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\u25cf\u53c8\u611b\u53c8\u6068\u7684\u514d\u75ab\u6a5f\u5236<\/strong><\/span><\/p>\n

\u4e00\u822c\u6211\u5011\u5c07\u5668\u5b98\u4f86\u6e90\u5206\u70ba\u81ea\u9ad4\u79fb\u690d\uff08autograft\uff09\u3001\u540c\u7cfb\u79fb\u690d\uff08isograft\uff09\u3001\u540c\u7a2e\u79fb\u690d\uff08allograft\uff09\u3001\u7570\u7a2e\u79fb\u690d\uff08xenograft\uff09\uff1b\u53ef\u60f3\u800c\u77e5\uff0c\u81ea\u9ad4\u79fb\u690d\u8207\u540c\u7cfb\u79fb\u690d\u6700\u6613\u6210\u529f\uff0c\u4f46\u5982\u6b64\u4e00\u4f86\u79fb\u690d\u5668\u5b98\u4f86\u6e90\u5927\u5927\u53d7\u9650\u3002\u5e73\u6642\u70ba\u6211\u5011\u62b5\u79a6\u5fae\u751f\u7269\u7b49\u5916\u4f86\u75c5\u539f\u4fb5\u8972\u7684\u514d\u75ab\u7cfb\u7d71\uff0c\u6b64\u523b\u5be6\u5728\u4ee4\u4eba\u82e6\u60f1\uff0c\u6210\u4e86\u59a8\u7919\u79fb\u690d\u7684\u6417\u86cb\u9b3c\u3002<\/p>\n

\u597d\u5728\u91dd\u5c0d\u514d\u75ab\u7cfb\u7d71\u7684\u7814\u7a76\u5f9e\u672a\u505c\u6b47\u30021948\u5e74\u8d77\u7684\u5341\u5e74\u4e2d\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\u4e86\u4e3b\u8981\u7d44\u7e54\u76f8\u5bb9\u6027\u8907\u5408\u9ad4\uff08Major histocompatibility complex\uff0c\u7c21\u7a31 MHC\uff09\uff0c\u4e5f\u89e3\u958b\u4e86\u514d\u75ab\u7cfb\u7d71\u5206\u8fa8\u300c\u81ea\u6211\u300d\u8207\u300c\u975e\u6211\u300d\u7684\u95dc\u9375\u3002\u9019\u7a2e\u5206\u5b50\u4f4d\u65bc\u7d30\u80de\u8868\u9762\uff0c\u6bcf\u500b\u500b\u9ad4\u90fd\u6709\u5176\u7368\u7279\u7684 MHC \u6a19\u8a18\u3002\u7b2c\u4e00\u578b MHC \u5b58\u5728\u65bc\u9ad4\u5167\u6240\u6709\u7d30\u80de\uff0c\u7576\u7d30\u80de\u53ef\u80fd\u53d7\u611f\u67d3\u6642\uff0c\u7d30\u80de\u5167\u7684\u6297\u539f\u88ab\u88c2\u89e3\u6210\u7247\u6bb5\uff0c\u8207\u7b2c\u4e00\u578b MHC \u7d50\u5408\u4e26\u8868\u73fe\u5728\u7d30\u80de\u819c\u4e0a\uff1b\u7576\u6bba\u624bT\u7d30\u80de\uff08CD8\uff09\u8fa8\u8b58\u51fa\u6b64\u6297\u539f\uff0c\u4fbf\u555f\u52d5\u514d\u75ab\u53cd\u61c9\u6bba\u6b7b\u53d7\u611f\u67d3\u7684\u7d30\u80de\u3002\u7b2c\u4e8c\u578b MHC \u5247\u5c08\u5c6c\u65bc\u5de8\u566c\u7d30\u80de\u3001\u6a39\u7a81\u7d30\u80de\u3001B\u7d30\u80de\uff1b\u9019\u4e9b\u7d30\u80de\u7531\u5916\u651d\u5165\u6297\u539f\u4e26\u88c2\u89e3\uff0c\u518d\u5448\u73fe\u65bc\u7d30\u80de\u8868\u9762\uff0c\u6d3b\u5316\u8f14\u52a9T\u7d30\u80de\uff08CD4\uff09\u3002<\/p>\n

