{"id":25354,"date":"2016-08-24T00:57:44","date_gmt":"2016-08-23T16:57:44","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=25354"},"modified":"2022-10-11T13:20:57","modified_gmt":"2022-10-11T05:20:57","slug":"%e3%80%90%e7%94%9f%e7%89%a9%e6%bc%94%e5%8c%96%e3%80%91%e9%ad%9a%e9%b0%ad%e5%92%8c%e6%89%8b%e6%8c%87%e8%85%b3%e8%b6%be%e7%99%bc%e8%82%b2%e7%9a%84%e7%95%b0%e6%9b%b2%e5%90%8c%e5%b7%a5%e4%b9%8b%e5%a6%99","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=25354","title":{"rendered":"\u3010\u751f\u7269\u6f14\u5316\u3011\u9b5a\u9c2d\u548c\u624b\u6307\u8173\u8dbe\u767c\u80b2\u7684\u7570\u66f2\u540c\u5de5\u4e4b\u5999"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u56db\u8db3\u52d5\u7269\u7684\u7956\u5148\u90fd\u50cf\u662f\u4eca\u5929\u5728\u6c34\u88e1\u6e38\u7684\u9b5a\u3002\u6211\u5011\u7956\u5148\u5f9e\u6c34\u4e2d\u6f14\u5316\u4e0a\u9678\u5730\u767c\u751f\u7684\u4e00\u9805\u5049\u5927\u8b8a\u9769\u662f\uff0c\u9b5a\u9c2d\u88ab\u624b\u6307\u548c\u8173\u8dbe\u53d6\u4ee3\u4e86\u3002\u79d1\u5b78\u5bb6\u767c\u73fe\uff0c\u539f\u4f86\u9b5a\u9c2d\u767c\u80b2\u4e2d\u95dc\u9375\u7684\u7d30\u80de\uff0c\u540c\u6a23\u5728\u624b\u6307\u548c\u8173\u8dbe\u7684\u767c\u80b2\u4e2d\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_25355\" aria-describedby=\"caption-attachment-25355\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-25355\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/08\/0822.png\" alt=\"Credit: Shubin Laboratory\" width=\"450\" height=\"336\"><figcaption id=\"caption-attachment-25355\" class=\"wp-caption-text\">Credit: Shubin Laboratory<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u9ec3\u8c9e\u7965<\/p>\n<p>\u5316\u77f3\u8b49\u64da\u986f\u793a\uff0c\u9678\u751f\u56db\u8db3\u52d5\u7269\u548c\u8f3b\u9c2d\u9b5a\u985e\u7684\u5171\u540c\u7956\u5148\u57284\u51043\u5343\u842c\u5e74\u524d\u9084\u751f\u6d3b\u5728\u6c34\u4e2d\uff0c\u800c\u9678\u751f\u56db\u8db3\u52d5\u7269\u7684\u7956\u5148\uff0c\u662f\u57283\u51046\u5343\u842c\u5e74\u524d\u6f14\u5316\u4e0a\u9678\u7684\u3002<\/p>\n<p>\u829d\u52a0\u54e5\u5927\u5b78\u7684\u6f14\u5316\u751f\u7269\u5b78\u5bb6Neil Shubin\u7b49\u4eba\uff0c\u7d93\u904e\u4e86\u4e09\u5e74\uff0c\u4f7f\u7528\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u548c\u9748\u654f\u7684\u7d30\u80de\u767c\u80b2\u5716\uff0c\u5728\u9b5a\u9c2d\u4e2d\u8ffd\u8e64\u767c\u80b2\u904e\u7a0b\u4e2d\u7d30\u80de\u7684\u53bb\u5411\uff0c\u56e0\u800c\u767c\u73fe\u4e86\u5728\u9b5a\u9c2d\u4e2d\u7684\u9c2d\u689d\uff0c\u6709\u53ef\u80fd\u548c\u624b\u6307\u53ca\u8173\u8dbe\u662f\u540c\u6e90\u7684\uff0c\u56e0\u70ba\u5b83\u5011\u90fd\u6709\u76f8\u540c\u7684\u767c\u80b2\u53f2\u3002<\/p>\n<p>Neil