{"id":24430,"date":"2016-05-20T00:19:47","date_gmt":"2016-05-19T16:19:47","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=24430"},"modified":"2018-08-03T14:38:20","modified_gmt":"2018-08-03T06:38:20","slug":"%e3%80%90%e5%9f%ba%e5%9b%a0%e8%a7%a3%e5%af%86%e3%80%91%e4%bd%a0%e4%bb%8a%e5%a4%a9%e7%9d%a1%e9%a3%bd%e4%ba%86%e5%97%8e%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=24430","title":{"rendered":"\u3010\u57fa\u56e0\u89e3\u5bc6\u3011\u4f60\u4eca\u5929\u7761\u98fd\u4e86\u55ce\uff1f"},"content":{"rendered":"

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\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

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\n\u5229\u7528\u57fa\u56e0\u5b9a\u5e8f\u6280\u8853\uff0c\u7814\u7a76\u5718\u968a\u53ef\u4ee5\u6bd4\u8f03\u9019\u5bb6\u65cf\u88e1\u6709\u7761\u7720\u63d0\u524d\u75c7\u5019\u7fa4\u7684\u4eba\u8ddf\u6c92\u6709\u7684\u6210\u54e1\uff0c\u770b\u770b\u4ed6\u5011\u7684\u57fa\u56e0\u907a\u50b3\u8a0a\u606f\u6709\u4ec0\u9ebc\u4e0d\u4e00\u6a23\u3002\u52a0\u4e0a\u7814\u7a76\u5c0d\u8c61\u662f\u4e00\u5bb6\u4eba\uff0c\u53ef\u4ee5\u8b93\u4e0d\u76f8\u95dc\u907a\u50b3\u8a0a\u606f\u5e72\u64fe\u5be6\u9a57\u7d50\u679c\u7684\u53ef\u80fd\u964d\u5230\u6700\u4f4e\u3002\u7814\u7a76\u5718\u968a\u9078\u5b9a\u4e86\u5abd\u5abd\uff08\u53d7\u8a66\u8005A\uff09\u3001\u5c0f\u8205\uff08\u53d7\u8a66\u8005B\uff09\u8207\u5169\u500b\u5152\u5b50\uff08\u53d7\u8a66\u8005C\u8207D\uff09\u3002\u9664\u4e86 D\u4ee5\u5916\uff0c\u5176\u4ed6\u4e09\u4eba\u90fd\u6709\u5bb6\u65cf\u6027\u7761\u7720\u63d0\u524d\u75c7\u5019\u7fa4\u8207\u5b63\u7bc0\u6027\u6182\u9b31\u75c7\u3002\u57fa\u56e0\u5b9a\u5e8f\u7d50\u679c\u767c\u73fe\uff0cA\u3001B\u3001C\u4e09\u4eba\u7684PERIOD3<\/em>\u57fa\u56e0\u6709\u5169\u500b\u9ede\u7a81\u8b8a\uff0c\u4f7f\u5176\u6240\u8868\u73fe\u7684\u86cb\u767d\u8cea\uff0c\u5728\u7b2c415\u8207\u7b2c417\u500b\u80fa\u57fa\u9178\u4e0a\uff0c\u5206\u5225\u6709\u812f\u80fa\u9178\u7a81\u8b8a\u70ba\u4e19\u80fa\u9178\uff08proline to alanine\uff09\uff0c\u8207\u7d44\u80fa\u9178\u7a81\u8b8a\u70ba\u7cbe\u80fa\u9178\uff08histidine to arginine\uff09\u7684\u8b8a\u7570\u3002\u6b64\u5916\uff0c\u5176\u4ed6\u5169\u767e\u4e94\u5341\u500b\u5065\u5eb7\u53d7\u8a66\u8005\u7684\u6aa2\u9ad4\uff0c\u90fd\u6c92\u6709\u9019\u5169\u500b\u7a81\u8b8a\u3002<\/p>\n

