{"id":23113,"date":"2015-12-04T00:22:11","date_gmt":"2015-12-03T16:22:11","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=23113"},"modified":"2018-08-01T16:43:16","modified_gmt":"2018-08-01T08:43:16","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%a0%94%e7%a9%b6%e3%80%91%e6%8d%b2%e5%9c%9f%e9%87%8d%e4%be%86%e7%9a%84%e9%b3%b6%e5%b0%be%e7%b4%a0-irisin-2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=23113","title":{"rendered":"\u3010\u91ab\u5b78\u7814\u7a76\u3011\u6372\u571f\u91cd\u4f86\u7684\u9cf6\u5c3e\u7d20( Irisin)"},"content":{"rendered":"

\u25a0\u904b\u52d5\u8cc0\u723e\u8499\u9cf6\u5c3e\u7d20(Irisin)\u662f\u4e0d\u662f\u771f\u7684\u5b58\u5728\u5462\uff1f<\/strong><\/span><\/p>\n

\"CC0
CC0 Public Domain<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

\u5728\u7814\u7a76\u9818\u57df\u88e1\u6253\u6efe\u591a\u5e74\uff0c\u89ba\u5f97\u505a\u79d1\u5b78\u88e1\u6700\u5feb\u6a02\u7684\u4e8b\u60c5\u5c31\u662f\u8207\u4eba\u4ea4\u6d41\u7684\u904e\u7a0b\u3002\u7814\u7a76\u5ba4\u88e1\u6cf0\u534a\u7684\u6642\u9593\u90fd\u662f\u5b64\u7368\u7684\uff0c\u4f46\u7814\u7a76\u6210\u679c\u537b\u5f97\u5728\u8ddf\u4e0d\u540c\u610f\u898b\u7684\u4ea4\u6d41\u3001\u6fc0\u76ea\u4e4b\u5f8c\uff0c\u624d\u80fd\u5728\u8faf\u8b49\u7684\u904e\u7a0b\u88e1\u751f\u6839\u767c\u82bd\u3002\u79d1\u5b78\u4e0a\u7684\u7a81\u7834\uff0c\u4e00\u76f4\u662f\u88ab\u7814\u7a76\u4eba\u54e1\u6240\u51dd\u805a\u7684\u5171\u8b58\u63a8\u8457\u8d70\u3002\u4f46\u5076\u723e\uff0c \u6709\u4e9b\u7099\u706b\u53ef\u71b1\u7684\u79d1\u5b78\u7814\u7a76\u5728\u5404\u5be6\u9a57\u5ba4\u4e4b\u9593\u5f15\u7206\u7684\u653b\u9632\uff0c\u9664\u4e86\u63ed\u9732\u4e86\u5c0d\u65b9\u7684\u76f2\u9ede\uff0c\u8b93\u65c1\u89c0\u8005\u53ef\u4ee5\u5728\u4e00\u7aba\u5c40\u5167\u4eba\u7684\u5c08\u696d\u898b\u89e3\u6642\u9577\u4e86\u898b\u8b58\uff0c\u66f4\u6210\u5c31\u4e86\u4e00\u4e9b\u6709\u8da3\u7684\u597d\u6545\u4e8b\u3002<\/p>\n

\u800cIrisin\u9019\u500b\u4ee5\u5e0c\u81d8\u5973\u795eIris\u547d\u540d\uff0c\u5728\u904b\u52d5\u5f8c\u7531\u808c\u8089\u7d30\u80de\u6240\u5206\u6ccc\u7684\u8cc0\u723e\u8499\uff0c\u6b63\u662f\u9019\u6a23\u4e00\u500b\u6545\u4e8b\u3002<\/p>\n