\u6025\u6027\u6392\u65a5\u7684\u76f4\u63a5\u8207\u9593\u63a5\u8def\u5f91\u5c31\u5efa\u7acb\u5728\u9019\u5169\u7a2e MHC \u5206\u5b50\u4e0a\u3002\u76f4\u63a5\u8def\u5f91\u4e2d\uff0c\u7570\u9ad4\u5668\u5b98\u4e0a\u7684\u7b2c\u4e00\u578b MHC \u88ab\u8fa8\u8b58\u70ba\u672a\u4f86\u7269\uff1b\u9593\u63a5\u8def\u5f91\u4e2d\uff0c\u5916\u4f86\u5668\u5b98\u88ab\u5206\u89e3\u70ba\u6297\u539f\u7247\u6bb5\uff0c\u900f\u904e\u7b2c\u4e8c\u578b MHC \u88ab\u5448\u73fe\uff0c\u800c\u555f\u52d5\u514d\u75ab\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u6709\u4e9b\u6848\u4f8b\u5728\u6578\u9418\u982d\u5167\u767c\u751f\u300c\u8d85\u6025\u6027\u6392\u65a5\u300d\uff1a\u9019\u985e\u578b\u7684\u6392\u65a5\u53cd\u61c9\u5927\u591a\u767c\u751f\u5728 ABO \u8840\u578b\u4e0d\u7b26\u3001\u53cd\u8986\u8f38\u8840\u3001\u591a\u6b21\u61f7\u5b55\u7684\u75c5\u4eba\u4e0a\u3002\u9019\u7fa4\u75c5\u4eba\u63a5\u89f8\u904e\u8f03\u591a\u5916\u4f86\u6297\u539f\uff0c\u9ad4\u5167\u539f\u672c\u5c31\u5b58\u5728\u8af8\u591a\u6297\u9ad4\uff1b\u6b64\u6642\u5012\u9709\u7684\u5916\u4f86\u5668\u5b98\u4e0d\u904e\u525b\u525b\u9032\u5165\u9ad4\u5167\uff0c\u5c31\u88ab\u8996\u70ba\u300c\u58de\u86cb\u300d\u7fa4\u8d77\u653b\u4e4b\u3002\u7576\u7136\uff0c\u300c\u6162\u6027\u6392\u65a5\u300d\u4e5f\u662f\u5b58\u5728\u7684\u3002\u5b83\u6240\u7522\u751f\u7684\u539f\u56e0\u5176\u5be6\u662f\u6025\u6027\u6392\u65a5\u6a5f\u5236\u7684\u7de9\u6162\u6301\u7e8c\u9032\u884c\uff0c\u96e3\u4ee5\u9810\u6599\u4e14\u4e0d\u6613\u8655\u7406\u3002<\/p>\n

\u5269\u4e0b\u7684\u8ab2\u984c\u4fbf\u662f\u5982\u4f55\u907f\u514d\u8207\u964d\u4f4e\u6392\u65a5\u53cd\u61c9\u4e86\u3002\u96d6\u8aaa\u5149\u662f MHC \u7684\u8b8a\u7570\u5c31\u5341\u5206\u591a\u6a23\uff0c\u5373\u4fbf\u662f\u89aa\u621a\u4e2d\u5c0b\u627e\uff0c\u4e5f\u96e3\u4ee5\u627e\u5230\u5b8c\u5168\u76f8\u7b26\u7684\u914d\u5c0d\u3002\u4f46\u6bcf\u591a\u4e00\u500b MHC \u4f4d\u7f6e\u4e0d\u543b\u5408\uff0c\u79fb\u690d\u7269\u5931\u6557\u7684\u6a5f\u7387\u4fbf\u4e0a\u534710~15%\uff0c\u662f\u6545\u7d44\u7e54\u76f8\u5bb9\u6027\u6e2c\u8a66\u4f9d\u820a\u8209\u8db3\u8f15\u91cd\u3002\u53e6\u5916\uff0c\u7d30\u80de\u6bd2\u6bba\u8a66\u9a57\u4e5f\u53ef\u4ee5\u6392\u9664\u6389\u9ad4\u5167\u5df2\u5b58\u6709\u6297\u9ad4\u7684\u914d\u5c0d\uff0c\u907f\u514d\u8d85\u6025\u6027\u6392\u65a5\u7684\u767c\u751f\u3002<\/p>\n

