{"id":26490,"date":"2016-12-16T00:02:29","date_gmt":"2016-12-15T16:02:29","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=26490"},"modified":"2018-08-03T15:29:55","modified_gmt":"2018-08-03T07:29:55","slug":"%e7%9d%a1%e7%be%8e%e4%ba%ba%e4%b9%9f%e5%81%9a%e5%a4%a2%e5%97%8e%ef%bc%9f%e9%97%9c%e6%96%bc%e7%9d%a1%e7%9c%a0%e8%aa%bf%e6%8e%a7%e7%9a%84%e5%9f%ba%e5%9b%a0%e7%a5%95%e5%af%86","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=26490","title":{"rendered":"\u7761\u7f8e\u4eba\u4e5f\u505a\u5922\u55ce\uff1f\u95dc\u65bc\u7761\u7720\u8abf\u63a7\u7684\u57fa\u56e0\u7955\u5bc6"},"content":{"rendered":"

\u25a0\u4f60\u5e73\u5747\u4e00\u5929\u8981\u7761\u591a\u4e45\u5462\uff1f\u6709\u4e9b\u4eba\u53ea\u9700\u8981\u5e7e\u5c0f\u6642\u7684\u7761\u7720\uff0c\u9694\u5929\u53c8\u53ef\u4ee5\u751f\u9f8d\u6d3b\u864e\uff0c\u6709\u4e9b\u4eba\u5247\u662f\u50cf\u7761\u7f8e\u4eba\u4e00\u6a23\uff0c\u7761\u6108\u591a\u6108\u597d\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u4f60\u90fd\u8a18\u5f97\u4f60\u6bcf\u5929\u665a\u4e0a\u505a\u904e\u7684\u5922\u55ce\uff1f\u7761\u7f8e\u4eba\u4e00\u6b21\u7761\u9019\u9ebc\u4e45\uff0c\u90a3\u5979\u9192\u4f86\u7684\u6642\u5019\uff0c\u9084\u8a18\u5f97\u5979\u4e4b\u524d\u505a\u904e\u7684\u5922\u55ce\uff1f<\/strong><\/span><\/p>\n

\"sleeping-beauty-disneyscreencaps-com-6056\"\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

\u4eba\u751f\u4e00\u8f29\u5b50\u88e1\u6709\u4e09\u5206\u4e4b\u4e00\u7684\u6642\u9593\u90fd\u5728\u7761\u89ba\u3002\u96d6\u8aaa\u300c\u4e00\u89ba\u89e3\u5343\u6101\u300d\uff0c\u4f46\u4e00\u76f4\u5230\u4e8c\u5341\u4e16\u7d00\u524d\uff0c\u7761\u89ba\u666e\u904d\u88ab\u770b\u4f5c\u662f\u500b\u6beb\u7121\u751f\u7522\u529b\u3001\u5b8c\u5168\u88ab\u52d5\u7684\u751f\u7406\u73fe\u8c61\uff1b\u4f3c\u4e4e\u53ea\u662f\u628a\u6211\u5011\u63a5\u6536\u5916\u754c\u523a\u6fc0\u7684\u611f\u5b98\u901a\u9053\u958b\u95dc\u95dc\u6389\uff0c\u8b93\u8eab\u9ad4\u8207\u8166\u888b\u90fd\u80fd\u5920\u5f97\u5230\u5b8c\u6574\u7684\u4f11\u606f\u3002\u4f46\u73fe\u5728\uff0c\u96a8\u8457\u76f8\u95dc\u7814\u7a76\u5c0d\u7761\u7720\u9818\u57df\u7684\u65e5\u76ca\u91cd\u8996\uff0c\u77ad\u89e3\u5f97\u6108\u6df1\u5165\uff0c\u6108\u662f\u767c\u73fe\u597d\u597d\u7761\u89ba\u7684\u91cd\u8981\u6027\u5c31\u50cf\u898f\u5f8b\u904b\u52d5\u4e00\u6a23\u3002\u7761\u7720\u4e0d\u8db3\u4e0d\u50c5\u6703\u8b93\u8166\u888b\u904b\u8f49\u901f\u5ea6\u6162\u5982\u9f9c\u901f\uff0c\u9577\u671f\u7761\u7720\u4e0d\u8db3\u66f4\u662f\u6703\u9020\u6210\u8a31\u591a\u5065\u5eb7\u4e0a\u5371\u5bb3\uff0c\u50cf\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u80a5\u80d6\u3002<\/p>\n