\u904b\u52d5\u5c0d\u5065\u5eb7\u7684\u597d\u8655\u662f\u4e0d\u52dd\u679a\u8209\u3002\u800c\u54c8\u4f5b\u5927\u5b78Spiegelman\u6559\u6388\u7684\u5be6\u9a57\u5ba4\uff0c\u4e00\u76f4\u5c0d\u9019\u500b\u8209\u4e16\u6df1\u4fe1\u4e0d\u7591\u7684\u572d\u81ec\u80cc\u5f8c\u904b\u4f5c\u7684\u5206\u5b50\u6a5f\u5236\u611f\u5230\u597d\u5947\uff1b\u4ed6\u6700\u597d\u5947\u7684\u662f\uff0c\u70ba\u4ec0\u9ebc\u904b\u52d5\u53ef\u4ee5\u4fc3\u4f7f\u88ab\u66b1\u7a31\u70ba\u300c\u80a5\u80d6\u6bba\u624b\u300d\u7684\u68d5\u8272\u8102\u80aa\u589e\u52a0\u3002Spiegelman\u6559\u6388\u5047\u8a2d\uff0c\u904b\u52d5\u6642\u6216\u904b\u52d5\u5f8c\uff0c\u808c\u8089\u7d30\u80de\u6703\u56e0\u800c\u88ab\u523a\u6fc0\u800c\u751f\u7522\u4e00\u4e9b\u7279\u5225\u7684\u86cb\u767d\u8cea\uff0c\u800c\u9019\u4e9b\u86cb\u767d\u8cea\u53ef\u4ee5\u7e7c\u800c\u5f15\u8d77\u4e0b\u6e38\u7684\u751f\u7406\u53cd\u61c9\uff0c\u800c\u8a98\u4f7f\u9020\u6210\u80a5\u80d6\u7684\u5143\u51f6\u300c\u767d\u8272\u8102\u80aa\u300d\uff0c\u8f49\u8b8a\u6210\u5c0d\u6297\u80a5\u80d6\u6700\u6709\u6548\u7684\u751f\u529b\u8ecd\u300c\u597d\u8102\u80aa\u300d\uff0c\u4e5f\u5c31\u662f\u68d5\u8272\u8102\u80aa\u3002<\/p>\n

\u90a3\u6642\u5019\uff0c\u5b78\u8853\u5708\u5df2\u6709\u5927\u81f4\u7684\u5171\u8b58\uff0c\u8a8d\u70ba\u904b\u52d5\u6240\u5e36\u4f86\u6709\u76ca\u5065\u5eb7\u7684\u597d\u8655\uff0c\u591a\u534a\u8ddf\u4e00\u500b\u8f49\u9304\u5171\u6d3b\u5316\u56e0\u5b50PGC1-\u03b1\u76f8\u95dc\u3002PGC1-\u03b1\u5728\u808c\u8089\u7d30\u80de\u3001\u8102\u80aa\u7d30\u80de\uff0c\u8207\u8a31\u591a\u5176\u4ed6\u4e0d\u540c\u5f62\u614b\u7684\u7d30\u80de\u88e1\uff0c\u90fd\u4e3b\u5c0e\u8457\u8ddf\u80fd\u91cf\u4ee3\u8b1d\u76f8\u95dc\u7684\u751f\u7406\u53cd\u61c9\u3002\u5728\u904b\u52d5\u4e4b\u5f8c\uff0c\u808c\u8089\u7d30\u80de\u7684PGC1-\u03b1\u86cb\u767d\u8cea\u8868\u73fe\u91cf\u6703\u589e\u52a0\u3002\u800c\u4e14\uff0c\u7576\u7814\u7a76\u4eba\u54e1\u5229\u7528\u57fa\u56e0\u8f49\u6b96\u6280\u8853\uff0c\u4f7f\u5c0f\u9f20\u808c\u8089\u7d30\u80de\u5167\u7684PGC1-\u03b1\u8868\u73fe\u91cf\u5347\u9ad8\u4e4b\u5f8c\uff0c\u9019\u4e9b\u5c0f\u9f20\u4e5f\u90fd\u4e0d\u6613\u80a5\u80d6\u6216\u662f\u7f79\u60a3\u7cd6\u5c3f\u75c5\u7b49\u4ee3\u8b1d\u75be\u75c5\u3002\u56e0\u6b64\uff0cSpiegelman\u6559\u6388\u6c7a\u5b9a\u5f9eSpiegelman\u6559\u6388\u8457\u624b\uff0c\u4ed6\u60f3\u8981\u627e\u51fa\u8f49\u9304\u5171\u6d3b\u5316\u56e0\u5b50PGC1-\u03b1\u6240\u8a98\u5c0e\u8868\u73fe\u7684\u4e0b\u6e38\u57fa\u56e0\u6709\u54ea\u4e9b\uff0c\u7136\u5f8c\u5f9e\u4e2d\u7be9\u9078\u51fa\u80fd\u8b93\u68d5\u8272\u8102\u80aa\u5728\u904b\u52d5\u5f8c\u589e\u751f\u7684\u95dc\u9375\u300c\u8a0a\u865f\u50b3\u905e\u4f7f\u8005\u300d\u662f\u8ab0\u3002<\/p>\n

