{"id":23168,"date":"2015-12-16T00:15:31","date_gmt":"2015-12-15T16:15:31","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=23168"},"modified":"2018-08-01T16:38:13","modified_gmt":"2018-08-01T08:38:13","slug":"%e3%80%90%e5%9f%ba%e5%9b%a0%e7%a0%94%e7%a9%b6%e3%80%91%e7%94%b7%e4%ba%ba%e7%9a%84%e9%ab%94%e9%87%8d%e6%94%b9%e8%ae%8a%e4%ba%86%e7%b2%be%e5%ad%90dna","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=23168","title":{"rendered":"\u3010\u57fa\u56e0\u7814\u7a76\u3011\u7537\u4eba\u7684\u9ad4\u91cd\u6539\u8b8a\u4e86\u7cbe\u5b50DNA"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u7537\u4eba\u771f\u7684\u8981\u6ce8\u610f\u81ea\u5df1\u7684\u8170\u570d\u4e86\uff0c\u56e0\u70ba\u6709\u79d1\u5b78\u8b49\u64da\u986f\u793a\uff0c\u7537\u4eba\u7684\u9ad4\u91cd\u6703\u5f71\u97ff\u7cbe\u5b50\u7684\u57fa\u56e0\u6d3b\u6027\uff0c\u9032\u800c\u907a\u50b3\u7d66\u5b69\u5b50\uff0c\u6c7a\u5b9a\u4ed6\u5011\u672a\u4f86\u904e\u91cd\u7684\u6a5f\u7387\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_23170\" aria-describedby=\"caption-attachment-23170\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-23170\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/12-mitos-dan-fakta-tentang-kesuburan-pria.jpg\" alt=\"\u00a9Thinkstock photos\/ Getty Images\" width=\"450\" height=\"225\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/12-mitos-dan-fakta-tentang-kesuburan-pria.jpg 670w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/12-mitos-dan-fakta-tentang-kesuburan-pria-300x150.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/12-mitos-dan-fakta-tentang-kesuburan-pria-600x300.jpg 600w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-23170\" class=\"wp-caption-text\">\u00a9Thinkstock photos\/ Getty Images<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u9ec3\u8c9e\u7965<\/p>\n<p>\u4e39\u9ea5\u54e5\u672c\u54c8\u6839\u5927\u5b78\u7684Romain Barr\u00e8s\u7b49\u4eba\u5229\u7528\u8868\u89c0\u907a\u50b3\u5b78\u7684\u65b9\u6cd5\uff08epigenetics\uff0c\u53c8\u8b6f\u70ba\u300c\u8868\u5fb5\u907a\u50b3\u5b78\u300d\u3001\u300c\u64ec\u907a\u50b3\u5b78\u300d\u3001\u300c\u8868\u907a\u50b3\u5b78\u300d\u3001\u300c\u5916\u907a\u50b3\u5b78\u300d\u4ee5\u53ca\u300c\u5f8c\u907a\u50b3\u5b78\u300d\uff09\uff0c\u767c\u73fe\u9ad4\u91cd\u4e0d\u540c\u7684\u7537\u4eba\uff0c\u4ed6\u5011\u7684\u7cbe\u5b50\u4e0a\u7684\u5316\u5b78\u4fee\u98fe\u4e5f\u6709\u6240\u4e0d\u540c\u3002\u8868\u89c0\u907a\u50b3\u5b78\u7814\u7a76\u7684\u662f\u5728\u4e0d\u6539\u8b8aDNA\u5e8f\u5217\u7684\u524d\u63d0\u4e0b\uff0c\u901a\u904e\u67d0\u4e9b\u6a5f\u5236\u5f15\u8d77\u53ef\u907a\u50b3\u7684\u57fa\u56e0\u8868\u73fe\u6216\u8868\u73fe\u578b\u7684\u8b8a\u5316\u3002<\/p>\n<p>\u9577\u671f\u4ee5\u4f86\u7684\u4e00\u4e9b\u89c0\u5bdf\u5df2\u767c\u73fe\u7236\u6bcd\u7684\u9ad4\u91cd\u5c0d\u5f8c\u4ee3\u6709\u9577\u9060\u7684\u5f71\u97ff\u3002\u5728\u4e8c\u6230\u6642\u7531\u65bc\u5fb7\u8ecd\u7684\u98df\u7269\u525d\u596a\uff0c\u57281944\u5e74\u8377\u862d\u9951\u9913\u7684\u51ac\u5929\u4e2d\u61f7\u5b55\u7684\u6bcd\u89aa\uff0c\u751f\u4e0b\u7684\u5152\u5973\u548c\u5b6b\u5152\u5973\uff0c\u66f4\u5bb9\u6613\u7f79\u60a3\u5fc3\u81df\u75c5\u3001\u7cd6\u5c3f\u75c5\u548c\u80a5\u80d6\uff1b\u5be6\u9a57\u4e5f\u767c\u73fe\u71df\u990a\u4e0d\u826f\u7684\u5b55\u9f20\uff0c\u5f8c\u4ee3\u66f4\u5bb9\u6613\u7f79\u60a3\u7cd6\u5c3f\u75c5\uff0c\u5176\u4e2d\u96c4\u6027\u5f8c\u4ee3\u7684\u7cbe\u5b50\u4e5f\u6709\u4e86\u8868\u89c0\u907a\u50b3\u7684\u6539\u8b8a\uff0c\u8b93\u5b6b\u5b50\u5bb9\u6613\u7f79\u60a3\u7cd6\u5c3f\u75c5\uff1b\u800c\u904e\u80d6\u7684\u96c4\u9f20\u548c\u5065\u5eb7\u7684\u6bcd\u9f20\u751f\u4e0b\u7684\u5f8c\u4ee3\uff0c\u4e5f\u8f03\u5bb9\u6613\u7f79\u60a3\u7cd6\u5c3f\u75c5\u3002\u9019\u4e9b\u8868\u89c0\u907a\u50b3\u7684\u6539\u8b8a\u539f\u672c\u662f\u70ba\u4e86\u8981\u901a\u77e5\u5f8c\u4ee3\u98df\u7269\u7684\u77ed\u7f3a\u8207\u5426\uff0c\u53ef\u662f\u537b\u5728\u98df\u7269\u8c50\u88d5\u6642\u9020\u6210\u5f8c\u4ee3\u7684\u4ee3\u8b1d\u554f\u984c\u3002<!