{"id":23628,"date":"2016-04-15T00:49:49","date_gmt":"2016-04-14T16:49:49","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=23628"},"modified":"2018-08-03T14:33:17","modified_gmt":"2018-08-03T06:33:17","slug":"%e3%80%90%e7%a0%94%e7%a9%b6%e8%b7%af%e4%b8%8a%e3%80%91%e9%97%9c%e6%96%bc%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e9%82%a3%e4%ba%9b%e9%98%b2%e4%b8%8d%e5%8b%9d%e9%98%b2%e7%9a%84%e5%82%b7%e5%bf%83%e4%ba%8b","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=23628","title":{"rendered":"\u3010\u7814\u7a76\u8def\u4e0a\u3011\u95dc\u65bc\u81e8\u5e8a\u8a66\u9a57\u90a3\u4e9b\u9632\u4e0d\u52dd\u9632\u7684\u50b7\u5fc3\u4e8b"},"content":{"rendered":"
\"\u6cd5\u570bBiotrial\u516c\u53f8\u5be6\u9a57\u5ba4\u3002\uff08Biotrial\u516c\u53f8\u7db2\u9801\uff09\"
\u6cd5\u570bBiotrial\u516c\u53f8\u5be6\u9a57\u5ba4\u3002\uff08Biotrial\u516c\u53f8\u7db2\u9801\uff09<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

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\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u5206\u70ba\u4e09\u671f\uff1b\u7b2c\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u76ee\u7684\u5f88\u55ae\u7d14\uff0c\u65e8\u5728\u62db\u52df\u5065\u5eb7\u7684\u5fd7\u9858\u8005\u4f86\u53c3\u8207\uff0c\u85c9\u7531\u6e2c\u8a66\u4e0d\u540c\u5291\u91cf\u7684\u7814\u767c\u65b0\u85e5\uff0c\u4f86\u89c0\u5bdf\u5be6\u9a57\u85e5\u7269\u5728\u5065\u5eb7\u4eba\u9ad4\u5167\u7684\u4ee3\u8b1d\u3001\u5438\u6536\u7b49\u5be6\u969b\u72c0\u6cc1\uff0c\u4e5f\u53ef\u4ee5\u540c\u6642\u89c0\u5bdf\u5be6\u9a57\u85e5\u7269\u662f\u4e0d\u662f\u5177\u6709\u6f5b\u5728\u7684\u526f\u4f5c\u7528\u3002\u7b2c\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57\u76f8\u5c0d\u65bc\u5176\u4ed6\u968e\u6bb5\u7684\u8a66\u9a57\u8981\u5b89\u5168\u8207\u53ef\u9810\u671f\u8a31\u591a\uff0c\u53d7\u8a66\u904e\u7a0b\u4e2d\u7684\u610f\u5916\u4e8b\u6545\u4e5f\u7f55\u6709\u8033\u805e\u3002<\/p>\n

\u800c2006\u5e74\u4e09\u6708\uff0c\u82f1\u570b\u502b\u6566\u51fa\u73fe\u4e00\u8d77\u5728\u7b2c\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u7684\u65b0\u85e5TGN1412\uff0c\u7576\u6642\u9020\u6210\u516d\u4f4d\u5065\u5eb7\u53d7\u8a66\u8005\u4f4f\u9662\uff0c\u5176\u4e2d\u81f3\u5c11\u56db\u4eba\u51fa\u73fe\u591a\u91cd\u5668\u5b98\u8870\u7aed\u75c7\u5019\u7fa4\u3002TGN1412\u662f\u4e00\u514d\u75ab\u88fd\u5291\uff0c\u7814\u767c\u7684\u6642\u5019\u5c07\u5b83\u8a2d\u8a08\u6210\u91dd\u5c0d\u514d\u75ab\u7d30\u80de\u7d30\u80de\u8868\u9762\u86cb\u767d\u8ceaCD28\u7684\u300c\u8d85\u7d1a\u6297\u9ad4\u300d\uff08Superantigen\uff09\u3002<\/p>\n

