{"id":25633,"date":"2016-10-14T00:49:40","date_gmt":"2016-10-13T16:49:40","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=25633"},"modified":"2018-08-03T15:17:02","modified_gmt":"2018-08-03T07:17:02","slug":"%e9%80%b2%e6%93%8a%e7%9a%84%e5%85%8d%e7%96%ab%e7%99%82%e6%b3%95%ef%bc%9a%e6%b2%bb%e7%99%82%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=25633","title":{"rendered":"\u9032\u64ca\u7684\u514d\u75ab\u7642\u6cd5\uff1a\u6cbb\u7642\u963f\u8332\u6d77\u9ed8\u75c7"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u963f\u8332\u6d77\u9ed8\u75c7\uff08Alzheimer\u2019s 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id=\"attachment_25635\" aria-describedby=\"caption-attachment-25635\" style=\"width: 420px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-25635 size-full\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/09\/dementia-851.jpg\" alt=\"SONY DSC\" width=\"420\" height=\"281\" \/><figcaption id=\"caption-attachment-25635\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/www.minddisorders.com\/ Photo by: damato<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n<p>\u4f60\u53ef\u80fd\u807d\u904e\u300c\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\u300d\uff08amyloid 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precursor protein\uff09\u800c\u4f86\u3002\u800c\u5b83\u4e5f\u56e0\u6b64\u50cf\u662f\u8b8a\u88dd\u5c0f\u4e11\u4e00\u6a23\uff0c\u6709\u8a31\u591a\u7a2e\u4e0d\u540c\u7684\u7570\u69cb\u7269\u3002\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u88e1\uff0c\u6700\u8b93\u5927\u5bb6\u54ac\u7259\u5207\u9f52\u7684\u662fA\u03b242\u3002A\u03b242\u55ae\u9ad4\u6703\u9ecf\u642d\u642d\u6b7b\u7e8f\u5728\u4e00\u8d77\u5f62\u6210\u805a\u5408\u9ad4\uff08oligomers\uff09\uff0c\u7136\u5f8c\u8b8a\u6210\u50cf\u662f\u7e96\u7dad\u7d72\uff08fibrils\uff09\u8207\u6591\u584a\u72c0\uff08plaques\uff09\u7684\u6c88\u7a4d\u75c5\u7076\u3002A\u03b242\u7684\u6c88\u7a4d\u6703\u5f15\u8d77\u514d\u75ab\u767c\u708e\u53cd\u61c9\uff0c\u7136\u5f8c\u50cf\u662f\u88ab\u63a8\u5012\u7684\u9aa8\u724c\u4e00\u6a23\uff0c\u5f15\u8d77\u795e\u7d93\u7d30\u80de\u5167\u69cb\u6210\u5fae\u5c0f\u7ba1\u7684\u4e00\u7a2e\u86cb\u767d\u8cea\u300c\u6dd8\u86cb\u767d\u300d\uff08Tau\uff09\u904e\u5ea6\u78f7\u9178\u5316\uff0c\u800c\u4f7f\u6dd8\u86cb\u767d\u4e00\u8d77\u6253\u7d50\u3002\u53d7\u5230\u5f71\u97ff\u7684\u795e\u7d93\u7d30\u80de\u8207\u795e\u7d93\u7a81\u89f8\u5c31\u6703\u9010\u6f38\u7522\u751f\u529f\u80fd\u7570\u5e38\uff0c\u751a\u81f3\u6b7b\u4ea1\u3002<\/p>\n<p>\u4f46\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u4e4b\u9593\u662f\u96de\u751f\u86cb\u9084\u662f\u86cb\u751f\u96de\uff0c\u4e00\u76f4\u5728\u79d1\u5b78\u5bb6\u4e4b\u9593\u6709\u5169\u6d3e\u610f\u898b\u3002\u652f\u6301\u5b9a\u7f6a\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\u7684\u4e00\u6d3e\uff0c\u89ba\u5f97\u9760\u6253\u64ca\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\uff0c\u5c31\u53ef\u4ee5\u626d\u8f49\u73fe\u4eca\u91ab\u7642\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u6cbb\u7642\u4e0a\u4e00\u76f4\u8655\u65bc\u4e0b\u98a8\u7684\u7a98\u6cc1\u3002\u6709\u8a31\u591a\u7684\u81e8\u5e8a\u5be6\u9a57\u4e5f\u4e00\u76f4\u5728\u9032\u884c\uff0c\u4f46\u7562\u7adf\u7d19\u4e0a\u8ac7\u5175\u7684\u7c21\u55ae\u7f8e\u597d\u5728\u73fe\u5be6\u88e1\u7e3d\u662f\u77e5\u6613\u884c\u96e3\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u91dd\u5c0d\