--more--><\/p>\n<p>Romain Barr\u00e8s\u7b49\u4eba\u6536\u96c6\u4e8613\u4f4d\u82d7\u689d\u7684\u7537\u4eba\uff08BMI\u4e2d\u503c\u70ba23\uff09\u4ee5\u53ca10\u4f4d\u904e\u80a5\u7684\u7537\u4eba\uff08BMI\u4e2d\u503c\u70ba32\uff09\u7684\u7cbe\u5b50\uff0c\u7136\u5f8c\u89c0\u5bdf\u90a3\u4e9b\u7cbe\u5b50\u88e1\u7684\u8868\u89c0\u907a\u50b3\u6a19\u8a18\u3002\u4ed6\u5011\u767c\u73fe\u5169\u7a2e\u8868\u89c0\u907a\u50b3\u6a19\u8a18\uff0c\u7121\u8ad6\u662f\u5c0f\u7247\u6bb5\u975e\u7de8\u78bcRNA\uff08small non-coding RNA\uff09\uff0c\u9084\u662fDNA\u7684\u7532\u57fa\u5316\uff0c\u5169\u7d44\u90fd\u6709\u986f\u8457\u5dee\u7570\u3002\u57fa\u56e0\u7684\u7532\u57fa\u5316\u6c7a\u5b9a\u4e86\u57fa\u56e0\u7684\u8868\u73fe\u8207\u5426\uff0c\u4ed6\u5011\u767c\u73fe\u6709\u8d85\u904e\u4e5d\u5343\u500b\u57fa\u56e0\u90fd\u6709\u4e86\u7532\u57fa\u5316\u7684\u8b8a\u5316\uff0c\u5176\u4e2d\u8a31\u591a\u57fa\u56e0\u548c\u8166\u767c\u80b2\u3001\u80c3\u53e3\u548c\u4ee3\u8b1d\u76f8\u95dc\u3002\u4f8b\u5982\u4ed6\u5011\u767c\u73fe\u5728\u904e\u91cd\u7537\u4eba\u7cbe\u5b50\u4e2d\uff0c\u8abf\u63a7\u5f71\u97ff\u80c3\u53e3\u7684\u57fa\u56e0<em>CART<\/em>\u7684\u5c0f\u7247\u6bb5\u975e\u7de8\u78bcRNA\u91cf\u8f03\u9ad8\uff0c<\/p>\n<p>\u70ba\u4e86\u77ad\u89e3\u6e1b\u91cd\u662f\u5426\u4e5f\u6703\u5f71\u97ff\u7cbe\u5b50\u7684\u8868\u89c0\u907a\u50b3\u6a19\u8a18\uff0c\u4ed6\u5011\u5f9e\u516d\u4f4d\u9032\u884c\u904e\u80c3\u5206\u6d41\u624b\u8853\u7684\u7537\u4eba\uff0c\u5206\u5225\u53d6\u5f97\u624b\u8853\u4e00\u9031\u5f8c\u548c\u4e00\u5e74\u5f8c\u7684\u7cbe\u5b50\u3002\u4ed6\u5011\u767c\u73fe\u67091,509\u500b\u57fa\u56e0\uff0c\u5728\u624b\u8853\u4e00\u9031\u5f8c\u5c31\u6709\u4e86\u986f\u8457\u7684\u7532\u57fa\u5316\u8b8a\u5316\uff0c\u4e00\u5e74\u5f8c\u67093,910\u500b\u57fa\u56e0\u6709\u4e86\u8b8a\u5316\u3002\u5176\u4e2d\u7d0440\uff05\u7684\u57fa\u56e0\u5728\u80d6\u7626\u7537\u4eba\u7684\u6bd4\u8f03\u4e2d\u4e5f\u6709\u5dee\u7570\u3002<\/p>\n<p>\u96d6\u7136\u9019\u500b\u7814\u7a76\u7684\u7d50\u679c\u610f\u7fa9\u91cd\u5927\uff0c\u53ef\u662f\u7531\u65bc\u6a23\u672c\u6578\u4e0d\u5920\u591a\uff0c\u672a\u4f86\u6050\u6015\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\uff0c\u624d\u80fd\u78ba\u7acb\u9019\u500b\u8da8\u52e2\u662f\u5426\u53ef\u518d\u73fe\uff0c\u4e26\u4e14\u4e5f\u9700\u8981\u66f4\u591a\u7814\u7a76\u4f86\u77ad\u89e3\u90a3\u4e9b\u8868\u89c0\u907a\u50b3\u8b8a\u5316\u662f\u5426\u771f\u7684\u6703\u5f71\u97ff\u5f8c\u4ee3\u7684\u751f\u7406\u3002<\/p>\n<figure id=\"attachment_23169\" aria-describedby=\"caption-attachment-23169\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-23169\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/1207-1024x1024.jpg\" alt=\"\u80a5\u80d6\u548c\u98df\u9053\u5206\u6d41\u624b\u8853\u6539\u8b8a\u4e86\u7cbe\u5b50\u7684\u8868\u89c0\u907a\u50b3\u6a19\u8a18\uff08Donkin and Versteyhe et al. Cell Metabolism. DOI: 10.1016\/j.cmet.2015.11.004\uff09\" width=\"650\" height=\"649\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/1207-1024x1024.