{"id":25199,"date":"2016-07-26T00:00:31","date_gmt":"2016-07-25T16:00:31","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=25199"},"modified":"2022-10-11T13:21:21","modified_gmt":"2022-10-11T05:21:21","slug":"%e3%80%90%e6%9d%90%e6%96%99%e7%a7%91%e6%8a%80%e3%80%91%e4%b8%8a%e8%bd%89%e6%8f%9b%e5%a5%88%e7%b1%b3%e6%9d%90%e6%96%99%e6%96%bc%e7%94%9f%e7%89%a9%e9%86%ab%e5%ad%b8%e7%9a%84%e6%87%89%e7%94%a8%e4%b8%8b","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=25199","title":{"rendered":"\u3010\u6750\u6599\u79d1\u6280\u3011\u4e0a\u8f49\u63db\u5948\u7c73\u6750\u6599\u65bc\u751f\u7269\u91ab\u5b78\u7684\u61c9\u7528(\u4e0b)"},"content":{"rendered":"<figure id=\"attachment_25201\" aria-describedby=\"caption-attachment-25201\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-25201\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/07\/0725-1024x658.png\" alt=\"\u5716\u7247\u4f86\u6e90\uff1aChen, G., Qiu, H., Prasad, P. N., &amp; Chen, X. (2014). Upconversion nanoparticles: design, nanochemistry, and applications in theranostics.Chemical reviews, 114(10), 5161-5214.\" width=\"650\" height=\"417\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/07\/0725-1024x658.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/07\/0725-300x193.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/07\/0725-768x493.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/07\/0725-800x514.png 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/07\/0725-600x385.png 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/07\/0725.png 1652w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption id=\"caption-attachment-25201\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff1aChen, G., Qiu, H., Prasad, P. N., &amp; Chen, X. (2014). Upconversion nanoparticles: design, nanochemistry, and applications in theranostics.Chemical reviews, 114(10), 5161-5214.<\/figcaption><\/figure>\n<p><span style=\"color: #333399;\"><strong>\u25a0\u5728\u672c\u7cfb\u5217<a style=\"color: #333399;\" href=\"http:\/\/case.ntu.edu.tw\/blog\/?p=25023\" target=\"_blank\" rel=\"noopener noreferrer\">(\u4e0a)<\/a>\u53ca<a style=\"color: #333399;\" href=\"http:\/\/case.ntu.edu.tw\/blog\/?p=25050\" target=\"_blank\" rel=\"noopener noreferrer\">(\u4e2d)<\/a>\u4ecb\u7d39\u4e86\u4e00\u5927\u5806\u539f\u7406\u5f8c\uff0c\u7d42\u65bc\u8981\u4ecb\u7d39\u5728\u751f\u91ab\u5f71\u50cf\u61c9\u7528 (Bioimaging)\u5566\uff01<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u65b9\u7a0b\u6bc5<\/p>\n<p>\u751f\u91ab\u5f71\u50cf\u76ee\u7684\u662f\u5c0d\u751f\u7269\u9ad4\u4e0d\u540c\u90e8\u5206\u9032\u884c\u986f\u5f71\uff0c\u53ef\u4ee5\u89c0\u5bdf\u6216\u4f5c\u75be\u75c5\u8a3a\u65b7\u3002\u4e0d\u50cf\u4e00\u822c\u87a2\u5149\u767c\u5149\u9700\u8981\u80fd\u91cf\u8f03\u5927\u7684\u7d2b\u5916\u5149\uff0c\u4e0a\u8f49\u63db\u73fe\u8c61\u6700\u5927\u7684\u597d\u8655\u662f\u5149\u6e90\u80fd\u91cf\u6bcb\u9808\u592a\u5f37\uff0c\u6ce2\u9577700nm-1000nm\u7d05\u5916\u5149\u5373\u53ef\uff0c\u5c0d\u751f\u7269\u9ad4\u7684\u50b7\u5bb3\u5c0f\uff0c\u61c9\u7528\u4e5f\u8f03\u5ee3\u6cdb\u3002\u5982\u540c\u672c\u7cfb\u5217(\u4e2d)\u6240\u63d0\uff0c\u85c9\u7531\u4fee\u98fe\u4e0a\u8f49\u63db\u7c92\u5b50\u4f7f\u5176\u8207\u76ee\u6a19\u7d50\u5408\u4fbf\u53ef\u4ee5\u884d\u751f\u51fa\u5404\u7a2e\u4e0d\u540c\u7684\u610f\u7528\uff0c\u4ee5\u4e0b\u6211\u5011\u5c07\u4ecb\u7d39\u5e7e\u500b\u4f8b\u5b50\uff1a<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u5168\u8eab\u87a2\u5149\u9020\u5f71<\/strong><strong>(Whole-Body Photoluminescent Imaging)<br \/>\n<\/strong><\/span>\u5168\u8eab\u6027\u9020\u5f71\u57fa\u672c\u4e0a\u5c31\u662f\u4e0d\u91dd\u5c0d\u7279\u5b9a\u76ee\u6a19\uff0c\u5c0d\u5168\u8eab\u8840\u7ba1\u6216\u6dcb\u5df4\u7cfb\u7d71\u9032\u884c\u9020\u5f71\uff0c\u672c\u6587\u5716\u4e2d\u7684\u4f8b\u5b50\u7686\u5c6c\u65bc\u9019\u500b\u985e\u5225\u3002<\/p>\n<p>\u9996\u5148\u5728\u6ce8\u5c04\u524d\u8981\u5148\u4fdd\u8b49\u7c92\u5b50\u5011\u5c0d\u751f\u7269\u9ad4\u4e0d\u6703\u7522\u751f\u8ca0\u9762\u5f71\u97ff\uff0c\u7f8e\u570b\u666e\u6797\u65af\u9813\u5927\u5b78(Princeton University)\u5c07 <span class='MathJax_Preview'><img src='https:\/\/case.ntu.edu.tw\/blog\/wp-content\/plugins\/latex\/cache\/tex_d515e85f8693f7b807588959b7d9baeb.gif' style='vertical-align: middle; border: none; padding-bottom:2px;' class='tex' alt=\"\" \/><\/span><script type='math\/tex'><\/script> \u7c92\u5b50\u6ce8\u5c04\u9032\u7dda\u87f2\u9ad4\u5167\u9032\u884c\u986f\u5f71(\u5982\u5716(a))\uff0c\u904e\u7a0b\u4e2d\u7dda\u87f2\u4e26\u6c92\u6709\u7522\u751f\u4efb\u4f55\u7570\u5e38\u60c5\u5f62\u3002\u7dda\u87f2\u96d6\u4e0d\u6bd4\u5176\u4ed6\u751f\u7269\uff0c\u4f46\u81f3\u5c11\u8aaa\u660e\u9019\u4e9b\u5948\u7c73\u7c92\u5b50\u662f\u5177\u751f\u7269\u76f8\u5bb9\u6027\u7684\u3002<!--more--><\/p>\n<p>\u5716(b)\u70ba\u5c0d\u5c0f\u578b\u52d5\u7269\u9032\u884c\u5c3e\u975c\u8108\u6ce8\u5c04\u6216\u76ae\u4e0b\u6ce8\u5c04\u7684\u9020\u5f71\uff0c\u5716\u4e2d\u53ef\u4ee5\u6e05\u695a\u770b\u5230\u4e0a\u8f49\u63db\u7c92\u5b50\u7684\u6240\u5728\u4f4d\u7f6e\u3002<\/p>\n<p>\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u66f4\u662f\u57282009\u5e74\u9996\u6b21\u4f7f\u7528\u4e0a\u8f49\u63db\u6280\u8853\u986f\u8001\u9f20\u6dcb\u5df4\u7cfb\u7d71\uff1b2010\u5e74\u4e2d\u570b\u8607\u5dde\u5927\u5b78\u9084\u53ef\u4ee5\u8b93\u8001\u9f20\u7684\u6dcb\u5df4\u7d50\u5206\u5225\u986f\u73fe\u4e0d\u540c\u984f\u8272(\u5982\u5716(c)(d))\u3002<\/p>\n<p>\u800c\u53e6\u4e00\u500b\u4f8b\u5b50\u70ba\u8840\u7ba1\u9020\u5f71(Vascular