{"id":25478,"date":"2016-09-30T00:36:19","date_gmt":"2016-09-29T16:36:19","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=25478"},"modified":"2018-08-03T15:05:35","modified_gmt":"2018-08-03T07:05:35","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%a0%94%e7%a9%b6%e3%80%91%e4%b8%8d%e4%b9%be%e4%b8%8d%e6%b7%a8%ef%bc%8c%e5%85%8d%e7%96%ab%e7%b3%bb%e7%b5%b1%e6%b2%92%e6%af%9b%e7%97%85%ef%bc%81","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=25478","title":{"rendered":"\u4e0d\u4e7e\u4e0d\u6de8\uff0c\u514d\u75ab\u7cfb\u7d71\u6c92\u6bdb\u75c5\uff01"},"content":{"rendered":"

\u25a0\u5c0f\u5b69\u5b50\u611b\u5403\u624b\u6307\u982d\uff0c\u5927\u4eba\u5011\u770b\u5230\u7684\u6642\u5019\u4e5f\u7e3d\u6232\u7a31\u5403\u6307\u982d\u7684\u5b69\u5b50\u5728\u300c\u5543\u96de\u817f\u300d\u3002\u7d10\u897f\u862d\u4e00\u500b\u8ffd\u8e64\u4e86\u5341\u5e7e\u5e74\u7684\u7814\u7a76\u767c\u73fe\uff0c\u4e0d\u8ad6\u662f\u300c\u5438\u624b\u6307\u300d\u9084\u662f\u300c\u54ac\u6307\u7532\u300d\uff0c \u9019\u4e9b\u7fd2\u6163\u53ef\u80fd\u771f\u7684\u662f\u597d\u597d\u9935\u990a\u514d\u75ab\u7cfb\u7d71\u3001\u8b93\u5b83\u4e0d\u6417\u86cb\u7684\u5927\u96de\u817f\u5462\uff01\u7121\u7368\u6709\u5076\uff0c\u7f8e\u570b\u829d\u52a0\u54e5\u5927\u5b78\u767c\u73fe\u90a3\u300c\u5927\u96de\u817f\u300d\uff0c\u6216\u8a31\u6b63\u662f\u7121\u6240\u4e0d\u5728\u7684\u5fae\u751f\u83cc\u53e2\uff01<\/strong><\/span><\/p>\n

\"pic\"\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

\u81ea1950\u5e74\u4e4b\u5f8c\uff0c\u904e\u654f\u6027\u75be\u75c5\u8207\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u7f79\u60a3\u4eba\u6578\u9010\u5e74\u6500\u5347\uff0c\u5438\u5f15\u4e86\u5b78\u8005\u5c08\u5bb6\u7684\u6ce8\u610f\u30021989\u5e74\u6642\uff0c\u82f1\u570b\u502b\u6566\u7684Strachan\u6559\u6388\u63d0\u51fa\u4e86\u300c\u885b\u751f\u5047\u8aaa\u300d\uff08hygiene hypothesis\uff09 \uff0c\u5617\u8a66\u7528\u5e7c\u7ae5\u5c0f\u6642\u5019\u611f\u67d3\u75c5\u53f2\u7684\u89d2\u5ea6\uff0c\u4f86\u89e3\u91cb\u70ba\u4ec0\u9ebc\u904e\u654f\u6027\u75be\u75c5\u8207\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u7684\u75c5\u60a3\u4eba\u6578\uff0c\u50cf\u5403\u4e86\u9b54\u85e5\u4e00\u6a23\u4e00\u76f4\u5c45\u9ad8\u4e0d\u4e0b\u3002<\/p>\n

