{"id":27092,"date":"2017-03-01T00:01:40","date_gmt":"2017-02-28T16:01:40","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=27092"},"modified":"2018-07-29T07:59:37","modified_gmt":"2018-07-28T23:59:37","slug":"%e3%80%8c%e6%88%91%e5%90%83%e9%80%99%e5%80%8b%e8%97%a5%e6%9c%83%e6%9c%89%e6%95%88%e5%97%8e%ef%bc%9f%e3%80%8d%ef%bc%8d%e6%86%82%e9%ac%b1%e7%97%87%e6%b2%bb%e7%99%82%e6%88%90%e6%95%88%e4%b9%8b%e9%a0%90","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=27092","title":{"rendered":"\u300c\u6211\u5403\u9019\u500b\u85e5\u6703\u6709\u6548\u55ce\uff1f\u300d\uff0d\u6182\u9b31\u75c7\u6cbb\u7642\u6210\u6548\u4e4b\u9810\u6e2c"},"content":{"rendered":"

\u25a0\u4e00\u822c\u800c\u8a00\uff0c\u7576\u6182\u9b31\u75c7\u60a3\u8005\u958b\u59cb\u63a5\u53d7\u4e00\u9805\u65b0\u7642\u7a0b\u6642\uff0c\u60f3\u77e5\u9053\u9019\u500b\u65b0\u6cbb\u7642\u6709\u6c92\u6709\u6548\uff0c\u5e73\u5747\u9700\u8981 8-12 \u5468\u7684\u6642\u9593\u3002\u5f88\u4e45\u5427\uff1f\u5982\u679c\u6211\u5011\u6c92\u8fa6\u6cd5\u767c\u5c55\u51fa\u4e00\u7a2e100%\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6cd5\uff0c\u90a3\u5c31\u53ea\u597d\u60f3\u8fa6\u6cd5\u9810\u6e2c\u4ec0\u9ebc\u4eba\u63a5\u53d7\u6cbb\u7642\u6703\u6709\u6548\u3001\u4ec0\u9ebc\u4eba\u63a5\u53d7\u6cbb\u7642\u4e0d\u6703\u6709\u6548\u4e86\u3002<\/strong><\/span><\/p>\n

\"\u5716\u8aaa\uff1a\u68b5\u8c37\u6240\u7e6a\u4e4bSorrowing
\u5716\u8aaa\uff1a\u68b5\u8c37\u6240\u7e6a\u4e4bSorrowing Old Man\uff0c1890\u3002<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u6797\u96ef\u83c1<\/p>\n

\u4e0d\u7ba1\u662f\u54ea\u7a2e\u75be\u75c5\uff0c\u6c92\u6709\u4e00\u7a2e\u6cbb\u7642\u85e5\u7269\u6216\u4ecb\u5165\u65b9\u5f0f\u53ef\u4ee5\u4fdd\u8b49\u6bcf\u4e00\u500b\u63a5\u53d7\u6cbb\u7642\u7684\u75c5\u60a3\u90fd\u80fd\u5920\u85e5\u5230\u75c5\u9664\u3002\u5c0d\u67d0\u4e9b\u75be\u75c5\u800c\u8a00\uff0c\u85e5\u7269\u7684\u7642\u6548\u662f\u5373\u523b\u6216\u986f\u800c\u6613\u898b\u7684\u3002\u53ef\u80fd\u5728\u4f7f\u7528\u85e5\u7269\u5e7e\u5929\u6216\u751a\u81f3\u5e7e\u500b\u5c0f\u6642\u4e4b\u5167\uff0c\u5c31\u53ef\u4ee5\u77e5\u9053\u85e5\u7269\u662f\u5426\u5c0d\u75c5\u60a3\u7522\u751f\u7642\u6548\uff0c\u6216\u662f\u4e0d\u662f\u8a72\u63db\u5225\u7a2e\u85e5\u4e86\u3002\u4f46\u5c0d\u65bc\u91cd\u9b31\u75c7(major depressive disorder\uff0c\u7c21\u7a31 MDD\u3002\u5373\u4e00\u822c\u8a8d\u77e5\u4e2d\u6240\u8b02\u7684\u6182\u9b31\u75c7\u6216\u6291\u9b31\u75c7)\u7684\u6cbb\u7642\u800c\u8a00\uff0c\u60f3\u77e5\u9053\u85e5\u7269\u6cbb\u7642\u662f\u4e0d\u662f\u8d77\u4e86\u4f5c\u7528\uff0c\u5e73\u5747\u9700\u89818-12\u5468\u7684\u6642\u9593\u3002<\/p>\n

