{"id":2624,"date":"2010-04-09T15:35:26","date_gmt":"2010-04-09T07:35:26","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=2624"},"modified":"2017-03-31T23:21:25","modified_gmt":"2017-03-31T15:21:25","slug":"%e3%80%90%e7%98%8b%e7%8b%82%e5%af%a6%e9%a9%97%e5%ae%a4%e3%80%91%e8%91%9b%e8%98%ad%e7%b4%a0%e5%8f%b2%e5%85%8b%e8%97%a5%e5%bb%a0%ef%bc%88gsk%ef%bc%89%e4%b8%8d%e6%83%b3%e8%a6%81%e6%9b%b4%e5%a4%9a","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=2624","title":{"rendered":"\u3010\u760b\u72c2\u5be6\u9a57\u5ba4\u3011\u845b\u862d\u7d20\u53f2\u514b\u85e5\u5ee0\uff08GSK\uff09\u4e0d\u60f3\u8981\u66f4\u591a\u514b\u6182\u679c"},"content":{"rendered":"<p><strong><span style=\"color: #003366;\"><strong><span style=\"color: #003366;\">\u25a0 \u4eca\u5e74\u4e8c\u6708\u845b\u862d\u7d20\u53f2\u514b\u85e5\u5ee0\u5a49\u8f49\u5730\u5ba3\u5e03\u5176\u4f01\u696d\u65b9\u91dd\u6709\u6240\u6539\u8b8a\uff0c\u672a\u4f86\u5c07\u4ee5\u7f55\u898b\u75be\u75c5\u7684\u7642\u6cd5\u70ba\u91cd\u9ede\uff0c\u800c\u4e0d\u518d\u5f9e\u4e8b\u75bc\u75db\u53ca\u6182\u9b31\u75c7\u85e5\u7269\u7684\u7814\u767c\u3002\u5f71\u97ff\u6240\u53ca\uff0c\u7814\u767c\u90e8\u9580\u7684\u9810\u7b97\u6e1b\u5c11\u4e86\u4e00\u534a\u3002\u845b\u862d\u7d20\u53f2\u514b\u7684\u85e5\u7269\u7814\u767c\u90e8\u9580\u526f\u7e3d\u88c1Patrick Vallance\u8aaa\uff0c\u7f55\u898b\u75be\u75c5\u7642\u6cd5\u7684\u7814\u767c\u300c\u98a8\u96aa\u6bd4\u8f03\u5c0f\uff0c\u7372\u5229\u6bd4\u8f03\u9ad8\u300d\uff0c\u6709\u5229\u65bc\u516c\u53f8\u7684\u6574\u9ad4\u71df\u904b\u3002<\/span><\/strong><\/span><\/strong><\/p>\n<figure id=\"attachment_2634\" aria-describedby=\"caption-attachment-2634\" style=\"width: 682px\" class=\"wp-caption alignnone\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-2634   \" title=\"Vincent_van_Gogh_Wheat Field with Crows(1890)\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/04\/Vincent_van_Gogh_1853-1890_-_Wheat_Field_with_Crows_1890.jpg\" alt=\"Vincent_van_Gogh_Wheat Field with Crows(1890)\" width=\"682\" height=\"319\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/04\/Vincent_van_Gogh_1853-1890_-_Wheat_Field_with_Crows_1890.jpg 1353w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/04\/Vincent_van_Gogh_1853-1890_-_Wheat_Field_with_Crows_1890-800x374.jpg 800w\" sizes=\"(max-width: 682px) 100vw, 682px\" \/><figcaption id=\"caption-attachment-2634\" class=\"wp-caption-text\">\u6709\u70cf\u9d09\u7684\u9ea5\u7530\uff081890\uff09\uff0c\u68b5\u8c37\u3002<\/figcaption><\/figure>\n<p><strong><span style=\"color: #003366;\">?