Strachan\u6559\u6388\u7684\u5047\u8aaa\u5f88\u7c21\u55ae\uff0c\u4ed6\u9996\u5148\u89c0\u5bdf\u5230\u4f86\u81ea\u5927\u5bb6\u5ead\u7684\u5c0f\u5b69\uff0c\u6216\u662f\u4e0a\u6709\u5144\u59ca\u7684\u5c0f\u5b69\uff0c\u6bd4\u8f03\u4e0d\u5bb9\u6613\u7f79\u60a3\u82b1\u7c89\u71b1\u9019\u7a2e\u904e\u654f\u6027\u75be\u75c5\u3002Strachan\u6559\u6388\u65bc\u662f\u5047\u8a2d\uff0c\u9019\u662f\u56e0\u70ba\u7576\u5bb6\u5ead\u88e1\u9762\u6709\u5176\u4ed6\u6bd4\u8f03\u5e74\u9577\u7684\u5b69\u5b50\u6642\uff0c\u5c31\u5bb9\u6613\u628a\u5916\u754c\u7684\u75c5\u539f\u83cc\u5e36\u56de\u5bb6\uff0c\u800c\u8b93\u5e74\u5e7c\u7684\u5b69\u5b50\u63d0\u65e9\u63a5\u89f8\u75c5\u83cc\u800c\u6709\u611f\u67d3\u75c7\u72c0\u3002\u800c\u5c0f\u5b69\u5728\u767c\u80b2\u65e9\u671f\u88ab\u82b1\u82b1\u4e16\u754c\u7684\u300c\u75c5\u83cc\u300d\u78e8\u7df4\u5f8c\uff0c \u9577\u5927\u4e4b\u5f8c\u7684\u514d\u75ab\u7cfb\u7d71\uff0c\u5c31\u6bd4\u8f03\u4e0d\u5bb9\u6613\u5c0d\u65e5\u5e38\u5468\u906d\u7684\u300c\u6297\u539f\u300d\u5927\u9a5a\u5c0f\u602a\u800c\u767c\u5c55\u51fa\u904e\u654f\u6027\u75be\u75c5\u3002<\/p>\n

Strachan\u6559\u6388\u4e0d\u4e7e\u4e0d\u6de8\u6c92\u95dc\u4fc2\u7684\u300c\u885b\u751f\u5047\u8aaa\u300d\uff0c\u5c31\u9019\u6a23\u4e00\u8def\u722d\u8b70\u4e0d\u65b7\u5730\u7d05\u5230\u4e86\u4e8c\u5341\u4e00\u4e16\u7d00\u7684\u73fe\u5728\u3002\u8a31\u591a\u6839\u64da\u300c\u885b\u751f\u5047\u8aaa\u300d\u800c\u8a2d\u8a08\u7684\u81e8\u5e8a\u7814\u7a76\uff0c\u5728\u9577\u6642\u9593\u8ffd\u8e64\u53d7\u8a66\u8005\u4e4b\u5f8c\uff0c\u4f3c\u4e4e\u4e5f\u6709\u4e86\u8ddfStrachan\u6559\u6388\u8ad6\u9ede\u9817\u4e00\u81f4\u7684\u7d50\u8ad6\u3002\u829d\u52a0\u54e5\u5927\u5b78\u7684Anne Sperling\u6559\u6388\u6700\u8fd1\u5728\u300a\u7f8e\u570b\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u671f\u520a\u300b\u4e0a\uff0c\u767c\u8868\u4e86\u4e00\u7bc7\u5f88\u6709\u8da3\u7684\u7814\u7a76\uff0c\u5927\u81f4\u6b78\u7d0d\u51fa\u4e00\u5957\u6bd4\u8f03\u7cbe\u7dfb\u7684\u89e3\u91cb\uff0c\u8b93\u300c\u885b\u751f\u5047\u8aaa\u300d\u80fd\u5728\u514d\u75ab\u7d30\u80de\u9019\u4e9b\u6230\u58eb\u7684\u5c64\u7d1a\u4e0a\uff0c\u6709\u8f03\u5b8c\u6574\u53c8\u5408\u7406\u7684\u8108\u7d61\u3002<\/p>\n

