{"id":24070,"date":"2016-03-25T00:00:56","date_gmt":"2016-03-24T16:00:56","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=24070"},"modified":"2018-08-03T14:27:21","modified_gmt":"2018-08-03T06:27:21","slug":"%e3%80%90%e9%80%b1%e6%9c%ab%e8%8c%b2%e5%8d%a1%e5%b0%88%e9%a1%8c%e5%a0%b1%e5%b0%8e%e3%80%91fighting-%e5%9c%a8%e8%a2%ab%e8%8c%b2%e5%8d%a1%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e5%be%8c","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=24070","title":{"rendered":"\u3010\u9031\u672b\u8332\u5361\u5c08\u984c\u5831\u5c0e\u3011Fighting! \u5728\u88ab\u8332\u5361\u75c5\u6bd2\u611f\u67d3\u5f8c\u2026"},"content":{"rendered":"

\u25a0\u7576\u88ab\u5e36\u6709\u8332\u5361\u75c5\u6bd2\u7684\u57c3\u53ca\u6591\u868a\u53ee\u54ac\u4e4b\u5f8c\uff0c\u662f\u54ea\u4e9b\u514d\u75ab\u7cfb\u7d71\u88e1\u7684\u5c0f\u5c0f\u5175\u4fdd\u8b77\u6211\u5011\u5462\uff1f\u5982\u679c\u8332\u5361\u75c5\u6bd2\u771f\u7684\u662f\u9020\u6210\u65b0\u751f\u5152\u5c0f\u8166\u75c7\u7684\u5143\u51f6\uff0c\u751f\u7406\u529f\u80fd\u53c8\u662f\u5728\u54ea\u4e00\u689d\u57ce\u6c60\u9632\u7dda\u4e0a\u5931\u5b88\u5462\uff1f<\/strong><\/span><\/p>\n

\"\u5716\u7247\u4f86\u6e90\uff1awww.independent.co.uk\/\"
\u5716\u7247\u4f86\u6e90\uff1awww.independent.co.uk\/<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

\u534a\u500b\u4e16\u7d00\u524d\uff0c\u5169\u7bc7\u8332\u5361\u75c5\u6bd2\u7684\u7814\u7a76\u540c\u6642\u767b\u4e0a\u300a\u7687\u5bb6\u71b1\u5e36\u91ab\u5b78\u5b78\u6703\u671f\u520a\u300b\uff0c\u90a3\u662f\u8332\u5361\u75c5\u6bd2\u7b2c\u4e00\u6b21\u8d70\u51fa\u4e86\u975e\u6d32\u70cf\u5e72\u9054\u7684\u68ee\u6797\uff0c\u767b\u4e0a\u91ab\u5b78\u671f\u520a\u800c\u70ba\u4eba\u6240\u77e5\u3002\u8ad6\u6587\u8868\u793a\uff0c\u96d6\u7136\u8332\u5361\u75c5\u6bd2\u7684\u81e8\u5e8a\u6848\u4f8b\u7f55\u6709\u8033\u805e\uff0c\u4f46\u9019\u4e26\u4e0d\u4ee3\u8868\u6211\u5011\u5c31\u80fd\u7b49\u9592\u8996\u4e4b\uff0c\u66f4\u4e0d\u80fd\u56e0\u6b64\u5192\u7136\u5047\u8a2d\u8332\u5361\u75c5\u6bd2\u4e0d\u611f\u67d3\u4eba\u985e\u3002\u5728\u75ab\u60c5\u6301\u7e8c\u64f4\u6563\u7684\u6b64\u523b\uff0cDick\u535a\u58eb\u7684\u8b66\u8a9e\u4e00\u8a9e\u6210\u8b96\u3002<\/p>\n