2012\u5e74\u6642\uff0cSpiegelman\u6559\u6388\u7684\u5be6\u9a57\u5ba4\u5728Nature<\/em>\u671f\u520a\u767c\u8868\u4e86\u6700\u65b0\u7684\u7814\u7a76\u6210\u679c\u3002\u4ed6\u5011\u767c\u73fe\u904b\u52d5\u5f8c\uff0cPGC1-\u03b1\u6703\u6d3b\u5316\uff0c\u4f7f\u53e6\u4e00\u500b\u86cb\u767d\u8ceaFNDC5\u7684\u8868\u73fe\u91cf\u589e\u52a0\u3002FNDC5\u662f\u4e00\u500b\u819c\u86cb\u767d\uff0c\u8868\u73fe\u5728\u7d30\u80de\u819c\u4e0a\u3002\u800c\u6709\u8da3\u7684\u662f\uff0c\u7576\u808c\u8089\u7d30\u80de\u5167FNDC5\u7684\u8868\u73fe\u91cf\u589e\u52a0\u6642\uff0c\u767d\u8272\u8102\u80aa\u4e5f\u540c\u6642\u6703\u6d3b\u5316\u4e00\u7cfb\u5217\u7684\u57fa\u56e0\u8868\u9054\uff0c\u555f\u52d5\u8b93\u81ea\u5df1\u8b8a\u8eab\u70ba\u68d5\u8272\u8102\u80aa\u7684\u5206\u5316\u53cd\u61c9\u3002Spiegelman\u5be6\u9a57\u5ba4\u9032\u800c\u767c\u73fe\uff0c\u9019\u662f\u56e0\u70ba\u5728\u904b\u52d5\u4e4b\u5f8c\uff0c\u6703\u4fc3\u4f7f\u808c\u8089\u7d30\u80de\u8868\u73fe\u5728\u7d30\u80de\u819c\u4e0a\u7684FNDC5\u88ab\u86cb\u767d\u9176\u5206\u89e3\uff0c\u5c07\u7d50\u69cb\u4e2d\u7684\u5176\u4e2d\u4e00\u500b\u7247\u6bb5\u88ab\u5206\u89e3\u91cb\u653e\u51fa\u4f86\uff0c\u5206\u6ccc\u5230\u7d30\u80de\u5916\u3002\u7814\u7a76\u5718\u968a\u5c07\u9019\u500b\u808c\u8089\u7d30\u80de\u6240\u5206\u6ccc\u7684\u808c\u7d30\u80de\u56e0\u5b50\uff0c\u547d\u540d\u70ba\u300cIrisin\u300d\u3002\u5728\u5e0c\u81d8\u53e4\u8001\u795e\u8a71\u88e1\uff0cIris\u662f\u8af8\u795e\u9593\u7684\u4fe1\u4f7f\uff0c\u5f80\u8fd4\u65bc\u5929\u4e0a\u4eba\u9593\uff0c\u5e38\u5316\u8eab\u70ba\u5f69\u8679\u5c07\u5584\u826f\u7684\u9748\u9b42\u5e36\u56de\u5929\u4e0a\u3002\u5728Spiegelman\u6559\u6388\u7684\u5be6\u9a57\u6a21\u578b\u88e1\uff0c\u904b\u52d5\u5f8c\uff0c\u808c\u8089\u7d30\u80de\u6240\u5206\u6ccc\u7684\u8cc0\u723e\u8499\u300cIrisin\u300d\uff0c\u4e5f\u5728\u808c\u8089\u7d30\u80de\u8207\u8102\u80aa\u7d30\u80de\u9593\u626e\u6f14\u8457\u4fe1\u5dee\u7684\u89d2\u8272\uff0c\u8b93\u767d\u8272\u8102\u80aa\u8f49\u5316\u70ba\u4ee5\u6d88\u8017\u80fd\u91cf\u70ba\u8077\u5fd7\u7684\u68d5\u8272\u8102\u80aa\u3002<\/p>\n

