8868\u73fe\u7684\u7d30\u80de\u6297\u539f\u3002\u9019\u4e9b\u7d30\u80de\u8868\u9762\u6297\u539f\u50cf\u662f\u7d81\u5728\u764c\u75c7\u7d30\u80de\u982d\u9802\u7684\u80e1\u863f\u8514\u4e00\u6a23\uff0c\u628a\u525b\u597d\u9577\u4e86\u80fd\u5920\u300c\u55c5\u805e\u300d\u5230\u90a3\u682a\u80e1\u863f\u8514\uff0c\u8868\u73fe\u8a72\u7279\u5b9a T \u7d30\u80de\u53d7\u9ad4\u7684\u514d\u75abT\u7d30\u80de\u5438\u5f15\u904e\u53bb\uff0c\u8b93\u8a72T\u7d30\u80de\u88ab\u6d3b\u5316\u3001\u9032\u800c\u5927\u91cf\u589e\u6b96\u3001\u5206\u5316\uff0c\u555f\u52d5\u5927\u898f\u6a21\u3001\u5177\u6709\u53ea\u91dd\u5c0d\u8a72\u764c\u75c7\u7d30\u80de\u540c\u985e\u5c08\u4e00\u6027\u7684\u514d\u75ab\u53cd\u61c9\u3002<\/p>\n<p>\u9019\u60f3\u6cd5\u5728\u7d19\u4e0a\u8ac7\u5175\u7684\u6642\u5019\uff0c\u807d\u5f97\u662f\u4eba\u4eba\u5fc3\u52d5\u3002\u4f46\u73fe\u5be6\u5c64\u9762\u4e0a\uff0c\u537b\u662f\u4ef6\u60f3\u4f86\u7c21\u55ae\u76f4\u63a5\uff0c\u505a\u8d77\u4f86\u537b\u56f0\u96e3\u91cd\u91cd\u7684\u4e8b\u60c5\u3002\u9996\u5148\uff0c\u8a72\u600e\u9ebc\u77e5\u9053\u54ea\u4e9b\u6297\u539f\u9069\u5408\u62ff\u4f86\u7576\u4f5c\u6a19\u5b9a\u764c\u75c7\u7d30\u80de\u7684\u8a98\u990c\uff1f\u9019\u4e9b\u8a98\u990c\u4e0d\u50c5\u8981\u300c\u764c\u75c7\u7d30\u80de\u5c08\u4e00\u300d\uff0c\u9084\u8981\u4ee5\u9069\u7576\u7684\u86cb\u767d\u8cea\u7247\u6bb5\u4f86\u8aaaT\u7d30\u80de\u80fd\u5920\u807d\u61c2\u7684\u8a71\u3002\u800c\u4e14\uff0c\u5c31\u50cf\u4e0d\u662f\u6240\u6709\u7684\u8a98\u990c\u90fd\u80fd\u8b93\u9b5a\u5152\u4e0a\u9264\u4e00\u6a23\uff0c\u5c31\u7b97\u627e\u5230\u4e86\u8a98\u990c\uff0c\u662f\u4e0d\u662f\u771f\u80fd\u8a98\u4f7fT\u7d30\u80de\u4e0a\u9264\uff0c\u555f\u52d5\u764c\u75c7\u7d30\u80de\u5c08\u4e00\u7684\u514d\u75ab\u53cd\u61c9\u5462\uff1f\u800c\u5728\u4e03\u6708\u521d\u7684 <em>Nature<\/em> \u671f\u520a\u4e0a\uff0c\u7f8e\u570b\u8207\u5fb7\u570b\u5404\u6709\u5718\u968a\u8b49\u660e\u6b64\u65b9\u6cd5\u53ef\u884c\u3002<\/p>\n<p>\u5728\u7f8e\u570b Dana-Farber Cancer Institute \u764c\u75c7\u4e2d\u5fc3\u7684 Catherine Wu \u535a\u58eb\u5718\u968a\uff0c\u548c\u5728\u5fb7\u570b Heidelberg University \u8207 The Cluster for Individualized Immune Intervention \u4e2d\u5fc3\u7684 Carmen Loquai \u53ca Ozlem Tureci \u535a\u58eb\u5718\u968a\uff0c\u5404\u81ea\u5b8c\u6210\u4e86\u4ee5\u76ae\u819a\u764c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u70ba\u4e3b\u7684\u7b2c\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u91dd\u5c0d\u500b\u5225\u60a3\u8005\u91cf\u8eab\u8a02\u505a\u4e00\u5957\u514d\u75ab\u7cfb\u7d71\u4f5c\u6230\u7b56\u7565\uff0c\u8b93\u514d\u75ab\u7cfb\u7d71\u767c\u52d5\u53ea\u91dd\u5c0d\u764c\u75c7\u7d30\u80de\u70ba\u4e3b\u7684\u653b\u64ca\u3002<\/p>\n<p>\u70ba\u4ec0\u9ebc\u9078\u64c7\u76ae\u819a\u764c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5462\uff1f\u9664\u4e86\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u5728\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u8eab\u4e0a\u4e00\u76f4\u6210\u6548\u986f\u8457\u4e4b\u5916\uff0c\u8981\u627e\u5230\u764c\u75c7\u5c08\u5c6c\u7684\u7279\u5225\u6297\u539f\uff0c\u6709\u8cf4\u8a72\u7a2e\u764c\u75c7\u6709\u9ad8\u983b\u7387\u7684\u57fa\u56e0\u7a81\u8b8a\uff0c\u8b93\u764c\u75c7\u7d30\u80de\u7522\u751f\u8ddf\u81ea\u8eab\u5065\u5eb7\u7d30\u80de\u4e0d\u540c\u7684\u65b0\u6297\u539f\uff08neoantigen\uff09\u3002\u57fa\u56e0\u7a81\u8b8a\u4e0d\u4e00\u5b9a\u6703\u9020\u6210\u86cb\u767d\u8cea\u80fa\u57fa\u9178\u5e8f\u5217\u7684\u6539\u8b8a\uff0c\u800c\u9020\u6210\u86cb\u767d\u8cea\u80fa\u57fa\u9178\u6539\u8b8a\u7684\u7a81\u8b8a\u80dc\u80bd\u7247\u6bb5\uff0c\u53c8\u4e0d\u4e00\u5b9a\u662f\u80fd\u5920\u6d3b\u5316T\u7d30\u80de\u53cd\u61c9\u7684\u597d\u6297\u539f\u3002\u56e0\u6b64\uff0c\u627e\u5230\u300c\u597d\u300d\u7684\u764c\u75c7\u65b0\u6297\u539f\uff0c\u662f\u771f\u50cf\u5728\u5927\u6d77\u88e1\u6488\u91dd\u4e00\u6a23\u3002\u800c\u9ed1\u8272\u7d20\u7624\u4e00\u76f4\u4ee5\u764c\u75c7\u7d30\u80de\u5167\u7684\u9ad8\u983b\u7387\u57fa\u56e0\u7a81\u8b8a\u7387\u70ba\u4eba\u6240\u77e5\uff0c\u5e73\u5747\u9ed1\u8272\u7d20\u7624\u764c\u7d30\u80de\u88e1\u5927\u6982\u6bcf\u4e00\u5146\u9e7c\u57fa\u5c0d\uff0c\u5c31\u6709\u8d85\u904e\u5341\u500b\u57fa\u56e0\u7a81\u8b8a\uff0c\u800c\u9019\u6a23\u7684\u4f30\u7b97\u8b93\u79d1\u5b78\u5bb6\u6709\u8db3\u5920\u7684\u4fe1\u5fc3\u53ef\u4ee5\u627e\u5230\u9069\u5408\u7684\u764c\u75c7\u65b0\u6297\u539f\u3002<\/p>\n<p>\u7f8e\u570b\u5718\u968a\u6536\u4e86\u5341\u500b\u5df2\u7d93\u7d93\u904e\u624b\u8853\u6cbb\u7642\uff0c\u4f46\u662f\u88ab\u8a3a\u65b7\u70ba\u9ad8\u5fa9\u767c\u98a8\u96aa\u7684\u9ed1\u8272\u7d20\u7624\u75c5\u4eba\u3002\u6536\u96c6\u75c5\u4eba\u764c\u7d30\u80de\u8207\u6b63\u5e38\u7d30\u80de\u7684\u6aa2\u9ad4\uff0c\u9032\u884c