{"id":25279,"date":"2016-08-18T00:00:55","date_gmt":"2016-08-17T16:00:55","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=25279"},"modified":"2018-08-03T14:59:30","modified_gmt":"2018-08-03T06:59:30","slug":"%e3%80%90%e8%ba%ab%e9%ab%94%e5%8f%8d%e6%87%89%e3%80%91%e8%9a%8a%e5%ad%90%e5%8f%ae%e7%82%ba%e4%bb%80%e9%ba%bc%e6%9c%83%e7%99%a2%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=25279","title":{"rendered":"\u3010\u8eab\u9ad4\u53cd\u61c9\u3011\u868a\u5b50\u53ee\u70ba\u4ec0\u9ebc\u6703\u7662\uff1f"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u590f\u65e5\u708e\u708e\u868a\u5b50\u591a\uff0c\u7a76\u7adf\u70ba\u4ec0\u9ebc\u88ab\u868a\u5b50\u54ac\u5f8c\u6703\u7662\u5462\uff1f<\/strong><\/span><\/p>\n<figure id=\"attachment_25280\" aria-describedby=\"caption-attachment-25280\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-25280\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/08\/Aedes_aegypti.jpg\" alt=\"\u57c3\u53ca\u6591\u868a\uff08Aedes aegypti\uff09\u3002\u5716\u7247\u4f86\u6e90\uff1aWiki\" width=\"450\" height=\"300\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/08\/Aedes_aegypti.jpg 1600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/08\/Aedes_aegypti-600x400.jpg 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/08\/Aedes_aegypti-800x534.jpg 800w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-25280\" class=\"wp-caption-text\">\u57c3\u53ca\u6591\u868a\uff08Aedes aegypti\uff09\u3002\u5716\u7247\u4f86\u6e90\uff1aWiki<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n<p>\u7b46\u8005\u5f9e\u5c0f\u88ab\u868a\u5b50\u53ee\u4e86\u4ee5\u5f8c\uff0c\u5c31\u6703\u816b\u4e00\u5927\u5305\uff0c\u9084\u6703\u5f88\u7662\u3002\u4e4b\u524d\u66fe\u9047\u5230\u88ab\u868a\u5b50\u54ac\u4e0d\u6703\u6c34\u816b\u4e5f\u4e0d\u6703\u767c\u7662\u7684\u4eba\uff0c\u8b93\u7b46\u8005\u8d85\u7fa8\u6155\u7684\uff01<\/p>\n<p>\u5176\u5be6\u88ab\u868a\u5b50\u53ee\u6703\u767c\u7662\u662f\u56e0\u70ba\uff0c\u868a\u5b50\u6ce8\u5165\u7684\u553e\u6db2\u6703\u4f7f\u6211\u5011\u7522\u751f\u767c\u708e\u53cd\u61c9\uff1b\u800c\u868a\u5b50\u7684\u553e\u6db2\u4e2d\u542b\u6709\u80fd\u4f7f\u8840\u7ba1\u64f4\u5f35\u7684\u6210\u5206\uff0c\u52a0\u4e0a\u53ee\u54ac\u6703\u4f7f\u8840\u7ba1\u7834\u88c2\uff0c\u65bc\u662f\u5c31\u9020\u6210\u4e86\u6c34\u816b\u3002<\/p>\n<p>\u4f46\u662f\uff0c\u8b93\u6211\u5011\u767c\u7662\u3001\u6c34\u816b\u986f\u7136\u5c0d\u868a\u5b50\u6c92\u6709\u4ec0\u9ebc\u597d\u8655\u3002\u6709\u8a31\u591a\u6b21\u7b46\u8005\u56e0\u70