\u5927\u90e8\u5206\u7684\u4eba\u5728\u611f\u67d3\u8332\u5361\u75c5\u6bd2\u4e4b\u5f8c\uff0c\u75c7\u72c0\u90fd\u4e0d\u751a\u56b4\u91cd\uff0c\u4e5f\u56e0\u6b64\u8332\u5361\u75c5\u6bd2\u6240\u53d7\u5230\u7684\u95dc\u6ce8\uff0c\u8981\u6bd4\u8ddf\u5b83\u540c\u5c6c\u65bc\u9ec3\u8cea\u75c5\u6bd2\u5c6c\u7684\u5176\u4ed6\u75c5\u6bd2\uff08\u50cf\u662f\u767b\u9769\u71b1\u75c5\u6bd2\uff09\u8981\u5c11\u5f97\u8a31\u591a\u3002\u5728\u6cd5\u570bMIVEGEC\u7814\u7a76\u4e2d\u5fc3\uff0cMisse\u535a\u58eb\u9451\u65bc\u8332\u5361\u75c5\u6bd2\u9577\u671f\u88ab\u6f20\u8996\uff0c\u6c7a\u5b9a\u5c07\u8332\u5361\u75c5\u6bd2\u5982\u4f55\u5728\u868a\u87f2\u53ee\u54ac\u4e4b\u5f8c\u3001\u611f\u67d3\u4eba\u985e\u7d30\u80de\u7684\u76f8\u95dc\u6839\u672c\u554f\u984c\u4e00\u4e00\u91d0\u6e05\u3002\u53bb\u5e74\uff0c\u7814\u7a76\u6210\u679c\u767c\u8868\u5728Journal of Virology<\/em>\uff0c\u4e0d\u50c5\u6210\u529f\u6551\u63f4\u3001\u8b93\u6211\u5011\u5c0d\u8332\u5361\u75c5\u6bd2\u4e0d\u81f3\u65bc\u4e00\u554f\u4e09\u4e0d\u77e5\uff0c\u66f4\u8b93\u7814\u7a76\u4eba\u54e1\u5728\u9762\u5c0d\u4f86\u52e2\u6d36\u6d36\u7684\u5c0f\u8166\u75c7\u6fc0\u589e\u75c5\u4f8b\u7a81\u8972\u6642\uff0c\u80fd\u5920\u63a8\u6e2c\u80cc\u5f8c\u53ef\u80fd\u7684\u75c5\u7406\u6a5f\u5236\u3002<\/p>\n

Misse\u535a\u58eb\u7684\u7814\u7a76\u5718\u968a\u9996\u5148\u6536\u96c6\u4eba\u985e\u76ae\u819a\u7d30\u80de\u6aa2\u9ad4\u3002\u4ed6\u5011\u5f9e\u4e09\u4f4d\u525b\u7d93\u904e\u8179\u90e8\u6574\u5f62\u624b\u8853\u7684\u5065\u5eb7\u6210\u5e74\u4eba\u8eab\u4e0a\u53d6\u5f97\u76ae\u819a\u7d44\u7e54\uff0c\u4e26\u5229\u75282013\u5e74\u5728\u6cd5\u5c6c\u6ce2\u5229\u5c3c\u897f\u4e9e\u5c0e\u81f4\u75ab\u60c5\u7684\u75c5\u6bd2\u682a\uff0c\u4f86\u6a21\u64ec\u8332\u5361\u75c5\u6bd2\u611f\u67d3\u4eba\u985e\u7d30\u80de\u3002\u7814\u7a76\u767c\u73fe\uff0c\u76ae\u819a\u7d44\u7e54\u4e2d\u7684\u7e96\u7dad\u6bcd\u7d30\u80de\u3001\u8207\u8868\u76ae\u89d2\u8cea\u7d30\u80de\u90fd\u5f88\u5bb9\u6613\u88ab\u8332\u5361\u75c5\u6bd2\u611f\u67d3\u3002\u5728\u75c5\u6bd2\u611f\u67d3\u5f8c\u768424\u5c0f\u6642\u5167\uff0c\u7d30\u80de\u4e2d\u5c31\u53ef\u4ee5\u5075\u6e2c\u5230\u75c5\u6bd2\u86cb\u767d\uff1b\u4e09\u5929\u5167\uff0c\u5168\u90e8\u7684\u7d30\u80de\u90fd\u8b8a\u6210\u4e86\u75c5\u6bd2\u88fd\u9020\u5de5\u5ee0\uff1b\u7b2c\u4e94\u5929\u6642\uff0c\u75c5\u6bd2\u91cf\u5247\u9054\u5230\u6700\u9ad8\u5cf0\u3002<\/p>\n