8-12 \u5468\uff01\u60f3\u60f3\u770b\u5982\u679c\u54ea\u5929\u4f60\u751f\u75c5\u4e86\uff0c\u7d50\u679c\u91ab\u751f\u8ddf\u4f60\u8aaa\u9700\u8981\u9023\u7e8c\u5403\u5169\u3001\u4e09\u500b\u6708\u7684\u85e5\u624d\u80fd\u77e5\u9053\u9019\u85e5\u5c0d\u4f60\u7684\u75c5\u6709\u6c92\u6709\u6548\uff0c\u90a3\u662f\u600e\u9ebc\u6a23\u7684\u5fc3\u60c5\uff1f\u518d\u4f86\uff0c\u842c\u4e00\u7576\u4f60\u4e56\u4e56\u5403\u4e86\u5169\u3001\u4e09\u500b\u6708\u7684\u85e5\uff0c\u4e26\u4e14\u6301\u7e8c\u5fcd\u53d7\u5404\u7a2e\u6216\u5927\u6216\u5c0f\u7684\u526f\u4f5c\u7528\u4ee5\u5f8c\uff0c\u624d\u767c\u73fe\u9019\u85e5\u6c92\u6cd5\u6cbb\u4f60\u7684\u75c5\uff0c\u90a3\u53c8\u6703\u662f\u600e\u9ebc\u6a23\u7684\u5fc3\u60c5\uff1f\u800c\u4e14\u5225\u5fd8\u4e86\uff0c\u9019\u6642\u75c5\u9084\u6c92\u6cbb\u597d\uff0c\u9084\u8981\u7e7c\u7e8c\u82b1\u6642\u9593\u8a66\u4e0b\u4e00\u7a2e\u85e5\u2026\u3002\u9019\u6b77\u7a0b\u6709\u591a\u6298\u9a30\u4eba\uff0c\u5149\u7528\u60f3\u7684\u90fd\u89ba\u5f97\u53ef\u6015\uff0c\u66f4\u5225\u63d0\u9019\u6703\u8017\u8cbb\u591a\u5c11\u91ab\u7642\u8cc7\u6e90\u548c\u793e\u6703\u6210\u672c\u4e86\u3002<\/p>\n

\u90a3\u9ebc\uff0c\u5982\u679c\u6709\u8fa6\u6cd5\u5728\u6cbb\u7642\u958b\u59cb\u524d\uff0c\u5c31\u80fd\u6e96\u78ba\u9810\u6e2c\u6bcf\u500b\u75c5\u60a3\u4f7f\u7528\u6bcf\u7a2e\u85e5\u7269\u6216\u6cbb\u7642\u4e4b\u5f8c\u7684\u53cd\u61c9\uff0c\u9032\u800c\u5f9e\u4e2d\u9078\u64c7\u5c0d\u6bcf\u500b\u75c5\u60a3\u6700\u6709\u5229\u7684\u6cbb\u7642\u65b9\u5f0f\uff0c\u662f\u4e0d\u662f\u65e2\u80fd\u63d0\u9ad8\u75c5\u60a3\u798f\u7949\uff0c\u53c8\u80fd\u7bc0\u7701\u91ab\u7642\u8cc7\u6e90\u548c\u793e\u6703\u6210\u672c\u5462\uff1f\u53ea\u662f\uff0c\u9019\u9ebc\u7f8e\u597d\u7684\u9858\u671b\u6709\u53ef\u80fd\u6210\u771f\u55ce\uff1f<\/p>\n