CD28\u86cb\u767d\u8cea\u8868\u73fe\u5728\u514d\u75ab\u7d30\u80deT\u7d30\u80de\u4e0a\uff1b\u4f86\u81eaCD28\u7684\u523a\u6fc0\u8a0a\u865f\uff0c\u662f\u8b93T\u7d30\u80de\u80fd\u5920\u7cbe\u78ba\u5224\u65b7\u60c5\u52e2\uff0c\u6c7a\u5b9a\u662f\u4e0d\u662f\u8981\u6d3b\u5316\u7684\u91cd\u8981\u95dc\u9375\u4e4b\u4e00\u3002\u5982\u679cT\u7d30\u80de\u53ea\u63a5\u6536\u5230\u5f9e\u300cT\u7d30\u80de\u53d7\u5668\u300d\uff08T cell receptors\uff09\u7684\u8a0a\u606f\uff0c\u800c\u6c92\u6709\u540c\u6642\u63a5\u6536\u5230\u4f86\u81eaCD28\u7684\u523a\u6fc0\u8a0a\u606f\uff0cT\u7d30\u80de\u5c31\u6703\u5c07\u9019\u6b21\u4e8b\u4ef6\u5224\u65b7\u70ba\u5047\u8b66\u5831\u800c\u4e0d\u4e88\u7406\u6703\u3002T\u7d30\u80de\u5fc5\u9808\u8981\u540c\u6642\u63a5\u6536\u5230\u4f86\u81eaT\u7d30\u80de\u53d7\u5668\u8207CD28\u7684\u523a\u6fc0\u624d\u80fd\u5920\u88ab\u6d3b\u5316\uff0c\u5728\u96d9\u91cd\u8a0a\u606f\u628a\u95dc\u4e0b\uff0c\u514d\u75ab\u7cfb\u7d71\u624d\u4e0d\u6703\u770b\u5230\u9ed1\u5f71\u5c31\u4e82\u958b\u69cd\u3002<\/p>\n

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\u4e00\u8f49\u773c\uff0cTGN1412\u7684\u610f\u5916\u5feb\u6eff\u5341\u5e74\u4e86\uff0c\u800c\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u53c8\u5728\u7b2c\u4e00\u671f\u767c\u751f\u4ee4\u4eba\u9707\u9a5a\u7684\u610f\u5916\u3002<\/p>\n

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FAAH\u5728\u4eba\u9ad4\u5167\u53ef\u4ee5\u5c07\u5167\u751f\u6027\u5927\u9ebb\u7d20\uff08endocannabinoids\uff09\u5206\u89e3\u6389\u3002\u60f3\u7576\u7136\u723e\uff0cFAAH\u7684\u6291\u5236\u5291\u53ef\u4ee5\u6e1b\u7de9\u5167\u751f\u6027\u5927\u9ebb\u7d20\u5728\u9ad4\u5167\u88ab\u4ee3\u8b1d\u6389\u7684\u901f\u5ea6\uff0c\u800c\u7d2f\u7a4d\u7684\u5167\u751f\u6027\u5927\u9ebb\u7d20\u5c31\u53ef\u4ee5\u7e7c\u7e8c\u300c\u767c\u63ee\u5176\u6240\u9577\u300d\uff0c\u6d3b\u5316\u4e0b\u6e38\u76f8\u95dc\u7684\u751f\u7406\u6a5f\u8f49\uff0c\u5f71\u97ff\u75bc\u75db\u3001\u60c5\u7dd2\u3001\u98df\u617e\uff0c\u751a\u81f3\u808c\u8089\u904b\u52d5\u7684\u63a7\u5236\u3002<\/p>\n

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\u4e0d\u82e5\u5916\u751f\u6027\u5927\u9ebb\u7d20\u4ee5\u300c\u4eba\u6d77\u6230\u8853\u300d\u4e4b\u59ff\u4f5c\u7528\u5728\u6574\u500b\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u4e0a\uff0c\u4eba\u9ad4\u5927\u8166\u4e2d\u5167\u751f\u6027\u5927\u9ebb\u7d20\u7cfb\u7d71\u7684\u8abf\u63a7\u8981\u7cbe\u7dfb\u8a31\u591a\uff0c\u5167\u751f\u6027\u5927\u9ebb\u7d20\u7684\u5408\u6210\u662f\u8d70\u300c\u5b8c\u5168\u5ba2\u88fd\u5316\u8a02\u55ae\u300d\u6a21\u5f0f\u3002\u4e5f\u5c31\u662f\u8aaa\uff0c\u5927\u8166\u53ea\u6709\u5728\u6709\u9700\u8981\u7684\u6642\u5019\uff0c\u624d\u6703\u555f\u52d5\u5167\u751f\u6027\u5927\u9ebb\u7d20\u7684\u5408\u6210\uff1b\u800c\u4e14\uff0c\u5728\u9019\u8abf\u7bc0\u6a21\u5f0f\u4e0b\u5408\u6210\u7684\u5167\u751f\u6027\u5927\u9ebb\u7d20\u53ef\u4ee5\u975e\u5e38\u5c08\u4e00\u5730\u5728\u9700\u8981\u7684\u300c\u6642\u9593\u300d\u8207\u300c\u8166\u5167\u5340\u57df\u300d\u88ab\u91cb\u653e\u3002\u800c\u9019\u4e5f\u8b93\u5167\u751f\u6027\u5927\u9ebb\u7d20\u7684\u8a0a\u606f\u50b3\u5c0e\u8def\u5f91\u6210\u70ba\u65b0\u85e5\u958b\u767c\u76ee\u6a19\u7684\u6700\u4f73\u5019\u9078\u89d2\u8272\u3002\u6291\u5236FAAH\uff0c\u5c31\u80fd\u5920\u6291\u5236\u5167\u751f\u6027\u5927\u9ebb\u7d20\u88ab\u6c34\u89e3\u800c\u4ee3\u8b1d\uff0c\u9032\u800c\u5fae\u8abf\u5167\u751f\u6027\u5927\u9ebb\u7d20\u8a0a\u606f\u50b3\u5c0e\u76f8\u95dc\u7684\u751f\u7406\u53cd\u61c9\u3002<\/p>\n