imaging)\uff0c\u5716(e)(f)\u6240\u793a\uff0c\u54c8\u4f5b\u5927\u5b78\u91ab\u5b78\u9662\u4f7f\u7528\u4e0a\u8f49\u63db\u73fe\u8c61\u8b93\u8840\u7ba1\u73fe\u5f62\uff0c\u5e6b\u52a9\u5fc3\u8840\u7ba1\u75be\u75c5\u53ca\u5176\u4ed6\u764c\u75c7\u7684\u8a3a\u65b7\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u7d30\u80de\u6210\u50cf<\/strong><strong>(Cellular Imaging)<br \/>\n<\/strong><\/span>\u5168\u8eab\u6027\u9020\u5f71\u4e0d\u9700\u8981\u8003\u616e\u5948\u7c73\u7c92\u5b50\u8207\u7279\u5b9a\u76ee\u6a19\u7d50\u5408\u7684\u554f\u984c\uff0c\u4f46\u79d1\u5b78\u5bb6\u7576\u7136\u5e0c\u671b\u80fd\u5c0d\u7279\u5b9a\u7d30\u80de\u9032\u884c\u6210\u50cf\uff0c2008\u5e74\u65b0\u52a0\u5761\u570b\u7acb\u5927\u5b78\u4fee\u98fe <span class='MathJax_Preview'><img src='https:\/\/case.ntu.edu.tw\/blog\/wp-content\/plugins\/latex\/cache\/tex_fadb87f14246e7ac42bd68172d504265.gif' style='vertical-align: middle; border: none; padding-bottom:2px;' class='tex' alt=\"\" \/><\/span><script type='math\/tex'><\/script> \u7c92\u5b50\uff0c\u4f7f\u5176\u53ef\u4ee5\u8207\u4eba\u985e\u5927\u8178\u764c\u7d30\u80de(HT29 adenocarcinoma cells)\u53ca\u5375\u5de2\u764c\u7d30\u80de(OVCAR3 ovarian carcinoma cells)\u7d50\u5408\u4e26\u986f\u5f71\u3002\u5c0d\u4e0a\u8f49\u63db\u7c92\u5b50\u9032\u884c\u4fee\u98fe\uff0c\u8b93\u7c92\u5b50\u8207\u7279\u5b9a\u76ee\u6a19\u7d50\u5408\u662f\u9019\u985e\u7814\u7a76\u6700\u91cd\u8981\u7684\u4e00\u74b0\uff0c\u900f\u904e\u4e0a\u8f49\u63db\u73fe\u8c61\u89c0\u5bdf\u767c\u5149\u4f4d\u7f6e\uff0c\u5373\u53ef\u77e5\u9053\u5176\u5728\u751f\u7269\u9ad4\u5167\u6216\u9ad4\u5916\u7684\u5206\u5e03\u3002\u4f46\u672a\u7d93\u4fee\u98fe\u7684\u7c92\u5b50\u4e5f\u53ef\u4ee5\u7d93\u7531\u7d30\u80de\u7684\u5167\u541e\u4f5c\u7528(cellular endocytosis)\u9032\u884c\u986f\u5f71\uff0c\u76ee\u524d\u6587\u737b\u4e2d\u5df2\u6709\u5c0d\u4e73\u764c\u7d30\u80de(SKBR-3\u53caMCF-7)\u3001\u5c0f\u9f20\u80da\u80ce\u7e96\u7dad\u6bcd\u7d30\u80de (Mouse embryonic fibroblast cell line, NIH-3T3)\u6216\u809d\u764c\u7d30\u80de(Huh-7 liver cancer cells)\u7b49\u7b49\u9032\u884c\u9020\u5f71\u7684\u4f8b\u5b50\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u4e3b\u52d5<\/strong><strong>\u9776\u5411\u9020\u5f71<\/strong><strong>(<\/strong><strong>Active Targeting<\/strong><strong>)<br \/>\n<\/strong><\/span>\u9664\u4e86\u91dd\u5c0d\u7d30\u80de\u6210\u50cf\uff0c\u5176\u4ed6\u7279\u5b9a\u76ee\u6a19(\u4f8b\u5982\u816b\u7624)\u7684\u986f\u5f71\u4e5f\u662f\u751f\u91ab\u7814\u7a76\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u4e00\u74b0\uff0c\u9019\u985e\u6280\u8853\u5c31\u5fc5\u9808\u4ef0\u8cf4\u66f4\u8907\u96dc\u7684\u7c92\u5b50\u8868\u9762\u4fee\u98fe\uff0c\u624d\u80fd\u8b93\u7c92\u5b50\u8207\u7279\u5b9a\u76ee\u6a19\u7d50\u5408\u986f\u5f71\u3002\u4e0a\u6d77\u5fa9\u65e6\u5927\u5b78\u6210\u529f\u4fee\u98fe <span class='MathJax_Preview'><img src='https:\/\/case.ntu.edu.tw\/blog\/wp-content\/plugins\/latex\/cache\/tex_eaa0241d86fc67b4704b7edb269db1a2.gif' style='vertical-align: middle; border: none; padding-bottom:2px;' class='tex' alt=\"\" \/><\/span><script type='math\/tex'><\/script> \u7c92\u5b50\uff0c\u986f\u5f71\u8001\u9f20\u76ae\u4e0b\u7684U87MG\u4eba\u985e\u8166\u795e\u7d93\u81a0\u8cea\u7624\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u6df1\u5c64\u7d44\u7e54\u6210\u50cf<\/strong><strong>(<\/strong><strong>Deep Tissue Imaging<\/strong><strong>)<br \/>\n<\/strong><\/span>\u81f3\u65bc\u66f4\u9032\u4e00\u6b65\u7684\u61c9\u7528\u5247\u70ba\u6df1\u5c64\u7d44\u7e54\u5f71\u50cf\uff0c\u4e0a\u8f49\u63db\u96c6\u6c23\u653e\u5927\u7d55\u7684\u4e2d\u5fc3\u601d\u60f3\u4fbf\u662f\u5165\u5c04\u80fd\u91cf\u8f03\u4f4e\u7684\u5149\u5b50\u5373\u53ef\u6536\u5230\u5f71\u50cf\uff0c\u4ee5\u964d\u4f4e\u5c0d\u751f\u7269\u9ad4\u7684\u50b7\u5bb3\uff0c\u4f46\u4f4e\u80fd\u91cf\u5149\u5b50\u9084\u6709\u4e00\u500b\u597d\u8655\uff1a\u7a7f\u900f\u80fd\u529b\u3002\u82e5\u6211\u5011\u5e0c\u671b\u5c0d\u6df1\u5c64\u7d44\u7e54\u9032\u884c\u9020\u5f71\uff0c\u9664\u4e86\u8981\u80fd\u8b93\u4e0a\u8f49\u63db\u7c92\u5b50\u8207\u76ee\u6a19\u7d50\u5408\u5916\uff0c\u4e5f\u8981\u80fd\u8b93\u5165\u5c04\u5149\u7a7f\u5f97\u5920\u6df1\u624d\u884c\uff0c\u6ce2\u9577700nm-1000nm\u5de6\u53f3\u9069\u7528\u65bc\u672c\u73fe\u8c61\u7684\u7d05\u5916\u5149\u6b63\u597d\u4f4d\u65bc\u751f\u7269\u7d44\u7e54\u5149\u5b78\u7a97\u53e3(\u53c8\u7a31\u8fd1\u7d05\u5916\u7a97\u53e3\u3001\u6cbb\u7642\u7a97\u53e3)\uff0c\u9019\u6bb5\u6ce2\u9577\u7bc4\u570d\u525b\u597d\u8eb2\u6389\u4e86\u4eba\u9ad4\u8840\u6db2\u3001\u7d44\u7e54\u53ca\u6c34\u7684\u5438\u6536\u5e36\uff0c\u8b93\u5149\u80fd\u5920\u62b5\u9054\u4eba\u9ad4\u6df1\u8655\uff0c\u6fc0\u767c\u4e0a\u8f49\u63db\u7c92\u5b50\u9032\u884c\u986f\u5f71\u3002\u96d6\u8aaa\u7a7f\u7684\u6df1\uff0c\u4f46\u8a0a\u865f\u5fae\u5f31\u53ca\u96dc\u8a0a\u904e\u5927\u7684\u554f\u984c\u537b\u4f9d\u820a\u5b58\u5728\u3002<\/p>\n<p>\u4e0a\u8ff0\u9019\u4e9b\u6280\u8853\u53ea\u662f\u751f\u7269\u9020\u5f71\u7684\u51b0\u5c71\u4e00\u89d2\uff0c\u5176\u4ed6\u61c9\u7528\u66f4\u6709\u6838\u78c1\u5171\u632f\u6210\u50cfMRI\u3001\u6b63\u96fb\u5b50\u767c\u5c04\u8a08\u7b97\u6a5f\u65b7\u5c64\u6383\u63cf(Positron