{"id":26261,"date":"2016-12-09T00:31:38","date_gmt":"2016-12-08T16:31:38","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=26261"},"modified":"2018-08-03T15:31:10","modified_gmt":"2018-08-03T07:31:10","slug":"%e5%bf%ab%e6%a8%82%e6%9c%83%e9%81%ba%e5%82%b3%e5%97%8e%ef%bc%9f%e5%be%9e%e6%80%9d%e8%a6%ba%e5%a4%b1%e8%aa%bf%e7%97%87%e7%9a%84%e5%9f%ba%e5%9b%a0%e5%9c%b0%e5%9c%96%e8%ab%87%e8%b5%b7","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=26261","title":{"rendered":"\u5feb\u6a02\u6703\u907a\u50b3\u55ce\uff1f\u5f9e\u601d\u89ba\u5931\u8abf\u75c7\u7684\u57fa\u56e0\u5730\u5716\u8ac7\u8d77"},"content":{"rendered":"

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\u4ed6\u5011\u63a5\u8457\u5728\u6591\u99ac\u9b5a\u52d5\u7269\u5be6\u9a57\u88e1\uff0c\u8abf\u63a7\u5176\u4e2d\u4e94\u500b\u57fa\u56e0\u7684\u8868\u73fe\u3002\u800c\u6539\u8b8a\u5176\u4e2d\u4e09\u500b\u57fa\u56e0\u7684\u8868\u73fe\uff0c\u679c\u771f\u5f71\u97ff\u6591\u99ac\u9b5a\u795e\u7d93\u7cfb\u7d71\u7684\u767c\u80b2\u3002<\/p>\n

\u5982\u679c\uff0c\u601d\u89ba\u5931\u8abf\u75c7\u6709\u4e86\u907a\u50b3\u57fa\u56e0\u4e0a\u7684\u89e3\u91cb\u57fa\u790e\uff0c\u90a3\u6bd4\u8f03\u6b63\u9762\u7684\u60c5\u7dd2\u7279\u8cea\uff0c\u50cf\u662f\u300c\u5feb\u6a02\u300d\u5462\uff1f\u5728 Molecular Psychiatry \u4e0a\u7684\u53e6\u5916\u4e00\u7bc7\u7814\u7a76\uff0c\u4e5f\u627e\u5230\u5bb9\u6613\u5feb\u6a02\u7684\u57fa\u56e0\u5462\uff01\u4ed6\u5011\u767c\u73fe\u5bb9\u6613\u5feb\u6a02\u3001\u8207\u6b63\u9762\u601d\u8003\u7684\u53d7\u8a66\u8005\uff0c\u5e36\u6709\u4e00\u500b\u57fa\u56e0\u591a\u578b\u6027rs322931\uff0c\u6703\u5f71\u97ff\u5230\u9644\u8fd1\u4e00\u500bmicroRNA\u7684\u8868\u73fe\uff08miR-181a\uff09\u3002\u5e36\u6709\u6b64\u57fa\u56e0\u591a\u578b\u6027\u7684\u53d7\u8a66\u8005\u5728\u53d7\u5230\u6b63\u5411\u523a\u6fc0\u7684\u6642\u5019\uff0c\u5927\u8166\u6df1\u5c64\u8655\u7ba1\u7406\u60c5\u7dd2\u7684\u5340\u57df\uff08\u50cf\u662f\u8179\u5074\u7d0b\u72c0\u9ad4\u548c\u674f\u4ec1\u6838\uff09\u6703\u88ab\u5f37\u70c8\u6d3b\u5316\uff0c\u800c\u4e14\u5728\u6050\u61fc\u5236\u7d04\u7684\u76f8\u95dc\u5be6\u9a57\u4e2d\uff0c\u4e5f\u6bd4\u8f03\u5bb9\u6613\u63a5\u6536\u5230\u5b89\u5168\u611f\u7684\u6697\u793a\u3002<\/p>\n

\u9019\u5169\u7bc7\u6709\u8da3\u7684\u7814\u7a76\uff0c\u90fd\u8b93\u6211\u5011\u5c0d\u907a\u50b3\u56e0\u5b50\u5728\u5927\u8166\u505a\u51fa\u60c5\u7dd2\u3001\u7cbe\u795e\u72c0\u614b\u53cd\u61c9\u88e1\u7684\u89d2\u8272\uff0c\u6709\u4e86\u66f4\u9032\u4e00\u6b65\u7684\u77ad\u89e3\u5462\u3002<\/p>\n

 <\/p>\n

\u539f\u59cb\u8ad6\u6587\uff1a<\/strong>
\n\u95dc\u65bc\u601d\u89ba\u5931\u8abf\u75c7\uff1aFromer M, Roussos P, Sieberts SK, et al. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat Neurosci. 2016 Nov;19(11):1442-1453. doi: 10.1038\/nn.4399. Epub 2016 Sep 26.
\n\u95dc\u65bc\u5feb\u6a02\u7684\u57fa\u56e0\uff1aWingo AP, et al.  Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs. Mol Psychiatry. 2016 Sep 6. doi: 10.1038\/mp.2016.143.  <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Gandal MJ, et al. The road to precision psychiatry: translating genetics into disease mechanisms. Nat Neurosci. 2016 Oct 26;19(11):1397-1407. doi: 10.1038\/nn.4409. Review.<\/li>\n
  2. Albert FW. Brains, genes and power. Nat Neurosci. 2016 Oct 26;19(11):1428-1430. doi: 10.1038\/nn.4424.<\/li>\n
  3. O'Donovan MC, Owen MJ. The implications of the shared genetics of psychiatric disorders. Nat Med. 2016 Nov;22(11):1214-1219. doi: 10.1038\/nm.4196.<\/li>\n
  4. Gratten J. Rare variants are common in schizophrenia. Nat Neurosci. 2016 Oct 26;19(11):1426-1428. doi: 10.1038\/nn.4422.<\/li>\n<\/ol>\n

    --<\/strong>
    \n\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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