DNA \u5b9a\u5e8f\uff0c\u627e\u51fa\u53ea\u6709\u5728\u75c5\u4eba\u764c\u7d30\u80de\u5167\u624d\u6709\u7684\u57fa\u56e0\u7a81\u8b8a\u3002\u63a5\u8457\uff0c\u4ed6\u5011\u5229\u7528\u96fb\u8166\u7a0b\u5f0f\u6311\u9078\u51fa\u80fd\u5920\u88ab\u5404\u500b\u75c5\u4eba\u4e3b\u8981\u7d44\u7e54\u76f8\u5bb9\u6027\u8907\u5408\u9ad4\uff08major histocompatibility complex\uff0c\u5e38\u7c21\u5beb\u70baMHC\uff09\u7d50\u5408\u7684\u65b0\u6297\u539f\u3002\u4ec0\u9ebc\u662f\u4e3b\u8981\u7d44\u7e54\u76f8\u5bb9\u6027\u8907\u5408\u9ad4 MHC\uff1f\u5728\u764c\u75c7\u7d30\u80de\u5167\u7684\u7a81\u8b8a\u86cb\u767d\u8cea\u88ab\u5206\u89e3\u6210\u5c0f\u7247\u6bb5\u7684\u80dc\u80bd\u4e4b\u5f8c\uff0c\u5177\u6709\u7279\u5b9a\u7279\u5fb5\u7684\u80dc\u80bd\u7247\u6bb5\u53ef\u4ee5\u7d50\u5408\u4e0a MHC\uff0c\u800c\u5f62\u6210\u7a69\u5b9a\u7684\u8907\u5408\u9ad4\u3002\u7d50\u5408\u4e86\u80dc\u80bd\u7247\u6bb5\u7684 MHC\uff0c\u50cf\u662f\u7d42\u65bc\u593e\u4e86\u71b1\u72d7\u7684\u5927\u4ea8\u5821\u4e00\u6a23\uff08\u71b1\u72d7\u50cf\u662f\u80dc\u80bd\u7247\u6bb5\uff0c\u800c\u5927\u4ea8\u5821\u9eb5\u5305\u50cf\u662fMHC\uff09\uff0c\u53ea\u6709\u71b1\u72d7\u593e\u5f97\u7a69\u7684\u5927\u4ea8\u5821\uff0c\u80fd\u5920\u5f15\u8d77T\u7d30\u80de\u7684\u6ce8\u610f\u529b\u3002\u800c\u50cf\u71b1\u72d7\u6709\u539f\u5473\u8207\u8fa3\u5473\u4e00\u6a23\uff0cMHC \u4e5f\u6709\u5169\u5927\u985e\uff1a\u7b2c\u4e00\u985e MHC\uff08MHC class I\uff09\u6703\u5f15\u8d77 CD8<sup>+<\/sup> T \u7d30\u80de\u53cd\u61c9\uff0c\u7b2c\u4e8c\u985e MHC\uff08MHC class II\uff09\u6703\u5f15\u8d77 CD4<sup>+<\/sup> T \u7d30\u80de\u53cd\u61c9\u3002CD4<sup>+\u00a0<\/sup>\u8207 CD8<sup>+\u00a0<\/sup>\u7d30\u80de\u662fT\u7d30\u80de\u7684\u5de6\u81c2\u53f3\u8180\uff0c\u6700\u597d\u5169\u96bb\u624b\u81c2\u90fd\u80fd\u6709\u653b\u64ca\u764c\u7d30\u80de\u65b0\u6297\u539f\u7684\u80fd\u529b\u3002<\/p>\n<p>\u7f8e\u570b\u5718\u968a\u70ba\u6bcf\u500b\u75c5\u4eba\u5404\u81ea\u6311\u4e86 16 \u5230 20 \u7d44\u764c\u75c7\u65b0\u6297\u539f\uff0c\u4ee5\u5408\u6210\u9577\u80dc\u80bd\u934a\u7684\u5f62\u5f0f\uff0c\u7d50\u5408\u514d\u75ab\u4f50\u5291\u70ba\u5176\u4e2d\u516d\u500b\u75c5\u4eba\u88fd\u6210\u500b\u4eba\u5316\u75ab\u82d7\u3002\u5728\u9577\u9054\u5169\u5e74\u5230\u5169\u5e74\u534a\u7684\u76e3\u6e2c\u89c0\u5bdf\u671f\uff0c\u9019\u4e9b\u539f\u672c\u88ab\u8a3a\u65b7\u70ba\u9ad8\u5fa9\u767c\u5371\u96aa\u7fa4\u7684\u75c5\u4eba\uff0c\u6709\u56db\u4eba\u6beb\u7121\u764c\u75c7\u5fa9\u767c\u8de1\u8c61\u3002\u53e6\u5916\u5fa9\u767c\u7684\u5169\u4eba\u5728\u63a5\u53d7 PD-1 \u6297\u9ad4 pembrolizumab \u7684\u6cbb\u7642\u4e4b\u5f8c\uff0c\u75c5\u60c5\u4e5f\u90fd\u53d7\u5230\u63a7\u5236\u3002<\/p>\n<p>\u5fb7\u570b\u5718\u968a\u6536\u4e86 13 \u500b\u75c5\u4eba\uff0c\u7528\u985e\u4f3c\u7684\u65b9\u6cd5\u70ba\u6bcf\u500b\u75c5\u4eba\u5404\u81ea\u6311\u9078\u51fa\u5341\u500b\u764c\u75c7\u65b0\u6297\u539f\uff08\u5176\u4e2d\u4e00\u500b\u75c5\u4eba\u5247\u53ea\u6311\u4e86\u4e94\u500b\uff09\uff0c\u7136\u5f8c\u63a1\u7528\u88fd\u7a0b\u8f03\u5feb\u7684 RNA \u75ab\u82d7\u5f62\u5f0f\uff0c\u70ba\u6bcf\u500b\u75c5\u4eba\u6ce8\u5c04\u5c08\u5c6c\u5316\u7684\u75ab\u82d7\u3002\u5176\u4e2d\u516b\u500b\u75c5\u4eba\u5728\u5169\u5e74\u5167\u90fd\u6c92\u6709\u764c\u75c7\u5fa9\u767c\u3002\u53e6\u5916\u4e94\u500b\u4eba\u5728\u88ab\u6536\u5165\u81e8\u5e8a\u8a66\u9a57\u7684\u524d\u5f8c\u4e0d\u4e45\uff0c\u4e0d\u5de7\u5c31\u5df2\u7d93\u51fa\u73fe\u5fa9\u767c\u73fe\u8c61\u3002\u800c\u5728\u5176\u4e2d\u56db\u500b\u4eba\u8eab\u4e0a\uff0c\u70ba\u5176\u91cf\u8eab\u8a02\u88fd\u7684\u764c\u75c7\u75ab\u82d7\u5728\u7d50\u5408 PD-1 \u6297\u9ad4\u6cbb\u7642\u6216\u662f\u5176\u4ed6\u764c\u75c7\u6cbb\u7642\u65b9\u6848\u4e4b\u5f8c\uff0c\u4e5f\u90fd\u6709\u6536\u5230\u6210\u6548\uff0c\u800c\u4e14\u75c5\u4eba\u8eab\u4e0a\u4e5f\u90fd\u53ef\u4ee5\u986f\u8457\u5075\u6e2c\u5230\u5177\u6709\u764c\u75c7\u7d30\u80de\u5c08\u4e00\u6027\u7684 T \u7d30\u80de\u53cd\u61c9\u3002<\/p>\n<p>\u800c\u6700\u8b93\u4eba\u632f\u596e\u7684\u662f\uff0c\u5169\u500b\u7368\u7acb\u7684\u7814\u7a76\u4e0d\u50c5\u90fd\u8b49\u5be6\uff0c\u91dd\u5c0d\u5404\u500b\u75c5\u4eba\u9ad4\u5167\u764c\u7d30\u80de\u6240\u91cf\u8eab\u8a02\u505a\u7684\u764c\u75c7\u75ab\u82d7\u4e0d\u50c5\u53ef\u4ee5\u63d0\u4f9b\u4fdd\u8b77\u4f5c\u7528\uff0c\u5728\u6240\u6709\u6536\u6cbb\u7684\u75c5\u4eba\u8eab\u4e0a\uff0c\u4e5f\u90fd\u6210\u529f\u6d3b\u5316\u4e86\u514d\u75ab\u7cfb\u7d71 CD4<sup>+\u00a0<\/sup>\u8207 