<\/span><\/strong><\/p>\n<p><strong>\u64b0\u6587<\/strong> \u2223 \u5f35\u8335\u60e0<\/p>\n<p>\u3000\u3000\u81ea\u5f9e1992\u5e74\u65b0\u4e00\u4ee3\u6297\u6182\u9b31\u85e5\u5291\u300c\u514b\u6182\u679c\u300d\uff08Seroxat\uff0c\u85e5\u540d\u662f\u5e15\u7f85\u897f\u4e01Paroxetine\uff09\u6838\u51c6\u4e0a\u5e02\u4ee5\u4f86\uff0c\u4e16\u754c\u7b2c\u4e8c\u5927\u85e5\u5ee0\u845b\u862d\u7d20\u53f2\u514b\uff08GlaxoSmithKline, GSK\uff09\u81f3\u5c11\u88ab\u544a\u4e86\u4e94\u5343\u6b21\uff0c\u9019\u500b\u6578\u5b57\u9084\u50c5\u6b62\u65bc\u7f8e\u570b\u5883\u5167\u3002\u514b\u6182\u679c\u662f\u9078\u64c7\u6027\u8840\u6e05\u7d20\u56de\u6536\u6291\u5236\u5291\uff08<a href=\"http:\/\/en.wikipedia.org\/wiki\/Selective_serotonin_reuptake_inhibitor\" target=\"_blank\">Selective Serotonin Reuptake Inhibitors<\/a>\uff0cSSRIs\uff09\u5bb6\u65cf\u7684\u4e00\u54e1\uff0c\u6709\u500b\u66f4\u5ee3\u70ba\u4eba\u77e5\u7684\u54e5\u54e5\u53eb\u505a\u767e\u6182\u89e3\uff08Prozac\uff09\u3002<\/p>\n<p>\u3000\u3000SSRIs\u7684\u51fa\u73fe\u662f\u70ba\u4e86\u89e3\u6c7a\u904e\u53bb\u6cbb\u7642\u6182\u9b31\u75c7\u85e5\u7269\u7684\u7f3a\u9677\uff0c\u4e09\u74b0\u6297\u6182\u9b31\u5291\uff08TCAs\uff09\u55ae\u80fa\u6c27\u5316\u6291\u5236\u5291\uff08MAOIs\uff09\u76f8\u8f03\u4e4b\u4e0b\u526f\u4f5c\u7528\u5f37\uff0c\u5b89\u5168\u5291\u91cf\u8f03\u96e3\u62ff\u634f\uff0c\u800c\u4e14\u5bb9\u6613\u8207\u5176\u4ed6\u85e5\u7269\u53ca\u98df\u7269\u7d50\u5408\u3002SSRIs\u7684\u85e5\u7269\u6a5f\u8f49\u5982\u540c\u540d\u7a31\u6240\u793a\uff0c\u662f\u900f\u904e\u6291\u5236\u8840\u6e05\u7d20\u7684\u5faa\u74b0\u518d\u7528\uff0c\u800c\u4f7f\u795e\u7d93\u7d30\u80de\u4e4b\u9593\u8840\u6e05\u7d20\u6fc3\u5ea6\u589e\u52a0\uff0c\u6e1b\u4f4e\u6182\u9b31\u60c5\u7dd2\u4ee5\u53ca\u67d0\u4e9b\u5f37\u8feb\u884c\u70ba\u7684\u767c\u751f\u3002\u904e\u53bb\u7684\u85e5\u7269\u540c\u6a23\u53ef\u4ee5\u6291\u5236\u8840\u6e05\u7d20\uff0c\u4e0d\u904e\u540c\u6642\u9084\u6709\u4e00\u4e9b\u5176\u4ed6\u7684\u4f5c\u7528\uff0c\u8af8\u5982\u5f71\u97ff\u53bb\u7532\u57fa\u814e\u4e0a\u817a\u7d20\uff08norepinephrine\uff09\u8207\u591a\u5df4\u80fa\uff08Dopamine\uff09\u7684\u4ee3\u8b1d\u3002<!