\u8332\u5361\u75c5\u6bd2\u53c8\u662f\u5982\u4f55\u9032\u5165\u76ae\u819a\u7d30\u80de\u5462\uff1fMisse\u535a\u58eb\u767c\u73fe\uff0c\u8332\u5361\u75c5\u6bd2\u7684\u8a6d\u8a08\u8ddf\u767b\u9769\u71b1\u75c5\u6bd2\u5f88\u76f8\u4f3c\u3002\u901a\u5e38\uff0c\u75c5\u6bd2\u90fd\u80fd\u5920\u5229\u7528\u8868\u9762\u7684\u5916\u5957\u819c\u86cb\u767d\uff0c\u4f86\u548c\u8868\u73fe\u5728\u4eba\u985e\u7d30\u80de\u8868\u9762\u7684\u86cb\u767d\u8cea\u76f8\u7d50\u5408\uff0c\u7136\u5f8c\u85c9\u7531\u5167\u55dc\u4f5c\u7528\u9032\u5165\u7d30\u80de\u3002\u800c\u8332\u5361\u75c5\u6bd2\u8207\u767b\u9769\u71b1\u75c5\u6bd2\uff0c\u9084\u6703\u5229\u7528\u7d30\u80de\u5916\u57fa\u8cea\u4e0a\u7684\uf9ce\u9178\u4e59\u91af\u809d\u7d20\uff08Heparan sulfate\uff09\u3002\uf9ce\u9178\u4e59\u91af\u809d\u7d20\u662f\u4e00\u7a2e\u5e36\u6709\u786b\u9178\u57fa\u7684\u591a\u91a3\uff0c\u5e38\u5728\u7d30\u80de\u5916\u57fa\u8cea\u4e0a\u7684\u86cb\u767d\u8cea\u4fee\u98fe\u4e2d\u770b\u5230\u3002\u8332\u5361\u75c5\u6bd2\u53ef\u4ee5\u9ecf\u9644\u5728\u786b\u9178\u4e59\u91af\u809d\u7d20\u4e0a\uff0c\u800c\u4e14\u9019\u6a23\u7684\u9644\u8457\u4e0d\u9700\u8981\u5c08\u4e00\u6027\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4f7f\u5f97\u4eba\u985e\u7d30\u80de\u50cf\u662f\u5728\u81ea\u5bb6\u9580\u53e3\u639b\u4e86\u6eff\u6eff\u7684\u300c\u9ecf\u75c5\u6bd2\u677f\u300d\u3002\u80de\u5916\u5927\u91cf\u7684\u75c5\u6bd2\uff0c\u66f4\u52a0\u901f\u4e86\u75c5\u6bd2\u80fd\u5920\u548c\u4eba\u985e\u7d30\u80de\u819c\u4e0a\u7684\u86cb\u767d\u8cea\u7d50\u5408\uff0c\u800c\u9032\u5165\u7d30\u80de\u3002<\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0c\u7814\u7a76\u5718\u968a\u9084\u5f9e\u5065\u5eb7\u53d7\u8a66\u8005\u8840\u6db2\u5167\u5206\u96e2\u51fa\u55ae\u6838\u7403\uff0c\u7136\u5f8c\u8a98\u5c0e\u5206\u5316\u70ba\u672a\u6210\u719f\u7684\u6a39\u7a81\u7d30\u80de\u3002\u8332\u5361\u75c5\u6bd2\u4e5f\u80fd\u8f15\u800c\u6613\u8209\u5730\u611f\u67d3\u672a\u6210\u719f\u7684\u6a39\