ba\u89ba\u5f97\u7662\u7662\u7684\u800c\u6c7a\u5b9a\u53bb\u6aa2\u8996\u767c\u7662\u7684\u90e8\u4f4d\uff0c\u7136\u5f8c\u5c31\u7576\u5834\u6d3b\u902e\u868a\u5b50\u4e00\u96bb\uff0c\u65bc\u662f\u7260\u5c31\u88ab\u6d88\u6ec5\u4e86\u3002\u986f\u7136\u5c0d\u868a\u5b50\u4f86\u8aaa\uff0c\u5f15\u767c\u767c\u708e\u53cd\u61c9\u3001\u8b93\u6211\u5011\u767c\u7662\u6c92\u6709\u4ec0\u9ebc\u597d\u8655\uff01\u96d6\u7136\u9019\u500b\u767c\u7662\u7684\u53cd\u61c9\uff0c\u5c0d\u6211\u5011\u597d\u50cf\u6709\u4e00\u7d72\u7d72\u7684\u597d\u8655\uff0c\u4e0d\u904e\u5230\u5e95\u70ba\u4ec0\u9ebc\u88ab\u868a\u5b50\u53ee\u6703\u767c\u7662\u5462\uff1f<!--more--><\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u53ee\u8207\u4e0d\u53ee<br \/>\n<\/strong><\/span>\u5229\u8332\u5927\u5b78\u7684\u7814\u7a76\u5718\u968a\uff0c\u70ba\u4e86\u8981\u4e86\u89e3\u767c\u7662\u7684\u76ee\u7684\u662f\u4ec0\u9ebc\uff0c\u4ed6\u5011\u7528\u5c48\u516c\u75c5\u75c5\u6bd2\uff08chikungunya virus\uff09\u7684\u8fd1\u89aa\uff1a\u68ee\u6797\u8166\u708e\u75c5\u6bd2\uff08Semliki Forest virus\uff0cSFV\uff09\u5728\u5c0f\u9f20\u8eab\u4e0a\u505a\u4e86\u7814\u7a76\u3002\u9996\u5148\uff0c\u4ed6\u5011\u628a\u75c5\u6bd2\u4ee5\u76ae\u4e0b\u6ce8\u5c04\u7684\u65b9\u5f0f\u6ce8\u5165\u5c0f\u9f20\uff0c\u540c\u6642\u4f34\u96a8\u8457\u868a\u5b50\u53ee\u54ac\u6216\u6c92\u6709\u868a\u5b50\u53ee\u3002\u63a5\u8457\u7814\u7a76\u5718\u968a\u4fbf\u89c0\u5bdf\u75c5\u6bd2\u8907\u88fd\u7684\u72c0\u6cc1\uff0c\u4ee5\u53ca\u75c5\u6bd2\u611f\u67d3\u64f4\u6563\u7684\u60c5\u5f62\u3002<\/p>\n<p>\u7d50\u679c\u975e\u5e38\u6709\u610f\u601d\u3002\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u5982\u679c\u53ea\u6709\u76ae\u4e0b\u6ce8\u5c04\u75c5\u6bd2\uff0c\u96d6\u7136\u611f\u67d3\u4e00\u958b\u59cb\u64f4\u6563\u5f97\u5f88\u5feb\uff0c\u4f46\u662f\u75c5\u6bd2\u7684\u6548\u50f9\uff08titer\uff09\u4e26\u4e0d\u9ad8\uff1b\u4f46\u662f\u82e5\u4f34\u96a8\u8457\u868a\u5b50\u53ee\u54ac\u6642\uff0c\u4e00\u958b\u59cb\u770b\u4f3c\u611f\u67d3\u64f4\u6563\u5f97\u8f03\u6162\uff0c\u4f46\u6700\u5f8c\u75c5\u6bd2\u5728\u8840\u4e2d\u7684\u6548\u50f9\uff0c\u537b\u6bd4\u6c92\u6709\u868a\u5b50\u53ee\u7684\u7d44\u5225\u9ad8\u4e86\u5341\u500d\uff01\u7576\u7814\u7a76\u5718\u968a\u7528\u6bd2\u6027\u8f03\u9ad8\u7684\u68ee\u6797\u8166\u708e\u75c5\u6bd2\u7b2c\u516d\u578b\uff08SFV6\uff09\u611f\u67d3\u5c0f\u9f20\u6642\uff0c\u6709\u868a\u5b50\u53ee\u54ac\u7684\u7d44\u5225\uff0c\u6bd4\u6c92\u6709\u868a\u5b50\u53ee\u54ac\u7684\u7d44\u5225\u8981\u63d0\u65e9\u9663\u4ea1\uff0c\u63db\u7528\u53e6\u4e00\u500b\u75c5\u6bd2\uff08Bunyamwera