\u800c\u9019\u6b21\u51fa\u4e8b\u7684BIA 10- 2474\uff0c\u662f\u4e00FAAH\u6291\u5236\u5291\uff0c\u539f\u672c\u8a08\u5283\u5fb5\u6c42128\u4f4d\u5065\u5eb7\u6210\u5e74\u4eba\uff0818\u523055\u6b72\uff09\u53c3\u8207\u7b2c\u4e00\u671f\u81e8\u5e8a\u5be6\u9a57\u3002\u51fa\u4e8b\u524d\uff0c\u81e8\u5e8a\u8a66\u9a57\u5df2\u7d93\u9032\u884c\u4e00\u6bb5\u6642\u9593\uff0c\u4e26\u4e14\u5728\u5df2\u63a5\u53d7\u7d66\u85e5\u7684\u516b\u5341\u4eba\u4e2d\uff0c\u4e26\u6c92\u6709\u89c0\u5bdf\u5230\u91cd\u5927\u7684\u526f\u4f5c\u7528\u3002\u4f46\u4e00\u6708\u51fa\u4e8b\u7684\u516d\u4f4d\u53d7\u8a66\u8005\u662f\u7b2c\u4e00\u6279\u63a5\u53d7\u591a\u6b21\u7d66\u85e5\uff0c\u4e26\u4e14\u7d66\u85e5\u5291\u91cf\u4e5f\u9ad8\u65bc\u4e4b\u524d\u7684\u53d7\u8a66\u8005\u3002\u76ee\u524d\uff0c\u76f8\u95dc\u8cc7\u8a0a\u4ecd\u7136\u4e0d\u591a\uff0c\u5230\u5e95\u662f\u54ea\u4e00\u500b\u74b0\u7bc0\u51fa\u932f\u4ecd\u6709\u5f85\u76f8\u95dc\u55ae\u4f4d\u8207\u7814\u7a76\u5b78\u8005\u7684\u6295\u5165\u3002<\/p>\n

BIA 10-2474\u4e26\u4e0d\u662f\u81e8\u5e8a\u4e0a\u88ab\u7814\u767c\u51fa\u4f86\u7684\u7b2c\u4e00\u652fFAAH\u6291\u5236\u5291\uff0c\u5176\u4ed6\u570b\u969b\u5927\u85e5\u5ee0\uff0c\u50cf\u662f\u9ed8\u514b\u8207\u8f1d\u745e\u4e5f\u90fd\u66fe\u4e3b\u6301\u904e\u76f8\u95dc\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\uff0c\u4e26\u4e14\u6c92\u6709\u51fa\u73fe\u904e\u985e\u4f3c\u7684\u526f\u4f5c\u7528\uff1b\u6697\u793a\u5fae\u8abf\u5927\u8166\u88e1\u5167\u751f\u6027\u5927\u9ebb\u7d20\u7684\u6fc3\u5ea6\uff0c\u5728\u904e\u5f80\u81e8\u5e8a\u7d93\u9a57\u4e0a\uff0c\u6216\u8a31\u4e0d\u81f3\u65bc\u6709\u91cd\u5927\u526f\u4f5c\u7528\u3002\u4f46\u5728\u8abf\u67e5\u524d\u7d50\u679c\u660e\u6717\u524d\uff0c\u6240\u6709\u7684\u5047\u8a2d\u7562\u7adf\u53ea\u662f\u63e3\u60f3\uff0c\u771f\u76f8\u5982\u4f55\uff0c\u53ea\u80fd\u7b49\u5f85\u62bd\u7d72\u525d\u7e6d\u5f8c\u7684\u7d50\u679c\u4e86\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong>
\n1. Declan Butler& Ewen Callaway. Scientists in the dark after French clinical trial proves fatal.<\/a> Nature News. <\/em>18 January 2016.
\n<\/a>2. Martin Enserink. More details emerge on fateful French drug trial.<\/a> Science.<\/em> 16 January 2016.
\n<\/a>3. Martin Enserink. What we know so far about the clinical trial disaster in France.<\/a> Science.<\/em> 15 January 2016.
\n4. Fowler CJ. The Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review. Handb Exp Pharmacol.<\/em> 2015;231:95-128. doi: 10.1007\/978-3-319-20825-1_4. Review. PMID: 26408159
\n5. Lau BK, Vaughan CW. Targeting the endogenous cannabinoid system to treat neuropathic pain. Front Pharmacol. <\/em>2014 Mar 3;5:28. doi: 10.3389\/fphar.2014.00028. eCollection 2014.<\/p>\n

--<\/span><\/strong>
\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/span><\/strong><\/p>\n

 <\/p>\n

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