{"id":24351,"date":"2016-05-05T00:06:03","date_gmt":"2016-05-04T16:06:03","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=24351"},"modified":"2022-10-11T13:23:04","modified_gmt":"2022-10-11T05:23:04","slug":"%e3%80%90%e7%94%9f%e7%89%a9%e5%a5%a7%e5%a6%99%e3%80%91%e7%94%9f%e7%89%a9%e6%9c%80%e5%b0%91%e9%9c%80%e8%a6%81%e5%b9%be%e5%80%8b%e5%9f%ba%e5%9b%a0%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=24351","title":{"rendered":"\u3010\u751f\u7269\u5967\u5999\u3011\u751f\u7269\u6700\u5c11\u9700\u8981\u5e7e\u500b\u57fa\u56e0\uff1f"},"content":{"rendered":"<figure id=\"attachment_24353\" aria-describedby=\"caption-attachment-24353\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-24353\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/04\/jcvi-syn3.0.jpg\" alt=\"\u5716\u7247\u4f86\u6e90\uff1aTom Deerinck and Mark Ellisman of the National Center for Imaging and Microscopy Research at the University of California at San Diego\" width=\"300\" height=\"334\"><figcaption id=\"caption-attachment-24353\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff1aTom Deerinck and Mark Ellisman<br \/>of the National Center for Imaging and<br \/>Microscopy Research at the University of California at San Diego<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n<p>\u81ea\u5f9e\u958b\u59cb\u9032\u884c\u57fa\u56e0\u9ad4\u5b9a\u5e8f\u5f8c\uff0c\u5230\u5e95\u6240\u8b02\u7684\u5fc5\u9700\u57fa\u56e0\uff08essential gene\uff09\u6709\u591a\u5c11\u500b\uff0c\u4e00\u76f4\u662f\u8a0e\u8ad6\u7684\u7126\u9ede\u3002\u4ee5\u591a\u7d30\u80de\u751f\u7269\u4f86\u770b\uff0c\u4eba\u6709\u5927\u7d04\u5169\u842c\u96f6\u4e94\u767e\u500b\u57fa\u56e0\u3001\u868a\u5b50\u6709\u4e00\u842c\u516b\u5343\u500b\u57fa\u56e0\uff0c\u800c\u64ec\u5357\u82a5\uff08<em>Arabidopsis thaliana<\/em>\uff09\u7adf\u6709\u5169\u842c\u4e03\u5343\u500b\u57fa\u56e0\uff01<\/p>\n<p>\u7576\u7136\uff0c\u591a\u7d30\u80de\u751f\u7269\u56e0\u70ba\u69cb\u9020\u6bd4\u8f03\u8907\u96dc\uff0c\u57fa\u56e0\u9ad4\u4e00\u5b9a\u6bd4\u8f03\u5927\uff0c\u9019\u662f\u7121\u5eb8\u7f6e\u7591\u7684\uff1b\u5982\u679c\u662f\u55ae\u7d30\u80de\u751f\u7269\u5462\uff1f\u55ae\u7d30\u80de\u751f\u7269\u5982\u67af\u8349\u687f\u83cc\uff08<em>Bacillus subtilis<\/em>\uff09\u6216\u5927\u8178\u687f\u83cc\uff08<em>Escherichia coli<\/em>\uff09\u7684\u57fa\u56e0\u9ad4\u5c31\u7c21\u55ae\u591a\u4e86\uff0c\u5927\u6982\u90fd\u53ea\u6709\u56db\u3001\u4e94\u5343\u500b\u57fa\u56e0\u3002\u5982\u679c\u628a\u4e0d\u540c\u7684\u55ae\u7d30\u80de\u751f\u7269\u7684\u57fa\u56e0\u62ff\u4f86\u300c\u8d85\u7d1a\u6bd4\u4e00\u6bd4\u300d\uff0c\u627e\u51fa\u5927\u5bb6\u90fd\u6709\u7684\u57fa\u56e0\uff0c\u6703\u767c\u73fe\u5927\u6982\u6709\u5169\u767e\u4e94\u5341\u500b\u5de6\u53f3\u7684\u57fa\u56e0\u7684\u4ea4\u96c6\u3002\u4f46\u662f\uff0c\u9019\u5169\u767e\u4e94\u5341\u591a\u500b\u57fa\u56e0\uff0c\u5c31\u662f\u5fc5\u9700\u57fa\u56e0\u55ce\uff1f\u55ae\u7d30\u80de\u751f\u7269\u771f\u7684\u53ea\u9700\u8981\u9019\u9ebc\u5c11\u7684\u57fa\u56e0\u5c31\u53ef\u4ee5\u5b58\u6d3b\u55ce\uff1f<!--more--><\/p>\n<p>\u7b54\u6848\u53ef\u80fd\u662f\u5426\u5b9a\u7684\u3002\u70ba\u4ec0\u9ebc\u5462\uff1f\u76ee\u524d\u6240\u77e5\u6700\u5c0f\u7684\u53ef\u4ee5\u7368\u7acb\u751f\u5b58\u7684\u500b\u9ad4\u662f\u751f\u6b96\u9053\u9ef4\u6f3f\u83cc\uff08<em>Mycoplasma genitalium<\/em>\uff09\uff0c\u4f46\u662f\u5b83\u9084\u6709525\u500b\u57fa\u56e0\uff0c\u6bd4\u4e0a\u8ff0\u7684\u4ea4\u96c6\u7d50\u679c\u9084\u591a\u4e86\u4e00\u500d\u591a\u3002\u90a3\u9ebc\uff0c\u9019\u4e9b\u300c\u591a\u51fa\u4f86\u300d\u7684\u57fa\u56e0\uff0c\u6703\u4e0d\u6703\u9084\u662f\u6709\u975e\u5fc5\u9700\u7684\u57fa\u56e0\u5462\uff1f<\/p>\n<p>J. Craig