\u25cf\u626d\u8f49\u4e7e\u5764\u7684\u6297\u6392\u65a5\u85e5\u7269<\/strong><\/span><\/p>\n

\u4e8b\u524d\u6e96\u5099\u56fa\u7136\u91cd\u8981\uff0c\u4f46\u832b\u832b\u4eba\u6d77\u4e2d\u8981\u627e\u5230\u914d\u5c0d\u76f8\u7b26\u7684\u4eba\u8ac7\u4f55\u5bb9\u6613\uff1b\u6297\u6392\u65a5\u7528\u85e5\u7684\u6232\u4efd\u96a8\u4e4b\u4e0a\u5834\u4e86\u3002\u8b14\u7a31\u300c\u7f8e\u570b\u4ed9\u4e39\u300d\u7684\u985e\u56fa\u9187\uff0c\u53ef\u4ee5\u6291\u5236\u767c\u708e\u53cd\u61c9\u7684\u7522\u751f\uff0c\u5f71\u97ff\u5e7e\u4e4e\u6bcf\u4e00\u7a2e\u514d\u75ab\u7d30\u80de\u3002\u4f46\u6708\u4eae\u81c9\u3001\u6c34\u725b\u80a9\u9019\u4e9b\u8b93\u4eba\u805e\u4e4b\u8272\u8b8a\u7684\u526f\u4f5c\u7528\u4e5f\u5982\u5f71\u96a8\u5f62\u3002\u79d1\u5b78\u5bb6\u8f49\u800c\u5411T\u7d30\u80de\u4e0b\u624b\uff0cT\u7d30\u80de\u591a\u682a\u6297\u9ad4\u53ef\u4ee5\u6e1b\u5c11T\u7d30\u80de\u7684\u4f5c\u7528\uff0c\u81f3\u4eca\u4ecd\u7528\u5728\u8f03\u56f0\u96e3\u7684\u6392\u65a5\u6848\u4f8b\u4e2d\u3002\u800c\u5f8c\uff0c\u91dd\u5c0d\u6210\u719fT\u7d30\u80de\u8868\u9762\u5206\u5b50 CD3 \u7684\u55ae\u682a\u6297\u9ad4 OKT3 \u4e5f\u4e0a\u5e02\u4e86\u3002\u4f46\u53ef\u80fd\u4f34\u96a8\u800c\u4f86\u7684\u662f\u60e1\u540d\u662d\u5f70\u300c\u7d30\u80de\u6fc0\u7d20\u91cb\u653e\u75c7\u5019\u7fa4\u300d\uff0c\u5927\u91cf\u6b7b\u4ea1\u7684T\u7d30\u80de\u91cb\u51fa\u7d30\u80de\u6fc0\u7d20\uff0c\u77ed\u6642\u9593\u5167\u4fbf\u6fc0\u5316\u7cfb\u7d71\u6027\u767c\u708e\u53cd\u61c9\u3002\u800c\u53cd\u8986\u4f7f\u7528\u5f8c\uff0c\u85e5\u7269\u6548\u679c\u4e5f\u6703\u6f38\u6e1b\u3002\u7a2e\u7a2e\u56e0\u7d20\u4e4b\u4e0b\uff0c\u53ea\u5f97\u9eef\u7136\u4e0b\u67b6\u3002<\/p>\n