\u4f46\u662f\u9019\u7bc7\u8ad6\u6587\u767c\u8868\u5f8c\uff0c\u537b\u5f15\u8d77\u8ed2\u7136\u5927\u6ce2\u3002\u5148\u662f\u6709\u5be6\u9a57\u5ba4\u6295\u66f8\u8868\u793a\uff0c\u904b\u52d5\u5f8c\u88ab\u6d3b\u5316\u7684\u57fa\u56e0\u591a\u9054\u4e0a\u5343\u500b\uff0c\u800c\u5728\u53d7\u6e2c\u8a66\u7684\u5e74\u8f15\u7537\u6027\u8eab\u4e0a\uff0c\u4e0d\u662f\u6240\u6709\u7684\u53d7\u8a66\u8005\u90fd\u80fd\u5920\u5075\u6e2c\u5230\u986f\u8457\u7684Irisin\u8868\u73fe\u3002\u5f8c\u4f86\u6709\u5be6\u9a57\u6307\u51fa\uff0c\u574a\u9593\u7528\u4f86\u5075\u6e2cIrisin\u8868\u73fe\u91cf\u7684\u6297\u9ad4\uff0c\u5176\u5c08\u4e00\u6027\u6709\u5f85\u5546\u69b7\uff0c\u9019\u6216\u8a31\u6703\u8b93\u8840\u6db2\u4e2d\u7684Irisin\u6fc3\u5ea6\u5b9a\u91cf\u906d\u5230\u8aa4\u5224\u3002\u50cf\u662f\u9019\u4e9b\u6311\u6230\u90fd\u9084\u4e0d\u5920\u8b93Spiegelman\u5be6\u9a57\u5ba4\u51b7\u6c57\u76f4\u5192\u4f3c\u7684\uff0c\u5f8c\u4f86\u53c8\u6709\u5be6\u9a57\u5ba4\u767c\u73fe\uff0c\u9664\u4e86\u4eba\u985e\u4e4b\u5916\u7684\u5176\u4ed6\u54fa\u4e73\u985e\u52d5\u7269\uff0c\u90fd\u7528ATG\u9019\u500b\u6700\u5178\u578b\u7684\u8d77\u59cb\u5bc6\u78bc\u5b50\uff08start codon\uff09\u4f86\u555f\u52d5FNDC5\u819c\u86cb\u767d\u7684\u8868\u73fe\u3002\u4f46\u662f\u5728\u4eba\u985e\u8eab\u4e0a\uff0c\u537b\u5728\u8d77\u59cb\u5bc6\u78bc\u5b50\u4e0a\u6709\u4e00\u500b\u9ede\u7a81\u8b8a\uff0c\u8b93\u4eba\u985e\u7d30\u80de\u5982\u679c\u8981\u8868\u73fe\u5b8c\u6574\u7684FNDC5\u86cb\u767d\u8cea\uff0c\u5c31\u5fc5\u9808\u7528\u4e00\u500b\u4e0d\u5e38\u898b\u7684\u8d77\u59cb\u5bc6\u78bc\u5b50ATA\uff0c\u4f86\u555f\u52d5FNDC5\u819c\u86cb\u767d\u7684\u751f\u6210\u3002\u800c\u5982\u679c\u4eba\u985e\u7d30\u80de\u8981\u4f7f\u7528\u4e0b\u6e38\u53e6\u4e00\u500b\u5178\u578b\u7684ATG\u4f86\u555f\u52d5FNDC5\u7684\u8868\u73fe\uff0c\u5c31\u6703\u8b93FNDC5\u8b8a\u6210\u4e00\u500b\u300c\u88ab\u780d\u982d\u300d\u800c\u8f03\u77ed\u7684\u86cb\u767d\u8cea\u3002\u8eab\u70baIrisin\u8cc0\u723e\u8499\u7684\u524d\u8eab\uff0cFNDC5\u662f\u4e0d\u662f\u5728\u4eba\u985e\u7d30\u80de\u5167\u53ef\u4ee5\u5982\u9810\u671f\u822c\u88ab\u8868\u73fe\uff0c\u81ea\u7136\u5c31\u6703\u76f4\u63a5\u5f71\u97ff\u5230Irisin\u662f\u4e0d\u662f\u771f\u5b58\u5728\u4eba\u985e\u9ad4\u5167\u7684\u8ad6\u8faf\u4e86\u3002<\/p>\n