\u70ba\u4ec0\u9ebc\u5e36\u6709\u7a81\u8b8aPERIOD3<\/em>\u57fa\u56e0\uff08PER3<\/em>\uff09\uff0c\u6703\u8b93\u4eba\u683c\u5916\u65e9\u7761\u65e9\u8d77\u5462\uff1f\u5085\u6559\u6388\u7684\u7814\u7a76\u5718\u968a\u5c07\u4ed6\u5011\u767c\u73fe\u7684\u5169\u500b\u9ede\u7a81\u8b8a\u8868\u73fe\u5728\u8001\u9f20\u8eab\u4e0a\uff0c\u5efa\u7acb\u4e86\u4e00\u682a\u5e36\u6709\u7a81\u8b8aPER3<\/em>\u57fa\u56e0\u7684\u57fa\u56e0\u8f49\u6b96\u8001\u9f20\uff08hPER3-P415A\/H417R<\/em>\uff09\uff0c\u8207\u4e00\u682a\u8868\u73fe\u6b63\u5e38\u57fa\u56e0\u7684\u57fa\u56e0\u8f49\u6b96\u9f20\uff08\u505a\u70ba\u63a7\u5236\u7d44\uff09\u3002\u4ee5\u8001\u9f20\u70ba\u5be6\u9a57\u6a21\u578b\u6240\u5f97\u5230\u7684\u7d50\u679c\uff0c\u8ddf\u5728\u4eba\u985e\u8eab\u4e0a\u89c0\u5bdf\u5230\u7684\u8868\u73fe\u578b\u985e\u4f3c\uff1a\u5e36\u6709\u7a81\u8b8aPER3<\/em>\u57fa\u56e0\u7684\u8001\u9f20\u4f5c\u606f\u5931\u8abf\uff0c\u4e5f\u90fd\u6709\u4e9b\u70ba\u985e\u4f3c\u6182\u9b31\u7684\u75c7\u72c0\u3002\u7814\u7a76\u4eba\u54e1\u767c\u73fe\uff0cPER3<\/em>\u5c0d\u611f\u77e5\u300c\u591c\u665a\u300d\u7684\u7bc0\u5f8b\u5f88\u91cd\u8981\uff0c\u5728\u6a21\u64ec\u51ac\u5929\u77ed\u65e5\u7167\u7684\u98fc\u990a\u74b0\u5883\u4e0b\uff0c\u7184\u71c8\u4e4b\u5f8c\uff0c\u5e36\u6709\u6b63\u5e38\u57fa\u56e0\u7684\u8001\u9f20\u958b\u59cb\u6d3b\u8e66\u4e82\u8df3\uff0c\u4f46\u5e36\u6709\u7a81\u8b8a\u57fa\u56e0\u7684\u8001\u9f20\u5247\u8981\u5728\u7184\u71c8\u56db\u5c0f\u6642\u4e4b\u5f8c\uff0c\u624d\u958b\u59cb\u6d3b\u8e8d\u8d77\u4f86\u3002\u800c\u4e14\uff0c\u7576\u628a\u8001\u9f20\u5c3e\u5df4\u62ce\u8d77\u4f86\uff0c\u8b93\u8001\u9f20\u88ab\u61f8\u540a\u5728\u534a\u7a7a\u4e2d\u6642\uff0c\u6b63\u5e38\u8001\u9f20\u90fd\u6703\u6399\u624e\uff0c\u60f3\u8981\u628a\u81ea\u5df1\u300c\u626d\u300d\u56de\u6b63\u5e38\u9ad4\u4f4d\uff0c\u4f46\u5e36\u6709\u7a81\u8b8a\u57fa\u56e0\u7684\u8001\u9f20\u537b\u90fd\u4e0d\u592a\u626d\u52d5\uff0c\u8ddf\u5176\u4ed6\u6709\u6182\u9b31\u75c7\u72c0\u7684\u8001\u9f20\u60c5\u6cc1\u985e\u4f3c\u3002<\/p>\n

\u70ba\u4ec0\u9ebcPER3<\/em>\u57fa\u56e0\u7a81\u8b8a\u4e4b\u5f8c\uff0c\u5728\u8001\u9f20\u8207\u4eba\u8eab\u4e0a\uff0c\u6703\u51fa\u73fe\u9019\u4e9b\u75c7\u72c0\u5462\uff1f\u8b93\u6211\u5011\u5148\u770b\u770b\u751f\u7406\u6642\u9418\u662f\u600e\u9ebc\u88ab\u8abf\u63a7\u7684\u5427\uff01\u4eba\u985e\u7684PERIOD\u86cb\u767d\u8cea\u5bb6\u65cf\u88e1\uff0c\u9084\u6709PER1\u8ddfPER2\u9019\u5169\u500b\u86cb\u767d\u8cea\uff0c\u5728\u751f\u7406\u6642\u9418\u7684\u8abf\u7bc0\u88e1\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\u8981\u89d2\u3002PER1\u8ddfPER2\u86cb\u767d\u8cea\u7684\u8868\u73fe\uff0c\u4ef0\u8cf4CLOCK\u8ddfBMAL1\u5169\u500b\u8f49\u9304\u56e0\u5b50\u7684\u555f\u52d5\u3002\u5728\u767d\u5929\u88e1\uff0cCLOCK\u548cBMAL1\u6703\u4fc3\u4f7fPER1<\/em>\u8ddfPER2<\/em>\uff0c\u8207\u5176\u5b83\u8a31\u591a\u57fa\u56e0\u7684\u8868\u73fe\u3002\u96a8\u8457\u4e00\u5929\u9010\u6f38\u904e\u53bb\uff0c\u6108\u4f86\u6108\u591a\u7684PER1\u8ddfPER2\u86cb\u767d\u8cea\u5728\u7d30\u80de\u8cea\u88e1\u5806\u7a4d\uff0c\u5f7c\u6b64\u6703\u548c\u5176\u5b83\u86cb\u767d\u8cea\u5f62\u6210\u8907\u5408\u9ad4\uff0c\u4e26\u88ab\u86cb\u767d\u9176CKI\u03b5\u8207GSK3\u78f7\u9178\u5316\u3002\u78f7\u9178\u5316\u5f8c\u7684PER1\/PER2\u8907\u5408\u9ad4\u53ef\u4ee5\u9032\u5165\u7d30\u80de\u6838\uff0c\u53bb\u6291\u5236CLOCK\u8207BMAL1\u7684\u6d3b\u6027\uff0c\u4e26\u88ab\u96a8\u4e4b\u964d\u89e3\u3002\u5728\u4e00\u5929\u751f\u7406\u6642\u9418\u7684\u5c3e\u5df4\uff0c\u7d30\u80de\u5167PER1\/PER2\u8907\u5408\u9ad4\u7684\u964d\u89e3\u5c0d\u65bc\u91cd\u65b0\u555f\u52d5\u4e0b\u4e00\u500b\u751f\u7406\u6642\u9418\u7684\u5faa\u74b0\u5c24\u5176\u91cd\u8981\u3002<\/p>\n