\u5728\u4e00\u9805\u6700\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u7d9c\u5408\u4e86\u4e09\u7a2e\u4e0d\u540c\u7684\u6307\u6a19\uff0c\u4ee5\u6975\u9ad8\u7684\u6b63\u78ba\u7387\u6210\u529f\u9810\u6e2c\u91cd\u9b31\u75c7\u75c5\u60a3\u5728\u670d\u7528\u85e5\u7269\u5f8c\u5176\u6182\u9b31\u75c7\u72c0\u662f\u5426\u80fd\u5920\u7372\u5f97\u6e1b\u7de9\uff01\u4e8b\u5be6\u4e0a\uff0c\u9019\u4e26\u975e\u4e00\u500b\u5168\u65b0\u7684\u7814\u7a76\u9818\u57df\u3002\u7814\u7a76\u8005\u65e9\u5f9e\u4e0a\u500b\u4e16\u7d00\u958b\u59cb\uff0c\u5c31\u5df2\u8457\u624b\u5c0b\u627e\u5408\u9069\u7684\u751f\u7269\u6307\u6a19(biomark)\uff0c\u671f\u671b\u80fd\u5920\u85c9\u7531\u4f7f\u7528\u9019\u4e9b\u6307\u6a19\uff0c\u5728\u91cd\u9b31\u75c7\u75c5\u60a3\u958b\u59cb\u670d\u85e5\u6216\u63a5\u53d7\u6cbb\u7642\u524d\uff0c\u5c31\u80fd\u6e96\u78ba\u9810\u6e2c\u85e5\u7269\u6216\u6cbb\u7642\u65b9\u5f0f\u7684\u6210\u6548\u3002\u800c\u9019\u500b\u7814\u7a76\u9818\u57df\u7684\u7d42\u6975\u76ee\u6a19\uff0c\u7576\u7136\u5c31\u662f\u5e0c\u671b\u80fd\u70ba\u6bcf\u4f4d\u75c5\u60a3\u91cf\u8eab\u6253\u9020\u6700\u9069\u5408\u3001\u7642\u6548\u6700\u4f73\u3001\u6700\u6709\u6548\u7387\u7684\u6cbb\u7642\u65b9\u6848\u4e86\u3002<\/p>\n

\u9019\u6bb5\u6642\u9593\u4ee5\u4f86\uff0c\u7814\u7a76\u8005\u4e0d\u65b7\u5617\u8a66\u4ee5\u4e0d\u540c\u7684\u5de5\u5177\u548c\u65b9\u6cd5\u4f86\u5c0b\u627e\u6700\u4f73\u7684\u751f\u7269\u6307\u6a19\u3002\u5404\u985e\u578b\u7684\u6307\u6a19\u5305\u542b\u50cf\u662f\u57fa\u56e0\u3001\u5167\u5206\u6ccc\u7cfb\u7d71\u3001\u514d\u75ab\u529f\u80fd\u3001\u8166\u90e8\u7d50\u69cb\u3001\u5927\u8166\u4e0d\u540c\u5340\u57df\u4e4b\u9593\u7684\u9023\u7d50\u7b49\u7b49\u3002\u5728\u9019\u4e4b\u4e2d\uff0c\u628a\u7126\u9ede\u653e\u5728\u5927\u8166\u7684\u7814\u7a76\u8005\uff0c\u767c\u73fe\u4e86\u5e7e\u500b\u5927\u8166\u5340\u57df\u7684\u6d3b\u5316\u7a0b\u5ea6\u53ef\u80fd\u53ef\u4ee5\u7528\u4f86\u7576\u4f5c\u6709\u6548\u7684\u6307\u6a19\uff0c\u50cf\u662f rACC(rostral anterior cingulate cortex\uff0c\u524d\u6263\u5e36\u8ff4\u76ae\u8cea\u5599\u90e8)\u3001\u674f\u4ec1\u6838\u3001\u8166\u5cf6\u548c\u524d\u984d\u8449\u7b49\u5340\u57df\u3002<\/p>\n