\u7d9c\u89c0\u52d5\u7269\u754c\uff0c\u5f9e\u868a\u87f2\u5230\u810a\u690e\u52d5\u7269\uff0c\u7761\u7720\u662f\u6975\u666e\u904d\u7684\u751f\u7406\u884c\u70ba\u3002\u4f46\u6709\u8da3\u7684\u662f\uff0c\u5982\u679c\u628a\u7126\u9ede\u653e\u5728\u6211\u5011\u8033\u719f\u80fd\u77e5\u7684\u7761\u7720\u5169\u968e\u6bb5\uff1a\u5feb\u901f\u52d5\u773c\u671f\u7761\u7720\uff08rapid eye movement sleep\uff0c\u7c21\u5beb\u70ba REMS\uff09\u8207\u975e\u5feb\u901f\u52d5\u773c\u671f\u7761\u7720\uff08non-rapid eye movement sleep\uff0c\u7c21\u5beb\u70baNREMS\uff09\uff0c\u6703\u767c\u73fe\u53ea\u6709\u54fa\u4e73\u985e\u52d5\u7269\u3001\u9ce5\u985e\uff0c\u8207\u4eca\u5e74\u525b\u88ab\u8b49\u5be6\u7684\u722c\u87f2\u985e\uff08\u6fb3\u6d32\u7345\u9b03\u8725\uff09\u6709\u9019\u5169\u968e\u6bb5\u7761\u7720\u7279\u5fb5\u3002 REMS\uff0c\u4e5f\u5c31\u662f\u5feb\u901f\u52d5\u773c\u671f\u7761\u7720\uff0c\u901a\u5e38\u8ddf\u6211\u5011\u80fd\u505a\u6829\u6829\u5982\u751f\u7684\u5922\u6709\u95dc\uff0c\u800c NREMS\uff0c\u4e5f\u5c31\u662f\u975e\u5feb\u901f\u52d5\u773c\u671f\u7761\u7720\uff0c\u5247\u548c\u6df1\u5ea6\u7761\u7720\u6709\u95dc\u3002<\/strong><\/p>\n

\u5feb\u901f\u52d5\u773c\u6642\u671f\u7761\u7720 REMS\uff0c\u8207\u975e\u5feb\u901f\u52d5\u773c\u6642\u671f\u7761\u7720 NREMS \u7684\u795e\u7d93\u50b3\u5c0e\u8ff4\u8def\u5927\u76f8\u9015\u5ead\uff0c\u7576\u8abf\u63a7\u5931\u5e38\u6642\uff0c\u4e5f\u5404\u81ea\u6703\u9020\u6210\u4e0d\u540c\u7684\u7761\u7720\u969c\u7919\u3002\u4f46\u53ef\u60dc\u7684\u662f\uff0c\u96d6\u7136\u6211\u5011\u5c0d\u638c\u63a7\u300c\u6e05\u9192\u300d\u7684\u795e\u7d93\u8ff4\u8def\u6240\u77e5\u751a\u8a73\uff0c\u537b\u9084\u662f\u4e0d\u6e05\u695a REMS\u3001NREMS \u7684\u795e\u7d93\u5b78\u6a5f\u8f49\u3002\u7814\u7a76\u9019\u500b\u554f\u984c\u7684\u56f0\u96e3\u9ede\u5728\u65bc\uff0c\u300c\u8ca0\u8cac\u8b93\u4eba\u7761\u8457\u300d\u7684\u795e\u7d93\u5143\u548c\u300c\u8b93\u4eba\u6e05\u9192\u300d\u7684\u795e\u7d93\u5143\uff0c\u901a\u5e38\u54e5\u5006\u597d\u822c\u932f\u843d\u5728\u5dee\u4e0d\u591a\u7684\u5927\u8166\u5340\u584a\u3002\u66f4\u68d8\u624b\u7684\u662f\uff0c\u4ee5\u6578\u91cf\u4f86\u8aaa\uff0c\u300c\u8ca0\u8cac\u7761\u8457\u300d\u7684\u795e\u7d93\u5143\u5b8c\u5168\u5be1\u4e0d\u6575\u773e\uff0c\u6bd4\u300c\u8b93\u4eba\u6e05\u9192\u300d\u7684\u795e\u7d93\u5143\u5c11\u5f88\u591a\u3002\u56e0\u6b64\uff0c\u5982\u679c\u60f3\u8981\u5c08\u4e00\u5730\u7814\u7a76\u300c\u8ca0\u8cac\u7761\u8457\u300d\u7684\u795e\u7d93\u5143\uff0c\u5c31\u50cf\u662f\u73a9\u5728\u4e00\u5806 C \u88e1\u9762\u5c0b\u627e\u5b57\u6bcd O \u7684\u904a\u6232\u4e00\u6a23\uff0c\u96e3\u514d\u56f0\u96e3\u91cd\u91cd\u3002<\/strong><\/p>\n