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\u7684\u6cbb\u7642\u7b56\u7565\u4e4b\u4e00\uff0c\u662f\u5e0c\u671b\u53ef\u4ee5\u7814\u767c\u51fa\u4e00\u6b3e\u5c08\u9580\u5c0d\u6297\u5b83\u7684\u6297\u9ad4\u3002\u5c24\u5176\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\u7684\u6c88\u7a4d\uff0c\u5f80\u5f80\u6bd4\u795e\u7d93\u9000\u5316\u75c7\u72c0\u51fa\u73fe\u7684\u6642\u9593\u9ede\u8981\u65e9\u597d\u591a\u5e74\u3002\u5728\u7f8e\u597d\u7684\u60f3\u50cf\u88e1\uff0c\u79d1\u5b78\u5bb6\u5e0c\u671b\u6297\u9ad4\u53ef\u4ee5\u767c\u63ee\u300c\u8fce\u982d\u75db\u64ca\u300d\u8207\u300c\u6697\u6316\u58d5\u5751\u300d 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blood barrier\uff1b\u5e38\u7528\u7c21\u5bebBBB\uff09\u7684\u81c9\u8272\u3002\u8840\u8166\u969c\u58c1\u5750\u93ae\u63a7\u7ba1\u8457\u4ec0\u9ebc\u7269\u8cea\u3001\u71df\u990a\u7269\u53ef\u4ee5\u901a\u904e\u8840\u7ba1\u58c1\uff0c\u9032\u5165\u5230\u5927\u8166\u9019\u500b\u8d85\u91cd\u8981\u7684\u5668\u5b98\u8f44\u5340\uff0c\u53ef\u4ee5\u8aaa\u662f\u6700\u56b4\u5cfb\u7684\u6d77\u95dc\u8207\u79fb\u6c11\u7f72\u4e86\u3002\u300c\u8fce\u982d\u75db\u64ca\u300d\u7b56\u7565\u9700\u8981\u6297\u9ad4\u53ef\u4ee5\u795e\u8272\u81ea\u82e5\u7684\u901a\u904e\u8840\u8166\u969c\u58c1\uff0c\u800c\u300c\u6697\u6316\u58d5\u5751\u300d\u5247\u5047\u8a2d\u985e\u6fb1\u7c89\u86cb\u767d\u53ef\u4ee5\u88ab\u52d5\u5730\u9760\u64f4\u6563\u4f5c\u7528\u7a7f\u68ad\u81ea\u5982\u3002<\/p>\n<p>\u4f46\u6211\u5011\u771f\u7684\u80fd\u5920\u8a2d\u8a08\u51fa\u4e00\u682a\u6297\u9ad4\u64d4\u6b64\u5927\u4efb\u55ce\uff1f\u64da\u4f30\u8a08\uff0c\u5728\u5468\u908a\u8840\u6db2\u7684\u6297\u9ad4\uff0c\u53ea\u6709\u5927\u7d040.1\uff5e0.2%\u7684\u6975\u5176\u5c11\u6578\u53ef\u4ee5\u901a\u900f\u904e\u8840\u8166\u969c\u58c1\uff0c\u9032\u5165\u5230\u5927\u8166\u7d44\u7e54\u6216\u662f\u8166\u810a\u9ad3\u6db2\u4e2d\u3002 \u4f46\u6700\u8fd1\uff0c\u4e00\u7bc7\u767c\u8868\u5728<em>Nature<\/em>\u671f\u520a\u7684\u81e8\u5e8a\u7814\u7a76\uff0c\u6709\u4e86\u904e\u53bb\u4e8c\u5341\u4e94\u5e74\u4f86\u6700\u5927\u5e45\u5ea6\u7684\u9032\u5c55\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u54e1\u85c9\u7531\u6536\u96c6\u6c92\u6709\u8a8d\u77e5\u3001\u8a18\u61b6\u529f\u80fd\u969c\u7919\u7684\u5065\u5eb7\u8001\u5e74\u4eba\u5468\u908a\u8840\u6db2\u6aa2\u9ad4\uff0c\u5efa\u7acb\u514d\u75ab\u6dcb\u5df4\u7403B\u7d30\u80de\u7684\u8cc7\u6599\u5eab\uff0c\u8a66\u8457\u641c\u5c0b\u54ea\u500bB\u7d30\u80de\uff0c\u53ef\u4ee5\u5206\u6ccc\u51fa\u80fd\u5920\u5c08\u4e00\u6027\u5730\u8fa8\u8a8d\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\u75c5\u7076\u7684\u6297\u9ad4\u3002\u7814\u7a76\u4eba\u54e1\u5206\u96e2\u51fa\u4e00\u682a\u55ae\u682a\u6297\u9ad4\u300caducanumab\u300d\uff0c\u5c0d\u6709\u795e\u7d93\u6bd2\u6027\u7684\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\uff08\u5305\u62ec\u805a\u5408\u9ad4\u8207\u7e96\u7dad\u7d72\uff09\u6709\u6975\u9ad8\u7684\u5c08\u4e00\u6027\u7d50\u5408\u529b\u3002\u5728\u9019\u7bc7\u7814\u7a76\u4e2d\uff0c\u4ed6\u5011\u62db\u52df\u4e86165\u4f4d\u75c5\u4eba\uff0c\u5206\u5225\u6709\u8457\u8f15\u5ea6\u5230\u4e2d\u5ea6\u7684\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u7136\u5f8c\u96a8\u6a5f\u5206\u5230\u7d66\u85e5\u7d44\u8207\u63a7\u5236\u7d44\u3002\u7d66\u85e5\u7d44\u7684\u75c5\u4eba\uff0c\u518d\u5206\u6210\u56db\u7d44\uff0c\u8a66\u9a57\u4e0d\u540c\u5291\u91cf\u7684aducanumab\u3002\u75c5\u4eba\u63a5\u53d7