u7a81\u7d30\u80de\uff0c\u5728\u7d30\u80de\u5167\u5927\u91cf\u9032\u884c\u8907\u88fd\u3002\u5728\u6211\u5011\u76ae\u819a\u8868\u76ae\u7d44\u7e54\uff0c\u90fd\u6709\u5e38\u99d0\u7684\u672a\u6210\u719f\u6a39\u7a81\u7d30\u80de\uff0c\u4ed6\u5011\u50cf\u662f\u6b66\u529f\u9ad8\u5f37\u7684\u9632\u5b88\u5de1\u885b\u5175\uff0c\u80fd\u5920\u5075\u6e2c\u3001\u541e\u566c\u5165\u4fb5\u7684\u75c5\u539f\u9ad4\uff0c\u4e26\u5c07\u4e4b\u5206\u89e3\u6210\u5c0f\u7247\u6bb5\u7684\u80dc\u80bd\uff0c\u5448\u73fe\u5728\u7d30\u80de\u8868\u9762\uff0c\u5c07\u5165\u4fb5\u75c5\u539f\u9ad4\u7684\u771f\u9762\u76ee\u662d\u544a\u514d\u75ab\u7cfb\u7d71\u88e1\u7684\u5404\u8def\u5c0f\u5175\u3002\u4f46\u5728\u767b\u9769\u71b1\u75c5\u6bd2\u611f\u67d3\u88e1\u767c\u73fe\uff0c\u88ab\u75c5\u6bd2\u611f\u67d3\u3001\u53c8\u80fd\u5920\u5230\u8655\u8db4\u8db4\u8d70\u7684\u6a39\u7a81\u7d30\u80de\uff0c\u53cd\u800c\u52a0\u901f\u4e86\u767b\u9769\u71b1\u75c5\u6bd2\u5728\u9ad4\u5167\u7684\u6563\u64ad\u3002\u4e5f\u56e0\u6b64\uff0c\u8332\u5361\u75c5\u6bd2\u80fd\u5920\u611f\u67d3\u672a\u6210\u719f\u7684\u6a39\u7a81\u7d30\u80de\uff0c\u6210\u4e86\u4ee4\u4eba\u982d\u75db\u7684\u4e8b\u3002<\/p>\n

\u800c\u9032\u5165\u4eba\u985e\u7d30\u80de\u5167\u7684\u8332\u5361\u75c5\u6bd2\uff0c\u6703\u89f8\u52d5\u9632\u885b\u6a5f\u5236\uff0c\u8b93\u5148\u5929\u514d\u75ab\u7cfb\u7d71\u7684\u8b66\u9234\u5927\u97ff\u3002Misse\u535a\u58eb\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u985e\u9438\u53d7\u9ad4\uff08Toll-like receptor;\u7c21\u5beb\u505aTLR\uff09\u4e2d\u7684TLR3\u53d7\u9ad4\uff0c\u96d6\u7136\u672c\u4f86\u5c31\u8ca0\u8cac\u5075\u6e2c\u96d9\u80a1RNA\u75c5\u6bd2\uff0c\u5c0d\u65bc\u55ae\u80a1RNA\u7684\u8332\u5361\u75c5\u6bd2\uff0c\u4e5f\u80fd\u4e00\u80a9\u6311\u8d77\u6297\u75c5\u6bd2\u514d\u75ab\u53cd\u61c9\u7684\u4e3b\u5c0e\u6b0a\u3002\u555f\u52d5\u6297\u75c5\u6bd2\u53cd\u61c9\u7684\u7d30\u80de\uff0c\u6703\u91cb\u653e\u51fa\u7b2c\u4e00\u578b\u8207\u7b2c\u4e8c\u578b\u5e72\u64fe\u7d20\uff0c\u90fd\u80fd\u5920\u6709\u6548\u5730\u6291\u5236\u75c5\u6bd2\u8907\u88fd\u3002\"02\"<\/p>\n