--more--><\/p>\n<figure id=\"attachment_2630\" aria-describedby=\"caption-attachment-2630\" style=\"width: 276px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"size-full wp-image-2630  \" title=\"Seroxat-antidepressant-pi-001\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/04\/Seroxat-antidepressant-pi-001.jpg\" alt=\"Seroxat-antidepressant-pi-001\" width=\"276\" height=\"166\" \/><figcaption id=\"caption-attachment-2630\" class=\"wp-caption-text\">\u514b\u6182\u679c\u7684\u722d\u8b70\uff1a\u6709\u8ad6\u8005\u8a8d\u70ba\u5b83\u6703\u63d0\u9ad8\u81ea\u6bba\u6a5f\u7387<\/figcaption><\/figure>\n<p>\u3000\u3000SSRIs\u7cfb\u5217\u85e5\u7269\u53ef\u4ee5\u60f3\u50cf\u6210\u662f\u6bd4\u8f03\u7cbe\u7d14\u7684\u85e5\u7269\uff0c\u5b83\u8207\u820a\u5f0f\u85e5\u7269\u4e4b\u9593\u7684\u5dee\u5225\u53ef\u6bd4\u7cbe\u7c73\u53ca\u7cd9\u7c73\u3002\u90a3\u9ebc\u70ba\u4f55SSRI\u7cfb\u7684\u514b\u6182\u679c\u6703\u53d7\u5230\u6279\u8a55\u5462\uff1f\u57fa\u672c\u4e0a\u9019\u662f\u4f86\u81ea\u65bc\u7cbe\u795e\u91ab\u5b78\u76ee\u524d\u7684\u4fb7\u9650\u2014\u2014\u4eba\u5011\u5176\u5be6\u4e0d\u77e5\u9053\u7a76\u7adf\u6182\u9b31\u75c7\u85e5\u7269\u7684\u54ea\u500b\u90e8\u5206\u767c\u751f\u4e86\u4f5c\u7528\u3002\u300c\u53bb\u856a\u5b58\u83c1\u300d\u7684\u7d50\u679c\uff0c\u6216\u8a31\u53ea\u662f\u5f04\u5de7\u6210\u62d9\uff0c\u56e0\u70ba\u6211\u5011\u6839\u672c\u4e0d\u77e5\u9053\u54ea\u4e9b\u90e8\u5206\u662f\u300c\u856a\u300d\uff0c\u54ea\u4e9b\u90e8\u5206\u662f\u300c\u83c1\u300d\u3002\u8a31\u591a\u79d1\u5b78\u5bb6\u76f8\u4fe1\uff0c\u8840\u6e05\u7d20\u5c0d\u4eba\u985e\u7684\u8a8d\u77e5\u548c\u60c5\u7dd2\u6709\u5f88\u5927\u7684\u5f71\u97ff\uff0c\u4f46\u4e5f\u50c5\u6b62\u65bc\u76f8\u4fe1\u800c\u5df2\uff0c\u78ba\u5207\u7684\u6a5f\u8f49\u4ecd\u5f85\u5206\u6790\u3002\u800c21\u4e16\u7d00\u7684\u6d41\u884c\u75be\u75c5\u300c\u6182\u9b31\u75c7\u300d\u5230\u5e95\u8ddf\u8840\u6e05\u7d20\u6709\u4ec0\u9ebc\u95dc\u9023\uff0c\u66f4\u662f\u5c1a\u5728\u9ed1\u7bb1\u4e4b\u4e2d\u3002<\/p>\n<p>\u3000\u3000\u63db\u53e5\u8a71\u8aaa\uff0c\u5118\u7ba1\u5404\u7a2e\u6182\u9b31\u75c7\u85e5\u7269\u63a8\u9673\u51fa\u65b0\uff0c\u4f46\u662f\u4e0d\u662f\u65b0\u7684\u85e5\u5fc5\u7136\u6bd4\u820a\u7684\u6709\u6548\uff0c\u9019\u662f\u53ef\u7591\u7684\u3002\u6b64\u5916\uff0c\u5b89\u5168\u6027\u7684\u8b70\u984c\u4e5f\u4e9f\u5f85\u91d0\u6e05\u3002\u845b\u862d\u7d20\u53f2\u514b\u85