Shubin\u539f\u662f\u53e4\u751f\u7269\u5b78\u5bb6\uff0c\u4ed6\u6700\u8f5f\u52d5\u7684\u767c\u73fe\u662f\u63d0\u5854\u5229\u514b\u9b5a\uff08Tiktaalik\uff09\u3002\u90a3\u662f\u4e00\u7a2e\u5df2\u6ec5\u7d55\u7684\u65e9\u671f\u9b5a\u985e\uff0c\u751f\u5b58\u65bc3\u51047\u5343\u842c\u5e74\u524d\u6ce5\u76c6\u7d00\u665a\u671f\uff0c\u88ab\u8a8d\u70ba\u662f\u9b5a\u985e\u53ca\u5169\u751f\u985e\u4e4b\u9593\u7684\u7269\u7a2e\u3002\u7260\u7684\u300c\u9c2d\u300d\u64c1\u6709\u539f\u59cb\u7684\u8155\u9aa8\u53ca\u55ae\u7d14\u7684\u8dbe\u982d\uff0c\u8868\u793a\u5b83\u5011\u53ef\u4ee5\u627f\u53d7\u91cd\u91cf\u3002\u96d6\u7136\u5f88\u53ef\u80fd\u7121\u6cd5\u4f7f\u7528\u5b83\u5011\u4f86\u884c\u8d70\uff0c\u4f46\u662f\u5b83\u5011\u53ef\u80fd\u53ef\u4ee5\u7528\u4f86\u652f\u6490\u8eab\u9ad4\uff0c\u5c31\u50cf\u4f0f\u5730\u633a\u8eab\u4e00\u6a23\u3002\u524d\u9c2d\u7684\u9aa8\u9abc\u986f\u793a\u51fa\u7260\u5011\u53ef\u80fd\u64c1\u6709\u8a31\u591a\u808c\u8089\u7d44\u7e54\uff0c\u9019\u8868\u793a\u7260\u5011\u64c1\u6709\u767c\u9054\u7684\u808c\u8089\uff0c\u800c\u4e14\u6709\u80fd\u529b\u50cf\u624b\u8155\u4e00\u6a23\u5f4e\u66f2\u3002\u9019\u4e9b\u985e\u4f3c\u624b\u8155\u7684\u7279\u5fb5\u53ef\u4ee5\u5e6b\u52a9\u63d0\u5854\u5229\u514b\u9b5a\u5728\u5feb\u901f\u79fb\u52d5\u6642\u7a69\u5b9a\u8eab\u9ad4\u7684\u5e95\u90e8\u3002<!--more--><\/p>\n<p>Neil Shubin\u6307\u51fa\uff0c\u591a\u5e74\u4f86\u79d1\u5b78\u5bb6\u4e00\u76f4\u8a8d\u70ba\u9c2d\u689d\u548c\u624b\u6307\u8173\u8dbe\u5b8c\u5168\u7121\u95dc\uff0c\u56e0\u70ba\u624b\u6307\u8173\u8dbe\u662f\u7531\u9aa8\u9abc\u5f62\u6210\uff0c\u9c2d\u689d\u50c5\u662f\u7c21\u55ae\u7684\u7d50\u7de0\u7d44\u7e54\uff0c\u5b83\u5011\u5728\u7d50\u69cb\u4e0a\u3001\u767c\u80b2\u4e0a\u548c\u7d44\u7e54\u5b78\u4e0a\u90fd\u5dee\u7570\u5f88\u5927\u3002\u4eba\u985e\u7684\u624b\u6307\u662f\u7531\u8edf\u9aa8\u767c\u80b2\u800c\u6210\uff0c\u5167\u542b\u8840\u7ba1\uff0c\u7a31\u70ba\u8edf\u9aa8\u5167\u6210\u9aa8\uff08Endochondral bone\uff09\uff0c\u800c\u9b5a\u9c2d\u7684\u9c2d\u689d\u5247\u4e0d\u662f\u5f9e\u8edf\u9aa8\u767c\u80b2\u800c\u6210\u4e26\u4e14\u4e0d\u542b\u8840\u7ba1\uff0c\u7a31\u70ba\u819c\u9aa8\uff08Dermal bone\uff0c\u6216\u7a31\u76ae\u8cea\u9aa8\uff09\u3002<\/p>\n<p>Neil Shubin\u5be6\u9a57\u5ba4\u7684\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u4e2d\u6751\u54f2\u4e5f\uff0c\u4f7f\u7528\u4e86\u57fa\u56e0\u7de8\u8f2f\u6280\u8853CRISPR \/ CAS\uff0c\u5728\u6591\u99ac\u9b5a\u4e2d\u522a\u9664\u548c\u80a2\u9ad4\u767c\u80b2\u6709\u95dc\u7684\u91cd\u8981\u57fa\u56e0\uff0c\u7136\u5f8c\u9078\u64c7\u6027\u7e41\u6b96\u6709\u591a\u500b\u6709\u76ee\u6a19\u7f3a\u5931\u7684\u6591\u99ac\u9b5a\u3002\u4ed6\u82b1\u4e86\u5169\u5e74\u591a\u5728\u958b\u59cb\u5728\u4f0d\u8332\u970d\u723e\u6d77\u6d0b\u751f\u7269\u5be6\u9a57\u5ba4\u7684\u5efa\u7acb\u548c\u96dc\u4ea4\u80b2\u7a2e\u6591\u99ac\u9b5a\u7a81\u8b8a\u54c1\u7cfb\uff1bNeil