{"id":23808,"date":"2016-02-24T00:57:11","date_gmt":"2016-02-23T16:57:11","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=23808"},"modified":"2018-08-02T14:21:01","modified_gmt":"2018-08-02T06:21:01","slug":"%e3%80%90%e5%9f%ba%e5%9b%a0%e7%a0%94%e7%a9%b6%e3%80%91%e5%b0%bc%e5%ae%89%e5%be%b7%e5%a1%94%e4%ba%badna%e5%8f%af%e8%83%bd%e5%bd%b1%e9%9f%bf%e4%ba%86%e6%88%91%e5%80%91%e7%9a%84%e5%81%a5%e5%ba%b7","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=23808","title":{"rendered":"\u3010\u57fa\u56e0\u7814\u7a76\u3011\u5c3c\u5b89\u5fb7\u5854\u4ebaDNA\u53ef\u80fd\u5f71\u97ff\u4e86\u6211\u5011\u7684\u5065\u5eb7\uff1f"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u79d1\u5b78\u5bb6\u767c\u73fe\uff0c\u73fe\u4ee3\u6b50\u6d32\u4eba\u548c\u4e9e\u6d32\u4eba\u90fd\u5e36\u6709\u5c3c\u5b89\u5fb7\u5854\u4ebaDNA\u6642\uff0c\u9707\u9a5a\u4e86\u5b78\u754c\u548c\u793e\u6703\uff0c\u53ef\u662f\u9019\u5e7e\u5e74\u904e\u53bb\uff0c\u5927\u5bb6\u90fd\u63a5\u53d7\u4e86\u9019\u500b\u4e8b\u5be6\u3002\u800c\u73fe\u5728\u53c8\u767c\u73fe\uff0c\u6211\u5011\u5e36\u6709\u7684\u5c3c\u5b89\u5fb7\u5854\u4ebaDNA\u53ef\u80fd\u5f71\u97ff\u4e86\u6211\u5011\u7684\u5065\u5eb7\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_23809\" aria-describedby=\"caption-attachment-23809\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-23809\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/0218-1024x768.jpg\" alt=\"Photo credit: Erich Ferdinand, CC BY 2.0\" width=\"450\" height=\"338\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/0218-1024x768.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/0218-300x225.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/0218-800x600.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/0218-600x450.jpg 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/0218.jpg 1269w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-23809\" class=\"wp-caption-text\">Photo credit: Erich Ferdinand, CC BY 2.0<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u9ec3\u8c9e\u7965<\/p>\n<p>\u73fe\u4ee3\u6b50\u6d32\u4eba\u548c\u4e9e\u6d32\u4eba\u5927\u6982\u5e36\u67091.5\uff05\u81f34\uff05\u7684\u5c3c\u5b89\u5fb7\u5783\u5854\u4ebaDNA\uff0c\u975e\u6d32\u4eba\u5247\u4e0d\u5e36\u6709\u5c3c\u5b89\u5fb7\u5854\u4eba\u7684DNA\u3002\u90a3\u4e9b\u5c3c\u5b89\u5fb7\u5854\u4ebaDNA\u53ef\u80fd\u5e6b\u52a9\u6211\u5011\u7684\u7956\u5148\u9069\u61c9\u65b0\u74b0\u5883\u3002\u4f46\u4e00\u9805\u65b0\u7814\u7a76\u537b\u986f\u793a\uff0c\u5c3c\u5b89\u5fb7\u5854\u4eba\u7684\u907a\u50b3\u8b8a\u7570\u53ef\u80fd\u548c\u589e\u52a0\u7f79\u60a3\u6182\u9b31\u75c7\u3001\u5fc3\u81df\u75c5\u3001\u904e\u654f\u8207\u5176\u4ed6\u75be\u75c5\u7684\u98a8\u96aa\u6709\u95dc\u3002<\/p>\n<p>\u79d1\u5b78\u5bb6\u6536\u96c6\u4e86\u5e7e\u500b\u5c3c\u5b89\u5fb7\u5854\u4eba\u3001\u4e00\u500b\u4e39\u5c3c\u7d22\u74e6\u4eba\u548c\u4e0a\u5343\u500b\u73fe\u4ee3\u4eba\u7684\u5168\u57fa\u56e0\u9ad4\u5e8f\u5217\uff0c\u9451\u5b9a\u51fa\u4e00\u842c\u5169\u5343\u500b\u5c3c\u5b89\u5fb7\u5854\u4eba\u7684\u907a\u50b3\u8b8a\u7570\u3002\u7f8e\u570b\u8303\u5fb7\u6bd4\u5927\u5b78\u7684\u6f14\u5316\u57fa\u56e0\u9ad4\u5b78\u5bb6 John Capra\u7b49\u4eba\u5206\u6790\u4e86\u5169\u842c\u516b\u5343\u4f4d\u6b50\u6d32\u88d4\u7f8e\u570b\u4eba\u7684DNA\u5e8f\u5217\u548c\u5065\u5eb7\u8a18\u9304\u96fb\u5b50\u8cc7\u6599\u5eab\u5f8c\uff0c\u767c\u73fe\u4f86\u81ea\u5c3c\u5b89\u5fb7\u5854\u4eba\u7684\u907a\u50b3\u8b8a\u7570\u4e9b\u5fae\u5730\u589e\u52a0\u4e86\u7f79\u60a3\u6182\u9b31\u75c7\u53ca\u5fc3\u81df\u75c5\u7684\u98a8\u96aa\u3002<!