\u73fe\u4eca\u8a31\u591a\u6297\u6392\u65a5\u85e5\u90fd\u8207\u8f14\u52a9 T \u7d30\u80de\u5206\u6ccc\u4e4b IL-2 \u5206\u5b50\u4e0d\u812b\u5e72\u7cfb\u3002IL-2 \u9664\u4e86\u56de\u982d\u523a\u6fc0\u8f14\u52a9 T \u7d30\u80de\u672c\u8eab\u7684\u589e\u751f\u4e4b\u5916\uff0c\u5728\u6bba\u624b T \u7d30\u80de\u5206\u5316\u8207\u7e41\u6b96\u4e2d\u4e5f\u6709\u5176\u89d2\u8272\u3002\u6297\u6392\u65a5\u85e5\u65e8\u5728\u4f54\u9818 IL-2 \u53d7\u9ad4\u7d50\u5408\u4f4d\uff0c\u4ee5\u963b\u65b7\u4e0b\u6e38\u7684\u53cd\u61c9\u3002\u73fe\u4eca\u6700\u5ee3\u70ba\u4f7f\u7528\u7684\u5247\u662fCyclosporin\u53caTacrolimus\uff1b\u5b83\u5011\u7684\u51fa\u73fe\u5927\u5e45\u63d0\u5347\u4e86\u79fb\u690d\u7684\u6210\u7e3e\uff0c\u4e5f\u662f\u7576\u4eca\u552f\u4e8c\u53ef\u4f9d\u55ae\u7368\u4f7f\u7528\u7684\u6297\u6392\u65a5\u85e5\uff0c\u76f4\u63a5\u963b\u65b7\u4e86\u7d30\u80de\u5167 IL-2 \u7684\u5408\u6210\u3002\u96d6\u7136Cyclosporin\u4ecd\u6709\u5f71\u97ff\u814e\u529f\u80fd\u3001\u6bdb\u9aee\u589e\u751f\u3001\u7259\u9f66\u80a5\u539a\u7b49\u526f\u4f5c\u7528\uff0cTacrolimus \u4e5f\u5e38\u9020\u6210\u8840\u7cd6\u904e\u9ad8\uff0c\u6b64\u4e8c\u85e5\u7269\u4ecd\u6709\u8209\u8db3\u8f15\u91cd\u7684\u5730\u4f4d\u3002\u53e6\u5916\uff0cMMF \u5247\u76f4\u63a5\u963b\u65b7\u7d30\u80de\u9031\u671f\uff0c\u6e1b\u5c11 T \u7d30\u80de\u7684\u589e\u6b96\uff0c\u4e0d\u5931\u70ba\u53e6\u7a2e\u9078\u64c7\uff1b\u4f46\u56e0\u70ba\u7279\u7570\u6027\u5dee\uff0c\u4e5f\u6709\u660e\u986f\u8178\u80c3\u9053\u526f\u4f5c\u7528\u3002<\/p>\n

\u96d6\u7136\u6297\u6392\u65a5\u85e5\u4e26\u975e\u5b8c\u7f8e\uff0c\u537b\u662f\u5c07\u79fb\u690d\u8b8a\u6210\u91ab\u7642\u4e0a\u53ef\u884c\u9078\u9805\u7684\u5927\u529f\u81e3\u3002\u7d2f\u8a08\u81f3\u4eca\uff0c\u809d\u79fb\u690d\u6210\u529f\u7387\u905470%\u4ee5\u4e0a\uff0c\u9020\u798f\u8a31\u591a\u809d\u786c\u5316\u3001\u7121\u6cd5\u5207\u9664\u809d\u816b\u7624\u7684\u75c5\u4eba\u3002<\/p>\n

\u25cf\u4ecd\u6709\u4e00\u500b\u5922\u2500\u2500\u79fb\u690d\u91ab\u5b78\u7684\u672a\u4f86<\/strong><\/span><\/p>\n