\u70ba\u671f\u4e00\u5e74\u591a\uff0c\u6bcf\u500b\u79ae\u62dc\u4e00\u6b21\u7684\u975c\u8108\u8f38\u6db2\u3002<\/p>\n<p>\u800c\u632f\u596e\u4eba\u5fc3\u7684\u662f\uff0caducanumab\u4e0d\u50c5\u53ef\u4ee5\u6709\u6548\u6e05\u9664\u75c5\u4eba\u8166\u5167\u7684\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\u6c88\u7a4d\uff0c\u9084\u6709\u6548\u5ef6\u7de9\u4e86\u75c5\u4eba\u795e\u7d93\u7cfb\u7d71\u9000\u5316\u7684\u81e8\u5e8a\u75c7\u72c0\u3002\u76ee\u524d\u63a8\u4f30\uff0caducanumab\u6703\u9019\u9ebc\u6709\u6548\uff0c\u53ef\u80fd\u662f\u56e0\u70ba\u5b83\u76ef\u68a2\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\u7684\u5c08\u4e00\u6027\u548c\u89aa\u548c\u529b\u90fd\u592a\u5f37\u5927\u4e86\u3002\u56e0\u6b64\uff0c\u5c31\u7b97\u6297\u9ad4\u8de8\u8d8a\u8840\u8166\u969c\u58c1\u7684\u6548\u7387\u5f88\u4f4e\uff0c\u4f46\u662f\uff0c\u5f48\u7121\u865b\u767c\u7684aducanumab\u9084\u662f\u5a01\u529b\u7121\u6cd5\u64cb\u3002\u800c\u4e14\uff0c\u6839\u64da\u9019\u7bc7\u7814\u7a76\uff0caducanumab\u986f\u7136\u80fd\u5920\u901a\u904e\u8840\u8166\u969c\u58c1\u53bb\u5927\u986f\u795e\u5a01\u3002\u76ee\u524d\uff0c\u81e8\u5e8a\u8a66\u9a57\u7b2c\u4e09\u671f\u7684\u7814\u7a76\u4e5f\u6b63\u5728\u5982\u706b\u5982\u837c\u7684\u9032\u884c\uff0c\u8b93\u4eba\u6eff\u5fc3\u671f\u5f85aducanumab\u7684\u597d\u6d88\u606f\u3002\u800c\u4e14\uff0caducanumab\u7684\u6210\u529f\uff0c\u7121\u557b\u662f\u5c0d\u652f\u6301\u300c\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\u662f\u5143\u5147\u300d\u9019\u4e00\u5047\u8aaa\u7684\u9663\u71df\uff0c\u6709\u4e86\u6700\u6709\u529b\u7684\u80cc\u66f8\uff1b\u9019\u5c0d\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u57fa\u790e\u7814\u7a76\uff0c\u4e5f\u662f\u5f88\u91cd\u8981\u7684\u8ca2\u737b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u539f\u59cb\u8ad6\u6587\uff1a<\/strong><br \/>\nSevigny J et al. The antibody aducanumab reduces A\u03b2 plaques in Alzheimer's disease. Nature. 2016 Aug 31;537(7618):50-6. doi: 10.1038\/nature19323.<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med. 2016 Jun 1;8(6):595-608. doi: 10.15252\/emmm.201606210. Review.<\/li>\n<li>Reiman EM. Alzheimer's disease: Attack on amyloid-\u03b2 protein. Nature. 2016 Aug 31;537(7618):36-7. doi: 10.1038\/537036a.<\/li>\n<li>Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002 Jul 19;297(5580):353-6. Review. Erratum in: Science 2002 Sep 27;297(5590):2209.<\/li>\n<li>Ferrero J et al. First-in-human, double-blind, placebo-controlled, single-dose escalation study of aducanumab (BIIB037) in mild-to-moderate Alzheimer's disease. Alzeimers Dement (NY). In the press.<\/li>\n<\/ol>\n<p><strong>--<\/strong><br \/>\n<span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u963f\u8332\u6d77\u9ed8\u75c7\uff08Alzheimer\u2019s d<\/p>\n","protected":false},"author":20,"featured_media":26637,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[2889,771,2582,2888,1233],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/10\/dementia-851.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25633"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25633"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25633\/revisions"}],"predecessor-version":[{"id":32662,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25633\/revisions\/32662"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/26637"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}