\u5982\u679c\u60f3\u8981\u7814\u7a76\u9019\u500b\u554f\u984c\uff0c\u8a72\u5982\u4f55\u4e0b\u624b\u5462\uff1f<\/strong><\/span><\/p>\n

\u900f\u904e\u8166\u6ce2\u5716\u8207\u808c\u96fb\u5716\uff0cREMS \u8207 NREMS \u5169\u968e\u6bb5\u7761\u7720\u90fd\u6709\u5404\u81ea\u7368\u7279\u7684\u7279\u5fb5\uff0c\u4e5f\u56e0\u6b64\u80fd\u548c\u300c\u6e05\u9192\u300d\u7684\u72c0\u614b\u5206\u958b\u3002\u9019\u8b93\u7814\u7a76\u4eba\u54e1\u53ef\u4ee5\u5229\u7528\u300c\u6b63\u5411\u907a\u50b3\u5b78\u300d\u7684\u5be6\u9a57\u65b9\u6cd5\u4f86\u5207\u5165\u6838\u5fc3\u3002<\/p>\n

\u4ec0\u9ebc\u662f\u6b63\u5411\u907a\u50b3\u5b78\u5462\uff1f\u81f4\u7a81\u8b8a\u5291\u53ef\u4ee5\u8a98\u767c\u57fa\u56e0\u7522\u751f\u9ede\u7a81\u8b8a\u3002\u9019\u4e9b\u7a81\u8b8a\u50cf\u5929\u5973\u6563\u82b1\u4e00\u6a23\uff0c\u96a8\u6a5f\u5206\u5e03\u5728\u57fa\u56e0\u9ad4\u5167\u5404\u8655\uff0c\u5c0d\u88ab\u8a98\u767c\u7a81\u8b8a\u7684\u57fa\u56e0\uff0c\u7522\u751f\u4e0d\u540c\u7a0b\u5ea6\u7684\u5f71\u97ff\u3002\u5982\u679c\uff0c\u6709\u8208\u8da3\u7684\u300c\u7a81\u8b8a\u7a2e\u300d\u7279\u5fb5\u53ef\u4ee5\u5177\u9ad4\u5730\u88ab\u63cf\u8ff0\uff0c\u85c9\u8457\u89c0\u5bdf\u5f8c\u4ee3\u7684\u8868\u73fe\u578b\uff0c\u5c31\u53ef\u4ee5\u6307\u8a8d\u51fa\u662f\u4e0d\u662f\u6709\u7b26\u5408\u5be6\u9a57\u76ee\u6a19\u7684\u7a81\u8b8a\u7a2e\u51fa\u73fe\u3002\u4e4b\u5f8c\uff0c\u53ef\u4ee5\u518d\u5229\u7528\u57fa\u56e0\u5b9a\u5e8f\u6280\u8853\uff0c\u4f86\u78ba\u5b9a\u6709\u5e78\u63a5\u5230\u5929\u5973\u6563\u7684\u82b1\u800c\u7a81\u8b8a\u7684\u57fa\u56e0\uff0c\u662f\u4f55\u65b9\u795e\u8056\u3002<\/p>\n