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/1207-150x150.jpg 150w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/1207-300x300.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/1207-800x799.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/1207.jpg 1192w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption id=\"caption-attachment-23169\" class=\"wp-caption-text\">\u80a5\u80d6\u548c\u98df\u9053\u5206\u6d41\u624b\u8853\u6539\u8b8a\u4e86\u7cbe\u5b50\u7684\u8868\u89c0\u907a\u50b3\u6a19\u8a18\uff08Donkin and Versteyhe et al. Cell Metabolism. DOI: 10.1016\/j.cmet.2015.11.004\uff09<\/figcaption><\/figure>\n<p><strong>\u539f\u5b78\u8853\u8ad6\u6587\uff1a<\/strong><br \/>\nDonkin and Versteyhe et al.: \"<a href=\"http:\/\/dx.doi.org\/10.1016\/j.cmet.2015.11.004\" target=\"_blank\" rel=\"noopener noreferrer\">Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans<\/a>\" Cell Metabolism. DOI: 10.1016\/j.cmet.2015.11.004<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><br \/>\n1. Gretchen Vogel. <a href=\"http:\/\/news.sciencemag.org\/biology\/2015\/12\/weight-gain-and-loss-can-alter-men-s-sperm\" target=\"_blank\" rel=\"noopener noreferrer\">Weight gain\u2014and loss\u2014can alter men\u2019s sperm.<\/a> Science| DOI: 10.1126\/science.aad7516. 3 December 2015.<br \/>\n2. Carl Zimmer.<a href=\"http:\/\/www.nytimes.com\/2015\/12\/08\/science\/parents-may-pass-down-more-than-just-genes-study-suggests.html\" target=\"_blank\" rel=\"noopener noreferrer\"> Parents May Pass Down More Than Just Genes, Study Suggests<\/a>. New York Times. 3 December 2015.<br \/>\n3. Andy Coghlan. <a href=\"https:\/\/www.newscientist.com\/article\/dn28622-obese-men-found-to-make-sperm-with-thousands-of-modified-genes\/\" target=\"_blank\" rel=\"noopener noreferrer\">Obese men found to make sperm with thousands of modified genes. <\/a>New Scientist. 3 December 2015.<\/p>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br style=\"color: #000000;\" \/><span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u9ec3\u8c9e\u7965 \u73fe\u65bc\u53f0\u7063\u4e2d\u592e\u7814\u7a76\u9662\u751f\u7269\u591a\u6a23\u6027\u7814\u7a76\u4e2d\u5fc3\u64d4\u4efb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff0c\u5f9e\u4e8b\u9ce5\u985e\u7684\u6f14\u5316\u907a\u50b3\u5b78\u3001\u57fa\u56e0\u9ad4\u5b78\u53ca\u6f14\u5316\u767c\u80b2 \u751f\u7269\u5b78\u7814\u7a76\u3002\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u7537\u4eba\u771f\u7684\u8981\u6ce8\u610f\u81ea\u5df1\u7684\u8170\u570d\u4e86\uff0c\u56e0\u70ba\u6709\u79d1\u5b78<\/p>\n","protected":false},"author":20,"featured_media":23170,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[2262,37,2260,2261,1590],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/12\/12-mitos-dan-fakta-tentang-kesuburan-pria.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/23168"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23168"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/23168\/revisions"}],"predecessor-version":[{"id":32414,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/23168\/revisions\/32414"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/23170"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23168"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23168"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23168"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}