CD8<sup>+\u00a0<\/sup>\u5169\u5927T\u7d30\u80de\u7cfb\u7d71\u3002\u5728\u500b\u4eba\u5316\u764c\u75c7\u75ab\u82d7\u6ce8\u5c04\u4e4b\u5f8c\uff0c\u6240\u6709\u75c5\u4eba\u9ad4\u5167\u90fd\u53ef\u4ee5\u5075\u6e2c\u5230\u764c\u75c7\u65b0\u6297\u539f\u5c08\u4e00\u6027\u7684T\u7d30\u80de\uff0c\u9019\u4e9b T \u7d30\u80de\u53ef\u4ee5\u5206\u6ccc\u4fc3\u4f7f\u767c\u708e\u53cd\u61c9\u76f8\u95dc\u7684\u7d30\u80de\u6fc0\u7d20\uff0c\u986f\u793a\u5176\u529f\u80fd\u5065\u5168\u3002\u5fb7\u570b\u5718\u968a\u7684\u7814\u7a76\u66f4\u9032\u4e00\u6b65\u5206\u6790\u51fa\u5728\u6240\u6709\u75c5\u4eba\u6240\u6311\u51fa\u7684 125 \u500b\u764c\u75c7\u65b0\u6297\u539f\u88e1\uff0c\u6709\u7d04\u767e\u5206\u4e4b\u4e03\u5341\u7684\u5c08\u4e00\u6027\u514d\u75ab\u53cd\u61c9\u662f\u5728\u75ab\u82d7\u6ce8\u5c04\u524d\uff0c\u7121\u6cd5\u88ab\u5075\u6e2c\u5230\u7684\uff0c\u986f\u793a\u70ba\u764c\u75c7\u75ab\u82d7\u6975\u70ba\u6210\u529f\u7684\u6d3b\u5316\u4e86\u90a3\u4e9b\u6975\u5176\u5c11\u6578\u3001\u537b\u80fd\u5920\u8fa8\u8a8d\u51fa\u764c\u7d30\u80de\u7279\u6b8a\u6297\u539f\u7684 T \u7d30\u80de\u3002<\/p>\n<p>\u9019\u5169\u7bc7\u7814\u7a76\uff0c\u4e0d\u50c5\u662f\u70ba\u500b\u4eba\u5316\u764c\u75c7\u6cbb\u7642\u7684\u65b0\u7b56\u7565\u92ea\u597d\u4e86\u7b2c\u4e00\u584a\u624e\u5be6\u7684\u588a\u8173\u77f3\uff0c\u66f4\u662f\u6253\u97ff\u4e86\u632f\u596e\u4eba\u5fc3\u7684\u7b2c\u4e00\u70ae\u3002\u4e4b\u5f8c\u7684\u5f8c\u7e8c\u7814\u7a76\u767c\u5c55\uff0c\u7121\u7591\u4ee4\u4eba\u671f\u5f85\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u539f\u59cb\u8ad6\u6587\uff1a<\/strong><\/p>\n<ol>\n<li>Sahin U et al. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature. 2017 Jul 13;547(7662):222-226. doi: 10.1038\/nature23003. Epub 2017 Jul 5. PMID: 28678784<\/li>\n<li>Ott PA et al. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017 Jul 13;547(7662):217-221. doi: 10.1038\/nature22991. Epub 2017 Jul 5. PMID: 28678778<\/li>\n<\/ol>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Melief CJM. Cancer: Precision T-cell therapy targets tumours. Nature. 2017 Jul 13;547(7662):165-167. doi: 10.1038\/nature23093. Epub 2017 Jul 5. No abstract available. PMID: 28678783<\/li>\n<li>Yee C, Lizee GA. Personalized Therapy: Tumor Antigen Discovery for Adoptive Cellular Therapy. Cancer J. 2017 Mar\/Apr;23(2):144-148. doi: 10.1097\/PPO.0000000000000255. Review. PMID: 28410303<\/li>\n<li>Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science. 