{"id":23870,"date":"2016-03-11T00:01:16","date_gmt":"2016-03-10T16:01:16","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=23870"},"modified":"2018-08-03T14:28:36","modified_gmt":"2018-08-03T06:28:36","slug":"%e3%80%90%e5%b0%88%e9%a1%8c%e5%a0%b1%e5%b0%8e%e3%80%91%e8%8c%b2%e5%8d%a1%e7%97%85%e6%af%92%e8%88%87%e5%b0%8f%e8%85%a6%e7%97%87%ef%bc%9a%e6%98%af%e5%a7%8b%e4%bd%9c%e4%bf%91%e8%80%85%e9%82%84%e6%98%af-2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=23870","title":{"rendered":"\u3010\u9031\u672b\u8332\u5361\u5c08\u984c\u5831\u5c0e\u3011\u8332\u5361\u75c5\u6bd2\u8207\u5c0f\u8166\u75c7\uff1a\u662f\u59cb\u4f5c\u4fd1\u8005\u9084\u662f\u74dc\u7530\u674e\u4e0b(\u4e0b)"},"content":{"rendered":"<p><span style=\"color: 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height=\"300\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/ss-160114-zika-birth-defect-brazil-05_c057f3fd811e1839d1d8e8cb24ebdc46.nbcnews-ux-1024-900.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/ss-160114-zika-birth-defect-brazil-05_c057f3fd811e1839d1d8e8cb24ebdc46.nbcnews-ux-1024-900-300x200.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/ss-160114-zika-birth-defect-brazil-05_c057f3fd811e1839d1d8e8cb24ebdc46.nbcnews-ux-1024-900-600x400.jpg 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/ss-160114-zika-birth-defect-brazil-05_c057f3fd811e1839d1d8e8cb24ebdc46.nbcnews-ux-1024-900-800x534.jpg 800w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-23877\" class=\"wp-caption-text\">credit:Felipe Dana \/ 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New England Journal of Medicine<\/em>\u4e0a\u6709\u4e00\u7bc7\u6848\u4f8b\uff0c\u63d0\u4f9b\u4e86\u66f4\u5f37\u800c\u6709\u529b\u7684\u8b49\u64da\u3002\u4e00\u4f4d25\u6b72\u7684\u6b50\u6d32\u5973\u6027\uff0c\u81ea2013\u5e74\u8d77\u5728\u5df4\u897f\u7576\u5fd7\u5de5\uff0c\u6240\u8655\u4e4b\u5730\u6b63\u662f\u8332\u5361\u75c5\u6bd2\u75ab\u5340\u4e4b\u4e00\u3002\u5979\u65bc2015\u5e74\u4e8c\u6708\u61f7\u5b55\uff0c\u5728\u61f7\u5b55\u5341\u4e09\u9031\u6642\uff0c\u56e0\u9ad8\u71d2\u3001\u7d05\u75b9\u3001\u808c\u8089\u9aa8\u982d\u75e0\u75db\u8207\u5f8c\u773c\u7aa9\u75db\u800c\u5c31\u91ab\uff0c\u800c\u88ab\u61f7\u7591\u662f\u8332\u5361\u75c5\u6bd2\u611f\u67d3\uff0c\u4f46\u6c92\u6709\u66f4\u9032\u4e00\u6b65\u7684\u6aa2\u9a57\u3002\u80ce\u5152\u5728\u5341\u56db\u5230\u4e8c\u5341\u9031\u7684\u8d85\u97f3\u6ce2\u6383\u63cf\u6aa2\u67e5\u90fd\u5b8c\u5168\u6b63\u5e38\uff0c\u5979\u5728\u5b55\u671f\u4e8c\u5341\u516b\u9031\u6642\u8fd4\u56de\u6b50\u6d32\u3002\u5728\u4e8c\u5341\u4e5d\u9031\u7684\u7522\u6aa2\u4e2d\u7b2c\u4e00\u