Misse\u535a\u58eb\u66f4\u767c\u73fe\uff0c\u5728\u611f\u67d3\u5f8c\uff0c\u8332\u5361\u75c5\u6bd2\u6703\u52ab\u6301\u7d30\u80de\u7684\u81ea\u566c\u4f5c\u7528\uff08Autophagy\uff09\u3002\u81ea\u566c\u4f5c\u7528\u50cf\u662f\u7d30\u80de\u5167\u7684\u8cc7\u6e90\u56de\u6536\u5834\uff0c\u80fd\u5920\u5c07\u8001\u820a\u7684\u80de\u5668\u8207\u86cb\u767d\u8cea\u5206\u89e3\uff0c\u4ee5\u7dad\u6301\u80de\u5167\u6046\u5b9a\uff1b\u800c\u4e14\uff0c\u5728\u6297\u75c5\u6bd2\u53cd\u61c9\u4e0a\uff0c\u4e5f\u662f\u8981\u8173\u4e00\u679a\uff0c\u80fd\u5920\u5c07\u5165\u4fb5\u7684\u75c5\u539f\u9ad4\u4e00\u8d77\u9001\u5230\u56de\u6536\u7ad9\u5206\u89e3\u6389\u3002\u4f46\u9053\u9ad8\u4e00\u5c3a\u3001\u9b54\u9ad8\u4e00\u4e08\uff0c\u5305\u62ec\u8332\u5361\u75c5\u6bd2\u5728\u5167\u7684\u8a31\u591a\u75c5\u6bd2\uff0c\u90fd\u80fd\u633e\u6301\u81ea\u566c\u4f5c\u7528\u76f8\u95dc\u7684\u86cb\u767d\u8cea\uff0c\u7528\u4f86\u4fc3\u9032\u75c5\u6bd2\u8907\u88fd\uff0c\u800c\u53cd\u5c07\u4eba\u985e\u7d30\u80de\u4e00\u8ecd\u3002\u800c\u4e5f\u5c31\u662f\u6839\u64da\u9019\u500b\u767c\u73fe\uff0c\u79d1\u5b78\u5bb6\u63a8\u65b7\u51fa\u8332\u5361\u75c5\u6bd2\u611f\u67d3\u53ef\u80fd\u5c0e\u81f4\u65b0\u751f\u5152\u5c0f\u8166\u75c7\u80cc\u5f8c\u7684\u539f\u56e0\u3002<\/p>\n

\u5c0e\u81f4\u5c0f\u8166\u75c7\u7684\u4e00\u500b\u53ef\u80fd\u539f\u56e0\uff0c\u662f\u7d30\u80de\u5167\u5931\u5e38\u7684\u4e2d\u5fc3\u9ad4\uff08Centrosomes\uff09\u529f\u80fd\u3002\u4eba\u985e\u7d30\u80de\u5728\u7d30\u80de\u6838\u9644\u8fd1\uff0c\u6709\u5169\u500b\u4e2d\u5fc3\u7c92\uff0c\u5408\u7a31\u70ba\u4e2d\u5fc3\u9ad4\uff1b\u5b83\u5011\u7684\u529f\u80fd\u9664\u4e86\u8033\u719f\u80fd\u8a73\u7684\u300c\u7d30\u80de\u5206\u88c2\u300d\uff0c\u5c0d\u7d30\u80de\u9077\u79fb\u3001\u6975\u5316\u7b49\u9700\u8981\u8abf\u63a7\u7d30\u80de\u9aa8\u67b6\u7684\u4e8b\uff0c\u90fd\u5341\u5206\u5728\u884c\u3002\u800c\u5728\u8001\u9f20\u5be6\u9a57\u4e2d\u767c\u73fe\uff0c\u4e2d\u5fc3\u9ad4\u8907\u88fd\u5931\u8abf\u662f\u8a98\u767c\u5c0f\u8166\u75c7\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u7576\u4e2d\u5fc3\u9ad4\u4e0d\u6b63\u5e38\u8907\u88fd\u800c\u7570\u5e38\u589e\u591a\u7684\u6642\u5019\uff0c\u6703\u6e1b\u6162\u7d30\u80de\u5206\u88c2\u7684\u901f\u5ea6\uff0c\u589e\u52a0\u7d30\u80de\u51cb\u4ea1\u7684\u98a8\u96aa