\u8981\u5982\u4f55\u77e5\u9053\u514d\u75ab\u7cfb\u7d71\u662f\u4e0d\u662f\u80fd\u70ba\u300c\u885b\u751f\u5047\u8aaa\u300d\u80cc\u66f8\u5462\uff1fSperling\u6559\u6388\u7684\u7814\u7a76\u5718\u968a\u5c07\u7126\u9ede\u96c6\u4e2d\u5230\u4e86\u7f8e\u570b\u5883\u5167\u5169\u96e2\u7fa4\u7d22\u5c45\u7684\u65cf\u7fa4\uff1aAmish\u548cHutterites\u3002Amish\u548cHutterites\u5206\u5225\u5728\u5341\u516b\u3001\u4e5d\u4e16\u7d00\u5f9e\u6b50\u6d32\u79fb\u5c45\u7f8e\u570b\u4e4b\u5f8c\uff0c\u4e00\u76f4\u90fd\u5c0d\u5916\u754c\u4fdd\u6301\u8457\u9694\u96e2\u7684\u52d9\u8fb2\u751f\u6d3b\u578b\u614b\u3002\u5169\u65cf\u7fa4\u7684\u767c\u6e90\u6975\u5ea6\u76f8\u8fd1\uff0c\u9577\u6642\u9593\u4e5f\u5728\u751f\u80b2\u7e41\u884d\u4e0a\u63a1\u53d6\u76f8\u5c0d\u300c\u9396\u570b\u300d\u7684\u614b\u5ea6\uff0c\u751f\u6d3b\u578b\u614b\u4e5f\u8fd1\u4f3c\uff0c\u8b93\u9019\u5169\u65cf\u7fa4\u6210\u70ba\u5728\u907a\u50b3\u57fa\u56e0\u3001\u8207\u751f\u6d3b\u74b0\u5883\u90fd\u50cf\u662f\u96d9\u80de\u80ce\u822c\u96f7\u540c\u3002\u4f46\uff0c\u76f8\u8f03\u65bcHutterites\u9858\u610f\u5229\u7528\u9ad8\u79d1\u6280\u6a5f\u5668\u8a2d\u5099\u4f86\u8655\u7406\u8fb2\u4f5c\uff0cAmish\u9084\u662f\u63a1\u53d6\u6700\u50b3\u7d71\u7684\u52d9\u8fb2\u65b9\u5f0f\u3002\u800c\uff0c\u6709\u8da3\u7684\u662f\uff0cHutterites\u65cf\u7fa4\u88e1\u5b69\u7ae5\u7f79\u60a3\u6c23\u5598\u7684\u6bd4\u4f8b\u5927\u7d04\u662f21.3%\uff0c\u904e\u654f\u6027\u9ad4\u8cea\u7684\u6bd4\u7387\u5247\u7d0433.3%\uff0c\u548c\u4e00\u822c\u7f8e\u570b\u5404\u57ce\u5e02\u7684\u6bd4\u4f8b\u5dee\u4e0d\u591a\u3002\u4f46Amish\u65cf\u7fa4\u88e1\uff0c\u6709\u6c23\u5598\u7684\u5b69\u7ae5\u6bd4\u7387\u53ea\u67095%\uff0c\u904e\u654f\u6027\u9ad4\u8cea\u7684\u6bd4\u7387\u5247\u66f4\u662f\u53ea\u67097%\u3002<\/p>\n

\u56e0\u70ba\u5169\u65cf\u7fa4\u751f\u6d3b\u578b\u614b\u7684\u76f8\u8fd1\uff0c\u8a31\u591a\u53ef\u80fd\u5f71\u97ff\u6c23\u5598\u7f79\u60a3\u7387\u7684\u56e0\u7d20\u4e5f\u5c31\u540c\u6642\u53d7\u5230\u63a7\u5236\u3002Hutterites\u8ddfAmish\u4e00\u6a23\uff1a\u5bb6\u5ead\u88e1\u624b\u8db3\u773e\u591a\uff0c\u54fa\u9935\u6bcd\u4e73\u6642\u9593\u9577\uff0c\u6c61\u67d3\u8207\u4e8c\u624b\u83f8\u4e5f\u5f9e\u4f86\u4e0d\u662f\u500b\u7169\u60f1\uff0c\u5b69\u7ae5\u80a5\u80d6\u7387\u4e5f\u6975\u4f4e\uff0c\u75ab\u82d7\u63a5\u7a2e\u4e5f\u751a\u666e\u53ca\uff1b\u98f2\u98df\u4e2d\u96d6\u5bcc\u542b\u6cb9\u8102\u3001\u9e7d\u8207\u751f\u725b\u5976\uff0c\u4f46\u90a3\u4e5f\u548cAmish\u65cf\u7fa4\u6c92\u6709\u4e0d\u540c\u3002\u90a3\u70ba\u4ec0\u9ebc\u6c23\u5598\u548c\u904e\u654f\u9084\u662f\u5728Hutterites\u65cf\u7fa4\u88e1\u5c45\u9ad8\u4e0d\u4e0b\u5462\uff1f<\/p>\n