6b21\u51fa\u73fe\u65b0\u751f\u5152\u4e0d\u6b63\u5e38\u7684\u5fb5\u5146\uff0c\u4e09\u5341\u4e8c\u9031\u7684\u8d85\u97f3\u6ce2\u6aa2\u67e5\u78ba\u8a8d\u80ce\u5152\u60a3\u6709\u5c0f\u8166\u75c7\uff0c\u5728\u5b55\u5a66\u8981\u6c42\u8207\u91ab\u9662\u502b\u7406\u59d4\u54e1\u6703\u6838\u51c6\u5f8c\uff0c\u5b55\u7a0b\u4e2d\u6b62\u3002<\/p>\n<p>\u4f86\u4e0d\u53ca\u8a95\u751f\u7684\u751f\u547d\u59cb\u4e00\u500b\u6bcd\u89aa\u8207\u5bb6\u5ead\u5fc3\u788e\uff0c\u4f46\u4ed6\u5011\u4e5f\u5c07\u611b\u7559\u7d66\u4e86\u79d1\u5b78\u7814\u7a76\u3002\u75c5\u7406\u89e3\u5256\u986f\u793a\u80ce\u5152\u8166\u90e8\u767c\u80b2\u56b4\u91cd\u9072\u6eef\uff0c\u8ddf\u5c0f\u8166\u75c7\u7684\u8a3a\u65b7\u76f8\u7b26\uff0c\u4e26\u4e14\u9664\u6b64\u4e4b\u5916\u4e00\u5207\u6b63\u5e38\u3002\u5728\u96fb\u5b50\u986f\u5fae\u93e1\u5e95\u4e0b\uff0c\u53ef\u4ee5\u6e05\u695a\u5728\u8166\u90e8\u7d30\u80de\u4e2d\u89c0\u5bdf\u5230\u75c5\u6bd2\u9846\u7c92\uff0c\u75c5\u6bd2\u9846\u7c92\u5927\u5c0f\u7d04\u70ba42\u5948\u7c73\u523052\u5948\u7c73\uff0c\u8ddf\u8332\u5361\u75c5\u6bd2\u7684\u5e73\u5747\u5927\u5c0f\u543b\u5408\u3002\u518d\u8005\uff0c\u5229\u7528\u5982\u4eca\u7576\u7d05\u7684\u6b21\u4e16\u4ee3\u9ad8\u901a\u91cf\u5b9a\u5e8f\uff08Next generation sequencing\uff09\u6280\u8853\uff0c\u7814\u7a76\u4eba\u54e1\u5728\u8166\u90e8\u6aa2\u9ad4\u4e2d\uff0c\u5075\u6e2c\u5230\u3001\u4e5f\u5206\u96e2\u51fa\u8332\u5361\u75c5\u6bd2\u5b8c\u5b8c\u6574\u6574\u7684\u907a\u50b3\u7269\u8cea\u6838\u7cd6\u6838\u9178\u5e8f\u5217\u3002\u4e26\u4e14\u6aa2\u9ad4\u4e2d\u5206\u96e2\u51fa\u4f86\u7684\u75c5\u6bd2\u5e8f\u5217\uff0c\u82072015\u5e74\u5728\u5df4\u897f\u8056\u4fdd\u7f85\u30012013\u5e74\u5728\u5357\u592a\u5e73\u6d0b\u6cd5\u5c6c\u6ce2\u5229\u5c3c\u897f\u4e9e\u6240\u63a1\u96c6\u5230\u7684\u6d41\u884c\u75c5\u6bd2\u682a\u5e8f\u5217\u6709\u9ad8\u905499.7%\u7684\u76f8\u4f3c\u6027\u3002\u7814\u7a76\u4eba\u54e1\u4e5f\u63a8\u65b7\u62c9\u4e01\u7f8e\u6d32\u75ab\u60c5\u7684\u75c5\u6bd2\u682a\uff0c\u8ddf\u5728\u6771\u5357\u4e9e\u6d41\u884c\u7684\u75c5\u6bd2\u682a\u8f03\u70ba\u76f8\u4f3c\u3002<\/p>\n<p>\u5728\u9019\u500b\u7bc0\u9aa8\u773c\u4e0a\uff0c\u6211\u5011\u5c0d\u8332\u5361\u75c5\u6bd2\u6240\u77e5\u7684\u5be6\u5728\u592a\u5c11\u3002\u5230\u5e95\u8332\u5361\u75c5\u6bd2\u662f\u4e0d\u662f\u9020\u6210\u5c0f\u8166\u75c7\u7684\u5143\u51f6\uff0c\u9084\u9700\u8981\u66f4\u591a\u7684\u5be6\u9a57\u7d50\u679c\u4f86\u52a0\u4ee5\u4f50\u8b49\u3002\u4f46\u5728\u5c0f\u8166\u75c7\u80ce\u5152\u7684\u8166\u90e8\u7d44\u7e54\u4e2d\u5206\u96e2\u51fa\u5b8c\u6574\u7684\u75c5\u6bd2\u57fa\u56e0\u9ad4\uff0c\u4e0d\u557b\u662f\u5f37\u800c\u6709\u529b\u7684\u