\u9762\u5c0d\u9019\u9ebc\u9ad8\u7684\u8cea\u7591\u8072\u6d6a\uff0cSpiegelman\u6559\u6388\u5be6\u9a57\u5ba4\u6c7a\u5b9a\u7528\u4e32\u806f\u5f0f\u8cea\u8b5c\u5100\u4f86\u5c0d\u9019\u5927\u8b0e\u984c\u4e0b\u5b9a\u8ad6\u3002\u4ed6\u5011\u8b93\u53d7\u8a66\u8005\u5206\u70ba\u5169\u7d44\uff0c\u4e26\u63a1\u96c6\u904b\u52d5\u8207\u4e0d\u904b\u52d5\u7684\u53d7\u8a66\u8005\u7684\u8840\u6db2\u6aa2\u9ad4\u3002\u4ed6\u5011\u540c\u6642\u5408\u6210\u5169\u7a2e\u653e\u5c04\u6027\u86cb\u767d\u8cea\u80dc\u80bd\uff0c\u5176\u4e2d\u4e00\u7a2e\u4f4d\u5728Irisin\u7684\u6700\u524d\u6bb5\uff0c\u53ea\u6709\u7576\u4eba\u985e\u7d30\u80de\u4f7f\u7528\u975e\u5178\u578b\u7684ATA\u8d77\u59cb\u5bc6\u78bc\u5b50\u4f86\u555f\u52d5FNDC5\u8868\u73fe\u6642\uff0c\u624d\u6709\u53ef\u80fd\u5b58\u5728\uff1b\u800c\u53e6\u4e00\u7a2e\u4f4d\u5728Irisin\u6bd4\u8f03\u5f8c\u6bb5\u7684\u4f4d\u7f6e\uff0c\u5982\u679c\u4eba\u985e\u7d30\u80de\u5167\u7684FNDC5\u662f\u65b7\u982d\u7684\uff0c\u4e5f\u53ef\u4ee5\u88ab\u5075\u6e2c\u5230\u3002\u9019\u5169\u6bb5\u4eba\u70ba\u5408\u6210\u7684\u80dc\u80bd\u90fd\u6709\u88ab\u653e\u5c04\u6027\u78b3\u6240\u6a19\u8a18\uff0c\u6240\u4ee5\u53ef\u4ee5\u8ddf\u6aa2\u9ad4\u5167\u86cb\u767d\u8cea\u6709\u6240\u5340\u9694\uff0c\u53c8\u53ef\u4ee5\u7576\u4f5c\u5b9a\u91cf\u7528\u7684\u53c3\u8003\u6307\u6a19\u3002<\/p>\n

\u800cSpiegelman\u6559\u6388\u7684\u5be6\u9a57\u7d50\u679c\u4e00\u7ffb\u5169\u77aa\u773c\u3002\u4eba\u985e\u7d30\u80de\u679c\u771f\u6709\u80fd\u529b\u8868\u73fe\u5b8c\u6574\u7684FNDC5\u86cb\u767d\u8cea\uff0c\u800c\u4e14\u5728\u4eba\u985e\u8840\u6db2\u88e1\uff0c\u53ef\u4ee5\u5075\u6e2c\u5230Irisin\u7684\u5b58\u5728\u3002\u800c\u4e14\uff0c\u5728\u904b\u52d5\u5f8c\u7684\u53d7\u8a66\u8005\u8eab\u4e0a\uff0cIrisin\u7684\u542b\u91cf\u679c\u771f\u6bd4\u8f03\u9ad8\u3002\u4ed6\u5011\u5be6\u9a57\u7d50\u679c\u767c\u8868\u5728\u5341\u6708\u4efd\u7684Cell Metabolism<\/em>\u671f\u520a\u4e0a\uff0c\u7c21\u7c21\u55ae\u55ae\u7684\u5169\u500b\u5716\u8207\u4e00\u5f35\u8868\u683c\uff0c\u6f02\u4eae\u7684\u70ba\u904b\u52d5\u8cc0\u723e\u8499Irisin\u6273\u56de\u4e00\u57ce\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Jedrychowski MP et al. Detection\u00a0and\u00a0Quantitation\u00a0of\u00a0Circulating\u00a0Human\u00a0Irisin\u00a0by Tandem Mass Spectrometry. Cell Metab.<\/em> 2015 Oct 6;22(4):734-40. doi: 10.1016\/j.cmet.2015.08.001. Epub 2015 Aug 13.<\/li>\n
  2. Albrecht E et al. Irisin - a myth rather than an exercise-inducible myokine. Sci Rep. 2015 Mar 9;5:8889. doi: 10.1038\/srep08889.<\/li>\n
  3. Bostr\u00f6m P et al. A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012 Jan 11;481(7382):463-8. doi: 10.1038\/nature10777.<\/li>\n
  4. Erickson HP. Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor? Adipocyte, 2013. 2, 289\u2013293<\/li>\n<\/ol>\n

    --<\/span><\/strong>
    \u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/span><\/strong><\/p>\n

     <\/p>\n

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