Shubin\u5be6\u9a57\u5ba4\u7684\u7814\u7a76\u751fAndrew Gehrke\u5229\u7528\u4e86\u4e00\u7a2e\u6539\u9032\u7684\u7d30\u80de\u6a19\u8a18\u6280\u8853\uff0c\u80fd\u5920\u7e6a\u88fd\u51fa\u52d5\u7269\u751f\u9577\u548c\u767c\u80b2\u6642\uff0c\u80da\u80ce\u7d30\u80de\u4f55\u6642\u9077\u79fb\u5230\u4f55\u5730\u3002<\/p>\n<p>\u4ed6\u5011\u628a\u7126\u9ede\u653e\u5728<em>HOX<\/em>\u57fa\u56e0\uff0c\u90a3\u662f\u5728\u52d5\u7269\u63a7\u5236\u5f9e\u982d\u5230\u5c3e\u7684\u9ad4\u7bc0\u767c\u80b2\u7684\u57fa\u56e0\uff0c\u4e5f\u63a7\u5236\u4e86\u5f9e\u80a9\u8180\u5230\u624b\u6307\u7684\u767c\u80b2\u3002\u4ed6\u5011\u8ffd\u8e64\u4e86\u5f9e\u525b\u53d7\u7cbe\u5230\u9577\u51fa\u9b5a\u9c2d\u7684\u904e\u7a0b\u4e2d\uff0c\u7d30\u80de\u7684\u53bb\u5411\u3002\u548c\u8001\u9f20\u624b\u8155\u53ca\u624b\u6307\u767c\u80b2\u6709\u95dc\u7684<em>HOXA-13<\/em>\u548c<em>HOXD-13<\/em>\u57fa\u56e0\uff0c\u5728\u5254\u9664\u7684\u72c0\u6cc1\u4e0b\uff0c\u624b\u8155\u53ca\u624b\u6307\u662f\u7121\u6cd5\u9577\u51fa\u7684\u3002\u4e2d\u6751\u54f2\u4e5f\u767c\u73fe\uff0c\u5982\u679c\u5728\u6591\u99ac\u9b5a\u628a\u76f8\u540c\u57fa\u56e0\u4e00\u8d77\u5254\u9664\uff0c\u7260\u5011\u7684\u9b5a\u9c2d\u6703\u5927\u5e45\u7e2e\u77ed\u3002\u9019\u4e9b\u57fa\u56e0\u5728\u6591\u99ac\u9b5a\u53c3\u8207\u4e86\u819c\u9aa8\u800c\u975e\u8edf\u9aa8\u5167\u6210\u9aa8\u7684\u767c\u80b2\u3002<\/p>\n<p>\u4ed6\u5011\u4f7f\u7528\u4e86\u9ad8\u80fd\u96fb\u8166\u65b7\u5c64\u6383\u63cf\u4f86\u7814\u7a76\u50b3\u7d71\u986f\u5fae\u93e1\u770b\u4e0d\u5230\u7684\u9b5a\u9c2d\u7d30\u5fae\u69cb\u9020\u3002\u767c\u73fe\u6709\u4e9b\u7279\u5b9a\u57fa\u56e0\u7684\u7f3a\u5931\u6703\u5931\u53bb\u9b5a\u9c2d\uff0c\u53ef\u662f\u88fd\u9020\u8edf\u9aa8\u7247\u7684\u5c0f\u9aa8\u982d\u7684\u6578\u91cf\u6703\u589e\u52a0\u3002\u5229\u7528\u7d30\u80de\u8ffd\u8e64\u6280\u8853\uff0c\u4ed6\u5011\u767c\u73fe\u624b\u6307\u548c\u8173\u8dbe\uff0c\u9084\u6709\u9c2d\u689d\u90fd\u662f\u7528\u76f8\u540c\u7684\u7d30\u80de\u88fd\u9020\u7684\u3002\u4ed6\u5011\u61f7\u7591\u90a3\u662f\u56e0\u70ba\u7a81\u8b8a\u9020\u6210\u7d30\u80de\u7121\u6cd5\u5f9e\u9b5a\u9c2d\u57fa\u90e8\u9077\u5f99\u4e0a\u53bb\u88fd\u9020\u9c2d\u689d\uff0c\u56e0\u800c\u5728\u57fa\u90e8\u88fd\u9020\u4e86\u66f4\u591a\u8edf\u9aa8\u3002\u9019\u500b\u767c\u73fe\u610f\u5473\u8457\uff0c\u9b5a\u9c2d\u7684\u767c\u80b2\u4e5f\u597d\uff0c\u624b\u6307\u548c\u8173\u8dbe\u7684\u767c\u80b2\u4e5f\u597d\uff0c\u90fd\u662f\u5229\u7528\u540c\u6a23\u7684\u5206\u5b50\u57fa\u5236\uff0c\u53ea\u662f\u5728\u9b5a\u9c2d\u90a3\u6a23\u7d30\u80de\u767c\u80b2\u6210\u4e86\u819c\u9aa8\uff0c\u800c\u5728