virus\uff09\u4e5f\u662f\u5982\u6b64\u3002<\/p>\n<p>\u7814\u7a76\u5718\u968a\u540c\u6642\u4e5f\u767c\u73fe\uff0c\u88ab\u868a\u5b50\u53ee\u54ac\u7684\u7d44\u5225\uff0c\u5728\u611f\u67d3\u5f8c3\u5c0f\u6642\u5167\uff0c\u53ef\u80fd\u662f\u7531\u65bc\u50b7\u53e3\u767c\u751f\u6c34\u816b\uff0c\u9020\u6210\u75c5\u6bd2\u7121\u6cd5\u6563\u64ad\uff1f\uff01\u4f46\u662f\u5230\u4e8624\u5c0f\u6642\u5f8c\uff0c\u75c5\u6bd2\u7684RNA\u53cd\u800c\u5927\u5e45\u589e\u52a0\u4e86\u3002<\/p>\n<p>\u6240\u4ee5\uff0c\u7a76\u7adf\u4e2d\u9593\u767c\u751f\u4e86\u4ec0\u9ebc\u4e8b\u5462\uff1f<\/p>\n<p>\u7814\u7a76\u5718\u968a\u6bd4\u8f03\u53ea\u6709\u88ab\u868a\u5b50\u53ee\u8207\u6c92\u6709\u88ab\u868a\u5b50\u53ee\u3001\u4f46\u662f\u88ab\u76ae\u4e0b\u6ce8\u5c04\u75c5\u6bd2\u7684\u5169\u7d44\u5c0f\u9f20\u768464\u500b\u8207\u5148\u5929\u514d\u75ab\u53cd\u61c9\u76f8\u95dc\u7684\u57fa\u56e0\u7684\u8868\u73fe\u3002\u7d50\u679c\u767c\u73fe\uff1a\u5728\u88ab\u868a\u5b50\u53ee\u54ac\u4e86\u4ee5\u5f8c\uff0c\u8207\u5438\u5f15\u55dc\u4e2d\u6027\u7403\uff08neutrophil\uff09\u76f8\u95dc\u7684\u7d30\u80de\u56e0\u5b50\uff08cytokine\uff09\u3001\u4ee5\u53ca\u5438\u5f15\u55ae\u6838\u7403\u7684\u7d30\u80de\u56e0\u5b50\u3001\u9084\u6709\u767d\u7d30\u80de\u4ecb\u7d20IL-1\u03b2\u8207IL-6\u7684\u57fa\u56e0\u8868\u73fe\u90fd\u4e0a\u6607\u4e86\uff1b\u9019\u4e9b\u73fe\u8c61\uff0c\u5728\u53ea\u6709\u76ae\u4e0b\u6ce8\u5c04\u75c5\u6bd2\u7684\u5c0f\u9f20\u4e2d\uff0c\u4e26\u6c92\u6709\u89c0\u5bdf\u5230\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u6709\u868a\u5b50\u53ee\u54ac\u7684\u7d44\u5225\uff0c\u50b7\u53e3\u8655\u5f88\u660e\u986f\u7684\u6709\u5927\u91cf\u7684\u55dc\u4e2d\u6027\u7403\u805a\u96c6\u3002\u5230\u5e95\u55dc\u4e2d\u6027\u7403\u662f\u4e0d\u662f\u5f15\u767c\u611f\u67d3\u64f4\u5927\u7684\u56e0\u7d20\u4e4b\u4e00\u5462\uff1f<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u55dc\u4e2d\u6027\u7403\u7684\u4f5c\u7528<br 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style=\"color: #008080;\">\u25cf\u55dc\u4e2d\u6027\u7403\u50f5\u5c4d\u5316<\/span><br \/>\n<\/strong>\u7e3d\u4e0a\u6240\u8ff0\uff0c\u7814\u7a76\u5718\u968a\u8a8d\u70ba\u7576\u868a\u5b50\u53ee\u54ac\u6211\u5011\u7684\u6642\u5019\uff0c\u5728\u6211\u5011\u8eab\u4e0a\u6240\u767c\u751f\u7684\u4e8b\u60c5\u662f\uff1a\u767c\u708e\u53cd\u61c9\u6703\u5c07\u55dc\u4e2d\u6027\u7403\u8207\u9aa8\u9ad3\u7d30\u80de\uff08myeloid