\u9019\u985e\u5be6\u9a57\u7684\u65b9\u6cd5\u539f\u5247\u4e0a\u662f\u8d81\u75c5\u60a3\u5728\u57f7\u884c\u67d0\u7a2e\u4f5c\u696d\u6642\u6383\u63cf\u4ed6\u5011\u7684\u5927\u8166\uff0c\u85c9\u6b64\u5f97\u77e5\u4ed6\u5011\u7684\u5927\u8166\u5728\u9032\u884c\u7279\u5b9a\u4f5c\u696d\u6642\u7684\u6d3b\u5316\u72c0\u614b\u6216\u529f\u80fd\u6027\u9023\u7d50\u3002\u800c\u6383\u63cf\u6642\u75c5\u60a3\u53ef\u80fd\u6703\u88ab\u8981\u6c42\u5fc5\u9808\u5f97\u57f7\u884c\u6ce8\u610f\u529b\u76f8\u95dc\u4f5c\u696d\u3001\u57f7\u884c\u529f\u80fd(executive functioning)\u4f5c\u696d\u3001\u60c5\u7dd2\u81c9\u5b54\u8fa8\u8b58\u4f5c\u696d\u3001\u6216\u751a\u81f3\u4e0d\u7528\u505a\u4efb\u4f55\u4e8b\u3002\u5176\u4e2d\uff0c\u6709\u4e0d\u5c11\u5be6\u9a57\u90fd\u767c\u73fe\uff0c\u5728\u6cbb\u7642\u958b\u59cb\u524d\uff0c\u90a3\u4e9b\u65e5\u5f8c\u5c0d\u6cbb\u7642\u6c92\u6709\u53cd\u61c9\u7684\u75c5\u60a3\u4ed6\u5011\u7684 rACC \u548c\u90a3\u4e9b\u5c0d\u6cbb\u7642\u6709\u53cd\u61c9\u7684\u75c5\u60a3\u76f8\u6bd4\u4e4b\u4e0b\u8f03\u4e0d\u6d3b\u8e8d(\u4f46\u4e5f\u6709\u5c11\u6578\u5be6\u9a57\u767c\u73fe\u76f8\u53cd\u7684\u7d50\u679c)\u3002\u53e6\u5916\u4e5f\u6709\u5be6\u9a57\u767c\u73fe\uff0c\u75c5\u60a3\u5728\u63a5\u53d7\u6cbb\u7642\u524d rACC \u7684\u6d3b\u5316\u7a0b\u5ea6\u548c\u6cbb\u7642\u7d50\u675f\u5f8c\u6182\u9b31\u75c7\u72c0\u7684\u6539\u5584\u7a0b\u5ea6\u6709\u6240\u76f8\u95dc\u3002\u662f\u4ee5\u90e8\u5206\u7814\u7a76\u8005\u8a8d\u70ba\uff0crACC\u9019\u500b\u5340\u57df\u7684\u6d3b\u5316\u7a0b\u5ea6\u9ad8\u4f4e\u6216\u8a31\u53ef\u7528\u4f86\u4f5c\u70ba\u9810\u6e2c\u6cbb\u7642\u65b9\u6cd5\u662f\u5426\u6703\u5c0d\u75c5\u60a3\u6709\u6548\u7684\u751f\u7269\u6307\u6a19\u3002<\/p>\n

\u53ea\u662f\uff0c\u7814\u7a76\u8005\u8a8d\u70ba\u904e\u5f80\u7684\u5be6\u9a57\u4ecd\u4e0d\u8db3\u4ee5\u7528\u4f86\u70ba\u6bcf\u4f4d\u75c5\u60a3\u7684\u6cbb\u7642\u6210\u6548\u505a\u6e96\u78ba\u9810\u6e2c\u3002\u800c\u767c\u8868\u5728\u671f\u520a Brain<\/em> \u7684\u9019\u500b\u65b0\u7814\u7a76\uff0c\u5247\u7d0d\u5165\u4e86\u4ee5\u5f80\u7684\u5be6\u9a57\u6240\u6c92\u6709\u4f7f\u7528\u904e\u7684\u6307\u6a19\uff0c\u4e26\u7d9c\u5408\u4e0d\u540c\u7684\u6307\u6a19\u4f86\u63d0\u5347\u9810\u6e2c\u7684\u6b63\u78ba\u6027\u3002\u5728\u8a72\u5be6\u9a57\u4e2d\uff0c\u75c5\u60a3\u5728\u958b\u59cb\u63a5\u53d7\u6cbb\u7642\u524d\u4e00\u908a\u63a5\u53d7\u529f\u80fd\u6027\u78c1\u632f\u9020\u5f71(fMRI)\u6383\u63cf\uff0c\u4e00\u908a\u9032\u884c\u4e00\u9805\u57f7\u884c\u529f\u80fd(executive functioning)\u4f5c\u696d\u3002\u9019\u500b\u4f5c\u696d\u53ef\u4ee5\u540c\u6642\u6e2c\u91cf\u6ce8\u610f\u529b\u3001\u898f\u5247\u8f49\u63db\u80fd\u529b\u3001\u8655\u7406\u901f\u5ea6\u3001\u4ee5\u53ca\u6291\u5236\u529f\u80fd\u3002\u6cbb\u7642\u958b\u59cb\u5f8c\uff0c\u75c5\u60a3\u9023\u7e8c\u670d\u7528\u5ea6\u6d1b\u897f\u6c40(duloxetine)\u6216\u827e\u53f8\u897f\u915e\u666e\u862d(escitalopram)\u81f3\u5c11\u4e03\u5468\u4ee5\u4e0a\u3002\u7814\u7a76\u8005\u4e0d\u4f46\u5c07\u529f\u80fd\u6027\u78c1\u632f\u9020\u5f71\u8cc7\u6599\u7684\u7a7a\u9593\u8a0a\u606f\u7576\u4f5c\u4e00\u500b\u6307\u6a19\uff0c\u540c\u6642\u9084\u7d0d\u5165\u4e86\u529f\u80fd\u6027\u78c1\u632f\u9020\u5f71\u8cc7\u6599\u7684\u6642\u9593\u8a0a\u606f\u3001\u4ee5\u53ca\u75c5\u60a3\u5728\u9032\u884c\u4f5c\u696d\u6642\u7684\u8868\u73fe\u4f5c\u70ba\u7b2c\u4e8c\u3001\u7b2c\u4e09\u500b\u6307\u6a19\u3002\u4ee5\u9019\u4e09\u500b\u6307\u6a19\u6240\u5efa\u7acb\u7684\u6a21\u578b\uff0c\u5176\u6210\u529f\u9810\u6e2c\u75c5\u60a3\u5728\u7642\u7a0b\u7d50\u675f\u5f8c\u5c0d\u85e5\u7269\u6cbb\u7642\u53cd\u61c9\u7684\u6b63\u78ba\u7387\u9ad8\u905490%\u3002<\/p>\n