Sperling\u6559\u6388\u767c\u73fe\uff0cAmish\u50b3\u7d71\u52d9\u8fb2\u7684\u751f\u6d3b\u578b\u614b\uff0c\u8b93\u4ed6\u5011\u7684\u5b69\u5b50\u81ea\u5c0f\u5c31\u9577\u671f\u66b4\u9732\u5728\u5fae\u751f\u7269\u83cc\u53e2\u88e1\u2014\u2014\u5c31\u50cf\u300c\u885b\u751f\u5b78\u8aaa\u300d\u88e1\u6240\u5efa\u8b70\u7684\u90a3\u6a23\u3002\u9664\u4e86\u5e38\u898b\u7684\u904e\u654f\u539f\uff0c\u5305\u62ec\u5875\u87ce\u3001\u8c93\u72d7\uff0c\u53ef\u4ee5\u5728Amish\u5bb6\u5ead\u88e1\u6aa2\u6e2c\u51fa\u4f86\u4e4b\u5916\uff0cAmish\u5bb6\u5ead\u88e1\u7a7a\u6c23\u5167\u61f8\u6d6e\u7070\u5875\u7684\u7d30\u83cc\u5167\u6bd2\u7d20\uff08endotoxin\uff09\u6aa2\u6e2c\u503c\uff0c\u66f4\u662f\u6bd4Hutterites\u5bb6\u5ead\u88e1\u9ad8\u51fa\u4e03\u500d\uff01<\/p>\n

Sperling\u6559\u6388\u9032\u4e00\u6b65\u63a1\u96c6Amish\u8207Hutterites\u65cf\u7fa4\u88e1\u5c0f\u5b69\u7684\u8840\u6db2\u6a23\u672c\uff0c\u5206\u6790\u4e4b\u5f8c\u767c\u73fe\uff0cAmish\u5c0f\u5b69\u56e0\u70ba\u9577\u671f\u66b4\u9732\u5728\u7d30\u83cc\u7b49\u5fae\u751f\u7269\u7684\u74b0\u5883\u88e1\uff0c\u8b93\u4ed6\u5011\u7684\u5148\u5929\u514d\u75ab\u7cfb\u7d71\u9577\u671f\u8655\u5728\u300c\u5fae\u8b66\u6212\u300d\u7684\u5099\u6230\u72c0\u6cc1\u4e0b\u3002Amish\u5b69\u5b50\u7684\u5148\u5929\u514d\u75ab\u7d30\u80de\u88e1\uff0c\u555f\u52d5\u5148\u5929\u514d\u75ab\u53cd\u61c9\u6240\u5fc5\u9700\u7684\u57fa\u56e0\u90fd\u88ab\u6d3b\u5316\uff0c\u5305\u62ecMyD88\u8207Trif\uff0c\u4e5f\u88fd\u9020\u6bd4\u8f03\u591a\u7684\u4fc3\u767c\u708e\u7d30\u80de\u6fc0\u7d20\u3002\u9019\u4e9b\u56e0\u70ba\u63a5\u89f8\u751f\u6d3b\u4e2d\u5fae\u751f\u83cc\u53e2\u800c\u88ab\u300c\u5fae\u555f\u52d5\u300d\u7684\u300c\u5fae\u767c\u708e\u300d\u72c0\u614b\uff0c\u63d0\u4f9b\u4e86Amish\u5c0f\u5b69\u6700\u7d55\u4f73\u7684\u4fdd\u8b77\u7f69\uff0c\u8b93\u4ed6\u5011\u7684\u514d\u75ab\u7cfb\u7d71\u4e0d\u81f3\u65bc\u53bb\u6417\u4e82\u800c\u8a98\u767c\u6c23\u5598\u3002\u6709\u8da3\u7684\u662f\uff0c\u5f9eAmish\u5bb6\u5ead\u88e1\u6536\u96c6\u5230\u7684\u7070\u5875\uff0c\u5728\u904e\u654f\u6027\u6c23\u5598\u7684\u8001\u9f20\u5be6\u9a57\u6a21\u578b\u88e1\uff0c\u4e5f\u80fd\u5c0d\u8001\u9f20\u63d0\u4f9b\u4fdd\u8b77\u4f5c\u7528\u3002<\/p>\n

\u90a3\u9019\u8ddf\u611b\u5438\u624b\u6307\u982d\u6216\u662f\u54ac\u6307\u7532\u7684\u5c0f\u5b69\u6709\u4ec0\u9ebc\u95dc\u806f\u5462\uff1f<\/strong><\/p>\n

