{"id":24957,"date":"2016-07-01T00:07:17","date_gmt":"2016-06-30T16:07:17","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=24957"},"modified":"2018-08-03T14:49:05","modified_gmt":"2018-08-03T06:49:05","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%a0%94%e7%a9%b6%e3%80%91%e8%85%a6%e5%85%a7%e4%b8%80%e9%87%9d%e6%89%ad%e8%bd%89%e4%b9%be%e5%9d%a4%ef%bc%8d%ef%bc%8d%e6%b2%bb%e7%99%82%e7%b3%96%e5%b0%bf%e7%97%85%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=24957","title":{"rendered":"\u3010\u91ab\u5b78\u7814\u7a76\u3011\u8166\u5167\u4e00\u91dd\u626d\u8f49\u4e7e\u5764\uff0d\uff0d\u6cbb\u7642\u7cd6\u5c3f\u75c5\uff1f\u5f9e\u8166\u4e0b\u624b\u3002"},"content":{"rendered":"

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\"sugar-candy-lovely-lips-hd-wallpaper\"
\u00a9 2014 wallpapers1080p.com<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

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\u6700\u8fd1\uff0c\u897f\u96c5\u5716\u83ef\u76db\u9813\u5927\u5b78\u91ab\u5b78\u9662\u7684Michael Schwartz\u6559\u6388\u5be6\u9a57\u5ba4\u767c\u8868\u4e86\u4e00\u7bc7\u5f88\u6709\u8da3\u7684\u7814\u7a76\uff0c\u5728\u81ea\u7136\u91ab\u5b78\u671f\u520aNature Medicine<\/em>\u4e0a\u3002Schwartz\u535a\u58eb\u5be6\u9a57\u5ba4\u628a\u7814\u7a76\u4e3b\u529b\u653e\u5728FGF1\u9019\u500b\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50\u4e0a\u3002FGF1\u53ef\u4ee5\u88ab\u795e\u7d93\u7d30\u80de\u3001\u795e\u7d93\u81a0\u7d30\u80de\u4e2d\u7684\u661f\u72c0\u7d30\u80de\uff08astrocytes\uff09\u8207\u7ba1\u819c\u7d30\u80de\uff08ependymal\uff09\u6240\u5206\u6ccc\uff0c\u800c\u4e14\u4e4b\u524d\u6709\u7814\u7a76\u767c\u73fe\uff0c\u5982\u679c\u76f4\u63a5\u5c07FGF1\u6ce8\u5c04\u5230\u8001\u9f20\u8166\u5ba4\u5167\uff0c\u53ef\u4ee5\u4fc3\u9032\u8001\u9f20\u5b78\u7fd2\u8207\u8a18\u61b6\u80fd\u529b\uff0c\u964d\u4f4e\u98df\u7269\u651d\u53d6\u91cf\uff0c\u751a\u81f3\u5c0d\u7f3a\u8840\u6027\u4e2d\u98a8\u8207\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u76f8\u95dc\u6240\u9020\u6210\u7684\u7d44\u7e54\u53d7\u640d\u90fd\u6709\u5e6b\u52a9\u3002\u800cFGF1\u8ddfFGF15\/19\u8207FGF21\u4e00\u6a23\uff0c\u90fd\u80fd\u8abf\u7bc0\u8840\u7cd6\u6046\u5b9a\u3002\u800c\u6700\u8b93Schwartz\u6559\u6388\u5c0dFGF1\u6975\u611f\u8208\u8da3\u7684\u539f\u56e0\u662f\uff0cFGF1\u50cf\u842c\u80fd\u9470\u5319\u4e00\u6a23\uff0c\u80fd\u5920\u7d50\u5408\u3001\u6d3b\u5316\u6240\u6709\u7684\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff0c\u800c\u4e14\u4e0d\u9700\u8981\u8f14\u52a9\u53d7\u9ad4\u7684\u53c3\u8207\u3002<\/p>\n