--more--><\/p>\n<p>\u5c3c\u5b89\u5fb7\u5854\u4eba\u907a\u50b3\u8b8a\u7570\u63d0\u9ad8\u4e861\uff05\u7f79\u60a3\u6182\u9b31\u75c7\u7684\u98a8\u96aa\uff0c\u4e0d\u904e\u67d0\u4e9b\u907a\u50b3\u8b8a\u7570\u537b\u964d\u4f4e\u4e86\u7f79\u60a3\u6182\u9b31\u75c7\u7684\u98a8\u96aa\uff1b\u53e6\u5916\uff0c\u5c3c\u5b89\u5fb7\u5854\u4eba\u907a\u50b3\u8b8a\u7570 \u4e5f\u53ef\u80fd\u63d0\u9ad8\u4e86\u5149\u5316\u6027\u89d2\u5316\u75c7\uff08actinic keratoses\uff09\u7684\u98a8\u96aa\uff0c\u90a3\u662f\u6700\u5e38\u898b\u7684\u4e00\u7a2e\u76ae\u819a\u764c\u75c7\u524d\u671f\u75c5\u7076\uff0c\u597d\u767c\u4e2d\u8001\u5e74\u4eba\uff0c\u8207\u9577\u6642\u9593\u7d2f\u7a4d\u7684\u967d\u5149\u66dd\u66ec\u50b7\u5bb3\u6709\u95dc\uff0c\u591a\u51fa\u73fe\u5728\u984f\u9762\u3001\u982d\u9838\u90e8\u3001\u524d\u81c2\u53ca\u624b\u80cc\u3002\u6b64\u5916\u5c3c\u5b89\u5fb7\u5854\u4eba\u907a\u50b3\u8b8a\u7570\u9084\u8ddf\u5c3f\u5931\u7981\u3001\u8180\u80f1\u75db\u7b49\u6ccc\u5c3f\u75be\u75c5\u76f8\u95dc\u3002\u96d6\u7136\u5c3c\u5b89\u5fb7\u5854\u907a\u50b3\u8b8a\u7570\u63d0\u9ad8\u4e86\u514d\u75ab\u529b\uff0c\u4f46\u662f\u5728\u73fe\u4ee3\u8f03\u885b\u751f\u7684\u751f\u6d3b\u4e2d\u537b\u53ef\u80fd\u9020\u6210\u4e86\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u3001\u767c\u708e\u548c\u904e\u654f\u3002<\/p>\n<p>Capra\u6307\u51fa\u90a3\u4e9b\u5c3c\u5b89\u5fb7\u5854\u4eba\u7684\u907a\u50b3\u8b8a\u7570\u975e\u5ea7\u843d\u5728\u57fa\u56e0\u5167\uff0c\u4f46\u53ef\u80fd\u5f71\u97ff\u4e86\u57fa\u56e0\u7684\u8868\u73fe\uff0c\u4f8b\u5982\u548c\u6182\u9b31\u75c7\u6709\u95dc\u7684\u907a\u50b3\u8b8a\u7570\u662f\u5728\u751f\u7406\u6642\u9418\u57fa\u56e0\u9644\u8fd1\u3002\u5176\u4ed6\u5c3c\u5b89\u5fb7\u5854\u4eba\u7684\u907a\u50b3\u8b8a\u7570\u53ef\u80fd\u5f71\u97ff\u4e86\u4eba\u5011\u7684\u83f8\u766e\u7b49\u7b49\u3002\u7814\u7a76\u767c\u8868\u5728\u300a\u79d1\u5b78\u300b(<em>Science)<\/em>\u3002<\/p>\n<p>\u5982\u679c\u5c3c\u5b89\u5fb7\u5854\u4eba\u7684\u907a\u50b3\u8b8a\u7570\u5c0d\u6211\u5011\u5065\u5eb7\u6709\u4e0d\u5229\u5f71\u97ff\uff0c\u70ba\u4f55\u4e0d\u88ab\u5929\u64c7\u6383\u9664\u800c\u907a\u7559\u8fc4\u4eca\u5462\uff1fCapra\u8a8d\u70ba\uff0c\u90a3\u53ef\u80fd\u662f\u56e0\u70ba\u6709\u4e9b\u907a\u50b3\u8b8a\u7570\u5728\u53e4\u4ee3\u662f\u6709\u5229\u7684\uff0c\u4f8b\u5982\u57fa\u56e0<em>SELP<\/em>\u7684\u6d3b\u6027\u63d0\u9ad8\u80fd\u5920\u5c0e\u81f4\u8840\u6813\uff0c\u53ef\u662f\u5728\u77f3\u5668\u6642\u4ee3\uff0c\u8a72\u57fa\u56e0\u80fd\u5920\u8b93\u53d7\u50b7\u7684\u4eba\u66f4\u5feb\u7652\u5408\u50b7\u53e3\u800c\u6709\u5229\u751f\u5b58\u3002\u800c\u63d0\u9ad8\u5149\u5316\u6027\u89d2\u5316\u75c7\u7684\u907a\u50b3\u8b8a\u7570\u5247\u53ef\u80fd\u662f\u70ba\u4e86\u8b93\u5c3c\u5b89\u5fb7\u5854\u4eba\u9069\u61c9\u6b50\u6d32\u7684\u77ed\u65e5\u7167\u3002<\/p>\n<p>