\u7d10\u897f\u862d\u5967\u5854\u54e5\u5927\u5b78\uff08University of Otago\uff09Hancox\u6559\u6388\u548c\u535a\u58eb\u73ed\u5b78\u751fStephanie Lynch\u5c0d\u300c\u885b\u751f\u5047\u8aaa\u300d\u7684\u89c0\u9ede\u975e\u5e38\u6709\u8208\u8da3\u3002\u4ed6\u5011\u89ba\u5f97\u5982\u679c\u300c\u885b\u751f\u5047\u8aaa\u300d\u70ba\u771f\uff0c\u800c\u4e14\u65e2\u7136\u6700\u95dc\u9375\u7684\u89d2\u8272\u5728\u5fae\u751f\u7269\u83cc\u53e2\uff0c\u90a3\u611b\u54ac\u624b\u6307\u982d\u8207\u6307\u7532\u7684\u5c0f\u670b\u53cb\uff0c\u662f\u4e0d\u662f\u4e5f\u80fd\u5920\u5f9e\u9ad2\u9ad2\u7684\u624b\u6307\u982d\u88e1\uff0c\u63a5\u89f8\u5230\u8db3\u5920\u7684\u5fae\u751f\u7269\u83cc\u53e2\u800c\u5f97\u5230\u4fdd\u8b77\u5462\uff1f<\/p>\n

\u65bc\u662f\u4ed6\u5011\u8ffd\u8e64\u4e86\u4e00\u7fa4\u5df2\u5c46\u5b78\u9f61\u5e74\u7d00\uff0c\u537b\u9084\u6212\u4e0d\u6389\u5438\u624b\u6307\u6216\u54ac\u6307\u7532\u7684\u5c0f\u670b\u53cb\u3002\u7576\u9019\u4e9b\u5c0f\u670b\u53cb\u6eff\u5341\u4e09\u6b72\u6642\uff0c\u76ae\u819a\u904e\u654f\u539f\u6e2c\u8a66\u986f\u793a\u9019\u4e9b\u5c0f\u5b69\u7684\u78ba\u6bd4\u8f03\u4e0d\u5bb9\u6613\u904e\u654f\u3002\u800c\u66f4\u6709\u8da3\u7684\u662f\uff0c\u7576\u9019\u4e9b\u5b69\u5b50\u6eff\u4e09\u5341\u4e8c\u6b72\u6642\uff0c\u90a3\u4fdd\u8b77\u7f69\u4f3c\u4e4e\u9084\u6301\u7e8c\u767c\u63ee\u8457\u9b54\u529b\uff0c\u8b93\u4ed6\u5011\u6bd4\u8f03\u4e0d\u5bb9\u6613\u904e\u654f\uff0c\u800c\u4e14\uff0c\u540c\u6642\u5438\u624b\u6307\u53c8\u54ac\u6307\u7532\u7684\u5c0f\u5b69\uff0c\u904e\u654f\u6a5f\u7387\u6bd4\u53ea\u6709\u4e00\u9805\u7fd2\u6163\u7684\u5c0f\u5b69\u8981\u66f4\u4f4e\u3002<\/p>\n

\u4e0d\u904e\uff0c\u5f9eAmish\u8207Hutterites\u7684\u6bd4\u8f03\u5206\u6790\u88e1\uff0c\u6216\u8a31\u9632\u6cbb\u904e\u654f\u7684\u6700\u597d\u65b9\u6cd5\u4e4b\u4e00\uff0c\u5c31\u662f\u591a\u53bb\u6236\u5916\u8d70\u8d70\uff0c\u8b93\u5927\u81ea\u7136\u5e6b\u5fd9\u990a\u4e00\u500b\u9ad2\u516e\u516e\u537b\u53c8\u4e0d\u7528\u88ab\u904e\u654f\u6240\u60f1\u7684\u5c0f<\/p>\n

 <\/p>\n

\u539f\u59cb\u8ad6\u6587\uff1a<\/strong><\/p>\n

    \n
  1. Lynch SJ, et al. Thumb-Sucking, Nail-Biting, and Atopic Sensitization, Asthma, and Hay Fever. Pediatrics.<\/em> 2016 Aug;138(2). pii: e20160443. doi: 10.1542\/peds.2016-0443. Epub 2016 Jul 11.<\/li>\n
  2. Stein MM, et al. Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. N Engl J Med<\/em>. 2016 Aug 4;375(5):411-21. doi: 10.1056\/NEJMoa1508749.<\/li>\n<\/ol>\n

    \u53c3\u8003\u8cc7\u6599\uff1a<\/strong>
    \n1. Chatila TA. Innate Immunity in Asthma. N Engl J Med<\/em>. 2016 Aug 4;375(5):477-9. doi: 10.1056\/NEJMe1607438.
    \n2.Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med<\/em> 2002;347:911-920
    \n3. Ege MJ, Mayer M, Normand AC, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med<\/em> 2011;364:701-709<\/p>\n

    --<\/strong>
    \n\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n

     <\/p>\n

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