\u4f46\uff0c\u6b63\u5411\u907a\u50b3\u5b78\u7684\u6982\u5ff5\u76f4\u767d\uff0c\u5be6\u969b\u64cd\u4f5c\u8d77\u4f86\u537b\u50cf\u662f\u73a9\u5927\u6a02\u900f\u4e00\u6a23\u3002\u4ee5\u7814\u7a76\u300c\u8ca0\u8cac\u5f15\u4eba\u7761\u89ba\u300d\u7684\u57fa\u56e0\u70ba\u4f8b\uff0c\u8981\u80fd\u5920\u7cbe\u78ba\u3001\u5927\u898f\u6a21\uff0c\u53c8\u9577\u6642\u9593\u7684\u8a18\u9304\u5be6\u9a57\u5c0f\u9f20\u7761\u7720\u6642\u7684\u8166\u6ce2\u5716\u8207\u808c\u96fb\u5716\uff0c\u5be6\u5728\u662f\u500b\u60f3\u4f86\u5c31\u6c57\u6d41\u6d79\u80cc\u7684\u6d69\u5927\u5de5\u7a0b\u3002\u4f46\uff0c\u65e5\u672c\u7b51\u6ce2\u5927\u5b78\u7d71\u5408\u7761\u7720\u91ab\u5b78\u7814\u7a76\u6240\u5728\u6700\u8fd1\u7684\u300a\u81ea\u7136\u300b\u671f\u520a\u4e0a\uff0c\u52c7\u6562\u5411\u9019\u500b\u5927\u5de5\u7a0b\u6311\u6230\u3002\u67f3\u6ca2\u6b63\u53f2\u548c\u8239\u6236\u5f18\u6b63\u5be6\u9a57\u5ba4\uff0c\u8a18\u9304\u4e86\u9023\u7e8c\u5169\u500b\u665a\u4e0a\uff0c\u8d85\u904e\u516b\u5343\u96bb\u5e36\u6709\u57fa\u56e0\u7a81\u8b8a\u8001\u9f20\u7761\u89ba\u6642\u7684\u8166\u6ce2\u5716\u8207\u808c\u96fb\u5716\u3002<\/p>\n

\u4ed6\u5011\u767c\u73fe\u6709\u4e00\u7d44\u57fa\u56e0\u7a81\u8b8a\u8001\u9f20\u300cSleepy<\/em>\u300d\uff0c\u50cf\u662f\u7761\u7f8e\u4eba\u822c\u7684\u4e00\u5929\u8981\u776115\u5c0f\u6642\uff0c\u6bd4\u4e00\u822c\u8001\u9f20\u5e73\u5747\u591a\u77613.5\u5c0f\u6642\u3002\u9019\u7fa4\u611b\u7761\u7684 Sleepy <\/em>\u8001\u9f20\uff0c\u6e05\u9192\u7684\u6642\u5019\u6d3b\u52d5\u529b\u548c\u884c\u70ba\u90fd\u6b63\u5e38\uff0c\u4e5f\u5c0d\u5496\u5561\u56e0\u7b49\u63d0\u795e\u7269\u8cea\u6709\u53cd\u61c9\uff0c\u986f\u793a\u7ba1\u63a7\u6e05\u9192\u7684\u795e\u7d93\u8ff4\u8def\u4e26\u6c92\u6709\u53d7\u5230\u5f71\u97ff\u3002\u4f46\u7576\u7761\u7f8e\u4eba\u8001\u9f20\u4e00\u7761\u8457\uff0c\u5c31\u6703\u9032\u5165\u66f4\u6df1\u7684 NREMS \u975e\u5feb\u901f\u52d5\u773c\u6642\u671f\uff0c\u4e5f\u5c31\u662f\u6df1\u5ea6\u7761\u7720\u3002\u800c\u4e14\u7576\u4ed6\u5011\u7761\u7720\u6642\u9593\u88ab\u525d\u596a\u7684\u6642\u5019\uff0c\u4e5f\u662f\u4ee5\u66f4\u6df1\u5c64\u7684 NREMS \u7761\u7720\u4f86\u4f5c\u70ba\u88dc\u511f\u3002\u6709\u8da3\u7684\u662f\uff0c\u9019\u7fa4\u8001\u9f20\u751f\u7406\u6642\u9418\u548c\u4e00\u822c\u8001\u9f20\u4e26\u6c92\u6709\u4e0d\u540c\uff0c\u986f\u793a\u751f\u7406\u6642\u9418\u7684\u8abf\u63a7\uff0c\u548c\u7761\u7720\u7684\u6a5f\u5236\uff0c\u4e26\u4e0d\u50cf\u4ee5\u524d\u6240\u4ee5\u70ba\u7684\u90a3\u6a23\u96e3\u5144\u96e3\u5f1f\u4e0d\u53ef\u5340\u5206\u3002<\/p>\n