\u7b49\uff0c\u6700\u7d42\u5c0e\u81f4\u5c0f\u9f20\u5927\u8166\u986f\u8457\u8b8a\u5c0f\u3001\u767c\u80b2\u9072\u7de9\u800c\u70ba\u5c0f\u8166\u75c7\u3002\u800c\uff0c\u8a31\u591a\u5728\u81ea\u566c\u4f5c\u7528\u4e2d\u6709\u91cd\u8981\u529f\u80fd\u7684\u86cb\u767d\u8cea\uff0c\u4e5f\u90fd\u6070\u5de7\u5c0d\u4e2d\u5fc3\u9ad4\u7684\u7a69\u5b9a\u6027\u6709\u8209\u8db3\u8f15\u91cd\u7684\u5f71\u97ff\u529b\uff08\u4f8b\u5982UVRAG\u86cb\u767d\uff09\u3002\u56e0\u6b64\uff0c\u7576\u8332\u5361\u75c5\u6bd2\u5f71\u97ff\u5230\u81ea\u566c\u4f5c\u7528\u7684\u6b63\u5e38\u529f\u80fd\u6642\uff0c\u4e5f\u6709\u53ef\u80fd\u6703\u727d\u7d2f\u4e2d\u5fc3\u9ad4\u7684\u7a69\u5b9a\u6027\uff0c\u800c\u7570\u5e38\u8907\u88fd\u7684\u4e2d\u5fc3\u9ad4\uff0c\u5c31\u6709\u53ef\u80fd\u662f\u58d3\u57ae\u80ce\u5152\u6b63\u5e38\u8166\u90e8\u767c\u80b2\u7684\u6700\u5f8c\u4e00\u6839\u7a3b\u8349\u4e86\u3002\u4f46\u76ee\u524d\uff0c\u5047\u8a2d\u4ecd\u50c5\u6b62\u65bc\u7d19\u4e0a\u8ac7\u5175\uff0c\u771f\u6b63\u7684\u95dc\u806f\u5982\u4f55\uff0c\u9084\u6709\u8cf4\u5404\u5be6\u9a57\u5ba4\u62bd\u7d72\u525d\u7e6d\u7684\u529f\u529b\u4e86\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Hamel R et al. Biology of Zika Virus Infection in Human Skin Cells. J Virol.<\/em> 2015 Sep;89(17):8880-96. doi: 10.1128\/JVI.00354-15. Epub 2015 Jun 17.<\/li>\n
  2. Tetro JA et al. Zika and microcephaly: causation, correlation, or coincidence? Microbes Infect.<\/em> 2016 Jan 14. pii: S1286-4579(16)00008-3. doi: 10.1016\/j.micinf.2015.12.010. [Epub ahead of print]<\/li>\n
  3. Marthiens V et al. Centrosome amplification causes microcephaly. Nat Cell Biol.<\/em> 2013 Jul;15(7):731-40. doi: 10.1038\/ncb2746. Epub 2013 May 12. PMID: 23666084<\/li>\n
  4. Bl\u00e1zquez AB et al. Stress responses in flavivirus-infected cells: activation of unfolded protein response and autophagy. Front Microbiol. <\/em>2014 Jun 3;5:266. doi: 10.3389\/fmicb.2014.00266. eCollection 2014.<\/li>\n<\/ol>\n

    --<\/span><\/strong>
    \u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/span><\/strong><\/p>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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