{"id":27496,"date":"2017-04-14T00:25:35","date_gmt":"2017-04-13T16:25:35","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=27496"},"modified":"2018-07-29T08:19:22","modified_gmt":"2018-07-29T00:19:22","slug":"%e9%b4%89%e7%89%87%e9%a1%9e%e6%ad%a2%e7%97%9b%e5%8a%91%e7%9a%84%e5%a5%bd%e8%98%8b%e6%9e%9c%e8%88%87%e5%a3%9e%e8%98%8b%e6%9e%9c%ef%bc%9a%e8%a9%b2%e6%80%8e%e6%a8%a3%e6%8a%8a%e5%a5%bd%e8%98%8b%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=27496","title":{"rendered":"\u9d09\u7247\u985e\u6b62\u75db\u5291\u7684\u597d\u8207\u58de\uff1a\u8a72\u600e\u6a23\u628a\u597d\u860b\u679c\u7559\u4e0b\u4f86\uff1f"},"content":{"rendered":"

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\"\"\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

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\u4f46\u5728\u4eca\u5e74\u4e8c\u6708\u7684 Nature Medicine<\/em>\u671f\u520a\u4e0a\uff0c\u7f8e\u570b\u52a0\u5dde\u53f2\u4e39\u4f5b\u5927\u5b78Gregory Scherrer\u6559\u6388\u5be6\u9a57\u5ba4\u5247\u70ba\u9d09\u7247\u985e\u6b62\u75db\u5291\u7684\u8010\u53d7\u6027\u8207\u4f9d\u8cf4\u6027\uff0c\u63d0\u51fa\u4e86\u5f88\u4e0d\u4e00\u6a23\u7684\u89c0\u9ede\u8207\u770b\u6cd5\u3002\u5982\u679c\u4ed6\u5011\u7684\u7814\u7a76\u5728\u4e4b\u5f8c\u7684\u8ffd\u8e64\u7814\u7a76\u88e1\u4f9d\u7136\u80fd\u5920\u7ad9\u7a69\u8173\u6b65\uff0c\u5247\u53ef\u4ee5\u63d0\u4f9b\u4e00\u500b\u53ef\u884c\u7684\u8fa6\u6cd5\uff0c\u8b93\u6211\u5011\u628a\u55ce\u5561\u985e\u6b62\u75db\u85e5\u7269\u4f5c\u7528\u88e1\u7684\u300c\u58de\u860b\u679c\u300d\u7279\u5225\u6311\u51fa\u4f86\u3002<\/p>\n

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\u9019\u600e\u9ebc\u8aaa\u5462\uff1fScherrer\u5be6\u9a57\u5ba4\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7576\u55ce\u5561\u7d50\u5408\u4e0a\u7684\u00b5\u578b\u9d09\u7247\u985e\u53d7\u9ad4\uff0c\u662f\u4f4d\u5728\u96b8\u5c6c\u65bc\u5468\u908a\u795e\u7d93\u7cfb\u7d71\u3001\u8ca0\u8cac\u5c07\u8a0a\u606f\u523a\u6fc0\u50b3\u5165\u810a\u9ad3\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684\u521d\u7d1a\u50b3\u5165\u795e\u7d93\u7e96\u7dad\u4e0a\u6642\uff0c\u5c31\u662f\u6703\u5c0e\u81f4\u300c\u58de\u860b\u679c\u300d\u7522\u51fa\u7684\u7f6a\u9b41\u798d\u9996\u3002\u7576\u5c0f\u9f20\u7684\u5468\u908a\u75db\u89ba\u63a5\u6536\u795e\u7d93\u4e0a\uff0c\u4e0d\u518d\u8868\u73fe\u00b5\u578b\u9d09\u7247\u985e\u53d7\u9ad4\u6642\uff0c\u7814\u7a76\u4eba\u54e1\u6240\u6295\u85e5\u7684\u55ce\u5561\u9084\u662f\u80fd\u767c\u63ee\u6b62\u75db\u6548\u679c\uff0c\u4f46\u5c0f\u9f20\u537b\u4e0d\u6703\u518d\u51fa\u73fe\u8010\u53d7\u6027\u7b49\u526f\u4f5c\u7528\u7684\u76f8\u95dc\u75c7\u72c0\u4e86\u3002\u53ef\u898b\u6b62\u75db\u6548\u679c\u8207\u8010\u53d7\u6027\u526f\u4f5c\u7528\uff0c\u4f3c\u4e4e\u662f\u5927\u8166\u4e2d\u6a1e\u8207\u5468\u908a\u50b3\u5c0e\u795e\u7d93\uff0c\u5169\u500b\u5929\u6c34\u4e00\u65b9\u3001\u4e95\u6c34\u4e0d\u72af\u6cb3\u6c34\u5404\u81ea\u4e3b\u5c0e\u7684\u4e8b\u3002<\/p>\n

\u66f4\u6709\u8da3\u7684\u662f\uff0c\u5728\u7d66\u6b63\u5e38\u5c0f\u9f20\u6295\u85e5\u55ce\u5561\u6642\uff0c\u5982\u679c\u4e5f\u540c\u6642\u7d66\u4e88\u53ea\u80fd\u4f5c\u7528\u5728\u5468\u908a\u795e\u7d93\u3001\u9032\u4e0d\u4e86\u810a\u9ad3\u4e2d\u6a1e\u795e\u7d93\u7684\u9d09\u7247\u53d7\u9ad4\u62ee\u6297\u5291\uff0c\u4e5f\u80fd\u5920\u5728\u4e0d\u5f71\u97ff\u75bc\u75db\u6291\u5236\u7684\u85e5\u6548\u4e0b\uff0c\u963b\u65b7\u9d09\u7247\u985e\u6b62\u75db\u5291\u7684\u8010\u53d7\u6027\u3002\u9019\u4e5f\u66f4\u6709\u529b\u5730\u63d0\u4f9b\u4e86\u652f\u6301Scherrer\u8ad6\u9ede\u5047\u8aaa\u7684\u8b49\u64da\u3002<\/p>\n

\u81f3\u65bc\u4e4b\u5f8c\u76f8\u95dc\u7814\u7a76\u7684\u767c\u5c55\u5982\u4f55\uff0c\u5012\u662f\u5f88\u8b93\u4eba\u671f\u5f85\uff01<\/p>\n

 <\/p>\n

\u539f\u59cb\u8ad6\u6587\uff1a<\/strong>Corder G, Tawfik VL, Wang D, Sypek EI, Low SA, Dickinson JR, Sotoudeh C, Clark JD, Barres BA, Bohlen CJ, Scherrer G. Loss of \u03bc opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia. Nat Med. 2017 Feb;23(2):164-173. doi: 10.1038\/nm.4262.<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Puig S, Gutstein HB. Opioids: keeping the good, eliminating the bad. Nat Med. 2017 Mar;23(3):272-273. doi: 10.1038\/nm.4277. Epub 2017 Jan 30.<\/li>\n
  2. Arnold C. Alternative analgesics: New drugs for pain seek to improve on ketamine's benefits. Nat Med. 2017 Jan 6;23(1):8-10. doi: 10.1038\/nm0117-8.<\/li>\n
  3. Volkow, N.D. & McLellan, A.T. Opioid abuse in chronic pain\u2013misconceptions and mitigation strategies. N. Engl. J. Med. 374, 1253\u20131263 (2016).<\/li>\n
  4. Chu, L.F., Angst, M.S. & Clark, D. Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin. J. Pain 24, 479\u2013496 (2008).<\/li>\n<\/ol>\n

    --<\/strong><\/span>
    \n\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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