\u5176\u5be6\u81e8\u5e8a\u4e0a\u6cbb\u7642\u91cd\u9b31\u75c7\u7684\u9078\u64c7\u5f88\u591a\uff0c\u5149\u662f\u85e5\u7269\u7684\u9078\u9805\u5c31\u53ef\u4ee5\u5217\u4e00\u9577\u4e32\uff0c\u9084\u6709\u8a8d\u77e5\u884c\u70ba\u6cbb\u7642\u8207\u5176\u4ed6\u5fc3\u7406\u6cbb\u7642\uff0c\u66f4\u5225\u63d0\u76ee\u524d\u5c1a\u8655\u65bc\u7814\u7a76\u968e\u6bb5\u7684\u4e00\u4e9b\u65b0\u8208\u7642\u6cd5\u3002\u4f46\u4e0a\u8ff0\u5be6\u9a57\u7684\u7d50\u679c\u53ea\u80fd\u7528\u5728\u5ea6\u6d1b\u897f\u6c40\u8207\u827e\u53f8\u897f\u915e\u666e\u862d\u5169\u7a2e\u85e5\u7269\u7684\u6cbb\u7642\u6210\u6548\u9810\u6e2c\uff0c\u80fd\u4e0d\u80fd\u9069\u7528\u5728\u5176\u4ed6\u7a2e\u985e\u7684\u6cbb\u7642\u65b9\u6cd5\u4e0a\uff0c\u76ee\u524d\u4ecd\u672a\u53ef\u77e5\u3002\u4e0d\u904e\uff0c\u80fd\u898b\u5230\u9019\u500b\u7814\u7a76\u9818\u57df\u6709\u6240\u524d\u9032\uff0c\u5df2\u7d93\u975e\u5e38\u632f\u596e\u4eba\u5fc3\u4e86\u54ea\uff01<\/p>\n

\u53c3\u8003\u6587\u737b<\/strong><\/p>\n

    \n
  1. Crane, N. A., Jenkins, L. M., Bhaumik, R., Dion, C., Gowins, J. R., Mickey, B. J., \u2026 Langenecker, S. A. (n.d.). Multidimensional prediction of treatment response to antidepressants with cognitive control and functional MRI. Brain<\/em>. https:\/\/doi.org\/10.1093\/brain\/aww326<\/a><\/li>\n
  2. Pizzagalli, D. A. (2011). Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response. Neuropsychopharmacology<\/em>, 36<\/em>(1), 183. https:\/\/doi.org\/10.1038\/npp.2010.166<\/a><\/li>\n
  3. Williams, L. M., Korgaonkar, M. S., Song, Y. C., Paton, R., Eagles, S., Goldstein-Piekarski, A., \u2026 Etkin, A. (2015). Amygdala Reactivity to Emotional Faces in the Prediction of General and Medication-Specific Responses to Antidepressant Treatment in the Randomized iSPOT-D Trial. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology<\/em>, 40<\/em>(10), 2398\u20132408. https:\/\/doi.org\/10.1038\/npp.2015.89<\/a><\/li>\n<\/ol>\n

    --<\/strong>
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     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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