e5\u5ee0\u5728\u7f8e\u570b\u906d\u8d77\u8a34\u7684\u539f\u56e0\u4e4b\u4e00\uff0c\u4fbf\u662f\u4ed6\u5011\u53ef\u80fd\u96b1\u779e\u4e86\u81e8\u5e8a\u5be6\u9a57\u5831\u544a\uff0c\u6c92\u6709\u8b66\u544a\u4f7f\u7528\u8005SSRI\u85e5\u54c1\u53ef\u80fd\u8a98\u767c\u9752\u5c11\u5e74\u8207\u5152\u7ae5\u7684\u81ea\u6bba\u884c\u70ba\u3002\u6709\u4e9b\u4eba\u751a\u81f3\u6fc0\u9032\u7684\u8a8d\u70ba\uff0c\u6182\u9b31\u75c7\u85e5\u7269\u6839\u672c\u6c92\u6709\u7528\u3002<\/p>\n<figure id=\"attachment_2641\" aria-describedby=\"caption-attachment-2641\" style=\"width: 133px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"size-full wp-image-2641  \" title=\"Ian Wilson@flicker\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2010\/04\/Ian-Wilson@flicker.jpg\" alt=\"Ian Wilson@flicker\" width=\"133\" height=\"180\" \/><figcaption id=\"caption-attachment-2641\" class=\"wp-caption-text\">GSK\u82f1\u570b\u7e3d\u90e8<\/figcaption><\/figure>\n<p>\u3000\u3000\u4f46\u7a76\u7adfSSRI\u771f\u7684\u6709\u90a3\u9ebc\u5371\u96aa\u55ce\uff1f\u6050\u6015\u4e5f\u4e0d\u898b\u5f97\u3002\u6709\u4e9b\u91ab\u5e2b\u8a8d\u70ba\uff0cSSRI\u85e5\u7269\u4e4b\u6240\u4ee5\u53ef\u80fd\u63d0\u9ad8\u81ea\u6bba\u7387\uff0c\u662f\u56e0\u70ba\u5b83\u5148\u89e3\u6c7a\u4e86\u6182\u9b31\u75c7\u4e2d\u7684\u4f4e\u884c\u52d5\u529b\u554f\u984c\uff0c\u4f46\u9084\u4f86\u4e0d\u53ca\u89e3\u6c7a\u6291\u9b31\u60c5\u7dd2\u7684\u554f\u984c\uff0c\u5728\u9ad8\u884c\u52d5\u529b\u3001\u4f4e\u843d\u60c5\u7dd2\u7684\u72c0\u614b\u4e4b\u4e0b\uff0c\u60a3\u8005\u81ea\u6bba\u6210\u529f\u7684\u53ef\u80fd\u6027\u56e0\u800c\u63d0\u9ad8\u4e86\u3002\u56e0\u6b64\uff0c\u554f\u984c\u4e0d\u5728\u65bcSSRI\u672c\u8eab\uff0c\u800c\u5728\u65bc\u600e\u9ebc\u4f7f\u7528\u5b83\u3002\u5f9e\u4e2d\u6211\u5011\u53ef\u4ee5\u63a8\u5c0e\u51fa\u4e00\u500b\u5047\u8a2d\uff0c\u6c92\u6709\u5fc3\u7406\u8aee\u5546\u914d\u5957\u7684\u6295\u85e5\u6cbb\u7642\uff0c\u6216\u8a31\u6bd4\u300c\u6c92\u6709\u6cbb\u7642\u300d\u9084\u5371\u96aa\u3002<\/p>\n<p>\u3000\u3000SSRI\u85e5\u7269\u4ecd\u5ee3\u6cdb\u5730\u5728\u5168\u7403\u4f7f\u7528\uff0c\u986f\u793a\u4eba\u5011\u9084\u662f\u76f8\u4fe1\u5b83\u5011\u6709\u7528\uff0c\u800c\u4e14\u4e5f\u76f8\u4fe1\u5229\u591a\u65bc\u5f0a\u3002\u7f8e\u570bFDA 