\u4e0d\u5f97\u4e0d\u63d0\u7684\u662f\uff0c\u5668\u5b98\u7684\u4f86\u6e90\u5982\u6b64\u6709\u9650\uff0c\u8a31\u591a\u75c5\u4eba\u671b\u7a7f\u79cb\u6c34\u537b\u7b49\u4e0d\u5230\u79fb\u690d\u7684\u6a5f\u6703\u3002\u91ab\u751f\u5011\u65bc\u662f\u60f3\u5230\u4e86\u8af8\u591a\u5f4c\u88dc\u7684\u65b9\u6cd5\uff0c\u4e5f\u5728\u514b\u670d\u6392\u65a5\u4e0a\u5c0b\u6c42\u66f4\u591a\u7a81\u7834\u3002\u4f8b\u5982\uff0c\u4ee5\u5f80\u8a8d\u70ba\u5fc5\u7136\u7522\u751f\u8d85\u6025\u6027\u6392\u65a5\u7684 ABO \u8840\u578b\u4e0d\u76f8\u7b26\u4e4b\u5668\u5b98\u79fb\u690d\uff0c\u5982\u4eca\u4e5f\u627e\u5230\u514b\u670d\u7684\u79d8\u8a23\u3002\u8d85\u6025\u6027\u6392\u65a5\u7684\u95dc\u9375\u5728\u65bc\u5df2\u5b58\u5728\u7684\u6297\u9ad4\uff0c\u79d1\u5b78\u5bb6\u7684\u8166\u7b4b\u4fbf\u52d5\u5230\u300c\u8840\u6f3f\u7f6e\u63db\u300d\u4e4b\u4e0a\u4e86----\u4f7f\u7528\u4e0d\u5177\u6709 A \u6216 B \u6297\u9ad4\u7684 AB \u578b\u8840\u8840\u6f3f\uff0c\u7f6e\u63db\u6389\u539f\u672c\u5177\u6709\u6297\u9ad4\u7684\u5668\u5b98\u53d7\u8d08\u8005\u8840\u6f3f\uff0c\u4f7f\u5f97\u4e0d\u540c\u8840\u578b\u79fb\u690d\u7684\u6210\u529f\u7387\u5f8c\u4f86\u5c45\u4e0a\uff0c\u8207\u540c\u8840\u578b\u8005\u7121\u7570\u3002\u5176\u4e2d\u5169\u6b72\u4ee5\u4e0b\u5e7c\u5152\u539f\u672c\u6297\u9ad4\u7684\u8868\u73fe\u5c31\u4e0d\u5f37\uff0c\u751a\u81f3\u7121\u9808\u52d5\u7528\u8840\u6f3f\u7f6e\u63db\u4fbf\u53ef\u4ee5\u6210\u529f\u3002\u9019\u500b\u7a81\u7834\u7121\u7591\u53c8\u662f\u7b49\u5019\u5668\u5b98\u7684\u75c5\u4eba\u4e4b\u4e00\u5927\u798f\u97f3\u3002<\/p>\n

\u79fb\u690d\u91ab\u5b78\u7684\u767c\u5c55\uff0c\u4f7f\u4ee5\u5f80\u8a8d\u5b9a\u7684\u7d55\u75c7\u75c5\u4eba\u6709\u4e86\u4e00\u7dda\u66d9\u5149\u3002\u5c07\u4f86\uff0c\u662f\u5426\u6709\u6a5f\u6703\u8b93\u5668\u5b98\u53d7\u8d08\u8005\u812b\u96e2\u514d\u75ab\u6291\u5236\u5291\uff1f\u300c\u514d\u75ab\u8010\u53d7\u6027\u300d\u7684\u6982\u5ff5\u8fd1\u671f\u5ee3\u53d7\u8a0e\u8ad6\u3002\u900f\u904e\u8abf\u7bc0T\u7d30\u80de\u6291\u5236T\u7d30\u80de\u7684\u529f\u80fd\uff0c\u6216\u662f\u653e\u5c04\u7dda\u7834\u58de\u9aa8\u9ad3\u6216\u80f8\u817a\u7d30\u80de\u91cd\u65b0\u4f5c\u514d\u75ab\u7d30\u80de\u9078\u64c7\uff0c\u5747\u662f\u5be6\u9a57\u7684\u65b9\u5411\u3002<\/p>\n

\u79fb\u690d\u91ab\u5b78\u5718\u968a\u7684\u5922\u60f3\uff0c\u4e0d\u5916\u4e4e\u6b64\uff1a\u5e0c\u671b\u5c07\u4f86\u4efb\u4f55\u4e00\u500b\u597d\u5fc3\u7684\u7a3b\u8349\u4eba\u9858\u610f\u6350\u8d08\u5668\u5b98\u6642\uff0c\u53d7\u8d08\u7684\u932b\u4eba\u90fd\u80fd\u5920\u6b23\u7136\u5730\u63a5\u53d7\u3002<\/p>\n

--<\/strong>
\n\u672c\u6587\u6574\u7406\u81ea\uff1a105\/12\/3 \u7531\u4f55\u660e\u5fd7\u91ab\u5e2b\u5728\u81fa\u5927\u601d\u4eae\u9928\u570b\u969b\u6703\u8b70\u5ef3\u6240\u4e3b\u8b1b\u4e4b\u300c\u7a3b\u8349\u4eba\u3001\u932b\u4eba\u548c\u81bd\u5c0f\u7345\u7684\u9858\u671b \u2500 \u8ac7\u300c\u5668\u5b98\u79fb\u690d\u300d<\/a>\u300d\u6f14\u8b1b\u5167\u5bb9\u3002<\/strong><\/p>\n

 <\/p>\n

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