PERIOD3 <\/em>\u57fa\u56e0\u6240\u8868\u73fe\u7684PER3\u86cb\u767d\u8cea\uff0c\u80fd\u5920\u8b93\u86cb\u767d\u8ceaPER1\u8ddfPER2\u6bd4\u8f03\u7a69\u5b9a\u3002\u800c\u7576PER3\u86cb\u767d\u8cea\u7a81\u8b8a\u4e4b\u5f8c\uff0c\u6703\u4f7f\u5f97\u5176\u529f\u80fd\u53d7\u5230\u5f71\u97ff\uff0c\u9023\u5e36\u5f71\u97ff\u5230PER1\u8207PER2\u7684\u86cb\u767d\u8cea\u7a69\u5b9a\u6027\u3002\u5728\u5e36\u6709\u7a81\u8b8a\u57fa\u56e0\u7684\u8001\u9f20\u7d30\u80de\u5167\uff0cPER2\u5728\u7d30\u80de\u8cea\u5167\u8207\u5728\u7d30\u80de\u6838\u5167\u7684\u86cb\u767d\u8cea\u91cf\u660e\u986f\u4e0b\u964d\u3002\u751f\u7406\u6642\u9418\u9031\u671f\u7684\u7dad\u6301\u4ef0\u8cf4PER1\/PER2\u8907\u5408\u9ad4\u8207CLOCK\/BMAL1\u5f7c\u6b64\u4e4b\u9593\u6d3b\u6027\u7684\u6d88\u9577\uff0c\u7576PER2\u86cb\u767d\u8cea\u7a69\u5b9a\u6027\u4e0b\u964d\u7684\u6642\u5019\uff0c\u5c31\u984d\u5916\u5c0d\u751f\u7406\u6642\u9418\u9031\u671f\u5404\u5f71\u97ff\u56e0\u5b50\u9593\u7684\u5fae\u5999\u5e73\u8861\u589e\u6dfb\u4e86\u8b8a\u6578\uff0c\u800c\u4f7f\u4eba\u985e\u6216\u662f\u8001\u9f20\u7684\u4f5c\u606f\u7d0a\u4e82\u4e86\u3002\u00a0\"\u793a\u610f\u5716-02\"<\/p>\n

\u539f\u59cb\u8ad6\u6587\uff1a<\/strong>
\n1. Zhang L, et al. (2016) A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proc Natl Acad Sci U S A. pii: 201600039. PMID: 26903630<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. McClung CA (2011) Circadian rhythms and mood regulation: Insights from pre-clinical models. Eur Neuropsychopharmacol 21(Suppl 4):S683\u2013S693.<\/li>\n
  2. Kaminski-Hartenthaler A, et al. (2015) Melatonin and agomelatine for preventing seasonal affective disorder. Cochrane Database Syst Rev 11:CD011271.<\/li>\n
  3. Johansson C, et al. (2003) Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology 28(4):734\u2013739.<\/li>\n
  4. Partonen T, et al. (2007) Three circadian clock genes, Per2, Arntl, and Npas2, contribute to winter depression. Ann Med 39(3):229\u2013238.<\/li>\n
  5. McCarthy MJ, Nievergelt CM, Kelsoe JR, Welsh DK (2012) A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response. PLoS One 7(2):e32091.<\/li>\n
  6. Kim H-I, et al. (2015) Association of CLOCK, ARNTL, and NPAS2 gene polymorphisms and seasonal variations in mood and behavior. Chronobiol Int 32(6):785\u2013791.<\/li>\n
  7. McClung CA (2007) Circadian genes, rhythms, and the biology of mood disorders. Pharmacol Ther 114(2):222\u2013232.<\/li>\n<\/ol>\n

    --<\/span><\/strong>
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     <\/p>\n

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