cell\uff0c\u5373\u55ae\u6838\u7403\u7684\u4e00\u7a2e\uff09\u5438\u5f15\u5230\u50b7\u53e3\uff0c\u7136\u5f8c\u90e8\u5206\u7684\u55dc\u4e2d\u6027\u7403\u8207\u9aa8\u9ad3\u7d30\u80de\u5c31\u88ab\u75c5\u6bd2\u611f\u67d3\u4e86\u3002\u63a5\u8457\uff0c\u611f\u67d3\u4fbf\u96a8\u8457\u55dc\u4e2d\u6027\u7403\u8207\u9aa8\u9ad3\u7d30\u80de\uff0c\u64f4\u6563\u5230\u5176\u4ed6\u7684\u7d44\u7e54\uff08\u5982\u6dcb\u5df4\u7d50\u3001\u8166\uff09\u53bb\u4e86\u3002\u76f8\u5c0d\u7684\uff0c\u5728\u6c92\u6709\u868a\u5b50\u53ee\u54ac\u7684\u72c0\u6cc1\u4e0b\uff0c\u7531\u65bc\u55dc\u4e2d\u6027\u7403\u8207\u9aa8\u9ad3\u7d30\u80de\u5728\u50b7\u53e3\u9644\u8fd1\u6578\u76ee\u4e0d\u591a\uff0c\u75c5\u6bd2\u611f\u67d3\u4e5f\u7121\u6cd5\u6210\u529f\u64f4\u6563\u3002<\/p>\n<p>\u4e5f\u5c31\u662f\u8aaa\uff0c\u55dc\u4e2d\u6027\u7403\u8207\u9aa8\u9ad3\u7d30\u80de\u672c\u4f86\u662f\u53bb\u5e6b\u5fd9\u6d88\u6ec5\u75c5\u6bd2\uff0c\u4f46\u5f88\u4e0d\u5e78\u7684\uff0c\u5c31\u50cf\u8a31\u591a\u50f5\u5c4d\u96fb\u5f71\u88e1\u9762\u7684\u60c5\u7bc0\u4e00\u6a23\uff1a\u8d95\u53bb\u6253\u50f5\u5c4d\u7684\u6751\u6c11\uff0c\u6709\u4e00\u90e8\u4efd\u4e5f\u88ab\u50f5\u5c4d\u7d66\u4fb5\u8972\uff0c\u6210\u4e86\u50f5\u5c4d\u5927\u8ecd\u7684\u4e00\u90e8\u4efd\uff0c\u4e26\u4e14\u56db\u6563\u53bb\u611f\u67d3\u66f4\u591a\u6d3b\u4eba\uff01<\/p>\n<p>\u6240\u4ee5\uff0c\u6211\u5011\u88ab\u868a\u5b50\u53ee\u4e86\u4ee5\u5f8c\u6703\u7662\uff0c\u771f\u7684\u662f\u500b\u5929\u5927\u7684\u58de\u6d88\u606f\u5462\uff01<\/p>\n<p><strong>\u53c3\u8003\u6587\u737b\uff1a<\/strong>Marieke Pingen et. al., 2016. Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection. Immunity. doi:10.1016\/j.immuni.2016.06.002<\/p>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br \/>\n<span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u590f\u65e5\u708e\u708e\u868a\u5b50\u591a\uff0c\u7a76\u7adf\u70ba\u4ec0\u9ebc\u88ab\u868a\u5b50\u54ac\u5f8c\u6703<\/p>\n","protected":false},"author":20,"featured_media":25280,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,791,1025],"tags":[2749,2748,1914,1543,425],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/08\/Aedes_aegypti.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25279"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25279"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25279\/revisions"}],"predecessor-version":[{"id":32618,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25279\/revisions\/32618"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/25280"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}