2004\u5e74\u8d77\u8981\u6c42SSRI\u7cfb\u5217\u85e5\u7269\u5fc5\u9808\u6a19\u793a\u300c\u63d0\u9ad8\u81ea\u6bba\u53ef\u80fd\u300d\u7684\u8b66\u544a\u6a19\u793a\uff08\u7a31\u70ba\u9ed1\u76d2\u5b50\u8b66\u544a\uff09\uff0c\u540c\u5e74\u82f1\u570b\u4e5f\u7981\u6b62\u4e86\u5305\u62ec\u514b\u6182\u679c\u5728\u5167\u7684\u591a\u6578SSRI\u85e5\u54c1\u88ab\u7528\u5728\u5152\u7ae5\u8eab\u4e0a\u3002<\/p>\n<p>\u3000\u3000\u845b\u862d\u7d20\u53f2\u514b\u85e5\u5ee0\u5c0d\u514b\u6182\u679c\u7684\u5c08\u5229\u5df2\u5230\u671f\uff0c\u4ed6\u5011\u986f\u7136\u5df2\u7d93\u53ad\u5026\u65bc\u7e7c\u7e8c\u767c\u660e\u5927\u5bb6\u7528\u5f97\u5230\u7684\u85e5\uff08\u8b6c\u5982\u666e\u62ff\u75bc\u8ddf\u514b\u6182\u679c\uff09\uff0c\u7136\u5f8c\u4e00\u76f4\u88ab\u544a\u3002\u4ed6\u5011\u8f49\u5411\u7814\u767c\u7f55\u898b\u75be\u75c5\u7528\u85e5\uff0c\u4e00\u65b9\u9762\u53ef\u80fd\u771f\u7684\u662f\u70ba\u4e86\u7f55\u75c5\u60a3\u8005\u8457\u60f3\uff0c\u53e6\u4e00\u65b9\u9762\u53ef\u80fd\u4e5f\u662f\u56e0\u70ba\u7f55\u898b\u75be\u75c5\u60a3\u8005\u300c\u6578\u91cf\u5c11\u5230\u96e3\u4ee5\u5f62\u6210\u81e8\u5e8a\u8a34\u8a1f\u8b49\u64da\u300d\u3002\u845b\u862d\u7d20\u53f2\u514b\u85e5\u5ee0\u7b56\u7565\u7684\u8f49\u8b8a\uff0c\u6216\u8a31\u53ea\u6709\u8a72\u516c\u53f8\u80a1\u6771\u6703\u611f\u5230\u9ad8\u8208\u3002<\/p>\n<p>?<\/p>\n<p><a href=\"http:\/\/www.gsk.com\/media\/pressreleases\/2010\/2010_pressrelease_10014.htm\" target=\"_blank\"><strong><span style=\"color: #800000;\">\u845b\u862d\u7d20\u53f2\u514b\u85e5\u5ee0\u65b0\u805e\u516c\u544a\uff1a2010\u5e742\u67084\u65e5<\/span><\/strong><\/a><\/p>\n<pre>\u5ef6\u4f38\u95b1\u8b80\uff1a<a href=\"http:\/\/www.epochtimes.com\/b5\/5\/8\/22\/n1026940.htm\" target=\"_blank\">\u514b\u6182\u679c\u589e\u52a0\u4e03\u500d\u81ea\u6bba\u98a8\u96aa\uff1f\u91ab\u5e2b\uff1a\u672a\u6709\u5b9a\u8ad6<\/a>?\u3001 <a href=\"http:\/\/140.116.253.135\/NewHomePage\/manager\/form\/periodical\/file\/SSRIs%E6%96%BC%E6%8A%97%E6%86%82%E9%AC%B1%E5%8A%91%E4%B9%8B%E8%A7%92%E8%89%B2.pdf\" target=\"_blank\">SSRI\u65bc\u6297\u6182\u9b31\u85e5\u4e4b\u89d2\u8272<\/a>\uff08\u6210\u91ab\u85e5\u8a8c\uff09<\/pre>\n<p><a type=\"box_count\" name=\"fb_share\" href=\"http:\/\/www.facebook.com\/sharer.php\">\u5206\u4eab\u5230facebook <\/a><\/p>\n<p><script src=\"http:\/\/static.ak.fbcdn.net\/connect.php\/js\/FB.Share\" type=\"text\/javascript\"><\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0 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