Venter Institute \u7684\u79d1\u5b78\u5bb6\u5011\uff0c\u70ba\u4e86\u8981\u89e3\u958b\u9019\u500b\u8b0e\u984c\uff0c\u5148\u4ee5\u8f49\u4f4d\u5b50\u8a98\u8b8a\u6280\u8853\uff08transposon mutagenesis\uff09\u627e\u51fa\u751f\u6b96\u9053\u9ef4\u6f3f\u83cc\u4e2d\u53ef\u80fd\u4e0d\u9700\u8981\u7684\u57fa\u56e0\uff0c\u518d\u5c07\u7d72\u72c0\u9ef4\u6f3f\u83cc\uff08<em>M. mycoides<\/em>\uff0c\u542b\u6709901\u500b\u57fa\u56e0\uff09\u7684\u57fa\u56e0\u9ad4\u5206\u6210\u516b\u6bb5\u4f86\u5408\u6210\u4ee5\u5f8c\uff08\u7a31\u70ba1.0\u7248\uff09\uff0c\u5c07\u65b0\u5408\u6210\u7684\u4eba\u9020\u57fa\u56e0\u9ad4\u7247\u6bb5\u5206\u6bb5\u7f6e\u5165\u4f86\u6e2c\u8a66\u9019\u4e9b\u7247\u6bb5\u7684\u300c\u53ef\u6d3b\u6027\u300d\u3002<\/p>\n<p>\u70ba\u4ec0\u9ebc\u4e0d\u4f7f\u7528\u751f\u6b96\u9053\u9ef4\u6f3f\u83cc\u7e7c\u7e8c\u505a\u5462\uff1f\u539f\u4f86\uff0c\u751f\u6b96\u9053\u9ef4\u6f3f\u83cc\u9577\u5f97\u592a\u6162\u4e86\uff0c\u6bcf16\u5c0f\u6642\u624d\u8907\u88fd\u4e00\u6b21\uff01\u6240\u4ee5\u53ea\u597d\u6539\u7528\u7d72\u72c0\u9ef4\u6f3f\u83cc\u3002\u7814\u7a76\u5718\u968a\u958b\u767c\u4e86\u5229\u7528\u5c71\u7f8a\u9ef4\u6f3f\u83cc\uff08<em>M. 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plasticity\uff09\u3002\u76ee\u524d\u4ed6\u5011\u5df2\u7d93\u767c\u73fe\uff0c\u57fa\u56e0\u7684\u6392\u5217\u9806\u5e8f\u4f3c\u4e4e\u4e0d\u592a\u91cd\u8981\uff1b\u800c\u66f4\u6539\u907a\u50b3\u5bc6\u78bc\u4f3c\u4e4e\u4e5f\u4e0d\u5f71\u97ff\u3002<\/p>\n<p>\u7a76\u7adf\u9019473\u500b\u57fa\u56e0\u662f\u4e0d\u662f\u5c31\u662f\u300c\u5fc5\u9700\u300d\u57fa\u56e0\uff1f\u7b46\u8005\u8a8d\u70ba\uff0c\u5927\u6982\u53ef\u4ee5\u628a\u9019473\u500b\u57fa\u56e0\u7a31\u70ba\u300c\u6700\u5c0f\u5fc5\u9700\u57fa\u56e0\u7d44\u300d\u5427\uff01\u7562\u7adf\u4e00\u822c\u7684\u5fae\u751f\u7269\uff08\u5373\u4f7f\u662f\u9ef4\u6f3f\u83cc\uff09\u9084\u662f\u9700\u8981\u6709\u4e00\u4e9b\u751f\u5b58\u6240\u9700\u7684\u5f48\u6027\uff0c\u4e0d\u80fd\u53ea\u80fd\u5b58\u6d3b\u5728\u4ee5\u8461\u8404\u7cd6\u4f5c\u70ba\u55ae\u4e00\u78b3\u6e90\u7684\u74b0\u5883\u88e1\u3002\u7576\u7136\uff0c\u9019\u500b\u8cc7\u8a0a\u9084\u662f\u975e\u5e38\u73cd\u8cb4\u7684\uff0c\u5c24\u5176\u662f\u90a379\u500b\u672a\u77e5\u529f\u80fd\u7684\u57fa\u56e0\uff0c\u5b83\u5011\u7a76\u7adf\u6709\u4ec0\u9ebc\u529f\u80fd\u5462\uff1f\u9019\u624d\u662f\u771f\u6b63\u5f15\u4eba\u5165\u52dd\u3001\u503c\u5f97\u7814\u7a76\u7684\u90e8\u5206\u5462\uff01<\/p>\n<p><strong>\u53c3\u8003\u6587\u737b\uff1a<\/strong>C.A. Hutchison III et. al., 2016. Design and synthesis of a minimal bacterial genome. Science.<\/p>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br style=\"color: #000000;\"><span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u64b0\u6587\uff5c\u8449\u7da0\u8212 \u81ea\u5f9e\u958b\u59cb\u9032\u884c\u57fa\u56e0\u9ad4\u5b9a\u5e8f\u5f8c\uff0c<\/p>\n","protected":false},"author":20,"featured_media":24353,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,6512,26,1025],"tags":[129,297,2494,2493,2248,1543],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/04\/jcvi-syn3.0.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/24351"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24351"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/24351\/revisions"}],"predecessor-version":[{"id":40875,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/24351\/revisions\/40875"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/24353"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}