\u7d93\u904e\u57fa\u56e0\u5b9a\u5e8f\uff0c\u767c\u73fe\u7761\u7f8e\u4ebaSleepy<\/em>\u8001\u9f20\u5e36\u6709\u7a81\u8b8a\u7684\u300cSik3<\/em>\u300d\u57fa\u56e0\uff0c\u6703\u8b93\u8868\u9054\u7684\u86cb\u767d\u8cea SIK3 \u5c11\u4e86\u4e00\u6bb5\u5e8f\u5217\u3002SIK3 \u5c6c\u65bc\u86cb\u767d\u8cea\u6d3b\u5316\u9176\uff0c\u9ad4\u7d30\u80de\u548c\u5927\u8166\u5404\u5340\u7d30\u80de\uff08\u4e0d\u55ae\u662f\u7761\u7720\u8abf\u63a7\u5340\u57df\uff09\u90fd\u53ef\u4ee5\u5075\u6e2c\u5230\u5b83\u7684\u8e64\u8de1\u3002\u6709\u8da3\u7684\u662f\uff0c\u5982\u679c\u5728\u679c\u8805\u6216\u7dda\u87f2\u8eab\u4e0a\u5f15\u8a98\u4e00\u6a21\u4e00\u6a23\u7684Sik3<\/em>\u7a81\u8b8a\uff0c\u6216\u662f\u5229\u7528\u57fa\u56e0\u8f49\u6b96\u6280\u8853\uff0c\u66f4\u5c08\u4e00\u6027\u7684\u5c07\u8a72\u7a81\u8b8a\u5f15\u9032\u8001\u9f20\u57fa\u56e0\u9ad4\u4e2d\u6642\uff0c\u4e5f\u90fd\u53ef\u4ee5\u89c0\u5bdf\u5230\u540c\u6a23\u7684\u611b\u7761\u73fe\u8c61\uff0c\u66f4\u78ba\u5b9a\u4e86 Sik3 <\/em>\u53ef\u4ee5\u8abf\u7bc0 NREMS \u7761\u7720\u3002<\/p>\n

\u800c\u7528\u540c\u6a23\u7684\u65b9\u6cd5\uff0c\u7814\u7a76\u4eba\u54e1\u4e5f\u767c\u73fe\u4e86\u53e6\u4e00\u7d44\u4e0d\u505a\u5922\u7684\u8001\u9f20\u300cDreamless<\/em>\u300d\uff0c\u5e36\u6709 Nalcn \u7684\u57fa\u56e0\u7a81\u8b8a\uff0c\u4f7f\u5f97 REMS \u5feb\u901f\u52d5\u773c\u7761\u7720\u6642\u9593\u53ea\u6709\u4e00\u822c\u8001\u9f20\u768444%\u3002<\/p>\n

\u6240\u4ee5\uff0c\u611b\u7761\u7684\u7761\u7f8e\u4eba\u5728\u7761\u9192\u5f8c\uff0c\u6703\u8a18\u5f97\u5979\u6240\u505a\u904e\u7684\u5922\u55ce\uff1f\u5982\u679c\uff0c\u5979\u4e5f\u5e36\u6709 Sik3 <\/em>\u7a81\u8b8a\u57fa\u56e0\uff0c\u90a3\u5979\u6240\u82b1\u7684\u6642\u9593\uff0c\u53ef\u90fd\u5728\u6bd4\u8f03\u4e0d\u505a\u5922\uff08\u4e5f\u60f3\u4e0d\u8d77\u4f86\uff09\u7684\u6df1\u5ea6\u7761\u7720 NREMS \u968e\u6bb5\u88e1\u5462\uff01<\/p>\n

 <\/p>\n

\u539f\u59cb\u8ad6\u6587\uff1a<\/strong>Funato H, et al. Forward-genetics analysis of sleep in randomly mutagenized mice. Nature. 2016 Nov 2;539(7629):378-383. doi: 10.1038\/nature20142.<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

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  4. Krueger JM, et al. Sleep function: Toward elucidating an enigma. Sleep Med Rev. 2016 Aug;28:46-54. doi: 10.1016\/j.smrv.2015.08.005. Epub 2015 Aug 28.<\/li>\n
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    --<\/strong><\/span>
    \n\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n

     <\/p>\n

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