2015 Apr 3;348(6230):69-74. doi: 10.1126\/science.aaa4971. Review. PMID: 25838375<\/li>\n<li>Ward JP, Gubin MM, Schreiber RD. The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer. Adv Immunol. 2016;130:25-74. doi: 10.1016\/bs.ai.2016.01.001. Epub 2016 Feb 10. Review. PMID: 26922999<\/li>\n<\/ol>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br \/>\n<span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0PD-1 \u8207 CTLA-4 \u6a19\u9776\u6cbb\u7642\u6240\u4f34\u96a8\u7684\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u76f8\u95dc\u526f\u4f5c\u7528\uff0c\u8b93\u91ab\u85e5\u7814\u7a76\u754c\u60f3\u8981\u627e\u51fa\u4e00\u500b\u66f4\u70ba\u5c08\u4e00\u6027\u7684\u764c\u75c7\u6cbb\u7642\u7b56\u7565\u3002\u5728\u7f8e\u570b\u7684 Catherine Wu \u535a\u58eb\u5718\u968a\uff0c\u548c\u5fb7\u570b\u7684 Carmen Loquai \u53ca Ozlem Tureci \u535a\u58eb\u5718\u968a\uff0c\u5404\u81ea\u5b8c\u6210\u4e86\u4ee5\u76ae\u819a\u764c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u70ba\u4e3b\u7684\u7b2c\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u91dd\u5c0d\u500b\u5225\u60a3\u8005\u91cf\u8eab\u8a02\u505a\u4e00\u5957\u514d\u75ab\u7cfb\u7d71\u4f5c\u6230\u7b56\u7565\uff0c\u8b93\u514d\u75ab\u7cfb\u7d71\u767c\u52d5\u53ea\u91dd\u5c0d\u764c\u75c7\u7d30\u80de\u70ba\u4e3b\u7684\u653b\u64ca\u3002<\/p>\n","protected":false},"author":20,"featured_media":29307,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,2977,1025],"tags":[938,1807,854,378],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2017\/08\/cancer.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29302"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29302"}],"version-history":[{"count":6,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29302\/revisions"}],"predecessor-version":[{"id":31842,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/29302\/revisions\/31842"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/29307"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29302"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29302"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}