emission tomography, PET)\u53caX\u5c04\u7dda\u96fb\u8166\u65b7\u5c64\u6383\u63cf(X-CT)\u7b49\u7b49\u3002\u9019\u5176\u4e2d\u7684\u6bcf\u500b\u7d30\u7bc0\u90fd\u662f\u9760\u7814\u7a76\u4eba\u54e1\u4e0d\u7720\u4e0d\u4f11\u7684\u6295\u5165\u63db\u4f86\u7684\uff0c\u624d\u80fd\u8b93\u751f\u91ab\u6280\u8853\u8d8a\u52a0\u9032\u6b65\uff0c\u9020\u798f\u4eba\u7fa4\uff0c\u53ef\u4ee5\u60f3\u898b\u7684\u662f\uff0c\u5229\u7528\u4e0a\u8f49\u63db\u73fe\u8c61\u6240\u884c\u7684\u751f\u91ab\u9020\u5f71\u5728\u672a\u4f86\u52e2\u5fc5\u9084\u6703\u662f\u751f\u91ab\u7814\u7a76\u7684\u4e00\u5927\u91cd\u9ede\u3002<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Chen, G., Qiu, H., Prasad, P. N., &amp; Chen, X. (2014). Upconversion nanoparticles: design, nanochemistry, and applications in theranostics. <em>Chemical reviews<\/em>,<em>114<\/em>(10), 5161-5214.<\/li>\n<li>Hilderbrand, Scott A., et al. \"Upconverting luminescent nanomaterials: application to in vivo bioimaging.\"<em>Chemical communications<\/em>&nbsp;28 (2009): 4188-4190.<\/li>\n<li>Lim, Shuang Fang, et al. \"In vivo and scanning electron microscopy imaging of upconverting nanophosphors in Caenorhabditis elegans.\"<em>Nano Letters<\/em>&nbsp;2 (2006): 169-174.<\/li>\n<li>Xiong, Liqin, et al. \"High contrast upconversion luminescence targeted imaging in vivo using peptide-labeled nanophosphors.\"<em>Analytical chemistry<\/em>&nbsp;21 (2009): 8687-8694.<\/li>\n<\/ol>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br \/>\n<span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u65b9\u7a0b\u6bc5 \u53f0\u5927\u6750\u6599\u7562\uff0c\u76ee\u524d\u65bcUCSD\u535a\u58eb\u73ed\u6399\u624e\u4e2d\u3002\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u5728\u672c\u7cfb\u5217(\u4e0a)\u53ca(\u4e2d)\u4ecb\u7d39\u4e86\u4e00\u5927\u5806\u539f\u7406<\/p>\n","protected":false},"author":20,"featured_media":25201,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1023,3293,6512],"tags":[2677,200,1593,2725,2727,2726],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/07\/0725.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25199"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25199"}],"version-history":[{"count":10,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25199\/revisions"}],"predecessor-version":[{"id":40871,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/25199\/revisions\/40871"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/25201"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25199"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}