\u65bc\u662f\uff0cSchwartz\u535a\u58eb\u5229\u7528\u7626\u7d20\u57fa\u56e0\u7f3a\u4e4f\u800c\u5c0e\u81f4\u80a5\u80d6\u7684\u8001\u9f20\u70ba\u5be6\u9a57\u6a21\u578b\uff0c\u4f86\u6aa2\u6e2cFGF1\u662f\u4e0d\u662f\u80fd\u5920\u66f4\u6709\u6548\u5730\u63a7\u5236\u8840\u7cd6\u3002Schwartz\u5be6\u9a57\u5ba4\u7684\u7814\u7a76\u4eba\u54e1\u5c07FGF1\u6ce8\u5c04\u5230\u8001\u9f20\u5074\u8166\u5ba4\u5167\uff0c\u5728\u7d66\u85e5\u516d\u5c0f\u6642\u5f8c\uff0c\u8001\u9f20\u7684\u7a7a\u8179\u8840\u7cd6\u503c\u6bd4\u6ce8\u5c04\u524d\u964d\u4f4e\u4e86\u767e\u5206\u4e4b\u4e8c\u5341\u4e94\uff0c\u800c\u4e14\u8001\u9f20\u7684\u8840\u7cd6\u503c\u5728\u76e3\u6e2c\u7684\u5341\u516b\u500b\u79ae\u62dc\u5167\uff0c\u4e00\u76f4\u90fd\u6210\u529f\u7dad\u6301\u5728\u5065\u5eb7\u3001\u6b63\u5e38\u503c\u7bc4\u570d\u88e1\u3002\u4ed6\u5011\u4e5f\u540c\u6642\u5be6\u9a57\u4e86\u53e6\u5916\u4e09\u7d44\u3001\u4e0d\u540c\u7684\u80a5\u80d6\u8001\u9f20\u6a21\u578b\uff0cFGF1\u5728\u7d66\u85e5\u4e4b\u5f8c\uff0c\u958b\u59cb\u4f5c\u7528\u7684\u6642\u9593\u96d6\u7136\u5728\u4e0d\u540c\u8001\u9f20\u6a21\u578b\u88e1\u9762\u6709\u6240\u5dee\u7570\uff08\u6700\u6162\u7684\u4e00\u7d44\u8981\u7b49\u5230\u7d66\u85e5\u4e00\u5929\u4e4b\u5f8c\uff09\uff0c\u4f46\u6240\u6709\u7684\u5be6\u9a57\u8001\u9f20\u6a21\u578b\u88e1\uff0cFGF1\u90fd\u80fd\u5920\u5728\u4e00\u6b21\u6027\u7d66\u85e5\u4e4b\u5f8c\uff0c\u986f\u8457\u4e14\u9577\u6548\u6027\u7684\u767c\u63ee\u5176\u964d\u8840\u7cd6\u7684\u6548\u529b\uff01\u518d\u8005\uff0c\u56e0\u70ba\u7814\u7a76\u4eba\u54e1\u6ce8\u5c04\u7684FGF1\u5291\u91cf\u53ea\u67093\u5fae\u514b\uff0c\u662fFGF1\u8981\u5728\u9031\u908a\u7d44\u7e54\u767c\u63ee\u6548\u7528\u7684\u5341\u5206\u4e4b\u4e00\u5291\u91cf\u800c\u5df2\uff0c\u56e0\u6b64\u4e5f\u53ef\u4ee5\u6392\u9664\u662f\u56e0\u70baFGF1\u4f5c\u7528\u5230\u9031\u908a\u7d44\u7e54\u800c\u7522\u751f\u7684\u526f\u4f5c\u7528\u3002Schwartz\u6559\u6388\u7814\u7a76\u5718\u968a\u7684\u767c\u8868\u7d50\u679c\uff0c\u7121\u7591\u70ba\u6211\u5011\u5411\u6839\u6cbb\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u7684\u76ee\u6a19\uff0c\u5927\u5927\u63a8\u9032\u4e86\u4e00\u6b65\uff01<\/p>\n

\u539f\u59cb\u8ad6\u6587\uff1a<\/strong>Scarlett JM et al. Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. Nat Med. 2016 May 23. doi: 10.1038\/nm.4101.<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Morton, G.J. et al. FGF19 action in the brain induces insulin-independent glucose lowering. J. Clin. Invest. 123, 4799\u20134808 (2013).<\/li>\n
  2. Marcelin, G. et al. Central action of FGF19 reduces hypothalamic AgRP\/NPY neuron activity and improves glucose metabolism. Mol. Metab. 3, 19\u201328 (2014).<\/li>\n
  3. Ryan, K.K. et al. Fibroblast growth factor 19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. Endocrinology 154, 9\u201315 (2013).<\/li>\n
  4. Grayson, B.E., Seeley, R.J. & Sandoval, D.A. Wired on sugar: the role of the CNS in the regulation of glucose homeostasis. Nat. Rev. Neurosci. 14, 24\u201337 (2013).<\/li>\n
  5. Fu, L. et al. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology 145, 2594\u20132603 (2004).<\/li>\n
  6. Xu, J. et al. Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models\u2014association with liver and adipose tissue effects. Am. J. Physiol. Endocrinol. Metab. 297, E1105\u2013E1114 (2009).<\/li>\n<\/ol>\n

    --<\/span><\/strong>
    \u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/span><\/strong><\/p>\n

     <\/p>\n

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