8b49\u64da\u4e4b\u4e00\u3002\u75ab\u60c5\u4e00\u7206\u767c\uff0c\u7e3d\u662f\u5982\u661f\u706b\u71ce\u539f\u822c\u8b93\u4eba\u63aa\u624b\u4e0d\u53ca\u3002\u4f46\u81e8\u5e8a\u91ab\u7642\u8207\u516c\u885b\u3001\u7814\u7a76\u4eba\u54e1\u7684\u5168\u529b\u6295\u5165\uff0c\u5e0c\u671b\u80fd\u8b93\u6211\u5011\u5c0d\u8332\u5361\u75c5\u6bd2\u591a\u4e00\u9ede\u4e86\u89e3\uff0c\u5728\u9632\u75ab\u5de5\u4f5c\u4e0a\u4e5f\u5c31\u66f4\u80fd\u4e0b\u5feb\u3001\u72e0\u3001\u6e96\u7684\u5224\u65b7\u3002<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><br \/>\n1. Mlakar J. et al. Zika Virus Associated with Microcephaly. N Engl J Med. 2016 Feb 10. PMID: 26862926<br \/>\n2. Rubin EJ, Greene MF, Baden LR. Zika Virus and Microcephaly. N Engl J Med. 2016 Feb 10. PMID: 26862812<br \/>\n3. Martines RB, et al. Notes from the Field: <a href=\"http:\/\/www.cdc.gov\/mmwr\/volumes\/65\/wr\/mm6506e1.htm\" target=\"_blank\" rel=\"noopener noreferrer\">Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses \u2014 Brazil, 2015<\/a>. Centers for Disease Control and Prevention. February 10, 2016.<br \/>\n4. de Paula Freitas B. et al. Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil. JAMA Ophthalmol. 2016 Feb 9. doi: 10.1001\/jamaophthalmol.2016.0267. PMID: 26865554<br \/>\n5. McCarthy M. Severe eye damage in infants with microcephaly is presumed to be due to Zika virus. BMJ. 2016 Feb 10;352:i855. doi: 10.1136\/bmj.i855. PMID: 26864344<\/p>\n<p><strong style=\"color: #000000;\"><span style=\"color: #333399;\">--<\/span><\/strong><br style=\"color: #000000;\" \/><strong style=\"color: #000000;\"><span style=\"color: #333399;\">\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u4e16\u754c\u885b\u751f\u7d44\u7e54\u767c\u4f48\u8b66\u8a0a\u7684\u540c\u6642\uff0c\u5404\u570b\u653f\u5e9c\u4e5f<\/p>\n","protected":false},"author":20,"featured_media":23877,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[2397,399,2398,2411,2396,1573],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/ss-160114-zika-birth-defect-brazil-05_c057f3fd811e1839d1d8e8cb24ebdc46.nbcnews-ux-1024-900.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/23870"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23870"}],"version-history":[{"count":5,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/23870\/revisions"}],"predecessor-version":[{"id":32503,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/23870\/revisions\/32503"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/23877"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23870"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}