\u624b\u6307\u548c\u8173\u8dbe\u5247\u767c\u80b2\u6210\u8edf\u9aa8\u5167\u6210\u9aa8\u3002<\/p>\n<p>\u9019\u500b\u6539\u5beb\u6559\u79d1\u66f8\u7684\u7814\u7a76\u767c\u73fe\u610f\u5473\u8457\uff0c\u5118\u91cf\u5916\u89c0\u518d\u4e0d\u76f8\u4f3c\uff0c\u6211\u5011\u4e5f\u5fc5\u9808\u91cd\u89aa\u601d\u8003\u9b5a\u9c2d\u548c\u624b\u6307\u53ca\u8173\u8dbe\u7684\u6f14\u5316\u95dc\u9023\uff01<\/p>\n<p><strong>\u539f\u5b78\u8853\u8ad6\u6587\uff1a<\/strong>Nakamura T, et al. Digits and fin rays share common developmental histories. Nature. 2016 Aug 17. doi: 10.1038\/nature19322. [Epub ahead of print]<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><br \/>\n1. John Easton. <a href=\"https:\/\/news.uchicago.edu\/article\/2016\/08\/18\/discovery-reveals-evolutionary-path-fins-fingers\" target=\"_blank\" rel=\"noopener noreferrer\">Discovery reveals evolutionary path from fins to fingers.<\/a> UChicagoNews. August 18, 2016.<br \/>\n2. Carl Zimmer. <a href=\"http:\/\/www.nytimes.com\/2016\/08\/18\/science\/from-fins-into-hands-scientists-discover-a-deep-evolutionary-link.html\" target=\"_blank\" rel=\"noopener noreferrer\">From Fins Into Hands: Scientists Discover a Deep Evolutionary Link.&nbsp;<\/a> New York Times. AUG. 17, 2016.<\/p>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br \/>\n<span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a<strong>\u9ec3\u8c9e\u7965 \u73fe\u4efb\u6559\u65bc\u570b\u7acb\u6e05\u83ef\u5927\u5b78\u5206\u5b50\u8207\u7d30\u80de\u751f\u7269\u7814\u7a76\u6240\u66a8\u751f\u547d\u79d1\u5b78\u7cfb\uff0c<wbr>\u5f9e\u4e8b\u9ce5\u985e\u7684\u6f14\u5316\u907a\u50b3\u5b78\u3001\u57fa\u56e0\u9ad4\u5b78\u53ca\u6f14\u5316\u767c\u80b2\u751f\u7269\u5b78\u7814\u7a76\u3002<wbr>\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u56db\u8db3\u52d5\u7269\u7684\u7956\u5148\u90fd\u50cf\u662f\u4eca\u5929\u5728\u6c34\u88e1\u6e38\u7684\u9b5a\u3002<\/p>\n","protected":false},"author":20,"featured_media":25355,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,6512,26,1026],"tags":[99,2782,2781,57,2780,2783,2779],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/08\/0822.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25354"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25354"}],"version-history":[{"count":5,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25354\/revisions"}],"predecessor-version":[{"id":40870,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25354\/revisions\/40870"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/25355"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25354"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25354"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}