\u9019\u4e9b\u767c\u73fe\u4e26\u975e\u610f\u5473\u8457\u5c3c\u5b89\u5fb7\u5854\u4eba\u7684\u907a\u50b3\u8b8a\u7570\u662f\u5c0e\u81f4\u75be\u75c5\u7684\u539f\u56e0\uff0c\u53ef\u80fd\u53ea\u662f\u5b83\u5011\u63a5\u8fd1\u771f\u5147\u800c\u88ab\u5075\u6e2c\u5230\u3002\u9019\u4e9b\u767c\u73fe\u6709\u52a9\u79d1\u5b78\u5bb6\u5f9eDNA\u4f86\u9810\u6e2c\u4eba\u985e\u7f79\u60a3\u75be\u75c5\u7684\u98a8\u96aa\uff0c\u4e26\u4e14\u77ad\u89e3\u6211\u5011\u7684\u7956\u5148\u662f\u5982\u4f55\u9069\u61c9\u65b0\u74b0\u5883\u3002<\/p>\n<p><strong>\u539f\u5b78\u8853\u8ad6\u6587\uff1a<\/strong><br \/>\nC.N. Simonti et al. The phenotypic legacy of admixture between modern humans and Neandertals. Science 12 Feb 2016: Vol. 351, Issue 6274, pp. 737-741. DOI: 10.1126\/science.aad2149<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><br \/>\n1. Ann Gibbons.<a href=\"http:\/\/www.sciencemag.org\/news\/2016\/02\/our-hidden-neandertal-dna-may-increase-risk-allergies-depression\" target=\"_blank\">Our hidden Neandertal DNA may increase risk of allergies, depressio.<\/a> Science. Feb. 11, 2016.\u00a0 DOI: 10.1126\/science.aaf4044<br \/>\n2. TINA HESMAN SAEY. <a href=\"https:\/\/www.sciencenews.org\/article\/neandertal-dna-may-raise-risk-some-modern-human-diseases\" target=\"_blank\">Neandertal DNA may raise risk for some modern human diseases. <\/a>Science News. FEBRUARY 11, 2016<br \/>\n3. Vanderbilt University. <a href=\"http:\/\/phys.org\/news\/2016-02-neanderthal-dna-subtle-significant-impact.html\" target=\"_blank\">Neanderthal DNA has subtle but significant impact on human trait. <\/a>Phys.org. February 11, 2016<\/p>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br style=\"color: #000000;\" \/><span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a<strong>\u9ec3\u8c9e\u7965 \u73fe\u4efb\u6559\u65bc\u570b\u7acb\u6e05\u83ef\u5927\u5b78\u5206\u5b50\u8207\u7d30\u80de\u751f\u7269\u7814\u7a76\u6240\u66a8\u751f\u547d\u79d1\u5b78\u7cfb\uff0c<wbr \/>\u5f9e\u4e8b\u9ce5\u985e\u7684\u6f14\u5316\u907a\u50b3\u5b78\u3001\u57fa\u56e0\u9ad4\u5b78\u53ca\u6f14\u5316\u767c\u80b2\u751f\u7269\u5b78\u7814\u7a76\u3002<wbr \/>\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u79d1\u5b78\u5bb6\u767c\u73fe\uff0c\u73fe\u4ee3\u6b50\u6d32\u4eba\u548c\u4e9e\u6d32\u4eba\u90fd\u5e36\u6709\u5c3c<\/p>\n","protected":false},"author":20,"featured_media":23809,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1026],"tags":[37,129,54,186,123,2387,1590],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2016\/02\/0218.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/23808"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23808"}],"version-history":[{"count":5,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/23808\/revisions"}],"predecessor-version":[{"id":32460,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/23808\/revisions\/32460"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/23809"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23808"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23808"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23808"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}